2BYV,1O7F


Conserved Protein Domain Family
DEP_Epac
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cd04437: DEP_Epac 
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DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by cyclic AMP, a second messenger that plays a role in the control of diverse cellular processes, such as cell adhesion and insulin secretion. Epac-like proteins share a common domain architecture, containing RasGEF, DEP and CAP-effector (cAMP binding) domains. The DEP domain is involved in membrane localization.
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Statistics
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PSSM-Id: 239884
Aligned: 15 rows
Threshold Bit Score: 164.824
Created: 18-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2BYV_E     194 AGKILRIAILSRAPHMIRDRKYHLKTYR----------------------QCCvGTELVDWMIQqtscVHSRTQAVGMWQ 251  house mouse
CAG03972     7 AARSVYSVMVEKNPGLIRDRKHHLKTYRcqmrglastfhlrpltltsstrQCCsGKELVDWLLKqsecLQSRSQVVGMWQ 86   Tetraodon nigrov...
AAS90633    61 AAKVLHTYLLTMSPAMMRDRKHHFRSHR----------------------QCCsGKELVDWLLGishgLQSRSQALGIWQ 118  African clawed frog
23240201    54 MGWALRTLLVADNSSCLKDRKVSGKLIR----------------------KCApGTELVDWLVNlspiVHTRAQAAGMWQ 111  fruit fly
NP_006096   58 AGRQLHRHLLATCPNLIRDRKYHLRLYR----------------------QCCsGRELVDGILAlglgVHSRSQVVGICQ 115  human
CAF89566    70 AGRAVRNAFLSHGPYPAKDKIHLARIIR----------------------RSYvGVELVQWLCEqclyVRCRTTAVRVWQ 127  Tetraodon nigrov...
AAI23127   116 AGRALRNAVRSQTPELIRDRMYLTCICR----------------------KSCvGSELVDWLLQhcpfVQCRYTAASIWQ 173  African clawed frog
Q8C0Q9      33 AGRALRNIIILQAADLVKDRVNLKGFYR----------------------RSCvGSELVDWLLEhcpfVQCRSMAIGVWQ 90   house mouse
CAG01995    52 AGKVLRNAILSRAPHMIRDRKYHLKTYR----------------------QCCvGTELVDWLVLqsacVLTRSHAVGMWQ 109  Tetraodon nigrov...
XP_424494   79 AGKLLFTYLTSTSPSLIRDHKHHLRHHR----------------------RCCsGKELVDWMLNaelgIQTRSQAIGVGQ 136  chicken

2BYV_E     252 VLLEDGVLNHVDQErHFQDKy-LFYRFLDDeredaplpt---eeekkecdEELQDTMLLLSQMgPDAHMRMILRK 322  house mouse
CAG03972    87 VLVDEGILLHVKQElNFHDKdaQFYRFRDDgcspnhv------tnereaeEELQEGLSLLAQLgPDALLTMILRK 155  Tetraodon nigroviridis
AAS90633   119 VLVDEGALVHVRQEpNFQDKdsQFYRFTRAepyvdpl------lsdrdteEEMQESLVFLSQLePAALLTMILRK 187  African clawed frog
23240201   112 ALLEEGVLAHVNKEqPFKDKc-FLYRFRIDeeggtaaagvpqaedlgaanEHIREALSALFQRgPDATLRMILRK 185  fruit fly
NP_006096  116 VLLDEGALCHVKHDwAFQDRdaQFYRFPGPepepvg---------themeEELAEAVALLSQRgPDALLTVALRK 181  human
CAF89566   128 VLLELGVLLSVDQRvVFSDSn-TYYQFSFEecdsasc-------efrtneGEWPEAVRLLLQLaPYVQFRSGGGA 194  Tetraodon nigroviridis
AAI23127   174 ILLKLGILLSVDKQlCFQDAy-VFYQFSSEecgnaa--------cefgreKGWLMGVRLLKQLvPLVPLTSNMCD 239  African clawed frog
Q8C0Q9      91 LLLDMGIMSSVDQHlYFQDNy-VFYQFSSDecsyly--------cefereEEWQKGVKLLLELvHLIPARAGICD 156  house mouse
CAG01995   110 ALLEERVLNHVDQDlGFQDKy-LFYRFLDDededtplps---eeekreseEELPETILFLAQIgPDALLRMILRK 180  Tetraodon nigroviridis
XP_424494  137 VLVDGGVLTHVKQEwHFQDKdtQFYRFAELelspepr-------vglrdaEELLEAVTFLAQLgPDALLTMALRK 204  chicken
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