Conserved Protein Domain Family
IDO

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pfam01231: IDO 
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Indoleamine 2,3-dioxygenase
Statistics
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PSSM-Id: 279560
View PSSM: pfam01231
Aligned: 191 rows
Threshold Bit Score: 385.293
Threshold Setting Gi: 339258474
Created: 11-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
pfam01231 is a member of the superfamily cl21721.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4PK5_A        31 ISKEYHIDEEVGFA-LPNPQENLPDFYNDWMFIAKHLpdlIESGQLRERVEKLNMLSIDHLTD-HKSQRLARLVLGCITM 108
gi 573874302  15 SLNKYHVSEEYGFV-LPAPLTDLPQYYQPWMQIARQLtelIDSHSLRSEVHKMPQLDTCYLQT-HRELRLAHLALSLLTM 92
gi 432874579  12 SLGPYQVSEDCGFL-LKEPLQELPpHYQPWMDIARHIpelVQSHELRSEIYKMPMLSSEFLQN-EKELRLAHLVLSMMTM 89
gi 542240043  14 SLESYHVSEELGFI-LPDPLQELPpYYQPWMDIALKIpelAQSHELRSRINKMPLLSSKFLQK-HKELRLAHLALTMMTM 91
gi 556964352  16 SLRKFHISEDYGFIcL-DPVAELPDYYQPWMKIAKNLpylIENSLLRCEVNKMPLLTTDHLKG-HRELRLAHLALSFITM 93
gi 542200152  12 dfdvFDISEEFGFL-LEEPLTHLPDYYQVWLDLANNLthlIESRKLQDLVDKMPVLSPDLLSN-HRELRLAHLALGFISM 89
gi 260823862   8 tLSDFYLSEERGFLpAEDPLESLPpYFSPWVELARDSpklLQQQQLRECVHKLPLLDHTRLQG-PLEWHLAHLLLSTISH 86
gi 52345908    7 NPKEFYVSEHYGFI-LQDPLEKLPeYYKPWMTIAENVcllIETKQVREAVRQMPELTIQHLSG-YREQRLARLILGHIVM 84
gi 156375508   8 fLEDYEVSPTRGFIqDEDPLQQLPeYFSPWEEVCERLpemWKDETTRHWIEQLPLLDHNKLTS-AREWWRANLVLVLMSH 86
gi 339258474 571 lLRDFHISAKLGFV-LENPEEHLPSYYNSWNNTAANIrhlLAAGNVRSTLENLPLLDVSSLCSsHRQLRLAHLQLATLVS 649
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4PK5_A       109 AYVW--GKghGD--VRKVLPRNIAVPYCQLSKKLELP-PILVYADCVLANWkkkdp--nkplTY---ENMDVLFSFRDGD 178
gi 573874302  93 GYVWqeGE--EG--TVKVLPQNLAVPYWEVSQRLGLP-PILTHADGVLANWrkt-----npeGPfemENLELILTLPGGD 162
gi 432874579  90 GYVWqeGE--KD--TVETLPCNLAVPLWNVSQSLGLP-PILTHADGVLANWmkk-----dpeGPfsmENLELLINLPGGD 159
gi 542240043  92 GYVWeeGE--KD--TVEILPRSLAVPYWEVSQRLGLP-PIITHADAVLANWkrk-----dpdGPfnmENLELLVSLPGGE 161
gi 556964352  94 GYVWqeGE--RD--TIKVLPRSLAKPFCEISQTLGLP-PIMVHADCVLANWkkk-----kvdGPleiENLDTILSLPGGE 163
gi 542200152  90 GYVW--QE--GQhaPAEILPKALALPFWLVSRRLGLP-PILTYADSVLANWklkd----ptgDMs-iGNMDLIFSFPGGD 159
gi 260823862  87 AYVWqaGE--AG--VPDFLPRSVAVPWYRVSEHLGVP-PIISHHCVSLANWkkk-----dpkGPlelDNLQLLFCITCPR 156
gi 52345908   85 GYVW--QD--GEqgAIKALPRCLAVPYFNLSEVLGMP-PILVHADLVLANWrrk-----npqGPltiENLTTIVSLPGGD 154
gi 156375508  87 SYVW--CE--GEtnPKKVLPKSLAIPLVGVSEHLGMP-PILTHYCYAIYNWrvi-----disRPltlDNIKPINTFTGTP 156
gi 339258474 650 GYIW--CE--SEigVPKKVPRCLAVPYSQVSEKLGLQiGIAPHVTVALANYkqkcfcifnnkPFiadDHQLLYFNFFDDD 725
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4PK5_A       179 CSKGFFLVSLLVEIAAASAIKVIPTVFKAMQmqeRDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFF--SVLRIYLSG 256
gi 573874302 163 SVRGFFLVTLLVELAAVPGVKAIPRMINSMLqqdKQTVQAGLNDITQALKNMTDAIRLMHAHVDPAVFY--GIMRLYLSG 240
gi 432874579 160 SVRGFFLVTLLVEVAAVPAIKNIPVVINGVRcgdTNAVVQALENISQSIQDMTDALKLMHVYVDPSVFY--GIMRIFLSG 237
gi 542240043 162 SARGFFLVTLLVELAGVPAVKNIPTVINGVRcgdTEAVARGLEIISRSIEDMTDALKLMQVHVDPSVFY--GIMRIYLSG 239
gi 556964352 164 SSKGFFLVTLLVEIAAVPGIKAISEIINAVVqdnVDSLLCAFQTLTNSIGCMIAALKQMHGIISP---YlkHVAKIHLSF 240
