Conserved Protein Domain Family
Kazal_1

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pfam00050: Kazal_1 
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Kazal-type serine protease inhibitor domain
Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family.
Statistics
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PSSM-Id: 278479
View PSSM: pfam00050
Aligned: 25 rows
Threshold Bit Score: 51.902
Threshold Setting Gi: 118574367
Created: 11-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
2BUS_A         7 CAEFKDPk--vYCT---RESNPHCGSNGETYGNKCAF----CKAVM-KSGGKINLKHRGKC 57
gi 124847     12 CSNYKGKgsqiACP---RLHQPICGTDHKTYSNECMF----CALTL-NKKFEVRKLQDTAC 64
gi 124848      8 CSQYNRKgsgiTCS---KEWKPICGIDHKTYSNECMF----CQLNQ-NKRFQLRKLHDNKC 60
gi 118574367  95 CQDPTS------CPapiGEFEKVCSNDNKTFDSSCHFfatkCTLEGtKKGHKLHLDYIGPC 149
gi 134273    426 CQDPET------CPp-aKILDQACGTDNQTYASSCHLfatkCMLEGtKKGHQLQLDYFGAC 479
gi 1708509   422 CREFQKVs--pICT---MEYVPHCGSDGVTYSNRCFF----CNAYV-QSNRTLNLVSMAAC 472
gi 124847     68 CTEYSDM-----CT---MDYRPLCGSDGKNYSNKCSF----CNAVK-KSRGTIFLAKHGEC 115
gi 124848     64 CTNYSA-----ICT---MEYFPLCGSDGQEYSNKCLF----CNEVV-KRRGTLFLAKYGQC 111
gi 123983     14 CKVYTEA-----CT---REYNPICDSAAKTYSNECTF----CNEKM-NNDADIHFNHFGEC 61
gi 123986      7 CNVYRSHl--fFCT---RQMDPICGTNGKSYANPCIF----CSEKG-LRNQKFDFGHWGHC 57
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