Conserved Protein Domain Family
Holin_2-3
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pfam13272: Holin_2-3 (this model, PSSM-Id:290012 is obsolete and has been replaced by 433075)
Putative 2/3 transmembrane domain holin
Holin_2-3 is a putative holins with 2 or 3 transmembrane segments. It consists of many proteobacterial proteins ranging in size from about 70 aas to 120 aas. They have 2 or 3 predicted TMSs. Although some are annotated as phage proteins or holins, none appears to be functionally characterized.
Links
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Statistics
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PSSM-Id: 290012
Aligned: 16 rows
Threshold Bit Score: 91.5976
Created: 14-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7VLB5        13 LLSWVVSSLVLLIVIALVSPQQLPVVLYKLALVCMAAIIGYHLDRALFPYSSPGSYLainwkvyfkhqHTKNSDQAKPEY 92  [Haemophilus] d...
Q6D3G4         9 LTGWIMTSAFLFTVIGLISPQQLPVTVYKLSLISLAAVLGYWLDRSLFPKARPGLFL-----------EQGDEPVPRGRF 77  Pectobacterium ...
Q72D02        17 MGWCLALSVLLLGLVGLFSPQQLPVIIYKGSLLSLAGTGGYWLDRWAFPYARPDSYLvye------wkDEDEFSDGVEDY 90  Desulfovibrio v...
Q728A6        15 MLWCAFIALLFLLAVGCIAPQQLPVILYKASLILLAAFTGYWIDRWAFPYARPDSYLvsd------wrRQRGFVPCDAND 88  Desulfovibrio v...
AGC50749      25 fsiCVILTVLLFLALVIFSPRQLPVIHYKFALCLLAGLAGYWLDRVLFPFANPSGYLced-----wkeHINGCQTGRADY 99  Lawsonia intrac...
ACL07679      15 MLLCSLIAVALWLFLWHASPREALIVTYKVTLVMLAAVAAYWIDRWLFPYARPEGYLceew---rdriGSGDWPDGVDDF 91  Desulfovibrio v...
YP_001111251  10 LTSWLVAAIILVAAIALFSPQQLPVALYKLSLVSLAAVVAYWLDRGLFPYARPDSYLetd------wrYGPDGLTPEADY 83  Burkholderia ph...
WP_012612411  16 MGWCMALAVVLLLGVARFAPQNLPVIMYKGSLLTLASVGGYWLARWVFPYGRPDQWLtgdra-vtlaaSAGAMLSERMGV 94  Desulfovibrio v...
WP_014703413  10 LSGWLVVALVLIVLIALISPTQLPVVLYKLSLVTFATVLAYWLDRTLFYYARPHQLFae-----------aNGLHKDSQF 78  Methylophaga sp...
WP_013515330   6 MTSIIIPALALLAVVALAAPQQLAVIAYKVALITIAGVAGYCLDRALFPYARPHEYIgp-------lrRLGPTAQPRLWV 78  Desulfovibrio a...

Q7VLB5        93 PVHKGYELIFALV-------VLRRALIVGTVILGVTLGL 124 [Haemophilus] ducreyi
Q6D3G4        78 PVRDGHHTVFAAA-------MLRRALIVSAVCIGVAMGL 109 Pectobacterium atrosepticum
Q72D02        91 PVVENCQRLFIAA-------SLRRAAVMAVAMLAVGLGL 122 Desulfovibrio vulgaris str. Hildenborough
Q728A6        89 PIARGYARIFAAA-------LVRRAIIMGAAMLAVGLGL 120 Desulfovibrio vulgaris str. Hildenborough
AGC50749     100 PIVIEYQKSFCTA-------MLRQAAIVVGTMLAVSLGL 131 Lawsonia intracellularis N343
ACL07679      92 PVVTESKTLFMVA-------CLRRVVLMGAAMLAVGLGL 123 Desulfovibrio vulgaris str. 'Miyazaki F'
YP_001111251  84 RVAKGYELVFAAA-------MLRRALIvlgvvvgvalgl 115 Burkholderia phage phiE255
WP_012612411  95 SLPVGPGTVLAVAvgmacvsMICRALLILGAMLAVGLGL 133 Desulfovibrio vulgaris
WP_014703413  79 YDSNQLRLQASLA-------TLRRALIVLAVVLGMTLGL 110 Methylophaga sp. JAM7
WP_013515330  79 PCV--------VA-------QLRRAMIVAAAMLAVGLGL 102 Desulfovibrio aespoeensis
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