19113103 122 GTMGPAVGELTSPVMKNRAeSIFSPVTESFEAFTQGMqttpqragagvstatshtrrrssagtdpfspvspsnPNFLTPL 201 fission yeast 15805061 -------------------------------------------------------------------------------- Deinococcus radio... 15795074 23 AAIIQKNDAT-YQVDTPHGkRTKVKANNVFAEFDG----------------------------------------DMAAF 61 Neisseria meningi... 15676206 14 AAIIQKNDAT-YQVDTPHGkRTKVKANNVFAEFDG----------------------------------------DMAAF 52 Neisseria meningi... 17547498 2 QLLFEEGGEIRAGTVLSQQgEAYQVELPSAKRAKVK---------------------------------------SRDVL 42 Ralstonia solanac... 19075629 1 --------------------------------------------------------------------------MNYRQL 6 fission yeast 15639792 19 VHAIERGKDAKITIETEHG--LRRVRVKDVLLLHPGT------------------------------------VSSLVEL 60 Treponema pallidum 134917 341 FAPYLPQANIPELIQEGRLvAGILRVNKKNRSDAWVStdgaldadiyicg-----------skdrnralegdlVAVELLV 409 baker's yeast 17231942 18 GVVDRPDGKTRWFVVDERGqSHSLAPRQITYTVNGNTy----------------------------------kPSEIDRF 63 Nostoc sp. PCC 7120 7674330 18 AVVDRPDGKKDWVVIDQQGqSHKLKPQRVEYEIPGGPy----------------------------------tVDDLPSF 63 Synechocystis sp....
19113103 202 KPIdgNQEWQQSPLESPLSMHSLQESLhsvepespifqqaPQIPLSNASQQSYiNHSSDGASlpqssflnfnssgkrvsv 281 fission yeast 15805061 -------------------------------------------------------------------------------- Deinococcus radio... 15795074 62 LEN--AQAQAADIDTDLLWEVCGEE-----------------EFTAEAIAEEY-YGHAPTKTe----------------- 104 Neisseria meningi... 15676206 53 LEN--AQAQAADIDTDLLWEVCGEE-----------------EFTAEAIAEEY-YGHAPTKTe----------------- 95 Neisseria meningi... 17547498 43 LQF--AQPSAGELAQAAQALSSEIDLD-------------FLWECAPAEEFGFtDLAGEYFG------------------ 89 Ralstonia solanac... 19075629 7 FLLqnVNLESNYLLKRVCLSLKLSPCK-------------LTRKFHHACPSSS-KVLKYFR------------------- 53 fission yeast 15639792 61 LSAshIARISEESVQDAREFFGTEAPSf------------FELAELLWGASAAqSWAYWEQS------------------ 110 Treponema pallidum 134917 410 VDDvwESKKEKEEKKRRKDASMQHDLIplnss----ddyhNDASVTAATSNNFlSSPSSSDSlskddlsvr--------- 476 baker's yeast 17231942 64 LEE--VKPYLDPSSLEVAWELLVEDG----------------ETVTPSQMANL-LFSESNSAp----------------- 107 Nostoc sp. PCC 7120 7674330 64 LGE--VDQYLDPSSLEVAWELLIEEG----------------ESITPADLALL-LFSEQSPSq----------------- 107 Synechocystis sp....
19113103 282 saaaqqhknlflpylpqaslpkfigtgkllvgtlhinrKNRSDAYVITDVldepificgskdRNRTLEGDLVAVELldvn 361 fission yeast 15805061 -------------------------------------------------------------------------------- Deinococcus radio... 15795074 105 --------------------------------------LAATLIALYAAP------------MYFYKKAKGVFK------ 128 Neisseria meningi... 15676206 96 --------------------------------------LAATLIALYAAP------------MYFYKKAKGVFK------ 119 Neisseria meningi... 17547498 90 -----------------------------------------TDADATQQAa-----------LAIALHGSPVYFR----- 112 Ralstonia solanac... 19075629 54 --------------------------------------ITGCLINFGKQP------------ANDHHLWGHCGARLk--- 80 fission yeast 15639792 111 ---------------------------------------VQSAYFVCNEPa-----------AAVRIRSQQECASCa--- 137 Treponema pallidum 134917 477 ------------------------------rkrsstinNDSDSLSSPTKSgvrrr--sslkqRPTQKKNDDVEVEGqsll 524 baker's yeast 17231942 108 --------------------------------------SYAAHCLLSDDK------------LYFKQKGDAYEPRT---- 133 Nostoc sp. PCC 7120 7674330 108 --------------------------------------CYAAHALLAEDK------------LYFKQKGNHYEPRP---- 133 Synechocystis sp....
