1QL0


Conserved Protein Domain Family
NUC

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cd00091: NUC 
Click on image for an interactive view with Cn3D
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
Statistics
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PSSM-Id: 238043
Aligned: 30 rows
Threshold Bit Score: 140.198
Threshold Setting Gi: 4240149
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
1QL0_A       5 CAVGCPTGGssk---vsIVRHAYTLNNNSTTKFANWVAYHITkdt-----paSGKTRNWKTDPALNpadt--lapaDYTG 74   Serratia marcescens
BAA74853    88 FATLYSTRDri----pvYSAFRAPRPAPGGAEQRWLVEPQIDdpn----snlEEAINEAEAITSVNslgskqalntDYLD 159  human
CAB55635   144 YELIRVCFEpka--ettLYSEHVLHGANIAAKDIDSSRPSFKsstgfftvsmSTCYTQNSQLASMKillgdddlanAIIN 221  Marsupenaeus jap...
AAF49206   164 ATQYEVCFNede---evTRYVYHRLEPGNNYYATGVDRITFGaggyfagknvDKLYTQAVQKETIDkeld--mdssRFFD 238  fruit fly
AAF49208   170 AEQMQICFNeee---evTRYTRHKLEPGSNYYETGVARITFQtagffdgknvDKLYTQATQLETINnelg--gdaeKYFD 244  fruit fly
AAF49869   164 LQSYELCHDaea---eaTRYVHHVLYPSSYDYQHGVARPNFLeldfyggrdvNTKYTQVQQNITISnilg--ldasPYFN 238  fruit fly
AAF49869  1109 LQTYDVCHDels---evTRYVHHVLYPGSDQYQRSVSRPSFIpgdfyggkdvNTLYTQVQQNITVSeilg--mdasPYFN 1183 fruit fly
NP_038993  562 LPFGKPAVLlnrhhhciIKNDNYVTAYSKVNRLPLWTSFSIDityn--stniYNKTCYLQDMRVMYyke----pcrYYST 635  Fowlpox virus
AAH19813    65 FATLYSPGHri----pvFSAFRAARPASRSAEQRGLLEPQIDdpd----snlEEVIDEANAVTSVDnlgskqalnaDYID 136  house mouse
P06802     603 VPYGRPRILlkqhhvclLQQQQFLTGYSLDLLMPLWASYTFLrndq---fsrDDFSNCLYQDLRIPlspv--hkcsYYKS 677  house mouse
Feature 1             ## #                              #       #   #                          
1QL0_A      75 ANaalkVDRGHQAPLAslag-vsdWESLNYLSNITPQksdLNQGAWARLEDQERKLid---raDISSVYTVTGPLYerdm 150  Serratia marcescens
BAA74853   160 SD----YQRGQLYPFSlss---dvQVATFTLTNSAPMt-qSFQERWYVNLHSLMDRaltpqcgSGEDLYILTGTVPsdyr 231  human
CAB55635   222 PHeqyyFAKGHLAPDAdfvt-eaeQDATYYYINAVPQwqaFNNGNWKYLEFATRDLae----sHSTDLTIYTGGWGvltl 296  Marsupenaeus jap...
AAF49206   239 SAknifLARGHMGAKAdfvf-apeQRATFLFINAAPQwqtFNAGNWARVEDGVRAWva----kENKHVECWTGVWGvttl 313  fruit fly
AAF49208   245 SSsnvyLARGHLGAKAdfdy-apeQRATFLFINAAPQwqtFNAGNWARVEDGLRAWvs----kNKLNVNCYTGVYGvttl 319  fruit fly
AAF49869   239 FSddriLSRGHMIAKTdqif-gaaQHTTFLFINVAPQwqtFNGGNWEKVETSVRKFva----dRNLTTDCYTGTWGvstl 313  fruit fly
AAF49869  1184 TTgnvyLARGHLSAKTdfvf-gaaQKASFFFVNAAPQwqtFNGGNWERIEDSVRKFva----dENITVDCYTGTWGvstl 1258 fruit fly
