1K1G


Conserved Protein Domain Family
SF1_like-KH

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cd02395: SF1_like-KH (this model, PSSM-Id:239088 is obsolete and has been replaced by 411805)
Click on image for an interactive view with Cn3D
Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 defines an enlarged KH (hnRNP K) fold which is necessary and sufficient for BPS binding. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA.
Statistics
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PSSM-Id: 239088
View PSSM: cd02395
Aligned: 30 rows
Threshold Bit Score: 129.671
Threshold Setting Gi: 19074035
Created: 31-Jan-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
G-X-X-G motifRNA binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:G-X-X-G motif
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                ####                                                 
1K1G_A      8 SDKVMIPQdey------peINFVGLLIGPRGNTLKNIEKecnaKIMIRGKGSVKegkvgrkdg----qmlpgedepLHAL 77  human
BAC03643  132 KERVLIPVkqy------pkFNFVGKILGPQGNTIKRLQEetgaKISVLGKGSMRdkakeeelrkggdpkyahlnmdLHVF 205 human
AAL30071  140 KERVLIPVkqy------pkFNFVGKILGPQGNTIKRLQEetgaKISVLGKGSMRdkakeeelrkggdpkyahlnmdLHVF 213 chicken
NP_998400  60 KERILIPVkqy------pkFNFVGKILGPQGNTIKRLQEetgaKISVLGKGSMRdknkeeelrkngepkyahlsmeLHVF 133 zebrafish
AAH61709   83 QEKLYVPVkey------pdFNFVGRILGPRGLTAKQLEAetgcKIMVRGKGSMRdkkkeeqnrg--kpnwehlnedLHVL 154 zebrafish
AAF63417  105 QEKLYVPVkey------pdFNFVGRILGPRGLTAKQLEAetgcKIMVRGKGSMRdkkkeeqnrg--kpnwehlnedLHVL 176 human
AAH70801   84 QEKLYVPVkey------pdFNFVGRILGPRGLTAKQLEAetgcKIMVRGKGSMRdkkkeeqnrg--kpnwehlnedLHVL 155 African clawed frog
AAD00621   83 QEKLYVPVkey------pdFNFVGRILGPRGLTAKQLEAetgcKIMVRGKGSMRdkkkeeqnrg--kpnwehlnedLHVL 154 chicken
7504159   133 QTKVYIPEppvsidgkkvkCNYIGRILGPSGMSARMIENqydvTLLIRGAGSVRnkamdervr----krnehleepLHVL 208 Caenorhabditis ele...
3790614    81 TQKVFVPVkqy------pkFNFTGKILGPKGNSLRRLQEetqcKIAIKGRSSIRdrnkeeqlrstgdpryahlqkdLFLE 154 fruit fly
Feature 1                                                            
1K1G_A     78 VTAnt------mENVKKAVEQIRNILkqgietpedqndlrKMQLRELARLNGTLR 126 human
BAC03643  206 IEVfgp----pcEAYALMAHAMEEVKkflvpd--mmddicQEQFLELSYLNGVPE 254 human
AAL30071  214 IEVfgp----pcEAYALMAHAMEEVKkflvpd--mmddicQEQFLELSYLNGVPE 262 chicken
NP_998400 134 IEVfap----vpDAYMRMAHAMEEIKkflfpd--mmddicQEQFMEMKFLNGGQE 182 zebrafish
AAH61709  155 ITVedsq-nraeIKLKRAVEEVKKLLvpaaeg---edslkKMQLMELAILNGTYR 205 zebrafish
AAF63417  177 ITVedaq-nraeIKLKRAVEEVKKLLvpaaeg---edslkKMQLMELAILNGTYR 227 human
AAH70801  156 ITVedaq-nraeIKLKRAVEEVKKLLvpaaeg---edslkKMQLMELAILNGTYR 206 African clawed frog
AAD00621  155 ITVedaq-nraeIKLKRAVEEVKKLLipaaeg---edslkKMQLMELAILNGTYR 205 chicken
7504159   209 LIArhndktkceEILNKAAEKIESLLtpih------deykMDQLVSYAKMNGTYQ 257 Caenorhabditis elegans
3790614   155 VSTvat----paECYARIAYALAEIRkylipd--kndevsHEQLRELMEMDPESA 203 fruit fly

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