19113103 362 eIMQTKREkeekkirrnlslsgsskysvnskakmmsistpmalgmnrgvlsfersiekrkndyevtgqslsfvddvsLtp 441 fission yeast 15805061 -------------------------------------------------------------------------------- Deinococcus radio... 15795074 129 -AAPEETLkq------------------------------------------------------------------aLaa 141 Neisseria meningi... 15676206 120 -AAPEETLkq------------------------------------------------------------------aLaa 132 Neisseria meningi... 17547498 113 -----RKG------------------------------------------------------------------------ 115 Ralstonia solanac... 19075629 81 hTQSDLIDr----------------------------------------------------------------------- 89 fission yeast 15639792 138 -VQEEKKEa--------------------------------------------------------------------Rq- 147 Treponema pallidum 134917 525 lVEEEEINd--------------------------------------------------------------------Kyk 536 baker's yeast 17231942 134 -AAQVADRkh------------------------------------------------------------------qIev 146 Nostoc sp. PCC 7120 7674330 134 -SSQIEEIkh------------------------------------------------------------------qMrv 146 Synechocystis sp....
19113103 442 dsapKYAGHVVAVLNrpsgETCSGTLALYRPNSLalknqsshrrnsstssgetgkgpkIVWFKPSDKRIP---LIAISSD 518 fission yeast 15805061 1 ---------------------------------------------------------------------------MTQPE 5 Deinococcus radio... 15795074 142 --ieRKKQQDAQIDA----WAEALKRGEMPSEIAa----------------------dLKTILHAPDK-------QSLT- 185 Neisseria meningi... 15676206 133 --ieRKKQQDAQIDA----WAEALKRGEMPSEIAa----------------------dLKTILHAPDK-------QSLT- 176 Neisseria meningi... 17547498 116 ------RGRYQRAPEd---QLKAALAGLERKKQQ------------------------AAQQAAYEAELK---AMRLPEA 159 Ralstonia solanac... 19075629 90 ----FKNANLKSVNE----ENLKKFFSELENHGN------------------------IRQWLKDKFEKDk--RAAVCPT 135 fission yeast 15639792 148 ----ALKQAFIQELR----RVARSARNMAPTAQEgm---------------------hRVHVSQVNEQFT---PFLQEIE 195 Treponema pallidum 134917 537 plyaGHVVAVLDRIPg---QLFSGTLGLLRPSQQansdnnk-----------ppqspkIAWFKPTDKKVP---LIAIPTE 599 baker's yeast 17231942 147 --eaLKARGQQEFLT----RVEQALQGEAVEWQRh----------------------dRQRLEGLEKYGTllaDIVKVGL 198 Nostoc sp. PCC 7120 7674330 147 --qaQKEQEQQGFID----RVNQALAGEKVTWEGs----------------------dRLRLEALEKF------ILFPEQ 192 Synechocystis sp....
