Conserved Protein Domain Family
CysPc

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cd00044: CysPc (this model, PSSM-Id:28925 is obsolete and has been replaced by 238004)
Click on image for an interactive view with Cn3D
Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
Statistics
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PSSM-Id: 28925
View PSSM: cd00044
Aligned: 36 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 1-Nov-2000
Updated: 9-Mar-2011
Structure
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Program:
Drawing:
Aligned Rows:
 
catalytic site
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic site [active site]
Evidence:
  • Comment:has an active site cysteine; catalysis proceeds through a thioester intermediate.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1DF0_A       34 TLRNECLEAGALFQDPSFPalpsslgfke-----------------lgpyssktrgIEWKRPTEICAD------------ 84
gi 9366713  167 DTLAACIAKKTKFVDLIFPpgqeslqi---------------------gtphklkvIPWERPSMYLSDena--------- 216
gi 7656959  214 TTSKINGIEYVPFMNVDLRerfaypmpfcdrw-----------gklplspkqkttfSKWVRPEDLTNN------------ 270
gi 7507052  218 TTSNINNKLYVPFHNYDKVnefkgqqgkftdpe----------gkisltqkqrmklKCWKRVSELFEN------------ 275
gi 12082826 249 QLLEHCTANQVPYIDCSFRpcdrslsrp-------------------dvdvhnlqsLPWRRPCDYIPKsql--------- 300
gi 12082825 201 ELLKLCSDSLVRYADINFLpsnsmfsrl-------------------dgdgrfiqpVEVRRPSEFAQCde---------- 251
gi 10241545 102 TREDIILLQGAKLNGFIFPpwkaepsltefetgtngdvlftdkpdlhlsnlqrdifAGWKRPHELLSGqvdda-----gm 176
gi 4731363  104 TREEIILLEGAKLNGFIFPpwstspgsdefkredges-pftdkpdlhlsypqrkvfDGWKRPSELLAKdtedv-----yt 177
gi 11071673  75 LAEKIVYLSSRTNYGYALPweyatpvsalkksddl-----yvdatdgglrqsqhrdVSWLRIPHVFASs----------- 138
gi 17227865 198 KDLKTIVAAGNNFNIEDHVkwlsaqvangass------------gmsasnfesklvGRWFLGTVAPTPefngkkltytev 265
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              #                                                        
1DF0_A       85 ---PQFIIGgatrTDICQGALGDSWLLAAIASLTLNEE---------ILARVVPLdqsfq----enyaGIFHFQFWQYge 148
gi 9366713  217 -lhARLFRNnihpGNIDEGELGDSWFTGALACMAEFPD---------RVRDMFRHprsieegknereiGAYRVTFNKDgw 286
gi 7656959  271 ---PTMIYTvs-sFSIKQTIVSDCSFVASLAISAAYERrfn----kkLITGIIYPqnkdge-peynpcGKYMVKLHLNgv 341
gi 7507052  276 ---PTIIFSid-cHTIKQTVISDCSFISSLSIAALYEKrfk----kqLVTSIIFPqdangk-piynpaGKYMFKFHLNga 346
gi 12082826 301 devRLFRRSia-pSHVTQGELGDSYFTSAVACLAEMPD---------KIRDLFRHpvspsvgkaerrvGAYWVTLNCGgw 370
gi 12082825 252 -enIDAVRGvvlsSCVEAGTLGDSWFVSALSLLATDEE---------RVKAMFASttpa-----ekqmGAYRVLLNKDgw 316
gi 10241545 177 plnPVMTVSg--nTDLVQDVLTDCSVVASLCATTSRSErgl---ddtLLPIVYPCihnsmk-sdispsGKYIFRFYFNgc 250
gi 4731363  178 kvvPVMSVPg--kTDLVQDMLTDCSVVASLCATTSMLErgq---cthFLPMIYPSrgssq----pspsGKYIFRFYFNgc 248
gi 11071673 139 --dAVFTWSg--fETLYQDGLENCSFVASLLSIGVMEKrcn----ysLLKEALLDkssnhhlgtppssGRYDIKLFINgc 210
gi 17227865 266 kgnLFGSTNkaeiGDIHQGIINDCTFLAALGATFSRQSddsgnasssVIKNMIKDngdn-----tytvRFYSGKYYAPge 340
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1DF0_A      149 WVEVVVDDRLPTKDGE--LLFVHSaeg---sefWSALLEKAYAKINGcyeal-------sggaTTEGFEDFTGGIAEWYE 216