NP_038993  636 QKd---VTYGYLYPARa------tDFQSLLETNTVPMy-rNFKKIWEVFMSSILIEyv----qKHHVVNVMVGPVFdsns 701  Fowlpox virus
AAH19813   137 SD----YEIGQLYPFHlns---dlQMATFPLTNSVPMt-qSFRERWHMNLNSLMDRaliphcsEGKDLYILTGAVPsehr 208  house mouse
P06802     678 NSk---LSYGFLTPPRlnrvsnhiYSEALLTSNIVPMy-qSFQVIWHYLHDTLLQRya----hERNGINVVSGPVFdfdy 749  house mouse
Feature 1                                                                                      
1QL0_A     151 gk------------lpgtqkAHTIPSAYWKVIFInnsp--------avnhYAAFLFDQNTPkgad-------------fc 197  Serratia marcescens
BAA74853   232 -----------------vkdKVAVPEFVWLAACCavp----------gggWAMGFVKHTRDsdii-------------ed 271  human
CAB55635   297 ddingnpv-eiylgltedemVVPAPAITWKVVYEes------------ssRAVGVVGVNNPhitsppt------plcsdl 357  Marsupenaeus jap...
AAF49206   314 pnkngeqrqlylshdnngngLIPVPKLYFRVVIEps------------tkKGIVLIGVNNPhlsleeikr--dyilctdv 379  fruit fly
AAF49208   320 pnkdgvetplylakddnnngLIPVPKLYFRVVIDps------------shRGIVFVGVNNPhlteeqikr--dyvicddv 385  fruit fly
AAF49869   314 pdvdgierelyldfdennngLIPVPKIYFRVVIDrv------------trEGIVLIGINNPyltleqiqk--dyilcqdi 379  fruit fly
AAF49869  1259 pdvngigrelyldfdennngLIPVPKLYFRVIIDre------------srNGIVLLGVNNPhatieqiee--eyiicqdi 1324 fruit fly
NP_038993  702 ngirdsd--wlismssgynnKVYIPSDYFVILTYckdkdsslndcysnikTESFVVPNSDTyynescsrenitsvsyvrk 779  Fowlpox virus
AAH19813   209 -----------------vkgKVTIPEFVWLAACCavp----------gegWAMGFIKHTQDidvi-------------ed 248  house mouse
P06802     750 dgrydsleilkqnsrvirsqEILIPTHFFIVLTSckqlsetp-lecsaleSSAYILPHRPDniescthgk--resswvee 826  house mouse
Feature 1                                           
1QL0_A     198 qFRVTVDEIEKr---TGLIIWAGLPDDVQASLKSKPG 231  Serratia marcescens
BAA74853   272 vMVKDLQKLLP----FNPQLFQNNCGETEQDTEKMKK 304  human
CAB55635   358 cSSLAWIDFDVndlgHGYTYCCTVDDLRAAIPHVPDL 394  Marsupenaeus japonicus
AAF49206   380 sDRINWISWKKtditAGYSYACEVPEFRKKVTHLPEF 416  fruit fly
AAF49208   386 sDQVTYINWKTtdikAGWSYACEVADFLKTVKHLPAL 422  fruit fly
AAF49869   380 gHQLSWLTWYKedlhEGYSYACSVEDFIEVVKDLPLE 416  fruit fly
AAF49869  1325 gAQLSWVSWTKedlkKGYSYACTVEDFTAVVKDLPLQ 1361 fruit fly
NP_038993  780 iFSLHRVRIKDietvTSMSFYRNVYKTSSNVAYLKTY 816  Fowlpox virus
AAH19813   249 vMLRDLEKLLP----HKPQLFQDNCGEMEQDTEKMKK 281  house mouse
P06802     827 lLTLHRARVTDveliTGLSFYQDRQESVSELLRLKTH 863  house mouse

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