1EF1,1Y19,2AEH,2K00,3BIN,3PVL,3PZD,4DXA,4GXB


Conserved Protein Domain Family
FERM_C-lobe
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cd00836: FERM_C-lobe 
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FERM domain C-lobe
The FERM domain has a cloverleaf tripart structure composed of: (1) FERM_N (A-lobe or F1); (2) FERM_M (B-lobe, or F2); and (3) FERM_C (C-lobe or F3). The C-lobe/F3 within the FERM domain is part of the PH domain family. The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases (PTPs), the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the PH and PTB domains and consequently is capable of binding to both peptides and phospholipids at different sites.
Links
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Statistics
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PSSM-Id: 275389
Aligned: 27 rows
Threshold Bit Score: 53.918
Created: 4-Feb-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Structure:3BIN; Human DAL-1 binds TSLC1 peptide, contacts at 4A
    - View structure with Cn3D
  • Comment:The TSLC1 peptide binds to the alpha1C helix and the beta5C strand
  • Structure:1Y19; Mouse Talin FERM F3 binds PIPKIgamma peptide PTDERSWVYSPLHYSAR, contacts at 4A
    - View structure with Cn3D
  • Comment:binds to peptides in a similar mechanism to PTB domains
  • Structure:2K00; Chicken Talin FERM F3 binds Layilin Cytodomainlm, contacts at 4A
    - View structure with Cn3D
  • Structure:3PZD; Human Myosin X FERM domain binds DCC P3 domain, contacts at 4A
    - View structure with Cn3D
  • Comment:DCC P3 forms a single alpha-helix and binds to the alphabeta-groove formed by beta5 and alpha1 of the MyoX FERM F3 lobe
  • Structure:3PVL; Mouse Myosin VII MyTH4-FERM-SH3 domains binds CEN1 peptide, contacts at 4A
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                      #      ####                     
1EF1_A     199 GVNYFSIKNkk--------gsELWLGVDaLGLNIYEqndrltpkIGFPWse--irNISFNd-------KKFVIKPid--- 258  human
1Y19_B     101 GVSFFLVKEkmkgk---nklvPRLLGITkECVMRVDektk-eviQEWSLtn--ikRWAASp-------KSFTLDFgd--- 164  house mouse
2K00_A       1 GVSFFLVKEkmkgk---nklvPRLLGITkECVMRVDektk-eviQEWSLtn--ikRWAASp-------KSFTLDFgd--- 64   chicken
3BIN_A     190 GVDLHHAKDse--------gvEIMLGVCaSGLLIYRdrl---riNRFAWpk--vlKISYKr-------NNFYIKIrpgef 249  human
3PVL_A     476 FSRFYEAYKfsgpp---lpksDVIVAVNwTGVYFVDeqe--qvlLELSFpe--imAVSSSrgtk-mmaPSFTLATi---- 543  house mouse
4DXA_B     222 GAAFFTGQIftkaspsnhkviPVYVGVNiKGLHLLNmetk-allISLKYgc---fMWQLGdt-----dTCFQIHSme--- 289  human
AAV87212  2062 GSAFFEVKQttep----nfpeILLIAINkYGVSLIDprt---kdILTTHpftkisNWSSGn-------TYFHITIgnl-- 2125 house mouse
Q7XPJ0     466 NSVFFSVRKiddpi--gllpgRIILGINkRGVHFFRpvpk-eylHSAELr----dIMQFGssn---taVFFKMRVa---- 531  Japanese rice
EAW55665  3413 GSSFFFIQScsni----avpaPCILAINhNGLNFLSteth-elmVKFPLk----eIQSTRtqrptansSYPYVEIalgd- 3482 human
EDL38578  1373 GAKLFFAKPiapss---lgnnCVWLAVHeNGLSILEytsm-rlvTSYMYk----gLMTFGgy-----qEDFMVVVstqsk 1439 house mouse

Feature 1                          #   #  ##   
1EF1_A     259 -kkAPDFVFYAprlriNKRILALCXGNHELYX 289  human
1Y19_B     165 -yqDGYYSVQTt---eGEQIAQLIAGYIDIIL 192  house mouse
2K00_A      65 -yqDGYYSVQTt---eGEQIAQLIAGYIDIIL 92   chicken
3BIN_A     250 eqfESTIGFKLpnhraAKRLWKVCVEHHTFFR 281  human
3PVL_A     544 --kGDEYTFTSs---nAEDIRDLVVTFLEGLR 570  house mouse
4DXA_B     290 --nKMSFIVHTk---qAGLVVKLLMKLNGQLM 316  human
AAV87212  2126 -vrGSKLLCETs---lGYKMDDLLTSYISQML 2153 house mouse
Q7XPJ0     532 ---GVLHIFQFet-kqGEEICVALQTHINDVM 559  Japanese rice
EAW55665  3483 vaaQRTLQLQLe---qGLELCRVVAVHVENLL 3511 human
EDL38578  1440 drpTEKLLFAMak-hkILEITLLIASYINSFH 1470 house mouse

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