1DF0,1KFU


Conserved Protein Domain Family
CysPc

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cd00044: CysPc (this model, PSSM-Id:28925 is obsolete and has been replaced by 238004)
Click on image for an interactive view with Cn3D
Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
Statistics
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Aligned: 36 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 1-Nov-2000
Updated: 9-Mar-2011
Structure
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Program:
Drawing:
Aligned Rows:
 
catalytic site
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic site [active site]
Evidence:
  • Comment:has an active site cysteine; catalysis proceeds through a thioester intermediate.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1DF0_A     34 TLRNECLEAGALFQDPSFPalpsslgfke-----------------lgpyssktrgIEWKRPTEICAD------------ 84  Norway rat
CAB95475  167 DTLAACIAKKTKFVDLIFPpgqeslqi---------------------gtphklkvIPWERPSMYLSDena--------- 216 Trypanosoma brucei
NP_055111 214 TTSKINGIEYVPFMNVDLRerfaypmpfcdrw-----------gklplspkqkttfSKWVRPEDLTNN------------ 270 human
7507052   218 TTSNINNKLYVPFHNYDKVnefkgqqgkftdpe----------gkisltqkqrmklKCWKRVSELFEN------------ 275 Caenorhabditis ele...
AAG48627  249 QLLEHCTANQVPYIDCSFRpcdrslsrp-------------------dvdvhnlqsLPWRRPCDYIPKsql--------- 300 Trypanosoma brucei
AAG48626  201 ELLKLCSDSLVRYADINFLpsnsmfsrl-------------------dgdgrfiqpVEVRRPSEFAQCde---------- 251 Trypanosoma brucei
CAA91013  102 TREDIILLQGAKLNGFIFPpwkaepsltefetgtngdvlftdkpdlhlsnlqrdifAGWKRPHELLSGqvdda-----gm 176 Aspergillus nidulans
AAD28472  104 TREEIILLEGAKLNGFIFPpwstspgsdefkredges-pftdkpdlhlsypqrkvfDGWKRPSELLAKdtedv-----yt 177 Aspergillus oryzae
CAC14603   75 LAEKIVYLSSRTNYGYALPweyatpvsalkksddl-----yvdatdgglrqsqhrdVSWLRIPHVFASs----------- 138 Yarrowia lipolytica
NP_484413 198 KDLKTIVAAGNNFNIEDHVkwlsaqvangass------------gmsasnfesklvGRWFLGTVAPTPefngkkltytev 265 Nostoc sp. PCC 7120
Feature 1                            #                                                        
1DF0_A     85 ---PQFIIGgatrTDICQGALGDSWLLAAIASLTLNEE---------ILARVVPLdqsfq----enyaGIFHFQFWQYge 148 Norway rat
CAB95475  217 -lhARLFRNnihpGNIDEGELGDSWFTGALACMAEFPD---------RVRDMFRHprsieegknereiGAYRVTFNKDgw 286 Trypanosoma brucei
NP_055111 271 ---PTMIYTvs-sFSIKQTIVSDCSFVASLAISAAYERrfn----kkLITGIIYPqnkdge-peynpcGKYMVKLHLNgv 341 human
7507052   276 ---PTIIFSid-cHTIKQTVISDCSFISSLSIAALYEKrfk----kqLVTSIIFPqdangk-piynpaGKYMFKFHLNga 346 Caenorhabditis ele...
AAG48627  301 devRLFRRSia-pSHVTQGELGDSYFTSAVACLAEMPD---------KIRDLFRHpvspsvgkaerrvGAYWVTLNCGgw 370 Trypanosoma brucei
AAG48626  252 -enIDAVRGvvlsSCVEAGTLGDSWFVSALSLLATDEE---------RVKAMFASttpa-----ekqmGAYRVLLNKDgw 316 Trypanosoma brucei
CAA91013  177 plnPVMTVSg--nTDLVQDVLTDCSVVASLCATTSRSErgl---ddtLLPIVYPCihnsmk-sdispsGKYIFRFYFNgc 250 Aspergillus nidulans
AAD28472  178 kvvPVMSVPg--kTDLVQDMLTDCSVVASLCATTSMLErgq---cthFLPMIYPSrgssq----pspsGKYIFRFYFNgc 248 Aspergillus oryzae
CAC14603  139 --dAVFTWSg--fETLYQDGLENCSFVASLLSIGVMEKrcn----ysLLKEALLDkssnhhlgtppssGRYDIKLFINgc 210 Yarrowia lipolytica
NP_484413 266 kgnLFGSTNkaeiGDIHQGIINDCTFLAALGATFSRQSddsgnasssVIKNMIKDngdn-----tytvRFYSGKYYAPge 340 Nostoc sp. PCC 7120
Feature 1                                                                                     
1DF0_A    149 WVEVVVDDRLPTKDGE--LLFVHSaeg---sefWSALLEKAYAKINGcyeal-------sggaTTEGFEDFTGGIAEWYE 216 Norway rat
CAB95475  287 WTNVIIDDYLPCSGGH--PMFARSygdp--melWVSLAQKAYAKLHGgygfl-------vvgdPLRALQDLTGFPCSSFN 355 Trypanosoma brucei