gi 542200152 160 TCRGFFIVSLLVEMAASPGIMGALEVMHAIKvsdLTGIKNGLIKVTQSLKKMKENFKFMHNHVEPAAFH--GKLRIFVSG 237
gi 260823862 157 DFSWFALIPLQIEIDFIAALPLLVQAQKGVLegnSKSTRDALTAIIPVLKKIKQTLGRMKEQCDTEVFY--NQLRYFLSG 234
gi 52345908  155 SLQGFALVTLMVEVAAIPGVRAVCQAVNSLVsqdEPRLLQALKDLTESINRMSDALKLMHDYVDSDIFY--NTIRLFLSG 232
gi 156375508 157 SEDGFITVAVQVEMEFGKSVTSLIASQKAVLsddCQLLRKELFSVQQMISRLTNALLKIHDVCKPRDFY--CFIRVFLNG 234
gi 339258474 726 TNHWFFLATVEVEVEFSNALPAFFHLAKAIKgkdVSLLTEGLKNLATAIHRMHAKMRRLKERVDANEFY--HKLRPFLSG 803
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4PK5_A       257 wkG--NPQLSDGLVYEGf-wEDPkeFAGGSAGQSSVFQCFDVLLGIQQTaggghaaqFLQDMRRYMPPAHRNFLCSLESN 333
gi 573874302 241 wkD--NPLMAEGLVYEGv-rTEPlqYSGGSAAQSSLLHCFDELLGVQHEpes---gaFLTRMRDYMPPMHKQLVQDISSG 314
gi 432874579 238 wkD--NPSMPKGLIYEGvq-kEPmeYSGGSAAQSSLLHCFDELLGIKHEess---ssFLNRMRDYMPPAHKQLIQDISYQ 311
gi 542240043 240 wkD--NPCMPNGLVYEGvqaA-PmrYSGGSAAQSSLLHCFDELLGVKHDpks---asFLIYMRDYMPPLHKKLINDISLQ 313
gi 556964352 241 wrD--NPiMPDGLLYEGvsdG-PlhYSGGSAAQSTILHCIDEVLGICHSpea---caFLHRMRDYMPPFHKAFVSEISSS 314
gi 542200152 238 wrD--NPMLPRGVLYEGv-sDEPilLSGGSAAQSSAIQCFDALLCIQHEeet---gaFLTRMRDYMPPAHRQLIETLSVC 311
gi 260823862 235 wkD--NPALPRGLIYEGv-rDEPfqLSGGSAAQVATIQCLDEFLGIKHngr---egaFLMRMRDHMLPAHRNFIADVGNG 308
gi 52345908  233 wkD--NPSMPEGLLYEGv-aETPfsFSGGSAAQSSVFQAFDELLGIKHRaes---aeFLLRMREYMPPAHRHFVERIGKA 306
gi 156375508 235 wqS--TSALPEGLIYEGvs-sTPrqYPGGSAAESTVFQVLDAFLGIRHHsps--rtsFLKLMRKHMPPKHNEFITAVENG 309
gi 339258474 804 ttGpaFQSv-gGIILEGvanDQPmkLVGGSAAQSCAIQCLDTCLGVQHSada---gsFLKLMRQFMLPNQRCFLHWLETK 879
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4PK5_A       334 PSVREFVlskGDAG--LREAYDACVKALVSLRSYHLQIVTKYILIPASQqpken---------ktsedPSKLEAKGTGGT 402
gi 573874302 315 PSLRQYVldaADPQ--LTQAFSTCVSQLLSLRSYHINIVSRFITIPAARarqlknrse-gpaealsraPVALEERGTGGS 391
gi 432874579 312 PSLKSFVqqqNCGH--LKQTYHLCVSKLLALRNYHITVVSRFITVPAARtrqlrkqsqdledetvtraPIALEERGTGGS 389
gi 542240043 314 PSLRSFVqqqDCk--dLNNVFDLCVKKLLALRSYHINVVSRFITVPAARarqlrdqnhnsdgemisraPTALEERGTGGS 391
gi 556964352 315 PSVRQYIlssANSK--LCAMYDGCVAELVKFRNYHITVVSKYITIAAANakasqkeqd-tisgtrqsaPSALEQRGTGGS 391
gi 542200152 312 PPLRDFIlscSNs--dLCQAYNSCVSALVDLRNYHLNTVTKYVIIPGNHaqsvgc--------pfrgvGTALNTTGTGGS 381
gi 260823862 309 PSVRNFVsntDDQe--LRTAYNTCVSTLRDFRSLHISIIASYIVIPSKRakg--------------hkVEGLANVGTGGT 372
gi 52345908  307 PSLPGYVqqcGDp--eLLSAFNECVLSLTDFRSLHIRIVCKYVsaagara------------kmlgngVQHLQERGTGGS 372
gi 156375508 310 PSVRHYVensKDQR--LHEQYNACVTALQEYRNAHLSIVTKYIIIQANKdpe--------------npNRRLANKGTGGS 373
gi 339258474 880 VNVRSFLlstCAVQldSIQAYNDCIGAMTAFRRVHVALVNSYIVKPRQMeii-------------sepAQTLGDHGTAGT 946
                        410
                 ....*....|....*.
4PK5_A       403 DLMNFLKTVRSTTEKS 418
gi 573874302 392 GIMNFLKSVRDRTKEv 407
gi 432874579 390 GIMNFLKTVRDQTKDA 405
gi 542240043 392 SIMSFLKTVRDQTKDT 407
gi 556964352 392 SLMCFLKNIRDTTKEA 407
gi 542200152 382 NLMVFLKSVRNTTQKA 397
gi 260823862 373 GIMTFLKTVRDTTTAA 388
gi 52345908  373 NVMSFLKKVRGNCKEg 388
gi 156375508 374 DLVKFLQRVRDETKES 389
gi 339258474 947 TVMPFLisliqsteqc 962
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