2XVG,2XVK


Conserved Protein Domain Family
GH31_xylosidase_XylS

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cd06591: GH31_xylosidase_XylS 
Click on image for an interactive view with Cn3D
xylosidase XylS-like
XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in Sulfolobus solfataricus where it hydrolyzes isoprimeverose, the p-nitrophenyl-beta derivative of isoprimeverose, and xyloglucan oligosaccharides, and has transxylosidic activity. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. The XylS family corresponds to subgroup 3 in the Ernst et al classification of GH31 enzymes.
Statistics
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PSSM-Id: 269877
Aligned: 74 rows
Threshold Bit Score: 393.846
Created: 11-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic site
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2XVK; Cellvibrio japonicus alpha-xylosidase with bound 5-Fluoro-alpha-D-xylopyranosyl flouride, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          #                           ##                                 
2XVG_A        425 GKSVMLPKWAYGFWQSRERYKSSDEIIQNLKEYRDRKIPIDNIVLDWSYWPedawgSHDFDKQFFPDPKALVDKVH-AMN 503  Cellvibrio ja...
2XVK_A        425 GKSVMLPKWAYGFWQSRERYKSSDEIIQNLKEYRDRKIPIDNIVLDWSYWPedawgSHDFDKQFFPDPKALVDKVH-AMN 503  Cellvibrio ja...
Q82K34        201 GRTPMLPEWAAGFWQCKLRYRTQDELLAVAREYKRRGLPLDVIVCDFFHWThl--gEWKFDLDQWPDPAAMVAELA-ELG 277  Streptomyces ...
WP_016388398  230 GRVPQMPDYGMGLWQSRMRYYNQEQVIEVAEKYKELDIPVDVIIIDFFHWNkq--gDYAFDPRFFPNPAKMTKILS-DLG 306  Lactobacillus...
WP_019063396  248 GHPPLVPEWATGFWQSKLRYRTQDELLAVAREYKQRGLPLATIICDFFHWThm--gDWDFDRTDWPDPEGMVKELE-TLG 324  Streptomyces ...
EQB84928      238 GHSPKMPQYALGLWQSKLRYRNQNEVISVAKHYHDLHIPLSVIVIDYFHWPkq--gDFKFDKRYFPNPEKMVKDLK-RLN 314  Lactobacillus...
YP_003113366  237 GFPSPMPQWASGFWQSKLRYRTQEELLAVAREYAARELPLSVLVIDYLHWRhl--gDWDFDATAWPDPRALVEELR-ALG 313  Catenulispora...
EJD07261      289 GRQPTPPDFILGYQQSKLRYWNETQVLDVAQMFHDEQVNVSLIVVDFFAWKfq--gDWSFDPEFFPDPAGMAAKVKeLTG 366  Fomitiporia m...
EAW23703      268 GRAPTPPEASLGYIQSKLRYENQTEVELLAQQFKDHNIPVSMIVIDYQSWAhq--gDWALDPRLWPDVASMAKKVKdLTG 345  Neosartorya f...
WP_002341856  245 GRTPRLEPELLGLWQSKLRYQTLDELRTVYEGYNQRGISLSVLVVDYYHWTsd--gDFAFDSRYWEGIEDFAEEIK-KTG 321  Enterococcus ...
Feature 1                #                                                                        
2XVG_A        504 AQIMISVWPKFypttdNYKELNAKGFMfnrnldeknld------wigkgylnafYDPFSPEATAIFWKQIRDkin-vhGF 576  Cellvibrio ja...
2XVK_A        504 AQIMISVWPKFypttdNYKELNAKGFMfnrnldeknld------wigkgylnafYDPFSPEATAIFWKQIRDkin-vhGF 576  Cellvibrio ja...
Q82K34        278 VELVVSVWPSVsplseNHQLMEQRGYFigteygpmahadw-pdkgvastvqvafYDATNPEAREFVWSKVRDnylkpyGI 356  Streptomyces ...
