1QL0


Conserved Protein Domain Family
NUC

?
cd00091: NUC 
Click on image for an interactive view with Cn3D
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
Statistics
?
PSSM-Id: 238043
View PSSM: cd00091
Aligned: 30 rows
Threshold Bit Score: 140.198
Threshold Setting Gi: 4240149
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1QL0_A         5 CAVGCPTGGssk---vsIVRHAYTLNNNSTTKFANWVAYHITkdt-----paSGKTRNWKTDPALNpadt--lapaDYTG 74
gi 4240149    88 FATLYSTRDri----pvYSAFRAPRPAPGGAEQRWLVEPQIDdpn----snlEEAINEAEAITSVNslgskqalntDYLD 159
gi 5881881   144 YELIRVCFEpka--ettLYSEHVLHGANIAAKDIDSSRPSFKsstgfftvsmSTCYTQNSQLASMKillgdddlanAIIN 221
gi 7293840   164 ATQYEVCFNede---evTRYVYHRLEPGNNYYATGVDRITFGaggyfagknvDKLYTQAVQKETIDkeld--mdssRFFD 238
gi 7293843   170 AEQMQICFNeee---evTRYTRHKLEPGSNYYETGVARITFQtagffdgknvDKLYTQATQLETINnelg--gdaeKYFD 244
gi 7294527   164 LQSYELCHDaea---eaTRYVHHVLYPSSYDYQHGVARPNFLeldfyggrdvNTKYTQVQQNITISnilg--ldasPYFN 238
gi 7294527  1109 LQTYDVCHDels---evTRYVHHVLYPGSDQYQRSVSRPSFIpgdfyggkdvNTLYTQVQQNITVSeilg--mdasPYFN 1183
gi 9634700   562 LPFGKPAVLlnrhhhciIKNDNYVTAYSKVNRLPLWTSFSIDityn--stniYNKTCYLQDMRVMYyke----pcrYYST 635
gi 18044042   65 FATLYSPGHri----pvFSAFRAARPASRSAEQRGLLEPQIDdpd----snlEEVIDEANAVTSVDnlgskqalnaDYID 136
gi 18266807  603 VPYGRPRILlkqhhvclLQQQQFLTGYSLDLLMPLWASYTFLrndq---fsrDDFSNCLYQDLRIPlspv--hkcsYYKS 677
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ## #                              #       #   #                          
1QL0_A        75 ANaalkVDRGHQAPLAslag-vsdWESLNYLSNITPQksdLNQGAWARLEDQERKLid---raDISSVYTVTGPLYerdm 150
gi 4240149   160 SD----YQRGQLYPFSlss---dvQVATFTLTNSAPMt-qSFQERWYVNLHSLMDRaltpqcgSGEDLYILTGTVPsdyr 231
gi 5881881   222 PHeqyyFAKGHLAPDAdfvt-eaeQDATYYYINAVPQwqaFNNGNWKYLEFATRDLae----sHSTDLTIYTGGWGvltl 296
gi 7293840   239 SAknifLARGHMGAKAdfvf-apeQRATFLFINAAPQwqtFNAGNWARVEDGVRAWva----kENKHVECWTGVWGvttl 313
gi 7293843   245 SSsnvyLARGHLGAKAdfdy-apeQRATFLFINAAPQwqtFNAGNWARVEDGLRAWvs----kNKLNVNCYTGVYGvttl 319
gi 7294527   239 FSddriLSRGHMIAKTdqif-gaaQHTTFLFINVAPQwqtFNGGNWEKVETSVRKFva----dRNLTTDCYTGTWGvstl 313
gi 7294527  1184 TTgnvyLARGHLSAKTdfvf-gaaQKASFFFVNAAPQwqtFNGGNWERIEDSVRKFva----dENITVDCYTGTWGvstl 1258
gi 9634700   636 QKd---VTYGYLYPARa------tDFQSLLETNTVPMy-rNFKKIWEVFMSSILIEyv----qKHHVVNVMVGPVFdsns 701
gi 18044042  137 SD----YEIGQLYPFHlns---dlQMATFPLTNSVPMt-qSFRERWHMNLNSLMDRaliphcsEGKDLYILTGAVPsehr 208
gi 18266807  678 NSk---LSYGFLTPPRlnrvsnhiYSEALLTSNIVPMy-qSFQVIWHYLHDTLLQRya----hERNGINVVSGPVFdfdy 749
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1QL0_A       151 gk------------lpgtqkAHTIPSAYWKVIFInnsp--------avnhYAAFLFDQNTPkgad-------------fc 197
gi 4240149   232 -----------------vkdKVAVPEFVWLAACCavp----------gggWAMGFVKHTRDsdii-------------ed 271
gi 5881881   297 ddingnpv-eiylgltedemVVPAPAITWKVVYEes------------ssRAVGVVGVNNPhitsppt------plcsdl 357
gi 7293840   314 pnkngeqrqlylshdnngngLIPVPKLYFRVVIEps------------tkKGIVLIGVNNPhlsleeikr--dyilctdv 379
gi 7293843   320 pnkdgvetplylakddnnngLIPVPKLYFRVVIDps------------shRGIVFVGVNNPhlteeqikr--dyvicddv 385
gi 7294527   314 pdvdgierelyldfdennngLIPVPKIYFRVVIDrv------------trEGIVLIGINNPyltleqiqk--dyilcqdi 379
gi 7294527  1259 pdvngigrelyldfdennngLIPVPKLYFRVIIDre------------srNGIVLLGVNNPhatieqiee--eyiicqdi 1324
gi 9634700   702 ngirdsd--wlismssgynnKVYIPSDYFVILTYckdkdsslndcysnikTESFVVPNSDTyynescsrenitsvsyvrk 779
gi 18044042  209 -----------------vkgKVTIPEFVWLAACCavp----------gegWAMGFIKHTQDidvi-------------ed 248
gi 18266807  750 dgrydsleilkqnsrvirsqEILIPTHFFIVLTSckqlsetp-lecsaleSSAYILPHRPDniescthgk--resswvee 826
                        250       260       270
                 ....*....|....*....|....*....|....*..
Feature 1                                             
1QL0_A       198 qFRVTVDEIEKr---TGLIIWAGLPDDVQASLKSKPG 231
gi 4240149   272 vMVKDLQKLLP----FNPQLFQNNCGETEQDTEKMKK 304
gi 5881881   358 cSSLAWIDFDVndlgHGYTYCCTVDDLRAAIPHVPDL 394
gi 7293840   380 sDRINWISWKKtditAGYSYACEVPEFRKKVTHLPEF 416
gi 7293843   386 sDQVTYINWKTtdikAGWSYACEVADFLKTVKHLPAL 422
gi 7294527   380 gHQLSWLTWYKedlhEGYSYACSVEDFIEVVKDLPLE 416
gi 7294527  1325 gAQLSWVSWTKedlkKGYSYACTVEDFTAVVKDLPLQ 1361
gi 9634700   780 iFSLHRVRIKDietvTSMSFYRNVYKTSSNVAYLKTY 816
gi 18044042  249 vMLRDLEKLLP----HKPQLFQDNCGEMEQDTEKMKK 281
gi 18266807  827 lLTLHRARVTDveliTGLSFYQDRQESVSELLRLKTH 863

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap