1QUU,1CUN


Conserved Protein Domain Family
SPEC

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cd00176: SPEC (this model, PSSM-Id:29138 is obsolete and has been replaced by 238103)
Click on image for an interactive view with Cn3D
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here
Statistics
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PSSM-Id: 29138
Aligned: 168 rows
Threshold Bit Score: -1
Created: 1-Nov-2000
Updated: 10-Jan-2006
Structure
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Program:
Drawing:
Aligned Rows:
 
linker region
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:linker region
Evidence:
  • Comment:may form stabilizing contacts that favor dimerization
  • Comment:dimerization occurs in an antiparallel fashion

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
1QUU_A      15 LAEKFRQKASTHETWAygKEQILLQKdyesa-slteVRALLRKHEAFESDLa---aHQDRVEQIAAIAQELneldy---- 86   human
3024052    893 QLRHLQAEVKQVLGWIrnGESMLNASlvnas-slseAEQLQREHEQFQLAIe---kTHQSALQVQQKAEALlqagh---- 964  Norway rat
1174915    799 DINAYFKQLDELEKVIktKEEWVKHTsises-srqsLPSLKDSCQRELTNLl---gLHPKIEMARASCSALmsqps---- 870  human
4240211    193 FEHDFCKAKLALDNLLeeQAEFTGIGdsv-----mhVEQILKEHKKLEEKSq---eSLEKAQLLALVGDQLiq------- 257  human
6690788   1811 RLSRYLDEISTVEQRMasLQEALDSRets----llsTEELARRMNELSRDKd---qLAPQFEDCVRRGKDLislrdv--- 1880 fruit fly
465833    1431 SMQKVVTAIDDEICWFkeINVIFSSTnvgn--dvssNDVLKRKHQRLQLETq---rREQKVAKVVYLTTELvsshrrps- 1504 Caenorhabditis e...
465833     784 KLYEYDEESSTTSEWLreKMICADTIepke--desfNEVMVKKLEALTEEVen--yKPRIVETHALLEDALvtpntkdst 859  Caenorhabditis e...
4503613    228 LYTHLQGCTRQLSALAeqQRRILQQDwsdlmadpagVRREYEHFKQHELLS-----QEQSVNQLEDDGERMvelrh---- 298  human
7292359   3520 DTQLFLKDAEILEQWIssREPQLKDTklgd--sipqVEDLLRRHEDFEKTVaaqeeKFQAIKRITMLEQLFrhql----- 3592 fruit fly
2511779    115 EVLVFGRDAGMAEAWLcsQEPLVRSAelgc--tvdeVESLIKRHEAFQKSAvaweeRFCALEKLTALEEREkerkrkre- 191  human
Feature 1                                            ######                                    
1QUU_A      87 -----hdavnVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQlhlefak---------raapfnNWMEGAMEDL 152  human
3024052    965 -----ydadaIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQvcsvl-------------esleQEYRRDEDWC 1026 Norway rat
1174915    871 ------apdfVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYletl--------------ktlkDVLNDSENKA 930  human
4240211    258 ---------sHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEfhrql-------------dkvsQWCEAGIYLL 315  human
6690788   1881 -----tdtgvLRDRIKALESQWRNINISIDERAKLSKQKAEQQLAYEGlkd----------------qvlSWLASTEARV 1939 fruit fly
465833    1505 ---leykfveIDEKVAELTELLESNRQIAEIRTNRLEKWTEYFVTMNEirekeq----------lldqilDLKTGLPETV 1571 Caenorhabditis e...
465833     860 sqqtmklkavLARKQGEIESDYKALKKLVERKLKTLKAILQDADISHQiad-----------------ieQWIEVEQNQL 922  Caenorhabditis e...
4503613    299 -----pavgpIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEadsvsq----------tlaklnSNLDAKYSPA 363  human
7292359   3593 ------eqekISKLQEKERLEKERLEQLKQRELQRLADERRRAEKQHEhrqnaasqektpifsspmvtpaQTSGPQSPAL 3666 fruit fly
2511779    192 --eeerrkqpPAPEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQApsvn---------------gvcTDGEPSQPLL 254  human
Feature 1                                                                                      
1QUU_A     153 QDmfivh-------------------------------sieeiQSLITAHEQFKATLp------eADGERQSIMAIQNEV 195  human
3024052   1027 GGrdklgpaae------------------------mdhvipllSKHLEQKEAFLKACtla--rrnAEVFLKYIHRNNVSM 1080 Norway rat
1174915    931 QVslnvln------------------------------dlakvEKALQEKKTLDEILe------nQKPALHKLAEETKAL 974  human
4240211    316 ASqavdkc-----------------------------qsregvDIALNDIATFLGTV--------KEYPLLSPKEFYNEF 358  human
6690788   1940 NGlppvai------------------------------dldriKQQHDELKPICKDYr------dYAPTIDKINDIGAQY 1983 fruit fly
465833    1572 LAdverklqvlet-------------------vgdhmdtltikAEQMSDDEVIRTKVav----taIDQLRKKWLKMNEEL 1628 Caenorhabditis e...
465833     923 NRylasdsd----------------------------elptklDDVMTNIQRRRSNLtdikcnvvGQVQMQKIDDAFGML 974  Caenorhabditis e...
4503613    364 PGgpp-----------------------------------gapTELLQQLEAEEKRLavt---erATGDLQRRSRDVAPL 405  human
7292359   3667 SQvqlrppfgddnehlalqkssssgmfgdrlrrgsadanvkraESMKVQPKQAKRTPsftt-rrrAQSFRKNQKGEGFDL 3745 fruit fly
2511779    255 GQqrlehssfpe---------------------gpgpgsgdeaNGPRGERQTRTRGPap-----sAMPQSRSTESAHAAT 308  human
Feature 1                                                                          
1QUU_A     196 EKviqsyniris---------------------ssnpystvtMDELRTKWDKVKQLVPIRDQSLQEEL 242  human
3024052   1081 PSvashtrgp-------------------------eqqvkaiLSELLQRENRVLHFWTLKKRRLDQCQ 1123 Norway rat
1174915    975 EKnvhpdve---------------------------klykqeFDDVQGKWNKLKVLVSKDLHLLEEIA 1015 human
4240211    359 ELlltld-------------------------------akakAQKVLQRLDDVQEIFHKRQVSLMKLA 395  human
6690788   1984 DAlirpesparkrstyspikrtsplrrmsgdarspsptkggiLSPLSTGSSGFGSRRSSQDGFQLSEL 2051 fruit fly
465833    1629 KKmhqkikesief-------------------tkfvstcdtgIQCIREQEEKIGNLVRHQKPASNFEN 1677 Caenorhabditis elegans
465833     975 DVfsfevhr--------------------------irqkacrLEIFKKLESQTEDVIDAIQMKLEEIN 1016 Caenorhabditis elegans
4503613    406 PQrrnppqqplhvdsicd--------wdsgevqllqgeryklVDNTEPHAWVVQGPGGETKRAPAACF 465  human
7292359   3746 PPveiqgslerkh-------------------glqsggkkapVRSWKQFHTVLCGQLVCFFKDENDFL 3794 fruit fly
2511779    309 LPprgp---------------------------------epsAQEQMEGMLCRKQEMEAFGKKAANRS 343  human

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