1H4R,1GG3,1J19


Conserved Protein Domain Family
B41
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smart00295: B41 (this model, PSSM-Id:22745 is obsolete and has been replaced by 214604)
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Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in myosins, ezrin, radixin, moesin, protein tyrosine phosphatases. Plasma membrane-binding domain. These proteins play structural and regulatory roles in the assembly and stabilization of specialized plasmamembrane domains. Some PDZ domain containing proteins bind one or more of this family. Now includes JAKs.
Links
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Statistics
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PSSM-Id: 22745
Aligned: 55 rows
Threshold Bit Score: -1
Created: 14-Jul-2003
Updated: 14-Jul-2003
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1H4R_B     19 QPKTFTVRIVTMDAE-----------MEFNCEMKWKGKDLFDLVCRTLGL---------RETWFFGLQYTIKDT------ 72   human
3875583    11 SRRPKAL-IRLLDSQq----------IEVVLHSRLSVEDVLRLVAEKVDLs-------fPDSQYFCLGFSDNLNn----- 67   Caenorhabditis el...
2143945    35 KEDVRILKVCFYSNSfn--------pGKNFKLVKCTVQTEIQEIITSILLsgri-gpniQLAECYGLRLKHMKSd----- 100  Norway rat
1708579    30 VMKGLEIHFYLPDTHq----------LEYFKD-CHTAEDLCVEGCQEDATsh------lCADNLFALSEESQDL------ 86   common carp
17561792   67 SPKVVKFSIYFSRGErlsneeengieLNIESGKTADTKKLLFHLAKECGIdy------sAFSEMFAIWMISPLLevqlk- 139  Caenorhabditis el...
9297020  1254 SKKPIMLPVTFMDGTt----------KTLLTDSATTAKELCNALADKISL---------KDRFGFSLYIALFDKvsslgs 1314 human
3874641   602 SALDRCLRVGGRQEGp----------SRLEVT-SVLTRDVTRTKFPHSISv-------kLPNSEYQIVEFDGKQklc--- 660  Caenorhabditis el...
17568357   47 nEEKIFELLRRLPSTs----------NFFVFD-YWTIEDNFETCCRNQLSqftcycnsiVSRIGDSLNFACVDNghyrn- 114  Caenorhabditis el...
22265863 2514 GCQLRRQAFYISKDHn----------VSQTLRPITVAEEMIQELCNLLNVrs------lHEQQEFSLCYTVGKDk----- 2572 Caenorhabditis el...
3875038    90 TPMHKEARIQLPDMQm----------IDARVDFSVNSFKATKKLCRDLGI---------RYSEELSLKRYIPPEdlrrgt 150  Caenorhabditis el...

1H4R_B        --------------------------------------------------------------------------------      human
3875583       --------------------------------------------------------------------------------      Caenorhabditis el...
2143945       --------------------------------------------------------------------------------      Norway rat
1708579       --------------------------------------------------------------------------------      common carp
17561792      --------------------------------------------------------------------------------      Caenorhabditis el...
9297020  1315 gs------------------------------------------------------------------------------ 1316 human
3874641       --------------------------------------------------------------------------------      Caenorhabditis el...
17568357      --------------------------------------------------------------------------------      Caenorhabditis el...
22265863      --------------------------------------------------------------------------------      Caenorhabditis el...
3875038   151 sdadnmngplsmrpgeesvgpmtlrkaapifasqsnldmrrrgqspalsqsghifnahemgtlprhgtlprgvspspgay 230  Caenorhabditis el...

