3MNF,2P90,3GAA,3E35


Conserved Protein Domain Family
PAC2
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pfam09754: PAC2 (this model, PSSM-Id:220382 is obsolete and has been replaced by 430804)
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PAC2 family
This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 247 and 307 amino acids in length. These proteins function as a chaperone for the 26S proteasome. The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits.
Links
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Statistics
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PSSM-Id: 220382
Aligned: 129 rows
Threshold Bit Score: -1
Created: 22-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3MNF_A        11 AFEGWNDAGDAASTAVAHLDREW--KGEVFAALDAeDYYDfqvnrPTVWLD-G-Gvr-------kITWPTTRLSVVrvgg 79  Streptomyces av...
P36040         4 LVLPLVSVGNIPQLSIDWLLNSQanEWEYLEALDSkYLVEfvgplDRPEDG-SdSlykd---admKYSSALEVFYN---- 75  Saccharomyces c...
Q6FNF0         5 LIIPLIGTGNVPQLSIDLLLHSTn-SFNYVKRIDSkFCYPfsgplDHAAGE-DpKlyn----gktLFSSAIELFKQ---- 74  Candida glabrata
Q753Q7        26 LVLPLVSAGNVPQLCADVLLHSTpgEFRFVRELDGqWLHPfvgplDYVEGQ-EsLlyrd--apgkRVTTPLELFYC---- 98  Eremothecium go...
Q6CV80         4 LLLPLVSTGNVSQLCVDLVLHSEsdEFTFVKELDSiWLHSfigplDFVEGS-SkPlyhdckgskkQFTTPLELFYN---- 78  Kluyveromyces l...
Q7QFU9        16 FIVPSVSVGNVPQLAADAVIETL--QLEPIGLLWSpALVPivgapAFEHTG-Gs----------dAITTTAELYVS---- 78  Anopheles gambi...
Q293V1        18 VIIPSICVGNAAQLACDLLIASK--QLKRIGSVTHpALIPvfgpsAYQHEPn-------------EKVSSCELYEG---- 78  Drosophila pseu...
EDK36344      17 IIVPSISMANVPQLAVDLLIHTL--KLEKVGSLDDkYLYPfsapfDRMPEE-N-Pk--------lGISSAVEIYYS---- 80  Pichia guillier...
XP_001525899  23 LIIPTISIGNIPQLTIDLLIHTY--NFNKIGILNDtFLYPfaspiDYSPQHsE-Pk--------eGISHAIEIYHN---- 87  Lodderomyces el...
XP_001647499   4 LVIPLVSTGNVPQLSTDLILHTLsnEFQFVQAVDStFVHPfvgplDYVFGQ-D-DpelyknvphkQYSTGLELFHN---- 77  Vanderwaltozyma...
P36040         4 LVLPLVSVGNIPQLSIDWLLNSQanEWEYLEALDSkYLVEfvgplDRPEDG-SdSlykd---admKYSSALEVFYN---- 75  Saccharomyces c...
Q6FNF0         5 LIIPLIGTGNVPQLSIDLLLHSTn-SFNYVKRIDSkFCYPfsgplDHAAGE-DpKlyn----gktLFSSAIELFKQ---- 74  Candida glabrata
Q753Q7        26 LVLPLVSAGNVPQLCADVLLHSTpgEFRFVRELDGqWLHPfvgplDYVEGQ-EsLlyrd--apgkRVTTPLELFYC---- 98  Eremothecium go...
Q6CV80         4 LLLPLVSTGNVSQLCVDLVLHSEsdEFTFVKELDSiWLHSfigplDFVEGS-SkPlyhdckgskkQFTTPLELFYN---- 78  Kluyveromyces l...
Q7QFU9        16 FIVPSVSVGNVPQLAADAVIETL--QLEPIGLLWSpALVPivgapAFEHTG-Gs----------dAITTTAELYVS---- 78  Anopheles gambi...
Q293V1        18 VIIPSICVGNAAQLACDLLIASK--QLKRIGSVTHpALIPvfgpsAYQHEPn-------------EKVSSCELYEG---- 78  Drosophila pseu...
EDK36344      17 IIVPSISMANVPQLAVDLLIHTL--KLEKVGSLDDkYLYPfsapfDRMPEE-N-Pk--------lGISSAVEIYYS---- 80  Pichia guillier...
