3BLH,3BLQ,4BCF


Conserved Protein Domain Family
STKc_CDK9_like

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cd07840: STKc_CDK9_like 
Click on image for an interactive view with Cn3D
Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes, yeast BUR1, C-type plant CDKs (CdkC), and similar proteins. CDK9, BUR1, and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2, and participates in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270832
View PSSM: cd07840
Aligned: 34 rows
Threshold Bit Score: 404.254
Threshold Setting Gi: 223999831
Created: 29-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ####    #            # #                                  #               
3BLH_A     20 YEKLAKIGQGTFGEVFKARHRktgQKVALKKVLMen---ekEGFPITALREIKILQLLk-HENVVNLIEICRtkaspy-n 94  human
3BLQ_A     20 YEKLAKIGQGTFGEVFKARHRktgQKVALKKVLMen---ekEGFPITALREIKILQLLk-HENVVNLIEICRtkaspy-n 94  human
4BCF_A     20 YEKLAKIGQGTFGEVFKARHRktgQKVALKKVLMen---ekEGFPITALREIKILQLLk-HENVVNLIEICRtkaspy-n 94  human
XP_642396  64 YEIISKIGEGISGSVFKAIKKgteEMVALKNFKGw------TEGDRASKEECSLLQQLrhIPYITPVIDIYTnfe----- 132 Dictyostelium disc...
XP_653785   7 FDIQFELGSGTYSTVYYGKNNktgEIVALKEMKEfr---enCGFAQTTARELKILQQLk-HQNIVRLYGVTTsekyc--- 79  Entamoeba histolyt...
CAB78124  156 FEKLDKIGQGTYSSVYRARDLetgKMVAMKKVRFvn---mdPESVRFMAREINILRKLd-HPNVMKLECLVTskl----- 226 thale cress
XP_651330  15 YEIINQIGCGAYASVYKARTKttgKLVAIKQLKNdr----dQGFPVTSLREIQLLQEIh-HPNIIQLIEVLHandfi--- 86  Entamoeba histolyt...
Q871M9     26 YEVLGKLGEGTFGEVHRARSRktgALVALKKIIMhn---erDGFPITALREIKLLKLLs-HKNVLRLEEMAIehpprtdk 101 Neurospora crassa
EAR88001   26 YRLIAEVGSGTYGRVYKAECLrtkQYVALKKFESkddkikeDGFPITAVREILLLKQLd-HVNIIKLREIILskpsek-n 103 Tetrahymena thermo...
CAK61994   14 YKVIAEVGSGTYGKVYKAKCLktnDFVALKKIDTkdqkimaEGFPITAIREIKLLKIMn-HKNILRLREIIVskashr-n 91  Paramecium tetraur...
Feature 1              ####  #  #                                          ## #          #    
3BLH_A     95 rckgSIYLVFDFCEHDLAGLLsnvl--vkfTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITrdGVLKLADFGLA 172 human
3BLQ_A     95 rckgSIYLVFDFCEHDLAGLLsnvl--vkfTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITrdGVLKLADFGLA 172 human
4BCF_A     95 rckaSIYLVFDFCEHDLAGLLsnvl--vkfTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITrdGVLKLADFGLA 172 human
XP_642396 133 --tsEYIIVFPYFEHDLSGLLseh----rlSIPQVKCYFKQLLEGINEIHNAGVMHRDIKAANLLVNnkGSLFIGDLGTA 206 Dictyostelium disc...
XP_653785  80 egegNIFLIFEYMPHDLQSLLyststtsllSIGQLKGYMKQLLIGIQYLHSIGIVHRDLKPSNLLINneGYLKIADFGLA 159 Entamoeba histolyt...
CAB78124  227 --sgSLYLVFEYMEHDLSGLAlrpg--vkfTESQIKCYMKQLLSGLEHCHSRGILHRDIKGPNLLVNndGVLKIGDFGLA 302 thale cress
XP_651330  87 erntTISLVFEFMPHDLSSFLkceeivskvAIGQLKGYMLQILQAIQFLHSNNIIHRDIKTGNILISddNHIKLGDFGLA 166 Entamoeba histolyt...
Q871M9    102 rtrpIVYMVTPYMDHDLSGLLdnps--vrfTEPQVKCYLLQLLEGLKYLHANHILHRDMKAANLLINnkGVLQIADFGLA 179 Neurospora crassa
EAR88001  104 dyrgSTFLVFDYMDHDFAGLHrnk---hefSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNnqGEVKIADFGLA 180 Tetrahymena thermo...
CAK61994   92 nfrgSTFLVFDYYDHDFAGLHrqr---nifTLPQLKCIFKQLLEGVKYLHDSKIIHRDLKCANILMNnkGQVTLADFGLA 168 Paramecium tetraur...
Feature 1                                                                                     
