Conserved Protein Domain Family
ATG13

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pfam10033: ATG13 (this model, PSSM-Id:220532 is obsolete and has been replaced by 313287)
Autophagy-related protein 13
Members of this family of phosphoproteins are involved in cytoplasm to vacuole transport (Cvt), and more specifically in Cvt vesicle formation. They are probably involved in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage.
Statistics
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PSSM-Id: 220532
View PSSM: pfam10033
Aligned: 39 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 22-Dec-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam10033 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74698839   109 IYHFYTTTANLVIQSRLahlrssl--lnapidITSPPAAAVS--SHAKLSRWFGLHI---PESDLFKDELRLWRSltcll 181
gi 75202704    18 VSHFFPKALHIVLNSRIpsl---------qsrGRTRERLSGL--NVRKSDKWFNLVM---GDRPAALEKLHSWHRn---- 79
gi 75273928    50 IFEFFAKSLHIILESRTpfmssrnfsgeqmicSPSSSSSSSS--SVRPRDKWFNLAL---RECPAALESFDIGRRs---- 120
gi 75271213    14 ITEFFAKSLHIILESRSpyess------rnftRPSPPSSPLS--GSQPRDRWFNLAL---RDCPAVLENFDLWRQs---- 78
gi 74764954     9 IRKTISKISQCILLSRV---------------------ETSS--VSRRVNKTFHLET---EESDIHRQEIDRIVLknd-- 60
gi 74947989    17 IKFLVLKSTQVVVQSRL---------------GEKMQTQCNP--LA--GSDWFNIAV---QDHPEVLDETKRALNlktge 74
gi 74802827    18 IRQLAMKAAQIIVQSRL---------------GEKIATESNP--NS-TSTDWFNISItdqQSILDVLVETKKILAdggqh 79
gi 121956300   19 VKIMAMKSAQIIVQARL---------------GEKIRTDCNP--RT-SGNDWFNIAI---VDQPDVLAETKKVLQisqhe 77
gi 125540477   22 VPQFHLKALHAILAVRA---------------PRPLAAAPAPaaSFRRRDRWFHLPLh-aPAPPASAEHLPEp------- 78
gi 123437314   21 TREFLNKVIECIYYSRC---------------PGEIA-------DFREDDFQFSLKI---PRSQSLRQLTSSHKI----- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74698839   182 asdahdsdhptstsAVPDLIIDVLLDLSAVSANHSILLLSRRSNNLSAqssadssiripihrhssgrasplssttpplRI 261
gi 75202704    80 --------------ILDSMIIDIILVHPISNDNLDDDDDHSDSVVRSA------------------------------ET 115
gi 75273928   121 --------------SLEPLVVDVVLVVRPLVGDQSG--------KRELirnfsgkdyqsgw----nsdqdelgcetknEQ 174
gi 75271213    79 --------------NLEPLVIDIVLLCRDSTSNTAAGS----------------------------------------GK 104
gi 74764954    61 --------------mriLFVIEIHFDENVGLGL---------------------------------------------NT 81
gi 74947989    75 ----------silqRLP-LCVEISLKTte-----------------------------------------------gdQM 96
gi 74802827    80 ---------esiitRLP-LCVEISLQTae-----------------------------------------------ggSM 102
gi 121956300   78 ----------sivtRLP-LCVEISLQTve-----------------------------------------------gdNM 99
gi 125540477   79 -------------sPGEPLVVDVYLTPSGggg--------------------------------------------gsEA 101
gi 123437314   71 ---------------HGFVKLDIIIVNP--------------------------------------------------DK 85