XP_001525899  23 LIIPTISIGNIPQLTIDLLIHTY--NFNKIGILNDtFLYPfaspiDYSPQHsE-Pk--------eGISHAIEIYHN---- 87  Lodderomyces el...
XP_001647499   4 LVIPLVSTGNVPQLSTDLILHTLsnEFQFVQAVDStFVHPfvgplDYVFGQ-D-DpelyknvphkQYSTGLELFHN---- 77  Vanderwaltozyma...

3MNF_A        80 EKprdLVLVRG--IEPS-XRWRSFCNE-LL-AFAHELGVELVVVLGALLG-DTPH--TRPv--PVSGVTsDPDLA----- 144 Streptomyces av...
P36040        76 KKr-gLFAIQQrtPLVSvNYLNNFIVEiIL-PFLSKYNISEICIWDSLYA-MEDE----------------NGVIv---- 132 Saccharomyces c...
Q6FNF0        75 KDe-qIYVIQQrtPIIP-GYLNNFIVEtLI-PVLHEYQITELIVLDSFGA-LDGV--------VESLNGsGSFFNv---- 138 Candida glabrata
Q753Q7        99 EQr-qLYLVQQrsPVVQ-GYENEFCKEvLL-PLLEELAPQRVVVLDSVGE-FETEv-------PVHTETmESRFSv---- 163 Eremothecium go...
Q6CV80        79 RRl-dLYVIQQrsPVIA-GYENQFFKEvII-PLIKSYGIESVIVLDSAGA-LDPSv-------PFSNANyQHQYAt---- 143 Kluyveromyces l...
Q7QFU9        79 QEk-kLLVLQLraPLVG-PLRQTFLDE-LS-DFVRDRKFSHAILLSSCFS-HEKFdiRT----GPFRYVaNEQYEa---- 145 Anopheles gambi...
Q293V1        79 VEd-kLLVIQFraPWIA-RHTRNFQQQ-LV-ELIK--GAKRVIILSGSFG-FEKRviEA----SPWAYRaSENFKl---- 143 Drosophila pseu...
EDK36344      81 KEl-qVTAIQQrsPILP-GFTEHYVNEtIA-PFLSQHKFRNVWILDSVDA-GMSE--GLPs--GTMKVFsNSEML----- 147 Pichia guillier...
XP_001525899  88 NEl-nLVVVQQrsPIIP-SYTSLFVQN-VInPFIKHSGIQKVVLLNSQDL-GLVK--GLPhqgGSHGFNnETELE----- 156 Lodderomyces el...
XP_001647499  78 ESk-dLYVLQQrsPVIQ-GYLNNFIKRsIV-PLLNKYGIDEVVIVDSYGAlDEDV--LVP---SSIATRnGNPFSlgvid 149 Vanderwaltozyma...
P36040        76 KKr-gLFAIQQrtPLVSvNYLNNFIVEiIL-PFLSKYNISEICIWDSLYA-MEDE----------------NGVIv---- 132 Saccharomyces c...
Q6FNF0        75 KDe-qIYVIQQrtPIIP-GYLNNFIVEtLI-PVLHEYQITELIVLDSFGA-LDGV--------VESLNGsGSFFNv---- 138 Candida glabrata
Q753Q7        99 EQr-qLYLVQQrsPVVQ-GYENEFCKEvLL-PLLEELAPQRVVVLDSVGE-FETEv-------PVHTETmESRFSv---- 163 Eremothecium go...
Q6CV80        79 RRl-dLYVIQQrsPVIA-GYENQFFKEvII-PLIKSYGIESVIVLDSAGA-LDPSv-------PFSNANyQHQYAt---- 143 Kluyveromyces l...
Q7QFU9        79 QEk-kLLVLQLraPLVG-PLRQTFLDE-LS-DFVRDRKFSHAILLSSCFS-HEKFdiRT----GPFRYVaNEQYEa---- 145 Anopheles gambi...
Q293V1        79 VEd-kLLVIQFraPWIA-RHTRNFQQQ-LV-ELIK--GAKRVIILSGSFG-FEKRviEA----SPWAYRaSENFKl---- 143 Drosophila pseu...
EDK36344      81 KEl-qVTAIQQrsPILP-GFTEHYVNEtIA-PFLSQHKFRNVWILDSVDA-GMSE--GLPs--GTMKVFsNSEML----- 147 Pichia guillier...