3BLH_A    173 RAFSLAknsq-------pnrYXNRVVTLWYRPPELLLGer--------------------------------------dY 207 human
3BLQ_A    173 RAFSLAknsq-------pnrYXNRVVTLWYRPPELLLGer--------------------------------------dY 207 human
4BCF_A    173 RAFSLAknsq-------pnrYXNRVVTLWYRPPELLLGer--------------------------------------dY 207 human
XP_642396 207 TSYTKRs------------vFSSKVVTLWYRAPELLLGst--------------------------------------qY 236 Dictyostelium disc...
XP_653785 160 RPITYRe-------------CNYNVITLNYRPPELLLGct--------------------------------------lY 188 Entamoeba histolyt...
CAB78124  303 NIYHPEqd----------qpLTSRVVTLWYRAPELLLGat--------------------------------------eY 334 thale cress
XP_651330 167 RKQDDVg------------iYTNNMVTLWYRPPELLLGet--------------------------------------rY 196 Entamoeba histolyt...
Q871M9    180 RHYEGDipqpgkgsgegkrdYTSLVVTRWYRPPELLMHlk--------------------------------------rY 221 Neurospora crassa
EAR88001  181 RLLNPNnp-----------kYTNKVVTLWYRAPELLLGakeyteqhilkelirniksiqlsllisiylkltvqssifkkS 249 Tetrahymena thermo...
CAK61994  169 RTLSNVsn----------pkYTYKVVTLWYRAPELLLGqt--------------------------------------nY 200 Paramecium tetraur...
Feature 1                                                                                     
3BLH_A    208 GPPIDLWGAGCIMAEMWTrSPIMQGNtEQHQLALISQLCGSITPEVWPNvdnye-lyekLELVKGQKRKVKDRLKayv-- 284 human
3BLQ_A    208 GPPIDLWGAGCIMAEMWTrSPIMQGNtEQHQLALISQLCGSITPEVWPNvdnye-lyekLELVKGQKRKVKDRLKayv-- 284 human
4BCF_A    208 GPPIDLWGAGCIMAEMWTrSPIMQGNtEQHQLALISQLCGSITPEVWPNvdnyelyeklELVKGQKRKVKDRLKAyv--- 284 human
XP_642396 237 GPEIDMWSIGCVLIELVTsRNFLPGSsEQQQLEAICKLCGTPTDEIWPNvsqlq-nfnqISHLPVYPSRLRTVFKnf--- 312 Dictyostelium disc...
XP_653785 189 GSEIDMWSIGCIIFECFIkRPPFQAAtEAELLAQIYSICGSPNPNIASQykf----wknLMPNQSYPNRLNDFLSqcq-- 262 Entamoeba histolyt...
CAB78124  335 GPGIDLWSVGCILTELFLgKPIMPGRtEVEQMHKIFKFCGSPSDDYWQKtklp--latsFKPQQPYKRVLLETFKnl--- 409 thale cress
XP_651330 197 KGEVDMWSVGCVFLEIFKhRPVFHGKtENEQLSKIWEICGTPTDLEWPQfkemk-mfqtLALPTPQKRILKDVFKgy--- 272 Entamoeba histolyt...
Q871M9    222 TTAIDMWGVGCVFAEMLEgKPVLQGEsDLHQLELVWDLCGTPSEETMPGwrtlp-ggqaFSSKPRPGNLARRFEKh---- 296 Neurospora crassa
EAR88001  250 NKQIDMWSVGCIFIELAVgENLLRGEnEPRQLDKIYELCGSPNTQNWPEvdklq-lwkdMKPKRNFERKLREQVIerkk- 327 Tetrahymena thermo...
CAK61994  201 NTQIDMWSLGCIFTELITgDVLFKGDiEYRQMEKIYELCGSANEQNWPNcvnlr-qweeFKPRRNYERLLTKHIKelcqi 279 Paramecium tetraur...
Feature 1                                         
3BLH_A    285 ----rdPYALDLIDKLLVLDPAQRIDSDDALNHDFF 316 human
3BLQ_A    285 ----rdPYALDLIDKLLVLDPAQRIDSDDALNHDFF 316 human
4BCF_A    285 ----rdPYALDLIDKLLVLDPAQRIDSDDALNHDFF 316 human
XP_642396 313 -----sNDFIELLEGLLTLNPKKRLTAEQALQSPFF 343 Dictyostelium discoideum AX4
XP_653785 263 ----cnQNLSILLQNLLNVNPLERLSADKALHSSFF 294 Entamoeba histolytica HM-1:IMSS
CAB78124  410 -----pPSALALVDKLLSLEPAKRGTASSTLSSKFF 440 thale cress
XP_651330 273 -----dPIFMDLIDHLLQLNPKSRFTADEALQHKYF 303 Entamoeba histolytica HM-1:IMSS
Q871M9    297 -----gPVVISLLKELFKLDWRSRINAIDALNHPYF 327 Neurospora crassa
EAR88001  328 ---nidPQFLNLLDGIMVLNPKKRFTVQQCLDHEFF 360 Tetrahymena thermophila SB210
CAK61994  280 qnkqidQVTLDLIEQLLILDPTKRLNAAQALNHEFF 315 Paramecium tetraurelia

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