1H4R_B     73 -------------------------------------------------------VAWLKMDKKVLDHDVSk-----EEP 92   human
3875583    68 -------------------------------------------------------FHWLDGSVILYDLVASts--npKGT 90   Caenorhabditis el...
2143945   101 ------------------------------------------------------eIHWLHPQMTVGEVQDKyeclhvEAE 126  Norway rat
1708579    87 -------------------------------------------------------WYAPNHAFKITEETSI--------- 102  common carp
17561792  140 --------------------------------------------------syhrpYECRQGWSTLLERFAK--------- 160  Caenorhabditis el...
9297020  1317 ------------------------------------------------dhvmdaiSQCEQYAKEQGAQERN-------AP 1341 human
3874641   661 ----------------------------------------------------dalSTWETRSRDAQRGRVIs-----DCA 683  Caenorhabditis el...
17568357  115 --------------------------------------------------vmfsiNYLI--DQKLFDKVVKp----kTGK 138  Caenorhabditis el...
22265863 2573 ------------------------------------------------------hLNYCKNDNYLMDIITEse--hkKLP 2596 Caenorhabditis el...
3875038   231 ndtmrrtpimpsisfsegleneqfddalihsprlapsrdtpvfrpqnyvekaainRGWLDSSRSLMEQGIF-------EG 303  Caenorhabditis el...

1H4R_B     93 VTFHFLAKFYPENa----------------------------EEELVQEITQH--LFFLQVKKQILDEKIYCP------- 135  human
3875583    91 LTLSHHVRFFVDT-----------------------------IYEVQCASTAK--LFFFDIHNQLARHELLVT------- 132  Caenorhabditis el...
2143945   127 WRYDLQIRYLPEDf----------------------------MESLKEDRTTLl-YFYQQLRNDYMQRYASKVs------ 171  Norway rat
1708579   103 -KLHYRMRFYFTNwhapvrtespvwrhslfkhkgvsvspkgpEGTPLLDAASLe-YLFAQGQYDFLRGLAPVRapqneae 180  common carp
17561792  161 ETDIQLFNQDEPIlmlrrnas--------------ltcdkefELLQDHPKCAK--YLIYDASEMLLLGRLHLLs------ 218  Caenorhabditis el...
9297020  1342 WRLFFRKEVFTPW------------------------------HSPSEDNVATn-LIYQQVVRGVKFGEYRCEk------ 1384 human
3874641   684 AALSLRMRHYWGH------------------------------LALTETPIERq-FLVWRASEEIVNGRIPLS------- 725  Caenorhabditis el...
17568357  139 NIVIYKVKLLTNL-------------------------------------NLSn-KILFQFQDQVISGSLPCP------- 173  Caenorhabditis el...
22265863 2597 FQFYLKRTVWVHP--------------------------------LRYDNAAYidSMFDQVIDDYLRGSLISTnslgq-l 2643 Caenorhabditis el...
3875038   304 DIILLRFKFMNFF-----------------------------DLNPKYDPVRIn-QLYEQAKWSILLDEFDHT------- 346  Caenorhabditis el...

1H4R_B    136 ----PEASVLLASYAVQAKYGDYDPS------------------------------------------------------ 157  human
3875583   133 ----SEDYFELVAILVSVFVPDCQEHtta--------------------------------------------------- 157  Caenorhabditis el...
2143945   172 ----EGMALQLGCLELRRFFKDMPHNaldk-------------------------------------------------- 197  Norway rat
1708579   181 kheiENECLGMAVLAITHHAKSNDLPl----------------------------------------------------- 207  common carp
17561792  219 ----LENTIRVAAFLFCLQFGNFDETr----------------------------------------------------- 241  Caenorhabditis el...
9297020  1385 ----EDDLAELASQQYFVDYGSEMILe----------------------------------------------------- 1407 human
3874641   726 ----NQLCESLAALYAQMVFGDANQSl----------------------------------------------------- 748  Caenorhabditis el...
17568357  174 ----KEEAAYLASIQLSVEEQWPSNKrtqtirrhllkgqfgrirdlaqkimvtpwevdqnlyct---------------- 233  Caenorhabditis el...
22265863 2644 taatTEEIIKLAAYLFLLL-PDNPKG------------------------------------------------------ 2668 Caenorhabditis el...
3875038   347 ----EEEATLFAALQLQATLQRDSPEpeennkddvdilldeleqnldaaalnrrsdltqvpeladylkymkpkklaafkg 422  Caenorhabditis el...

