Conserved Protein Domain Family
SPEC

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cd00176: SPEC (this model, PSSM-Id:29138 is obsolete and has been replaced by 238103)
Click on image for an interactive view with Cn3D
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here
Statistics
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PSSM-Id: 29138
View PSSM: cd00176
Aligned: 168 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 1-Nov-2000
Updated: 10-Jan-2006
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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linker region
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:linker region
Evidence:
  • Comment:may form stabilizing contacts that favor dimerization
  • Comment:dimerization occurs in an antiparallel fashion

cd00176 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00176:SPEC465833729235925117798928460892846030240528928460193496311693581QUU A112956750895774413567505762750677676551CUN A13479574413562493433134795366841813479876557506776750677636684181347971348007441356590212224934347505762267024249343413479859021222670247506776249343413479826702475057622493434750677672923597505762249343313479574413561174412675562275067767292359267024249343513479826702475057622493434134798590212267556227292359744135636684187505762267024249343413479875067761347957441356161334249343375057625902122765575067767292359750677675067761347957441356249343311744121347957441356134795249343375067767655249343513479516133411744127506776765524934357506776590212224934321129581174412134795112957112957750677666907883882177751299373032581004848173032587510926751092673032587303255757352111868411749153046716750030875735217512993730325573032587510926118685118684117491575129937303255730325511749157512993730325573032557510926118685117491511868538823131186847511952643428966907887510926669078875135877510926465833751358766907887303255751092611749151186841186851174915601492511827942402117510924170549545036131186851174915465833729235925117798928460892846030240528928460193496311693581QUU A112956750895774413567505762750677676551CUN A13479574413562493433134795366841813479876557506776750677636684181347971348007441356590212224934347505762267024249343413479859021222670247506776249343413479826702475057622493434750677672923597505762249343313479574413561174412675562275067767292359267024249343513479826702475057622493434134798590212267556227292359744135636684187505762267024249343413479875067761347957441356161334249343375057625902122765575067767292359750677675067761347957441356249343311744121347957441356134795249343375067767655249343513479516133411744127506776765524934357506776590212224934321129581174412134795112957112957750677666907883882177751299373032581004848173032587510926751092673032587303255757352111868411749153046716750030875735217512993730325573032587510926118685118684117491575129937303255730325511749157512993730325573032557510926118685117491511868538823131186847511952643428966907887510926669078875135877510926465833751358766907887303255751092611749151186841186851174915601492511827942402117510924170549545036131186851174915
cd00176 Sequence Cluster
cd00176 Sequence Cluster
Sub-family Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1QUU_A       15 LAEKFRQKASTHETWAygKEQILLQKdyesa-slteVRALLRKHEAFESDLa---aHQDRVEQIAAIAQELneldy---- 86
gi 3024052  893 QLRHLQAEVKQVLGWIrnGESMLNASlvnas-slseAEQLQREHEQFQLAIe---kTHQSALQVQQKAEALlqagh---- 964
gi 1174915  799 DINAYFKQLDELEKVIktKEEWVKHTsises-srqsLPSLKDSCQRELTNLl---gLHPKIEMARASCSALmsqps---- 870
gi 4240211  193 FEHDFCKAKLALDNLLeeQAEFTGIGdsv-----mhVEQILKEHKKLEEKSq---eSLEKAQLLALVGDQLiq------- 257
gi 6690788 1811 RLSRYLDEISTVEQRMasLQEALDSRets----llsTEELARRMNELSRDKd---qLAPQFEDCVRRGKDLislrdv--- 1880
gi 465833  1431 SMQKVVTAIDDEICWFkeINVIFSSTnvgn--dvssNDVLKRKHQRLQLETq---rREQKVAKVVYLTTELvsshrrps- 1504