19113103 519 QVPptfftnnDDFKDKVFLAGIKRWPTT---SLHPFGTLYESIGTIGDPKVEYKAILHDFSCHTYd--FPESLSHCVKRL 593 fission yeast 15805061 6 LTP-----------AQRTEVELLARGRA----D--KSRVLRDLKLPETPEAAHALLLRLGVWDEArtpYADRLRAALNAV 68 Deinococcus radio... 15795074 186 -YK-----------------AFTKAAD------ALKTSAYELAKKTGGITSIP-QYLQDG--------FEIKYFPKGTGF 232 Neisseria meningi... 15676206 177 -YK-----------------AFTKAAD------ALKTSAYELAKKTGGITSIP-QYLQDG--------FEIKYFPKGTGF 223 Neisseria meningi... 17547498 160 FRG--------------KALQLLFKPDKnsiEFKAFDAACTALGMSPMRLMVAVGGIANARALHEa-rFLSECFPKGIGF 224 Ralstonia solanac... 19075629 136 TTK-------SEEEKLENDFEYSFDLED----FSSENFRQYDRGDLLVFYRGSEGIELAACTGTN---VWNYSNVLTSIN 201 fission yeast 15639792 196 AFA----------LGHANRCKILQCALGc-eHREQAHEILLHFGFWPVYRNPYPDRLCPLFLSPAh--VSGSDGERAAQQ 262 Treponema pallidum 134917 600 LAPkdfvenaDKYSEKLFVASIKRWPIT---SLHPFGILVSELGDIHDPDTEIDSILRDNNFLSNe-yLDQKNPQKEKPS 675 baker's yeast 17231942 199 NYDsl---arAYPPPAPVLETMNMLGRP-----ATPQGAFQLLVDLGWWSATENLFLRRSSIPVQ---FPSKVLEVAQQR 267 Nostoc sp. PCC 7120 7674330 193 NHR-------------QALDILQTLGKP-----GRTDETQNLLIELGIWQRHENLFLRRSAYPNQ---FPAKVSDVAHAY 251 Synechocystis sp....
19113103 594 PTPIPAE-----ELQKRYNLRDKLTFMIG---TRDYALHIDTGS-IDGVITLGIHVADVAYYVKQDMPLDDEAANRVSEV 664 fission yeast 15805061 69 ELPVPDFd----PAEERLDLTHLPTFAIDdegNQDPDDAVGVEDlGGGLTRLWVHVADVAALVAPDSPLDLEARARGATL 144 Deinococcus radio... 15795074 233 PDLPLPEm----PDLPKADVT---AFSIDdesTTEVDDALSLTDlGNGIKRVGIHIAAPSLAIKQGDKMEKNIMERLSTV 305 Neisseria meningi... 15676206 224 PDLALPEm----PDLPKADVT---AFSIDdesTTEVDDALSLTDlDNGTKRVGIHIAAPSLAVKPGDKMEKNIMERLSTV 296 Neisseria meningi... 17547498 225 PDVTVPEp---aLDLPVADVR---AFSIDdvtTTEIDDAISVTPlDAATVRIGIHIAAPGFGIQRGEALDAIARQRLSTV 298 Ralstonia solanac... 19075629 202 ENGTIKE-----FRTSRVLLRCPNVFKKLkevQQPLSDVSVPSD------VLPFTIKLLKKISQRAQDLSRSHRNEFLRI 270 fission yeast 15639792 263 DVHTHRC-----VTQARTDCTHLAAYAIDgegTRDPDDAISFD---G--TYFWIHVASPAELVLPDSHADACARTRGRSL 332 Treponema pallidum 134917 676 FQPLPLTaesleYRRNFTDTNEYNIFAISe-lGWVSEFALHVRNnGNGTLELGCHVVDVTSHIEEGSSVDRRARKRSSAV 754 baker's yeast 17231942 268 LDFP-PTd----LDTNRLDLTHLKVYTVDdesTTEIDDGLSWEKlPDDRERLWVHIADPTRYLAPEDDLDLEARKRGSTV 342 Nostoc sp. PCC 7120 7674330 252 LTNP-PPd----PDQERFDLTTLKTYTIDdesTSEIDDGLSVETlADGGHRLWIHVADPTRLLSPNDELDLEARKRSTSL 326 Synechocystis sp....
19113103 665 QLL-QGSVPFLPKKVSEE-ISLIEGHDCLTISIVVQLDlKSGAVLQCSLGPSVIHPSSFISLESAQANLQT--------- 733 fission yeast 15805061 145 YLP-DRTIGMLPDELVAK-AGLGLHEVSPALSICLDLD-PDGNAEAVDVLLTRVK-VQRLAYQEAQARLEA--------- 211 Deinococcus radio... 15795074 306 YFP-GGKITMLPENWIAA-FSLDAGTYRPSISIYFDVD-NEFNVGAPTCKIEAVNIAENLRIQAIEPHFNAe-------- 374 Neisseria meningi... 15676206 297 YFP-GGKITMLPENWIAA-FSLDAGAHRPAVSIYFDVD-GEFNVGAPTCKIEAVNIATNLRIQAIEPHFNAe-------- 365 Neisseria meningi... 17547498 299 YFP-GDKITMLPESVVDR-YTLQEGRACPALSLYVTVDrATWAVSASETRCEIVTVAANLRHNLLDEIVTAealaagtgd 376 Ralstonia solanac... 19075629 271 LTEfNIPNKLDNSASFSDlLKFVYKTSKPSPYAKISLLhFLLTESKHFLISDHIFSEIQKVYFLPSSQNDSf-------d 343 fission yeast 15639792 333 YLP-EGAVRMLSDVVVDT-CALARDAVSPALSFKILLD-EHGDISCVHVLRSMVR-VTRLSYAEADSQRD---------- 398 Treponema pallidum 134917 755 FMP-QKLVNLLPQSFNDe-LSLAPGKESATLSVVYTLDsSTLRIKSTWVGESTISPSNILSLEQLDEKLSTg-------- 824 baker's yeast 17231942 343 YLP-TGMIPMFPEVLATGpMSLVQGRVCCALSFGVVLD-GTGAVQDFTIHPSLIKPTYRLTYEDVDEMLELgv------- 413 Nostoc sp. PCC 7120 7674330 327 YLP-TGMISMFPPELATGpMSLLQGQRCVALSFGVTLD-EVGAVRDFTIAPSWVKPTYRLTYEDVDEMLVLki------- 397 Synechocystis sp....
19113103 734 NEALQLVDASAHVLTkLRLKTDKKLDLQSL--YCFEFCDgQIPNIQN----------INMSIFEAF-PIACSLQQIEHWV 800 fission yeast 15805061 212 -G----EEPFVTLAR-LARASRRLREGEGA--LSIDLPE-VRVKADEt--------gASVFPLPKP-EMRTVVQECMTLA 273 Deinococcus radio... 15795074 375 ----aGLDEAGEMMF-AHHQDLIWFY---Q--FATALQK-ARGKYEPdr-------aPQYDYSIEL-DKEDNVSVVRRER 435 Neisseria meningi... 15676206 366 ----tGLDEAGEMMF-AHHQDLIWFY---Q--FATALQK-ARGKYEPdr-------aPQYDYSIEL-DEEGKVSVVRRER 426 Neisseria meningi... 17547498 377 YPFKDELAVLWPFAGaLYDARQQARIASGLkpEGAQKGD-YSFYLDPipeaegggerIRIEQRKRGsPLDKIVAELMILA 455 Ralstonia solanac... 19075629 344 DVVACLRQKSTPYLSfIKKARHLIQVSRDKykLPISTEEiKPVVYSQ----------VTWTEFEKK-LLRYLVQEMIAKS 412 fission yeast 15639792 399 ------TPALQPLFD-FARNNIARRKGRGA--VDICFPD-VHMRVDFpvqet-gqagKEMNAGDVP-DTQGKVPRVHIEA 466 Treponema pallidum 134917 825 -----SPTSYLSTVQeIARSFYARRINDPEa-TLLPTLS-LLESLDDek------vkVDLNILDRT-LGFVVINEIKRKV 890 baker's yeast 17231942 414 ----qAEPEIAAIAT-WATKRKSWRYNQGA--ISINMPE-AMIKVKNd--------dISIDILDDS-RSRQLVAEMMILA 476 Nostoc sp. PCC 7120 7674330 398 ----qGEPELPLLAE-AAKKRAQWRKSQGA--ITIKMPE-AIIKVNAde-------eVQIYLQETS-VSRQLVAEMMILA 461 Synechocystis sp....
19113103 801 N-EKVASHLMSVFpSKvILRKNQRPSD--FASLVAVSELTGVNLSASST----PSEIMTEIATTK--DKRTKMLLQLTLR 871 fission yeast 15805061 274 G-WGTAIFADDNEiPL-PFATQDYPTR------EVAG----------------DTLPAMWARR-------K--TLARTRF 320 Deinococcus radio... 15795074 436 GsPIDTLVSEMMIlAN-STWAQMLH---------DNDLPG-------------L-FR--VQPTGK--------VRMSTKS 481 Neisseria meningi... 15676206 427 GsPIDTLVSEMMIlAN-STWAQMLH---------DNDLPG-------------L-FR--VQPTGK--------VRMSTKS 472 Neisseria meningi... 17547498 456 N-STWGRMLADAGvPG-IYRTQKAWGMhrTRMQTYPAPHEGLGVAQYAWstspLRRYVDLVNQWQiaAVAQHGVMAKLVA 533 Ralstonia solanac... 19075629 413 IqSLPNTHLCQVY-KEvGLQTHERGLTs--DQFAKFLTDIGVWASWQPPrl-fQQEYSIAGLGTN---PQLDAVYERECN 485 fission yeast 15639792 467 Q--QSYESMSMVR----EFMLLAGEAAa----rFAFLHNLAFPYVSQER----P-QLPVQLPAG--------LAGEYKKR 523 Treponema pallidum 134917 891 N-STVAEKIYTKLgDLaLLRRQMQPIAtkMASFRKKIQNFGYNFDTNTAdeliKGVLKIKDDDVR---VGIEILLFKTMP 966 baker's yeast 17231942 477 G-EVAARYGQVHNiPL-PFRGQPQP---------ELPPED-------------E-LL--RLPAGF--------VRACAMR 521 Nostoc sp. PCC 7120 7674330 462 G-EVAGRFCQEHGiPV-PFRGQPQP---------ELPSDE-------------E-LL--SLPPGP--------VRECAVR 506 Synechocystis sp....
19113103 872 RMCN--ESEYTIGtsnakDVSHFVFSCPY-YTHFCHPTRRYIDICVQRQLREAFDGRPDFSKDYr---SLLSITQSCNTL 945 fission yeast 15805061 321 QPSP---------------GPHHGMGLDL-YAQATSPMRRYLDLVVHQQLRAFLAGRDPLSS--------KVMAAHIAES 376 Deinococcus radio... 15795074 482 --EP-----------------HIGMGVRH-YGWFTSPLRRAADYINQKQLISLIDDTAEPLYQN----SDAELFAALRDF 537 Neisseria meningi... 15676206 473 --EP-----------------HIGMGVQH-YGWFTSPLRRAADYINQKQLISLIDDTAEPLYQN----SDAELFAALRDF 528 Neisseria meningi... 17547498 534 PFKP--KDADLLA-----AVADFEATYAA-YAAHQSTMERY---WCLRWLKQEAR---------------TRTQAVVLKE 587 Ralstonia solanac... 19075629 486 HFKKfvKNELKDSl----ESQRVDLRHLKaFAFDSSSTKEIDDAISVEELGMSNSWLHIHVANP-----TSTVDIRSPLG 556 fission yeast 15639792 524 RAMK--ARRVSTT-----AAVHAALGLSQ-YSQVTSPLRRYVDLLAHQQLLACIDHAYAKAPAVgsaqTNETLALKLAQA 595 Treponema pallidum 134917 967 RARYfiAGKVDPD-----QYGHYALNLPI-YTHFTAPMRRYADHVVHRQLKAVIHDTPYTED-------MEALKITSEYC 1033 baker's yeast 17231942 522 RCMPk--SEMSIT-----PVRHAGLGLDT-YTQATSPIRRYSDLLTHFQLKAHLRGEVPPFTA-------EELKEVMMTV 586 Nostoc sp. PCC 7120 7674330 507 RCMPr--SEVGIT-----PSRHASLGLDL-YSQATSPIRRYTDLITHFQMKAYLRGEPLPFSG-------EQVQEILYSV 571 Synechocystis sp....
