Conserved Protein Domain Family
PVL_ORF50

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pfam07768: PVL_ORF50 
PVL ORF-50-like family
This is a family of sequences found in both bacteria and bacteriophages. This region is approximately 130 residues long and in some cases is found as part of the PVL (Panton-Valentine leukocidin) group of genes, which encode a member of the leukocidin group of bacterial toxins that kill leukocytes by creation of pores in the cell membrane. PVL appears to be a virulence factor associated with a number of human diseases.
Statistics
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PSSM-Id: 285065
View PSSM: pfam07768
Aligned: 3 rows
Threshold Bit Score: 137.776
Threshold Setting Gi: 122539479
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam07768 is a member of the superfamily cl06686.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122539155   3 IVKINGKPYKFTEHENELIKKNGLTPGMVAKRVRGGWALLEALHAPYGMRLAEYKEIVLSKIMERESKEREMAR------ 76
gi 122539051   7 IVRIHDKPYRFSKFEMELIESHGITAGMVSKRVKDGWELHEAMDAPEGTRLSEYREKKTIERLEQARLERKLER------ 80
gi 122539479   6 VIRVRIKGKLMTLREVS--EKYHISPELLRYRYKHKMRGDELLCGRKDSKSKEEVEYMKSQIKDEEKGREKIRKkailnr 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 122539155  77 -QRRKEAEL-----RKKKPHLFN-VPQKHSRDPYWFDTTYNQMFKKWQE 118
gi 122539051  81 -KRKREAEL-----RRKKPHLFN-VPQKHSRDPYWFDNTYNQMFKKWQE 122
gi 122539479  84 yQRNVRAEYeqerkRRLRPWLYDgTPQKHSRDPYWFDVTYNQMFKKWSE 132
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