NP_055111 342 PRKVIIDDQLPVDHKGe-LLCSYSnnk---selWVSLIEKAYMKVMGgydf--------pgsnSNIDLHALTGWIPERIA 409 human
7507052   347 WRKVLIDDYFPVDENNr-MMCSQTenk---gelWVSLLEKAYMKVMGgydf--------pgsnSNIDLNALTGWIPERIE 414 Caenorhabditis ele...
AAG48627  371 WRPTVIDDYLPAYREG--PEYAHCavdf--rrlWVALLEKAYAKIHHsysni-------asgdPLDPLQDLTGFPITRFD 439 Trypanosoma brucei
AAG48626  317 WKNILVDDFLPTVGGV--PCYARCidds--gelCLSLLQKAYAKLYGfyasi-------tggdTFFALQNFTGAPVYRFD 385 Trypanosoma brucei
CAA91013  251 FRKVVIDDRLPSSKTSr-SLYMIDrnhr--nfmWPALVEKAYLKLRGgyef--------pgsnSGTDLWVLTGWIPEQVF 319 Aspergillus nidulans
AAD28472  249 FRKVIIDDRLPSSKTSrsLHVIDRknp---nflWPALVEKAYLKLRGgydf--------pgsnSGTDLWVLTGWIPEQVF 317 Aspergillus oryzae
CAC14603  211 DRRITIDDRFPIREPS--LPNMYLrsytnptlvWPALLEKAFMKVLDgydy--------agshAGGDTFVLCKWFPEFVS 280 Yarrowia lipolytica
NP_484413 341 AQYVTVDRRIATNIAA--QRNDGVl--------WVALVEKAYAQWREwtdgrpgyniignggaLAPPLSFITGRKTNNYS 410 Nostoc sp. PCC 7120
Feature 1                                                                          #          
1DF0_A    217 Lrkp--------ppnLFKIIQKALEKGSLLGCSIDItsaads----------------eavtyqKLVKGHAYSVTGAEEV 272 Norway rat
CAB95475  356 Tafenak--mnggeeLFVHLLQYGQTSYQTILTVPTrgalklqga-----------sveayeatGLLPGHVYTVLSVMPF 422 Trypanosoma brucei
NP_055111 410 Mhsdsqt--fskdnsFRMLYQRFHKGDVLITASTGMmteae-------------------gekwGLVPTHAYAVLDIREF 468 human
7507052   415 Lsdtska---dpdevFRKLFDRFHRGDCLITLATGKmtedm-------------------qkrsGLVETHAYAVIDIRCV 472 Caenorhabditis ele...
AAG48627  440 Tdwesav---ngddkLFKRLVMYNKRGYITVLYTPPpaalkaaqpsdtspttearkprvtckelGLQAHSGYSVLQVKCF 516 Trypanosoma brucei
AAG48626  386 KawrdaatdeekknaLIQKITGYVEAHNPVILSVPTgrkaa------------------tavanGLREGYSYALLSVHNF 447 Trypanosoma brucei
CAA91013  320 Lhsdev----tadqiWSDLFKSFHSGDVLLTIGTGKltere-------------------qkelGLVSEHDYAILDMKEL 376 Aspergillus nidulans
AAD28472  318 Lhnddv----tgdqlWKRLYRSFHQGDVLLTIGTGEltere-------------------qrelGLVSEHDYAILDMKES 374 Aspergillus oryzae
CAC14603  281 Ltsyhd-----tnglWRYIYDSWLQGDVLLCLGTGSfsree-------------------adykGLLGEHDYAVLELREI 336 Yarrowia lipolytica
NP_484413 411 Ksr-----------iSFSLLEDALKAGKAITTSRSGkd------------------------tsFILGSHAYSVSNAYIS 455 Nostoc sp. PCC 7120
Feature 1                  #                                                             
1DF0_A    273 essgslQKLIRIRNPWGqvewtgkwndncpswn-----tvdpevranlterqeDGEFWMSFSDFLRHYSRLEICN 342 Norway rat
CAB95475  423 pe--ynLRLLLLRNSWAnhskhrwngawkrgsek--wkqypgvaaacagacdaDGVLCVEWSEALALFAGCGVCF 493 Trypanosoma brucei
NP_055111 469 k----gLRFIQLKNPWShlrwkgrysendvknwtp-elqkylnfdprtaqkidNGIFWISWDDLCQYYDVIYLSW 538 human
7507052   473 e----tKRLLKVKNPWThsrwkgnfsdkdkvnwta-kmknalafdpevaaekdDGIFWIDYESVRHFFDVIYVNW 542 Caenorhabditis elegans
AAG48627  517 ee--mgLFLLQVRNPWStgeewkgrwsksdklweeypsvqsacfpsgmespkdDNMFWLQWSDALNVFAGGGVCH 589 Trypanosoma brucei
AAG48626  448 pe--enITLLKMFNPWEpampwsgqwregsdkwt---ehseiqsscepcfeahDGIFFIEWSEAVEVFNGCGVLY 517 Trypanosoma brucei
CAA91013  377 k----gRRQFLIKNPWAgtdavypalfad-------------pgpfpnspflsPGTFWMDCEMVLQNFENLYLNW 434 Aspergillus nidulans
AAD28472  375 k----gRRQLLVKNPWAgadtapgdngsls----------asqdlphnppsfePGTFWMDCEKLLQHFENLYLNW 435 Aspergillus oryzae
CAC14603  337 qdgcntAHILRIRDPLLfgpfsnpknplveesn-----rlaklvdgknvdmasRGEIWMDFNQATREYQSLYLNW 406 Yarrowia lipolytica
NP_484413 456 as---gEQRVVVRNPWGvdgka--------------------------ksganDGFINLSYQEFINSFNLGVSVS 501 Nostoc sp. PCC 7120

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