gi 9366713  287 WTNVIIDDYLPCSGGH--PMFARSygdp--melWVSLAQKAYAKLHGgygfl-------vvgdPLRALQDLTGFPCSSFN 355
gi 7656959  342 PRKVIIDDQLPVDHKGe-LLCSYSnnk---selWVSLIEKAYMKVMGgydf--------pgsnSNIDLHALTGWIPERIA 409
gi 7507052  347 WRKVLIDDYFPVDENNr-MMCSQTenk---gelWVSLLEKAYMKVMGgydf--------pgsnSNIDLNALTGWIPERIE 414
gi 12082826 371 WRPTVIDDYLPAYREG--PEYAHCavdf--rrlWVALLEKAYAKIHHsysni-------asgdPLDPLQDLTGFPITRFD 439
gi 12082825 317 WKNILVDDFLPTVGGV--PCYARCidds--gelCLSLLQKAYAKLYGfyasi-------tggdTFFALQNFTGAPVYRFD 385
gi 10241545 251 FRKVVIDDRLPSSKTSr-SLYMIDrnhr--nfmWPALVEKAYLKLRGgyef--------pgsnSGTDLWVLTGWIPEQVF 319
gi 4731363  249 FRKVIIDDRLPSSKTSrsLHVIDRknp---nflWPALVEKAYLKLRGgydf--------pgsnSGTDLWVLTGWIPEQVF 317
gi 11071673 211 DRRITIDDRFPIREPS--LPNMYLrsytnptlvWPALLEKAFMKVLDgydy--------agshAGGDTFVLCKWFPEFVS 280
gi 17227865 341 AQYVTVDRRIATNIAA--QRNDGVl--------WVALVEKAYAQWREwtdgrpgyniignggaLAPPLSFITGRKTNNYS 410
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                            #          
1DF0_A      217 Lrkp--------ppnLFKIIQKALEKGSLLGCSIDItsaads----------------eavtyqKLVKGHAYSVTGAEEV 272
gi 9366713  356 Tafenak--mnggeeLFVHLLQYGQTSYQTILTVPTrgalklqga-----------sveayeatGLLPGHVYTVLSVMPF 422
gi 7656959  410 Mhsdsqt--fskdnsFRMLYQRFHKGDVLITASTGMmteae-------------------gekwGLVPTHAYAVLDIREF 468
gi 7507052  415 Lsdtska---dpdevFRKLFDRFHRGDCLITLATGKmtedm-------------------qkrsGLVETHAYAVIDIRCV 472
gi 12082826 440 Tdwesav---ngddkLFKRLVMYNKRGYITVLYTPPpaalkaaqpsdtspttearkprvtckelGLQAHSGYSVLQVKCF 516
gi 12082825 386 KawrdaatdeekknaLIQKITGYVEAHNPVILSVPTgrkaa------------------tavanGLREGYSYALLSVHNF 447
gi 10241545 320 Lhsdev----tadqiWSDLFKSFHSGDVLLTIGTGKltere-------------------qkelGLVSEHDYAILDMKEL 376
gi 4731363  318 Lhnddv----tgdqlWKRLYRSFHQGDVLLTIGTGEltere-------------------qrelGLVSEHDYAILDMKES 374
gi 11071673 281 Ltsyhd-----tnglWRYIYDSWLQGDVLLCLGTGSfsree-------------------adykGLLGEHDYAVLELREI 336
gi 17227865 411 Ksr-----------iSFSLLEDALKAGKAITTSRSGkd------------------------tsFILGSHAYSVSNAYIS 455
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                    #                                                             
1DF0_A      273 essgslQKLIRIRNPWGqvewtgkwndncpswn-----tvdpevranlterqeDGEFWMSFSDFLRHYSRLEICN 342
gi 9366713  423 pe--ynLRLLLLRNSWAnhskhrwngawkrgsek--wkqypgvaaacagacdaDGVLCVEWSEALALFAGCGVCF 493
gi 7656959  469 k----gLRFIQLKNPWShlrwkgrysendvknwtp-elqkylnfdprtaqkidNGIFWISWDDLCQYYDVIYLSW 538
gi 7507052  473 e----tKRLLKVKNPWThsrwkgnfsdkdkvnwta-kmknalafdpevaaekdDGIFWIDYESVRHFFDVIYVNW 542
gi 12082826 517 ee--mgLFLLQVRNPWStgeewkgrwsksdklweeypsvqsacfpsgmespkdDNMFWLQWSDALNVFAGGGVCH 589
gi 12082825 448 pe--enITLLKMFNPWEpampwsgqwregsdkwt---ehseiqsscepcfeahDGIFFIEWSEAVEVFNGCGVLY 517
gi 10241545 377 k----gRRQFLIKNPWAgtdavypalfad-------------pgpfpnspflsPGTFWMDCEMVLQNFENLYLNW 434
gi 4731363  375 k----gRRQLLVKNPWAgadtapgdngsls----------asqdlphnppsfePGTFWMDCEKLLQHFENLYLNW 435
gi 11071673 337 qdgcntAHILRIRDPLLfgpfsnpknplveesn-----rlaklvdgknvdmasRGEIWMDFNQATREYQSLYLNW 406
gi 17227865 456 as---gEQRVVVRNPWGvdgka--------------------------ksganDGFINLSYQEFINSFNLGVSVS 501

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