gi 465833   784 KLYEYDEESSTTSEWLreKMICADTIepke--desfNEVMVKKLEALTEEVen--yKPRIVETHALLEDALvtpntkdst 859
gi 4503613  228 LYTHLQGCTRQLSALAeqQRRILQQDwsdlmadpagVRREYEHFKQHELLS-----QEQSVNQLEDDGERMvelrh---- 298
gi 7292359 3520 DTQLFLKDAEILEQWIssREPQLKDTklgd--sipqVEDLLRRHEDFEKTVaaqeeKFQAIKRITMLEQLFrhql----- 3592
gi 2511779  115 EVLVFGRDAGMAEAWLcsQEPLVRSAelgc--tvdeVESLIKRHEAFQKSAvaweeRFCALEKLTALEEREkerkrkre- 191
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                             ######                                    
1QUU_A       87 -----hdavnVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQlhlefak---------raapfnNWMEGAMEDL 152
gi 3024052  965 -----ydadaIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQvcsvl-------------esleQEYRRDEDWC 1026
gi 1174915  871 ------apdfVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYletl--------------ktlkDVLNDSENKA 930
gi 4240211  258 ---------sHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEfhrql-------------dkvsQWCEAGIYLL 315
gi 6690788 1881 -----tdtgvLRDRIKALESQWRNINISIDERAKLSKQKAEQQLAYEGlkd----------------qvlSWLASTEARV 1939
gi 465833  1505 ---leykfveIDEKVAELTELLESNRQIAEIRTNRLEKWTEYFVTMNEirekeq----------lldqilDLKTGLPETV 1571
gi 465833   860 sqqtmklkavLARKQGEIESDYKALKKLVERKLKTLKAILQDADISHQiad-----------------ieQWIEVEQNQL 922
gi 4503613  299 -----pavgpIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEadsvsq----------tlaklnSNLDAKYSPA 363
gi 7292359 3593 ------eqekISKLQEKERLEKERLEQLKQRELQRLADERRRAEKQHEhrqnaasqektpifsspmvtpaQTSGPQSPAL 3666
gi 2511779  192 --eeerrkqpPAPEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQApsvn---------------gvcTDGEPSQPLL 254
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1QUU_A      153 QDmfivh-------------------------------sieeiQSLITAHEQFKATLp------eADGERQSIMAIQNEV 195
gi 3024052 1027 GGrdklgpaae------------------------mdhvipllSKHLEQKEAFLKACtla--rrnAEVFLKYIHRNNVSM 1080
gi 1174915  931 QVslnvln------------------------------dlakvEKALQEKKTLDEILe------nQKPALHKLAEETKAL 974
gi 4240211  316 ASqavdkc-----------------------------qsregvDIALNDIATFLGTV--------KEYPLLSPKEFYNEF 358
gi 6690788 1940 NGlppvai------------------------------dldriKQQHDELKPICKDYr------dYAPTIDKINDIGAQY 1983
gi 465833  1572 LAdverklqvlet-------------------vgdhmdtltikAEQMSDDEVIRTKVav----taIDQLRKKWLKMNEEL 1628
gi 465833   923 NRylasdsd----------------------------elptklDDVMTNIQRRRSNLtdikcnvvGQVQMQKIDDAFGML 974
gi 4503613  364 PGgpp-----------------------------------gapTELLQQLEAEEKRLavt---erATGDLQRRSRDVAPL 405
gi 7292359 3667 SQvqlrppfgddnehlalqkssssgmfgdrlrrgsadanvkraESMKVQPKQAKRTPsftt-rrrAQSFRKNQKGEGFDL 3745
gi 2511779  255 GQqrlehssfpe---------------------gpgpgsgdeaNGPRGERQTRTRGPap-----sAMPQSRSTESAHAAT 308
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                                                           
1QUU_A      196 EKviqsyniris---------------------ssnpystvtMDELRTKWDKVKQLVPIRDQSLQEEL 242
gi 3024052 1081 PSvashtrgp-------------------------eqqvkaiLSELLQRENRVLHFWTLKKRRLDQCQ 1123
gi 1174915  975 EKnvhpdve---------------------------klykqeFDDVQGKWNKLKVLVSKDLHLLEEIA 1015
gi 4240211  359 ELlltld-------------------------------akakAQKVLQRLDDVQEIFHKRQVSLMKLA 395
gi 6690788 1984 DAlirpesparkrstyspikrtsplrrmsgdarspsptkggiLSPLSTGSSGFGSRRSSQDGFQLSEL 2051
gi 465833  1629 KKmhqkikesief-------------------tkfvstcdtgIQCIREQEEKIGNLVRHQKPASNFEN 1677
gi 465833   975 DVfsfevhr--------------------------irqkacrLEIFKKLESQTEDVIDAIQMKLEEIN 1016
gi 4503613  406 PQrrnppqqplhvdsicd--------wdsgevqllqgeryklVDNTEPHAWVVQGPGGETKRAPAACF 465
gi 7292359 3746 PPveiqgslerkh-------------------glqsggkkapVRSWKQFHTVLCGQLVCFFKDENDFL 3794
gi 2511779  309 LPprgp---------------------------------epsAQEQMEGMLCRKQEMEAFGKKAANRS 343

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