WP_016388398  307 IKTMVSVWPQVdnqskNFIEMRKRGLLvknnqgipiq--------mdfegnvrfLDFTNPKAQKFLWQMLKKnyq-dkGI 377  Lactobacillus...
WP_019063396  325 VKLAVSVWPTVepgsvNYTALRDAGLLvgdrhgglltfpwpsrghgadhqpmayLDSTEPGARRYLWQQLREhyr-elGV 403  Streptomyces ...
EQB84928      315 VELMVSVWPNIdctseNYNEMNEKGYLvrvdngksit--------mtfhgnttfFDTTNPKARQFVWDKIKRnyy-qkEV 385  Lactobacillus...
YP_003113366  314 VEPAVSVWPSVsplsaTFTPMREAGMLatadngaaltgaw-pdaasgaeigvafYDATDDRARAFLWDRLHTnyy-klGI 391  Catenulispora...
EJD07261      367 AEMMVSLWPSVedlsvNYIEMQQEGLLattrdgtgit-------dsfagvytrlIDSTNPAAREFLWKRLNDsyf-snGI 438  Fomitiporia m...
EAW23703      346 AEMMASLWPSVadnseNYLELIANGLLsatrsgpgtt-------dswngsyirnIDSTNPAARAFLWKTLKRnyy-dkGI 417  Neosartorya f...
WP_002341856  322 TQLMVSLWPTVteesrYYQSYRNNQLLirsvtnkd-----------slfagkalLDFFHPESKTFLRQVLDEnyr-skGI 389  Enterococcus ...
Feature 1            # #                                                                          
2XVG_A        577 DAWWLDAVEPdihsnltfekrkw----------lmtpnargngaeiFNAYAVPHAEGVYQGELAtdg--------dkrSF 638  Cellvibrio ja...
2XVK_A        577 DAWWLDAVEPdihsnltfekrkw----------lmtpnargngaeiFNAYAVPHAEGVYQGELAtdg--------dkrSF 638  Cellvibrio ja...
Q82K34        357 RSFWLDACEPelkpgfqenl----------------ryyagpgpetGNLYPRENSRTFYEGMLAage---------teVV 411  Streptomyces ...
WP_016388398  378 SMFWLDEAEPeytvydyrny----------------ryykgnvmkvGNIYPMYYTKAVYDGYKSegk---------dkII 432  Lactobacillus...
WP_019063396  404 AAFWLDACEPdltpelaara----------------vyavgpgiqvGNLYGLAQARAVAEGLQQdgd---------drPF 458  Streptomyces ...
EQB84928      386 KHFWLDEAEPeystydfdny----------------rlhlgrnsqvGNIYPTLYAKGFYEGEKKegq---------hnPI 440  Lactobacillus...
YP_003113366  392 RAFWLDGCEPeirpaphtlt-----------------yaagvgsevANLYPREHARGVFERMRAage---------peVL 445  Catenulispora...
EJD07261      439 HNFWIDQADGgslgepfvnngqdminsl-pyartftqyflgtqegsGKMYPWLHQQAIDEGFSNlttsydvgratsceFM 517  Fomitiporia m...
EAW23703      418 KNFWIDQADGgalgeayenngqssyiesipfslpnvlyaagtqlsaGKLYPWAHQQAIEEGYRNatgtkm---geacdHI 494  Neosartorya f...
WP_002341856  390 SLFWADQAEPemdvyqhkey----------------liyegslekyANKYPLHYLQAIQKNPERsn-----------tEP 442  Enterococcus ...
Feature 1            #             #  #                                #                          
2XVG_A        639 ILTRSGFGGIQRTGsAIWSGDIVSRWSDMKDQIAAGIGTNLAGVTNWTFDIGGFtpedrfrhgkkgfvgswtaldaeqvd 718  Cellvibrio ja...
