Conserved Protein Domain Family
DSRM

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cd00048: DSRM 
Click on image for an interactive view with Cn3D
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, RNases H1, and dsRNA dependent adenosine deaminases.
BioAssay Targets and Results
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CID: 6419764
AID: 606664
GI: 125527
IC50: 0.1µM
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Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay
Target Name: Interferon-induced, double-stranded RNA-activated protein kinase
Chemical Name: Indirubin E804
IC50: 0.1µM
CID: 56662963
AID: 606664
GI: 125527
IC50: 0.1µM
more
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay
Target Name: Interferon-induced, double-stranded RNA-activated protein kinase
Chemical Name: CHEMBL1802629
IC50: 0.1µM
CID: 56669806
AID: 606664
GI: 125527
IC50: 0.1µM
more
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay
Target Name: Interferon-induced, double-stranded RNA-activated protein kinase
Chemical Name: CHEMBL1802782
IC50: 0.1µM
Statistics
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PSSM-Id: 28930
View PSSM: cd00048
Aligned: 154 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 1-Nov-2000
Updated: 9-Mar-2011
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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dsRNA binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:dsRNA binding site [nucleic acid binding site]
Evidence:

cd00048 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00048:DSRM9229939216016313384384152375501522886244328391338438415228862216016392299391409021575101891284416172929717531196622601813476442158883771798757016125807753119025005521113431318203192250054911730937531195158388371710608175457821579385725005545738536250055871063971713768213507897492906157929407531276753119475311881592681615895025753118925005531335776315615052753127515674631159031701680384513878708609410917106097531197172315997531191753119315828634172277762500556158072721524132315220196671563415242329152423291751126446614912715636503972500541391343625005413650397391343625005571DI2 A12849779179452701507905263065838502471QU6 A9506993573450846543172972981EKZ A9789804722953413495097898041519663151965938502511519663729729875049259629651129540298473175121597770273777027717065337770273777027377702777512160170653296338389633665120850174650711515047366782831255277498101586013729921221340552829669181427077986247546826675434010834850151504114490937115580507798626171007513495070238581519663702385812643664630658152409327485642450558174856421285326015207991450558133343803334381179452707302074175517247520835162157199229939216016313384384152375501522886244328391338438415228862216016392299391409021575101891284416172929717531196622601813476442158883771798757016125807753119025005521113431318203192250054911730937531195158388371710608175457821579385725005545738536250055871063971713768213507897492906157929407531276753119475311881592681615895025753118925005531335776315615052753127515674631159031701680384513878708609410917106097531197172315997531191753119315828634172277762500556158072721524132315220196671563415242329152423291751126446614912715636503972500541391343625005413650397391343625005571DI2 A12849779179452701507905263065838502471QU6 A9506993573450846543172972981EKZ A978980472295341349509789804151966315196593850251151966372972987504925962965112954029847317512159777027377702771706533777027377702737770277751216017065329633838963366512085017465071151504736678283125527749810158601372992122134055282966918142707798624754682667543401083485015150411449093711558050779862617100751349507023858151966370238581264366463065815240932748564245055817485642128532601520799145055813334380333438117945270730207417551724752083516215719
cd00048 Sequence Cluster
cd00048 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #     ##                                                        ####  #         
1DI2_A         1 MPVGSLQELAvqk----gwrLPEYTVaQESGpph--krEFTITCRVet---------fVETGSGTSKQVAKRVAAEKLLT 65
gi 129540    285 RPIDKLAKSKlfhky-stlgHIEYRWvDGAGgs---aeGYVIACIFng--------keVARAWGANQKDAGSRAAMQALE 352
gi 466149    275 DPKKALQKFFere-----gfDMNFEF-SEQGqgh--thKWVCSIELpveidgvdraftASATVSTSKKDAQIQCALDACR 346
gi 9629651    23 DKISTLKMVAdyy-----qkEVKYDFdAVESpre--apVFRCTCRFlg---------yTIMTQGIGKKNPKQEAARQMLL 86
gi 7023858   111 AIYRPLDPKPfpnyranynfRGMYNQrYHCPvp----kIFYVQLTVgn---------nEFFGEGKTRQAARHNAAMKALQ 177
gi 2500541   177 NAKARLNQYFqke-----kiQGEYKY-TQVGpdh--nrSFIAEMTIyikqi---grriFAREHGSNKKLAAQSCALSLVR 245
gi 7485642   869 GSITALRELCase-----glEMAFQSqRQLPsdmvhrdELHAQVEIdg--------rvVGEGVGSTWDEARMQAAERALS 935
gi 3913436   171 NSKKALNEFLqkm----rlpQVNYGTkIRESntv-ktmETTAQIFVpqin-----knlVGKGTGSNKKVSEAACAMNIVR 240
gi 12643664   94 DPYSRMQSTYnyn-----mrGGAYPPrYFYPfpv-pplLYQVELSVgg---------qQFNGKGKTRQAAKHDAAAKALR 158
gi 3650397   166 NAKAKLHQFMqmn-----kiQADYRY-TPVGpdh--arSFMAEMKIfvkql---nrtiTGRESGSNKQTASKSCALSLVR 234

                 ..
Feature 1          
1DI2_A        66 KF 67
gi 129540    353 VL 354
gi 466149    347 IL 348
gi 9629651    87 LL 88
gi 7023858   178 AL 179
gi 2500541   246 QL 247
gi 7485642   936 SV 937
gi 3913436   241 QM 242
gi 12643664  159 IL 160
gi 3650397   235 QL 236

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