XP_001525899  88 NEl-nLVVVQQrsPIIP-SYTSLFVQN-VInPFIKHSGIQKVVLLNSQDL-GLVK--GLPhqgGSHGFNnETELE----- 156 Lodderomyces el...
XP_001647499  78 ESk-dLYVLQQrsPVIQ-GYLNNFIKRsIV-PLLNKYGIDEVVIVDSYGAlDEDV--LVP---SSIATRnGNPFSlgvid 149 Vanderwaltozyma...

3MNF_A       145 -----RTXDL---------EET---KY-----E-----GP---TGIVGILQEAC-THAG----------------VPAVS 177 Streptomyces av...
P36040       133 -----RPQEVyslgefyfdDEAellSN-----LhlndqES---MVNNWLHFTPTsFQDK----------------ISV-- 181 Saccharomyces c...
Q6FNF0       139 -----GTCNLssvndliqqFDDhlnLR-----Nng---qV---NRVKAFNFDDKgIQQD----------------ITT-- 184 Candida glabrata
Q753Q7       164 -----ATCNVtsisdvakeFAEglqLD-----Eqn--dLS---VNSTLFSFRQGsFQRG----------------IST-- 210 Eremothecium go...
Q6CV80       144 -----AKCQLesldnitlqFQTrlsIQ-----Dde---hS---IVNQVFHFDTAsFQQN----------------FSA-- 189 Kluyveromyces l...
Q7QFU9       146 -----QSPDAahlkddrwtKHSggvIH----------------------------------------------------- 167 Anopheles gambi...
Q293V1       144 -----AHAAQlgnpdlikwKEHtgeAI-----Y----------------------------------------------- 166 Drosophila pseu...
EDK36344     148 -----R---V---------SLEslnIG-----G-----GN---KLPD--------------------------------- 164 Pichia guillier...
XP_001525899 157 -----NGHVE---------VFSladLMnckfeE-----LK---LSSASITETES-ETRNntsndanidddesfafVKSIF 213 Lodderomyces el...
XP_001647499 150 lnsigDMSRV---------FDTslnLG-----E-----NSnqtSNIASTLFTFT-EQ----------------------S 187 Vanderwaltozyma...
P36040       133 -----RPQEVyslgefyfdDEAellSN-----LhlndqES---MVNNWLHFTPTsFQDK----------------ISV-- 181 Saccharomyces c...
Q6FNF0       139 -----GTCNLssvndliqqFDDhlnLR-----Nng---qV---NRVKAFNFDDKgIQQD----------------ITT-- 184 Candida glabrata
Q753Q7       164 -----ATCNVtsisdvakeFAEglqLD-----Eqn--dLS---VNSTLFSFRQGsFQRG----------------IST-- 210 Eremothecium go...
Q6CV80       144 -----AKCQLesldnitlqFQTrlsIQ-----Dde---hS---IVNQVFHFDTAsFQQN----------------FSA-- 189 Kluyveromyces l...
Q7QFU9       146 -----QSPDAahlkddrwtKHSggvIH----------------------------------------------------- 167 Anopheles gambi...
Q293V1       144 -----AHAAQlgnpdlikwKEHtgeAI-----Y----------------------------------------------- 166 Drosophila pseu...
EDK36344     148 -----R---V---------SLEslnIG-----G-----GN---KLPD--------------------------------- 164 Pichia guillier...
XP_001525899 157 -----NGHVE---------VFSladLMnckfeE-----LK---LSSASITETES-ETRNntsndanidddesfafVKSIF 213 Lodderomyces el...
XP_001647499 150 lnsigDMSRV---------FDTslnLG-----E-----NSnqtSNIASTLFTFT-EQ----------------------S 187 Vanderwaltozyma...

3MNF_A       178 LWAAVPhyvsqppNPKATLAL---------------L-NRL-EDL------I-D----VRIpL-GELPEDArawQvgvdq 228 Streptomyces av...
P36040       182 -------------DQPIFKIL---------------F-QILnASQrpk-alR-S----IKY-C-SCLANEGdnsL----- 219 Saccharomyces c...
Q6FNF0       185 -------------EQDIFKVV---------------Y-HLTnTSNlq---lN-K----IKY-Y-STFVHEGdnsE----- 220 Candida glabrata
Q753Q7       211 -------------EQFIFKFS---------------Y-HLLhSPLarsadfA-E----LSY-V-SIFIHEGdnnE----- 249 Eremothecium go...
