Conserved Protein Domain Family
ZnMc_salivary_gland_MPs

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cd04272: ZnMc_salivary_gland_MPs 
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.
Statistics
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PSSM-Id: 239800
View PSSM: cd04272
Aligned: 14 rows
Threshold Bit Score: 234.168
Threshold Setting Gi: 52858347
Created: 30-Jun-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063
  • Comment:Based on similarity to sequences with known structures.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 71726984 182 FEVELHIICDqkhqsn-fdkneDLIGYMAVFMNAANLRYLDirnpkVRFLLVGITRRKENPfapdnh--------gttdt 252
gi 67906164 173 VRVEVFIVVDyrhysy-fsknqDLLAYLCVMANGANLRYLEakdpgISLMLTGMALSKDDKfdsvsde-------eylfd 244
gi 71726990 170 VTIELFVVSDrphhqh-fqttiQLIQYLCVMVNSMNLRYADtdsprVIFLLTGVEKDEHSPyrngnd--------kyles 240
gi 71726986 181 VTVELFVISDkihqqr-ftqtqRLLSYMCVMVNSANLRLQDtsaprIKLLLVGLERVHNAWnepylkgd-----dkymdd 254
gi 78707567 313 IYPEVLVIVDydgyrlhggdnlQVKRYFISFWNGVDLRYRLlkgprIRISIAGIIISRGRDatpylernr--vgrdaids 390
gi 5911708  176 IYPEVYLVADsafakefnfdvnAVTRYFAVLTNAANLRYESfkspkVQLRIVGITMNKNPAdepyihnirgyeqyrnilf 255
gi 89277230 180 FPVELHMISDkehqrs-yknneELISYLAVMMNAVTLRYLDmtnpkISFLLVGVTRAKDHDfgrnng--------geiea 250
gi 84570462 170 VTIELFIVSGsshhke-fnqtkFLILYLCVTVNSLNLRYAAtssprIQLLLTGVQQDKDDSykigqe--------gymna 240
gi 22164294  55 IYPEVHLVVDsafakefnfdvyEVTRYFAVLTNAANLRYASfqspkVQLRITGITMNKSPAdepyihnirgyekyrnilf 134
gi 71726992 182 MFPEVFVVCDswfqae-fvksmNVTVYMIITFQVVSIRYSAlrnpkVYPVLRGIELSTLQQekkyyvyl----nsasidg 256
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 71726984 253 tETLNRLQAYEAEKRvpg-khDALLLVtgldl--vkvqnGHLEKGIAGRAFMAAVCs-------SHGVGVAEDTAttyMG 322
gi 67906164 245 eLCIKGFREYSIKKKdefgrpDVVYLLtgrdv--ftiheGKMTTRGLGIGYLSGVCs-------HSFVALGEDKPgffTG 315
gi 71726990 241 aSSLEQFRSYAYGKRhqfgnpDVTFLItgydvy-stasgGSKSTSVLGIGYVGGLCt-------EYFVALGEDSAglyTG 312
gi 71726986 255 tATITNLVEHIKTRKhlygdpDAVYLAtgrdm--yamdsGAPDTRRKGLAFVAGVCt-------ELFVAIGEDNAgsyDG 325
gi 78707567 391 aAALTDMGKYLFRERrlp-vyDIAVAItkldmcrrtsayGECNRGTAGFAYVGGACvvnkrlekVNSVAIIEDTGg-fSG 468
gi 5911708  256 kETLEDFNTQMKSKHfyr-taDIVFLVtaknm--sewvgSTLQSWTGGYAYVGTACs-------EWKVGMCEDRPtsyYG 325
gi 89277230 251 aEMLRGLGQYKNQGRipg-nyDVVYLMtgldm--irfskGKKIKGIAGRAKMSTVCt-------ERGLGEGEDTPhayTG 320
gi 84570462 241 aGTLENFKAYVVTKMlefgkpDVVYLMtadnv--ystsgGKADTNSLGIGYVTGVCt-------EFRVALGEDTPgfyNG 311
gi 22164294 135 kETLEDFNTHMRSRSfya-taDIVFLVtaknm--sewagRTLQSWTGGYAYVGTACs-------QWKVGMCEDRPtsyYG 204
gi 71726992 257 yKSLLKLVTFVTERNdtyqtfDMVYFVtrydmv-avyddGSRQNSLQGYAFVGSACs-------KNREQLGEDTAysyRG 328
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1            ##  # ### #                                                            
gi 71726984 323 VNTVAHELAHILGSDHDtsprc-------------pwreGYLMSYvdgglrkyRLSQCSQDSIRDVYRglnsqCKR 385
gi 67906164 316 LRTFTHEVAHTLGATHDgqeadnnvpgh-psavgcswdlGHIMSYvqngrsqyFFSQCSLLQMQHVIRakgqsCWE 390
gi 71726990 313 MHTLTHECGHVLGAAHDesrpvswikgd-pgsmaclwkeGHIMSYvdggvkhhHFSKCSLAQIRNVVIlrglvCWQ 387
gi 71726986 326 MHALTHEVAHLLGAAHDgdapktnivpghpgalacpfsqGYIMSYvntgtnyhRFSPCSVVQIRYVMRlrgplCWQ 401
gi 78707567 469 IIVAAHEVGHLLGAVHDgspppsylgg--pgaqrcrwedGYIMSDlrhtergfRWSACTVQSFHHFLNgdtatCLH 542
gi 5911708  326 AYVFAHELAHNLGCQHDgdganswvkgh-igsadcpwddGYLMSYkmederqyKFSPYCQREVRNLYRrpefkCLT 400
gi 89277230 321 VNTLAHELAHTLGSDHDetpec-------------pwadGYLMSYvdgglrkyKLSRCSQNSIRQYVGrlsdkCIR 383
gi 84570462 312 MHTMTHETAHVLGSEHDesaptpsvkdh-pgsmscpwkaGFIMSYvnngpdhhKFSSCSINQMRHVIKirgrsCWT 386
gi 22164294 205 AYVFAHELAHNLGCQHDgdganswvkgh-igsadcpwddGYLMSYkmqderqyKFSYCCQREVRNLYKrpefkCLT 279
gi 71726992 329 IRTMTHELAHALGCSHDgtaapgivtaftpdslqcpwehGYIMSYyeidirsmQFSRCCRYDIQRMSWayeggCLH 404

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