Conserved Protein Domain Family
IlGF_insulin_like

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cd04367: IlGF_insulin_like 
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IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and differentiation, and reproduction. On a cellular level they affect cell cycle, apoptosis, cell migration, and differentiation. With the exception of the insulin-like growth factors, the active forms of these peptide hormones are composed of two chains (A and B) linked by two disulfide bonds; the arrangement of four cysteines is conserved in the "A" chain: Cys1 is linked by a disulfide bond to Cys3, Cys2 and Cys4 are linked by interchain disulfide bonds to cysteines in the "B" chain. This alignment contains both chains, plus the intervening linker region, arranged as found in the propeptide form. Propeptides are cleaved to yield two separate chains linked covalently by the two disulfide bonds.
Links
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Statistics
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PSSM-Id: 239833
View PSSM: cd04367
Aligned: 27 rows
Threshold Bit Score: 64.3844
Threshold Setting Gi: 60672480
Created: 24-Aug-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Display:
 
putative
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:putative receptor binding surface
Evidence:
  • Comment:receptor-binding interactions determined for insulin by alanine-scanning
  • Citation:PMID 9148904

cd04367 is part of a hierarchy of related CD models.
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cd04367 is a member of the superfamily cl02453.
cd00101:IlGF_likecd04365:IlGF_relaxin_likecd04366:IlGF_insulin_bombyxin_likecd04367:IlGF_insulin_likecd04368:IlGF1EFE A1246156067244460672458833039401245816067245060672452606724546067245612451345382573743859594084096409345587821205366813517223109240260126439994720923084794565124651606724786067248012436568364774157876141WQJ I224061223076752138671891304309011071847218323902731124266902733228308831IGL  9209079546240418031882315836810303217492272751EFE A1246156067244460672458833039401245816067245060672452606724546067245612451345382573743859594084096409345587821205366813517223109240260126439994720923084794565124651606724786067248012436568364774157876141WQJ I224061223076752138671891304309011071847218323902731124266902733228308831IGL  920907954624041803188231583681030321749227275
cd04367 Sequence Cluster
cd04367 Sequence Cluster
Sub-family Hierarchy
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 cd04367 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #  # #                                                                    
1EFE_A        2 VNQHLCGSHLVEALyLVCGERGFFYTPktrry-----------------------------pgdvkRGIVEQCCTSICSL 52
gi 64093     28 TTGHLCGKDLVNALyIACGVRGFFYDPtkmkrdtgalaaflplayaednesqddesiginevlkskRGIVEQCCHKRCSI 107
gi 124365    23 QAEYLCGSTLADVLsFVCGNRGYNSQPrrsvskraidfiseq---------qakdymgamphirrrRGLVEECCYNVCDY 93
gi 124651    26 SSQHLCGSNLVEALyMTCGRSGFYRPHdrreledlqveqaelgl------eagglqpsalemilqkRGIVDQCCNNICTF 99
gi 4558782   27 GPQHLCGSHLVDALyLVCGDRGFFYNPrrdvdpllgflppkaggav-vqggenevtfkdqmemmvkRGIVEECCHKPCTI 105
gi 12053668  25 TPQHLCGSHLVDALyLVCGPTGFFYNPkrdvepllgflppksaqe----tevadfafkdhaelirkRGIVEQCCHKPCSI 100
gi 47209230  21 PIQHLCGSQLVDTLyFICGERGFYADGnhphkrdvea-------------------llghnepkvkRGIVEQCCHKPCSI 81
gi 60672478   2 VGQRLCGSQLVDTLySVCRHRGFYRPN---------------------------------------DGIVDQCCTNICSR 42
gi 60672480   2 VSRRLCGSNLVDALfLLCERNGFYRPN---------------------------------------DGIVDQCCINTCTT 42
gi 84794565  24 PSQHLCGSSLVDALyLVCGPRGFFYTNrgrrdletllallsnlag----yeaadadplkekvmkmkRGIVEQCCHRPCTI 99

                ....*...
Feature 1            #  
1EFE_A       53 YQLEnYCN 60
gi 64093    108 YDLEnYCN 115
gi 124365    94 SQLEsYCN 101
gi 124651   100 NQLQnYCN 107
gi 4558782  106 FDLQnYCN 113
gi 12053668 101 FELQnYCN 108
gi 47209230  82 YHLQrYCD 89
gi 60672478  43 NQLLtYCN 50
gi 60672480  43 NQLLnYCN 50
gi 84794565 100 YHLEdYCS 107

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