31BI,2MIB,2ILA,1IRP,1ITB


Conserved Protein Domain Family
IL1
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cd00100: IL1 (this model, PSSM-Id:28984 is obsolete and has been replaced by 466776)
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Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
Links
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Statistics
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PSSM-Id: 28984
Aligned: 15 rows
Threshold Bit Score: -1
Created: 1-Nov-2000
Updated: 10-Jan-2006
Structure
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Program:
Drawing:
Aligned Rows:
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receptorreceptor
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding site
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ##         # #  # #  #  #       #                                       
31BI        7 NCTLRDs-QQKSLVMSGpyELKALHLQgqDMEQQVVFSMSFVqgeesndkIPVALGLKEKNLYLSSVlkddkpTLQLESV 85  human
2ILA       17 EFILNDa-LNQSIIRANaqYLTAAALH--NLDEAVKFDMGAYksskddakITVILRISKTQLYVTAQde--dqPVLLKEM 91  human
1IRP       13 AFRIWDv-NQKTFYLRNn-QLVAGYLQgpNVNLEEKIDVVPIe------pHALFLGIHGGKMCLSCVksgdetRLQLEAV 84  human
1ITB_A      7 NCTLRDs-QQKSLVMSGpyELKALHLQgqDMEQQVVFSMSFVqgeesndkIPVALGLKEKNLYLSCVlkddkpTLQLESV 85  human
124302    120 KCKLQDr-EQKSLVLASpcVLKALHLLsqEMNREVVFCMSFVqgeerdnkIPVALGIKDKNLYLSCVkkgdtpTLQLEEV 198 Bos taurus
1170531   122 DYTFRDi-SQKSLVLSGsyELRALHLNgqNMNQQVVFRMSFVhgeenskkIPVVLCIKKNNLYLSCVmkdgkpTLQLEML 200 cat
124305    121 ECKLQDk-DHKSLVLAGphMLKALHLLtgDLKREVVFCMSFVqgddsnnkIPVTLGIKGKNLYLSCVmkdntpTLQLEDI 199 pig
124314     37 AFRIWDv-NQKTFYLRNn-QLVAGYLQgpNAKLEERIDVVPLe------pQLLFLGIQRGKLCLSCVksgdkmKLHLEAV 108 Oryctolagus cuniculus
124315     38 AFRIWDt-NQKTFYLRNn-QLIAGYLQgpNTKLEEKIDMVPId------fRNVFLGIHGGKLCLSCVksgddtKLQLEEV 109 Norway rat
124296    133 ECILNDalNQSIIRDMSgpYLTATTLN--NLEEAVKFDMVAYvsee-dsqLPVTLRISKTQLFVSAQne--dePVLLKEM 207 Bos taurus

Feature 1           ###           # # ###                    #                    
31BI       86 DpknyPKKKM---EKRFVFNKIEINNKLEFESAQFPNWYISTSQaenMPVFLGGtk-ggQDITDFTMQ 149 human
2ILA       92 Pe---IPKTItgsETNLLFFWETHGTKNYFTSVAHPNLFIATKQd--YWVCLAGg---pPSITDFQIL 151 human
1IRP       85 NitdlSENRKq--DKRFAFIRSDSGPTTSFESAACPGWFLCTAMeadQPVSLTNmpdegVMVTKFYFQ 150 human
1ITB_A     86 DpknyPKKKM---EKRFVFNKIEINNKLEFESAQFPNWYISTSQaenMPVFLGGtk-ggQDITDFTMQ 149 human
124302    199 DpkvyPKRNM---EKRFVFYKTEIKNTVEFESVLYPNWYISTSQieeRPVFLGHfr-agQDITDFRME 262 Bos taurus
1170531   201 DpkvyPKKKM---EKRFVFNKTEIKGNVEFESSQFPNWYISTSQaeeMPVFLGNtk-ggQDITDFIME 264 cat
124305    200 DpkryPKRDM---EKRFVFYKTEIKNRVEFESALYPNWYISTSQaeqKPVFLGNsk-grQDITDFTME 263 pig
124314    109 NitdlGKNKEq--DKRFTFIRSNSGPTTTFESASCPGWFLCTALeadQPVSLTNtpddsIVVTKFYFQ 174 Oryctolagus cuniculus
124315    110 NitdlNKNKEe--DKRFTFIRSETGPTTSFESLACPGWFLCTTLeadHPVSLTNtpkepCTVTKFYFQ 175 Norway rat
124296    208 Pe---TPKIIk-dETNLLFFWEKHGSMDYFKSVAHPKLFIATKQe--KLVHMASg---pPSITDFQIL 266 Bos taurus

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