2XVK_A        639 ILTRSGFGGIQRTGsAIWSGDIVSRWSDMKDQIAAGIGTNLAGVTNWTFDIGGFtpedrfrhgkkgfvgswtaldaeqvd 718  Cellvibrio ja...
Q82K34        412 TLNRSAWAGSQRYGaALWSGDIGTDFATLRRQIAAGLNTALSGIPWWNTDIGGFhggdp------------------ddp 473  Streptomyces ...
WP_016388398  433 NLVRCAWAGSQRFGaLVWSGDVRSDFISLQNQIVAGLQMGMSGIPWWTTDTGGFhggdi------------------nse 494  Lactobacillus...
WP_019063396  459 SLIRSAWAGSQRYGaALWSGDIRPTFESLAQQVRAGLNVAMSGIPWWNTDIGGFgggdp------------------tdp 520  Streptomyces ...
EQB84928      441 SLIRSAWAGSQKYGsLVWSGDIDSSFRSFKYQYQAGLNIGLAGIPWWTSDIGGFhggss------------------tds 502  Lactobacillus...
YP_003113366  446 SLTRSAWAGSQRYGvALWSGDIDTTFEAFADAIRAGLNVAMSGLPWWTTDIGGFhggdp------------------ddp 507  Catenulispora...
EJD07261      518 SLTRSTFAGGQRFCsYMWSGDTISRFDVMLQQVTAGVSAGASGISSWTLDIGGFsglni------------------std 579  Fomitiporia m...
EAW23703      495 SLSRSGYIGSQRFCsMIWSGDTTSVWDTLAVQVASGLSAAATGWGWWTMDAGGFqadptvpw-----------ssnidtp 563  Neosartorya f...
WP_002341856  443 TLIRSAWFNAQKYGaLAWSGDIESSFDSLRRQVQVGLSMGISGITWWTSDIGGFhsgns------------------qsp 504  Enterococcus ...
Feature 1                              #                                            
2XVG_A        719 eWQELNTRWYQFGAFVPLYRSHGQnpyrei---------------fniadEGTEVYNAMVWYTKLR 769  Cellvibrio japonicus
2XVK_A        719 eWQELNTRWYQFGAFVPLYRSHGQnpyrei---------------fniadEGTEVYNAMVWYTKLR 769  Cellvibrio japonicus
Q82K34        474 aYREVMVRWFQFGALSPLMRLHGFrdpgtplgpg------mtggpnevwsYGEEAGAILEKYLRLR 533  Streptomyces avermitilis
WP_016388398  495 dFRELLIRWFEFSTFSPVLRLHGErlpfeevtapdgsevlhtgapnelwsFGDKVLEILKKFVRLR 560  Lactobacillus paracasei
WP_019063396  521 aYQEVMVRWFQYGAFSPVMRLHGDrqpnwptfsad-----mtggpnevwsYGREAYPILSAHLHLR 581  Streptomyces prunicolor
EQB84928      503 eFKELLIRWFEFAVYCPILRMHGDrephefpidnqv---egtgapneiwsFGKETFDILRKQVNIR 565  Lactobacillus gasseri
YP_003113366  508 aYRELVVRWFQFGVFCPVFRLHGHreprvshgtvg-----dgggpnevwsYGPEAYQTITALLRLR 568  Catenulispora acidiphila DS...
EJD07261      580 fGKELFVKWLSMGVFLPYMRVHGDrdctippntvps---fanncpnepwaYGEENFEIIKGYISLR 642  Fomitiporia mediterranea MF...
EAW23703      564 eYRELYVRWFQWAAFLPFMRTHGSrkcnvqnay---------tcnnepwsYGEENTPIIVSYIQLR 620  Neosartorya fischeri NRRL 181
WP_002341856  505 vFKELMIRWFQFAVFSPILRMHGDrqphtqkignsgggvrtsggpneiwsFGEEVEGILTRFIHIR 570  Enterococcus faecium

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