1H4R_B        --------------------------------------------------------------------------------      human
3875583       --------------------------------------------------------------------------------      Caenorhabditis el...
2143945       --------------------------------------------------------------------------------      Norway rat
1708579       --------------------------------------------------------------------------------      common carp
17561792      --------------------------------------------------------------------------------      Caenorhabditis el...
9297020       --------------------------------------------------------------------------------      human
3874641       --------------------------------------------------------------------------------      Caenorhabditis el...
17568357      --------------------------------------------------------------------------------      Caenorhabditis el...
22265863      --------------------------------------------------------------------------------      Caenorhabditis el...
3875038   423 fkraffsfrdlylsyhqsssdvnsaplghfslkgcevsqdvsvgqqkyhiklllptaegmidfilkcdsehqyarwmaac 502  Caenorhabditis el...

1H4R_B    158 ------------------------------------------VHKRGFLAQEELLPKRVINly---------qMTPEMWE 186  human
3875583   158 ----------------------------------------eaISRIMPMSHPPYILLKTDQs---------------EVE 182  Caenorhabditis el...
2143945   198 --------------------------------------ksnfELLAKEVGLDLFFPKQMQEn-----------LKPKQFR 228  Norway rat
1708579   208 ------------------------------------------SGVGAETSYKRFIPDSLNRtik------qrnFSHVYVY 239  common carp
17561792  242 -----------------------------------------hDVAFIRNHIDEILPERTCDsivattifgkaiNKKTVQE 280  Caenorhabditis el...
9297020  1408 ---------------------------------------------RLLNLVPTYIPDREITpl----------ktLEKWA 1432 human
3874641   749 ------------------------------------------SDQQFEFISQRFYPSKMLDva-----------ciKSLR 775  Caenorhabditis el...
17568357  234 -----pprfpnesanasraqsvveeiqhrsrtptllrcitntDGLMSEEMQAQCLPVDLRGdr----------rtIKLVK 298  Caenorhabditis el...
22265863 2669 ---------------------------------------------LNAKTLPQIVPKSVIEpk---------hRHQEEMV 2694 Caenorhabditis el...
3875038   503 rlasrgksmadssyqqevesiknllkmqsgngnengnsntasRKAAAVKLPNDFNVDEYISskyv-----rraRSKQQIQ 577  Caenorhabditis el...

1H4R_B    187 ERITAWYAEH--------RGRARDEAEMEYLKIAQDLE-MYGVNYF 223  human
3875583   183 RRVFEKFRYY--------RRLPVGTGMISFIKLAEKSE-SYGYRMY 219  Caenorhabditis elegans
2143945   229 KMIQQTFQQY--------ASLREEECVMKFFNTLAGFA-NIDQETY 265  Norway rat
1708579   240 NNVFKNFLNEfnsktiqdSNITLYDLKVKYLSTLETLTqGLGRETI 285  common carp
17561792  281 ERLLSEWKNIs------kIGDKSKKEHDLLMELTQNSS-CYGAAWF 319  Caenorhabditis elegans
9297020  1433 QLAIAAHKKGi-------YAQRRTDAQ-KVKEDVVSYA-RFKWPLL 1469 human
3874641   776 LQINSNWSEL--------IGMSENECVRVILQVLGKWP-LFGSDLH 812  Caenorhabditis elegans
17568357  299 ERKRKLFHSQ--------VYESEIGMKKLYIQTAKKLA-AFGCKVF 335  Caenorhabditis elegans
22265863 2695 TRISRQLKMFg-------GRMRPAEAKSHFLELLSTWP-TFGVLHY 2732 Caenorhabditis elegans
3875038   578 QRVSDAHGNV--------RQLTATEAKLQYIRAWQALP-EHGIHYF 614  Caenorhabditis elegans
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