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74698839   262 VLERWRLQFK----------------PSHPSPPPDLATFYKR----SVVHFRALFTLLCSLPSNRLAAKIealkvanskS 321
gi 75202704   116 VIERWVVQYEnpl----------imsPQSSDSATRYQKVYKK----SIILLRSLYAQTRLLPAYRVSRQL---------S 172
gi 75273928   175 IIERWVVQYDnrkir------esvttSSRRSSSNKLQVMYKK----ATLLLRSLFVMVRLLPAYKIFREL---------N 235
gi 75271213   105 IIERWVIQYEarksgggngngsknngRKSRNSSAEDHSLYRAtyqgSTVLLRSLHLLVRLLPAYSLFREL---------N 175
gi 74764954    82 IVESWRIIFD----------------PREIDNSVELPKFYKN----VIILIRTIYAMLRNIPCYSLFKNFs--------K 133
gi 74947989    97 VLEVWSLDLLqpqngas---patndlNPEGQTLKAAHAIYNR----MGIMLKSLISLTRTTPAYKLSRRQc--------- 160
gi 74802827   103 ILECWTLSIRt---------------DQTNAPQRANQVIYNR----MSLLLKSLLSVTRVTPAYRVSRIKr--------- 154
gi 121956300  100 ILEVWSLSVQa---------------DQCDPASRTTHSVYNR----MGLLLKSLLSVTRSTPAYKLSRRQs--------- 151
gi 125540477  102 VVESWTVSCEpwsaga-----raggtAAASGEGLAVNRAYKR----CITLLRSVYTALRLLPAYRVF-RLl--------C 163
gi 123437314   86 LLERWIIEHRplskq-------esevFTQHYSTEEKHLIYQK----FSSCLRSVFCILNALPAQSIALNLk--------N 146
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74698839   322 RGADAtfttssvpslsyrnhvgshDaQMNIGCRLSmdadsyqarpdsaeiAITQPLpaeQHLPHLndlnpdesgtplgtS 401
gi 75202704   173 SSLAS-------------------S-GYDLIYKVS---------------SFSDIF---SGPVTE--------------T 200
gi 75273928   236 SSGQI-------------------F-KFKLVPRVP---------------SIVEPF---TRKEEA--------------E 263
gi 75271213   176 SSGRI-------------------R-PLNLSHKIS---------------SFVEPF---TRAEDA--------------E 203
gi 74764954   134 NRSAT-------------------C-SVNYQLRVCds------------qSITTPS---FPLST---------------S 163
gi 74947989   161 -----------------------pD-SYGIFYRIYvdrpqv---------------------------------htlgeG 183
gi 74802827   155 -----------------------aD-SYDIYYRIYtgepqt---------------------------------nqlgdG 177
gi 121956300  152 -----------------------aD-SYQIFYRIYigepqt---------------------------------hqlgdG 174
gi 125540477  164 ASGQA-------------------Y-NYEMGFRVG---------------SFAAPF---TRSEEA--------------A 191
gi 123437314  147 YTAQD-------------------R-KISA----Lcgdfkm---ledqrfSLDEG------------------------H 175
                         330       340       350
                  ....*....|....*....|....*....|.
gi 74698839   402 HGhyaTRNLVPVATPIGHLELSVSYRKCTDY 432
gi 75202704   201 MK---EFRFAPVEVPPGRLCASVTYRSDLSD 228
gi 75273928   264 MQ---KFSFTPVETICGRLCLSVLYRSLSDV 291
gi 75271213   204 MK---HYAFAPIETLFGRLSLSVSYVPVLEV 231
gi 74764954   164 IK---TVSFTAIPTPMGILKIDLSYKENLTR 191
gi 74947989   184 HK---HVKIGQLSTIVGSLVMSVAYRTKLTI 211
gi 74802827   178 YN---QVRVGQLCTQIGTLNMAVAYRTKITF 205
gi 121956300  175 HK---QIRVGQLCTQIGTLAMAVAYRTKMTI 202
gi 125540477  192 MS---TRRFAPVETQLGRLVVSVQYLPSLaa 219
gi 123437314  176 TK---QVALPPVLTPVGKTIIRCQYLKEPEk 203
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