2C9W


Conserved Protein Domain Family
SOCS_SOCS_like

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cd03717: SOCS_SOCS_like 
Click on image for an interactive view with Cn3D
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.
Statistics
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PSSM-Id: 239687
View PSSM: cd03717
Aligned: 54 rows
Threshold Bit Score: 47.9766
Threshold Setting Gi: 49456349
Created: 1-Jun-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
elongin B/C
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:elongin B/C interaction
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ######     #      #     #             
2C9W_A        129 TSAPSLQHLCRLTINKC--TGAIWGLPLPtrLKDYLEEY 165  human
EAA14752      216 YGISTLQGACRDAILARvkKSAIPELPLPesLKNYLLQY 254  Anopheles gambiae str. PEST
XP_426126    1191 TFPFSLQYICRAVICRCttYDGIDDLPLPsmLQDFLKEY 1229 chicken
NP_001016844  478 TFPFSLQYICRAVICRSttYDGIDLLPLPsmLQDFLKEY 516  western clawed frog
AAH32862      479 TFPFSLQYICRAVICRCttYDGIDGLPLPsmLQDFLKEY 517  human
XP_688094     692 TFPFSLQHLARSSICRHttYDGIGALPLPptMQDFLKEY 730  zebrafish
NP_001017074  376 TFPFTLQHICRAAICTStnYDGIDALPVPssMKLYLKEY 414  western clawed frog
XP_392522     211 YGVSTLQSACRDAILQYtkRNAVDSLPLPrvLKDYLLYQ 249  honey bee
EAL25800      229 DGILSLQSACRNVILEHvpEDAVDDLPLPesIKRFLLRR 267  Drosophila pseudoobscura
XP_970089     242 YGVPTLQAACRDAILSHitKKAVSSLPLPnlLKKYLLYQ 280  red flour beetle

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