Conserved Protein Domain Family
Chitin_bind_4

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pfam00379: Chitin_bind_4 (this model, PSSM-Id:278791 is obsolete and has been replaced by 395303)
Insect cuticle protein
Many insect cuticular proteins include a 35-36 amino acid motif known as the R&R consensus. The extensive conservation of this region led to the suggestion that it functions to bind chitin. Provocatively, it has no sequence similarity to the well-known cysteine-containing chitin-binding domain found in chitinases and some peritrophic membrane proteins. Chitin binding has been shown experimentally for this region. Thus arthropods have two distinct classes of chitin binding proteins, those with the chitin-binding domain found in lectins, chitinases and peritrophic membranes (cysCBD) and those with the cuticular protein chitin-binding domain (non-cysCBD).
Statistics
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PSSM-Id: 278791
Aligned: 108 rows
Threshold Bit Score: 37.6248
Threshold Setting Gi: 122117335
Created: 13-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q17BL9  41 FQYSYESGNGiKV-----EDQGElkvvevpkedgtGTEQAQVSVQkGSYSYNAPDGTPITLQWTA-DENG-F 105 yellow fever mosquito
Q16RA0   7 YQFGYEVGPN---------GQFHh-----------ETRGPDGVTY-GCYGYIDPNGMLRVTHYVA-DSHG-Y 55  yellow fever mosquito
Q16Q12  27 YEFGFNIEGH---------QHRK------------ESKDINGIVM-GEFGFITADNVYHVTVY-AtDENGnF 75  yellow fever mosquito
P52302  31 YKFGFTIDEQ---------QHRA------------EKRDERGIIM-GEFGFITADGIYHVTVYAT-DEEGkF 79  fruit fly
Q9VV44  49 YSYGYSEPLS-SK------QETR---------------TLDGITQ-GYYSYRDAAGKLQTVNYVA-DNKG-F 95  fruit fly
Q9VV45  45 YAYGYMAPLY-SK------HETR---------------TVDGVIR-GTFSHIDANGETQTVDYVA-DAEG-F 91  fruit fly
Q16EK6  45 YSYGYADPNS-QK------HETK---------------DAHGVTH-GGYSYVDGDGHVQTVKYTAdPIHG-F 92  yellow fever mosquito
Q7QCN4   5 YAFTYSAGRS-PGhvdrtHSEVS---------------DGSGVVR-GSFSYVDPRNQVRTVEYTA-DSHG-F 57  Anopheles gambiae str. PEST
Q7K5J8  32 YVFSYQAGRA-PGhvdrqHTEVS---------------DGSGVIR-GAFSYVDPKNQVRTVQYVA-DEHG-F 84  fruit fly
Q7Q5L3  27 YDFQFKTRNY---------QRRE-------------GSDSNGRVN-GLYTYIDDVGEKHSVRYSAgSGTG-Y 74  Anopheles gambiae str. PEST
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