19113103 946 SNFYRNAQEKSLH--AYLCQLLHSINLRSGl---VKHKAFVLAVDQEYIDIVIYEFgLERRISLDLLPLsncdfneqkhe 1020 fission yeast 15805061 377 QMNADATRQAERL--SRRHHTLRFIAAQPE----RVWDAVVVDRRGAQATLLIPDLaFDVQVNTPAAPG----------- 439 Deinococcus radio... 15795074 538 DAAYTAYADFQRQ--MEAYWSLVYLQQQGT----SELTATIL----KEDLVRIEGLpLVTRATGIPFD------------ 595 Neisseria meningi... 15676206 529 DAAYTAYADFQRQ--MEAYWSLVYLQQQGT----SELTATIL----KEDLVRIEGLpLVTRATGIPFD------------ 586 Neisseria meningi... 17547498 588 GMVRFAEIPLMTR--VPELAQTARGTHVVL----DVLEIDEIGLEVSCRVVEVLAPaADAEVEAAALED----------- 650 Ralstonia solanac... 19075629 557 TFAERNFQTIYHPnkIVYMLPLNITQKYWS----LDSSSTAQRALTFSAKISKNGDiLDYKVRPSFISSv---------- 622 fission yeast 15639792 596 DEAARQATQAERV--SRRHWTLVYFLMHPH----TRYEAIVLEPLQPRAHVWLPAVaLEADVALGRQAQf---------n 660 Treponema pallidum 134917 1034 NFKKDCAYQAQEQ--AIHLLLCKTINDMGNttgqLLTMATVLQVYESSFDVFIPEFgIEKRVHGDQLPLikaefdgtnrv 1111 baker's yeast 17231942 587 TSTTQELTMVERQ--TNRYWALEYLRRHPE----EIWQVTVLMWLREDSNLALILLeDLGLQLPMVFKR----------- 649 Nostoc sp. PCC 7120 7674330 572 MPSSKEATLVERQ--TNRYWSLEFLRRNIN----EVWQGVMLRWLREDDGLGLILLeELGLELPHRFDR----------- 634 Synechocystis sp....
19113103 1021 LYLSWRTNAs---FFYASSSLEIDTPCFNDFKKKFLDSNGmckqICDMMDAQVRDL 1073 fission yeast 15805061 440 ----------------TALQVQFADIDLPQMRVRARSV------------------ 461 Deinococcus radiodurans 15795074 596 -ALPKSQ---------ALFKITELDAEKQFVSLNYIKAVA----PAGTTAGNAV-- 635 Neisseria meningitidis Z2491 15676206 587 -ALPKSQ---------ALFKITELDAEKQFVSLNYIKAVA----PAGTTAGNAV-- 626 Neisseria meningitidis MC58 17547498 651 ELAQAEA---------EAPAEPQPAADGEEIRAETGDAVA----PPQQDDGTSAAS 693 Ralstonia solanacearum 19075629 623 IKYTPQQLD----KALHSNRSIAKDIVSGPVDEETKGVSN----DHMKDILRIYEL 670 fission yeast 15639792 661 ERVMLRVVR------VRLATLEVHFSVCEHCHRGVTQAVEge-aEQPSXEEYVFGS 709 Treponema pallidum 134917 1112 LELHWQPGVdsatFIPADEKNPKSYRNSIKNKFRSTAAEIanieLDKEAESEPLIS 1167 baker's yeast 17231942 650 SVRLGEQ---------VLVKVSISDPQKDVIQFQ--EIIY----QEAQTAAN---- 686 Nostoc sp. PCC 7120 7674330 635 PISPGDR---------LSLKVSNADPHRDEIRFR--ELLA----NEA--------- 666 Synechocystis sp. PCC 6803
Jiyao W et al.(2023). "The conserved domain database in 2023.",