2NMB,1P5T,1X11,3SO6,1DDM,1SHC,3D8D,2CY4,3HQC,1NU2,1OQN,3DXC,2EJ8,1M7E,2YT2,2YS5,1XR0,1QQG,1IRS,1QQG,1J0W


Conserved Protein Domain Family
PTB
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cd00934: PTB (this model, PSSM-Id:241236 is obsolete and has been replaced by 269911)
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Phosphotyrosine-binding (PTB) PH-like fold
PTB domains have a common PH-like fold and are found in various eukaryotic signaling molecules. This domain was initially shown to bind peptides with a NPXY motif with differing requirements for phosphorylation of the tyrosine, although more recent studies have found that some types of PTB domains can bind to peptides lack tyrosine residues altogether. In contrast to SH2 domains, which recognize phosphotyrosine and adjacent carboxy-terminal residues, PTB-domain binding specificity is conferred by residues amino-terminal to the phosphotyrosine. PTB domains are classified into three groups: phosphotyrosine-dependent Shc-like, phosphotyrosine-dependent IRS-like, and phosphotyrosine-independent Dab-like PTB domains.
Links
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Statistics
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PSSM-Id: 241236
Aligned: 99 rows
Threshold Bit Score: 39.8343
Created: 1-Nov-2000
Updated: 1-Feb-2013
Structure
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Program:
Drawing:
Aligned Rows:
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peptide bindingphosphoinosit..
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:1NU2; Mouse Dab1 PTB domain binds peptide from the ApoER2 tail
    - View structure with Cn3D
  • Comment:Dab1 PTB has preference for unphosphorylated tyrosine within the NPxY motif
  • Structure:2NMB; Drosophila Numb binds a Phosphotyrosine peptide, contacts at 4A
    - View structure with Cn3D
  • Comment:Phosphotyrosine peptide contains the Gly-Pro-(p)Tyr motif
  • Comment:Numb binds diverse peptide motifs
  • Citation:PMID 9846878
  • Structure:1DDM; Drosophila Numb binds Nak (Numb-associated kinase) peptide, contacts at 4A
    - View structure with Cn3D
  • Structure:1X11; Human X11 Ptb domain binds betaAPP peptide
    - View structure with Cn3D
  • Comment:beta-amyloid precursor protein (betaAPP)
  • Citation:PMID 9321393
  • Structure:3DXC; Human Fe65-Ptb2 binds APP, contacts at 4A
    - View structure with Cn3D
  • Comment:Alzheimer disease amyloid precursor protein (APP)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
2NMB_A         30 CSFSVKYLGcvevfesrgmqvce-------ealkvlrqsrrrpvRGLLHVSGDGLRVVDDetk---------------gl 87   fruit fly
1NU2_A         18 VRYKAKLIGidevsaargdklcqdsmmklkgvvagarskgehkqKIFLTISFGGIKIFDEktg---------------al 82   house mouse
2YT2_A         19 TKFKVTNVDdegv----------------------------elgSGVMELTQSELVLHLHrr-----------------e 53   human
2YS5_A         19 TKFKVTNVDdegv----------------------------elgSGVMELTQSELVLHLHrr-----------------e 53   human
1XR0_B         12 NKFKVINVDddgn----------------------------elgSGIMELTDTELILYTRkr-----------------d 46   human
XP_001603609  128 HIWQVIMQKkglger------------------------knitgPYRLCLTDRVLSLVKLgaddksdsiefsxxxxxxxx 183  jewel wasp
XP_002401074   59 HVWQVNVKPkglgss------------------------rnitgPHRLCLTAKALTLVKMhtddedpe-----tldrysh 109  black-legged ...
1QQG_A        159 EVWQVILKPkglgqt------------------------knligIYRLCLTSKTISFVKLnse---------------aa 199  human
1IRS_A          7 EVWQVILKPkglgqt------------------------knligIYRLCLTSKTISFVKLnse---------------aa 47   human
XP_003484032  124 ERFNVYLMPspnl---------------------------dvhgECALQITYEHICLWDVqnp--------------rvk 162  pig

Feature 1                 ######                                      #                         # 
2NMB_A         88 IVDQTiekVSFCAPdrn--------------------------heRGFSYICRDgttrrWMCHGFLACkds---geRLSH 138  fruit fly
1NU2_A         83 QHHHAvheISYIAKdit--------------------------dhRAFGYVCGKeg--nHRFVAIKTAqa----aePVIL 130  house mouse
2YT2_A         54 AVRWPylcLRRYGYd-----------------------------sNLFSFESGRrcqtgQGIFAFKCSra-----eEIFN 99   human
2YS5_A         54 AVRWPylcLRRYGYd-----------------------------sNLFSFESGRrcqtgQGIFAFKCSra-----eEIFN 99   human
1XR0_B         47 SVKWHylcLRRYGYd-----------------------------sNLFSFESGRrcqtgQGIFAFKCAra-----eELFN 92   human
XP_001603609  184 WMEVEdnnIAQNMHtainnamtnssstkdegprqrlrsssaneasKPISVLQRRht--aQKLHSFSPLeeqrmhedQVAP 261  jewel wasp
XP_002401074  110 SLPVDimaGPKEPTike--------------------------eaAVDDYLMMAspvsgSESSFVHRPt------tLGSH 157  black-legged ...
1QQG_A        200 AVVLQlmnIRRCGHs-----------------------------eNFFFIEVGRsavtgPGEFWMQVDds-----vVAQN 245  human
1IRS_A         48 AVVLQlmnIRRCGHs-----------------------------eNFFFIEVGRsavtgPGEFWMQVDds-----vVAQN 93   human
XP_003484032  163 LISWPlsaLRRYGRd-----------------------------aAWFTFEAGRsasmpISDSIMQPLfi-----kRLLC 208  pig

Feature 1           #  
2NMB_A        139 AVGCA 143  fruit fly
1NU2_A        131 DLRDL 135  house mouse
2YT2_A        100 LLQDL 104  human
2YS5_A        100 LLQDL 104  human
1XR0_B         93 MLQEI 97   human
XP_001603609  262 LQEQN 266  jewel wasp
XP_002401074  158 AMDAP 162  black-legged tick
1QQG_A        246 MHETI 250  human
1IRS_A         94 MHETI 98   human
XP_003484032  209 ATMGL 213  pig

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