Conserved Protein Domain Family
ePHD_BRPF3
?
cd15703: ePHD_BRPF3 
Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This model includes the ePHD finger of BRPF3. BRF3 is a homolog of BRPF1 and BRPF2. It is a scaffold protein that forms a novel monocytic leukemic zinc finger protein (MOZ)/MOZ-related factor (MORF) H3 histone acetyltransferase (HAT) complex with other regulatory subunits. BRPF3 contains a plant homeodomain (PHD) finger followed by this non-canonical ePHD finger, a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain.
Links
?
Statistics
?
PSSM-Id: 277173
Aligned: 4 rows
Threshold Bit Score: 278.092
Created: 20-Mar-2014
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 12 residue positions
Conserved feature residue pattern:C C H C C C C C H C C HClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure evidence that human Borjeson-Forssman-Lehmann syndrome-associated protein PHF6 (PDB 4NN2) binds three Zn2+ ions through its ePHD finger
  • Comment:The extended PHD finger is characterized by Cys2HisCys5HisCys2His.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #                #  #                                #  #          #    #    
Q9ULD4        269 CILCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGlGAAIQCHKVNCYTAF 348  human
NP_001128279  273 CVLCPNQGGAFKQTSDGRWAHVVCAIWIPEVCFANTVFLEPVEGVNNIPSARWKLTCYLCKQKGrGAAIQCHKVNCYTAF 352  western clawe...
XP_005169382  305 CVLCPNRGGAFKQTSDGSWAHVICAIWIPEVCFANTVFLEPVEGVKNIPPARWKLTCYLCKQKGrGASIQCHKANCYRAF 384  zebrafish
EOA93228      255 CVLCPNKGGAFKQTSDGRWAHVVCAIWIPEVCFANTVFLEPIEGINNIPPARWKLTCYICKQKGmGAAIQCHKVNCYTAF 334  mallard

Feature 1         #  #                              #  #
Q9ULD4        349 HVTCAQRAGLFMKIEPMRETslNGTIFTVRKTAYCEAH 386  human
NP_001128279  353 HVTCAQRAGLFMKVEPVRETglNGTTFTVRKTAFCELH 390  western clawed frog
XP_005169382  385 HVTCAQRAGLYMKIDPVRETgtNGTTFTVKKTAYCENH 422  zebrafish
EOA93228      335 HVTCAQRAGLFMKIEPMRETsiNGTTFTVRKTAYCESH 372  mallard

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap