Conserved Protein Domain Family
DED_Caspase_10_r1

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cd08341: DED_Caspase_10_r1 
Death effector domain, repeat 1, of Caspase-10
Death effector domain (DED) found in caspase-10, repeat 1. Caspases are aspartate-specific cysteine proteases with functions in apoptosis and immune signaling. Initiator caspases are the first to be activated following death- or inflammation-inducing signals. Caspase-10 is an initiator of death receptor mediated apoptosis. Together with FADD, caspase-8 and the pseudo-caspase c-FLIP, it forms the death-inducing signaling complex (DISC), whose formation is triggered by the activation of type 1 tumor necrosis factor (TNF) receptors such as Fas, TNF receptor 1, and TRAIL receptor. It contains two N-terminal DED domains and a C-terminal caspase domain. DEDs comprise a subfamily of the Death Domain (DD) superfamily. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and CARD (Caspase activation and recruitment domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Statistics
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PSSM-Id: 260047
Aligned: 4 rows
Threshold Bit Score: 132.559
Created: 18-Nov-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putativecharge triad
Feature 1:putative DED1/DED2 interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure of the tandem DED domains of v-FLIP.
  • Comment:The tandem DED domains, DED1 and DED2, in FLIP are associated rigidly to form a single compact structure, with each domain playing a unique structural role and is not interchangeable with the other. This explains why both domains are required for FLIP function.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       ##   #  ## ##                                   #   #            
BAA94751       1 MDFNSMLLRIDDGLGREDIEALKFLCRDVLRKNKLLsvqSGHELFQQLMTEDLIneDNYFLLGELLYIINHHSLLHDLGT 80  African clawed ...
Q92851        18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEkssSASDVFEHLLAEDLLseEDPFFLAELLYIIRQKKLLQHLNC 97  human
XP_001370685   7 IKFNQQLLSINEKLEPEEIEALKFLCSDLISPRNLEdieSGHQLFQKFMDEDLLneGDYFLVAELLFLIKHHNLLQKIGY 86  gray short-tail...
EMP24338       9 IKFHQQLLVIDENLGTEEVEALKFLCSDLLSFKKLEaveSAQDIFQLLMAKDFLnkEDTFIVAELLYRIRCHFLLHKLGY 88  green seaturtle
Feature 1          
BAA94751      81 NK 82  African clawed frog
Q92851        98 TK 99  human
XP_001370685  87 TK 88  gray short-tailed opossum
EMP24338      89 TK 90  green seaturtle

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