Q6CV80       190 -------------DQPVFKLF---------------H-HLLyQSDln---lK-S----ITY-L-SKVVHEGdnsW----- 225 Kluyveromyces l...
Q7QFU9       168 -------------GGGFASKL---------------L-DGLtARQ------V-P----AVV-F-FMYVSEGdntA----- 200 Anopheles gambi...
Q293V1       167 -------------GGGNALQL---------------F-KAFdEAQ------V-Q----VML-L-FRYLIEGdnsT----- 199 Drosophila pseu...
EDK36344     165 -----Ptn---vcHSLYACKL---------------VaKLI-SPG------ArN----FELgTiVTYIYEGdnfN----- 205 Pichia guillier...
XP_001525899 214 QAFDVPtk---tlESKAASNNssnstnsissskvtnH-EST-LKG------L-D----LTV-L-VSYAYESdnfH----- 270 Lodderomyces el...
XP_001647499 188 LQQEISt------rQEVFKFV---------------Y-HLL-NSQ------L-NslktIKY-C-SLFVHEGdnsY----- 230 Vanderwaltozyma...
P36040       182 -------------DQPIFKIL---------------F-QILnASQrpk-alR-S----IKY-C-SCLANEGdnsL----- 219 Saccharomyces c...
Q6FNF0       185 -------------EQDIFKVV---------------Y-HLTnTSNlq---lN-K----IKY-Y-STFVHEGdnsE----- 220 Candida glabrata
Q753Q7       211 -------------EQFIFKFS---------------Y-HLLhSPLarsadfA-E----LSY-V-SIFIHEGdnnE----- 249 Eremothecium go...
Q6CV80       190 -------------DQPVFKLF---------------H-HLLyQSDln---lK-S----ITY-L-SKVVHEGdnsW----- 225 Kluyveromyces l...
Q7QFU9       168 -------------GGGFASKL---------------L-DGLtARQ------V-P----AVV-F-FMYVSEGdntA----- 200 Anopheles gambi...
Q293V1       167 -------------GGGNALQL---------------F-KAFdEAQ------V-Q----VML-L-FRYLIEGdnsT----- 199 Drosophila pseu...
EDK36344     165 -----Ptn---vcHSLYACKL---------------VaKLI-SPG------ArN----FELgTiVTYIYEGdnfN----- 205 Pichia guillier...
XP_001525899 214 QAFDVPtk---tlESKAASNNssnstnsissskvtnH-EST-LKG------L-D----LTV-L-VSYAYESdnfH----- 270 Lodderomyces el...
XP_001647499 188 LQQEISt------rQEVFKFV---------------Y-HLL-NSQ------L-NslktIKY-C-SLFVHEGdnsY----- 230 Vanderwaltozyma...

3MNF_A       229 laaedsEVAEYVQS-LEE 245 Streptomyces avermitilis MA-4680
P36040       220 ------DSQQFLQWiISQ 231 Saccharomyces cerevisiae S288c
Q6FNF0       221 ------DAYTFYNN-LML 231 Candida glabrata
Q753Q7       250 ------DALLLCTE-LPT 260 Eremothecium gossypii
Q6CV80       226 ------DAFQICEK-LAE 236 Kluyveromyces lactis
Q7QFU9       201 ------EGLMLARM-LNA 211 Anopheles gambiae str. PEST
Q293V1       200 ------DASLIVRE-LNE 210 Drosophila pseudoobscura
EDK36344     206 ------EAEKLSDK-VAE 216 Pichia guilliermondii ATCC 6260
XP_001525899 271 ------DAETMMQQ-LKE 281 Lodderomyces elongisporus NRRL YB-4239
XP_001647499 231 ------DASVLCEY-LPQ 241 Vanderwaltozyma polyspora DSM 70294
P36040       220 ------DSQQFLQWiISQ 231 Saccharomyces cerevisiae S288c
Q6FNF0       221 ------DAYTFYNN-LML 231 Candida glabrata
Q753Q7       250 ------DALLLCTE-LPT 260 Eremothecium gossypii
Q6CV80       226 ------DAFQICEK-LAE 236 Kluyveromyces lactis
Q7QFU9       201 ------EGLMLARM-LNA 211 Anopheles gambiae str. PEST
Q293V1       200 ------DASLIVRE-LNE 210 Drosophila pseudoobscura
EDK36344     206 ------EAEKLSDK-VAE 216 Pichia guilliermondii ATCC 6260
XP_001525899 271 ------DAETMMQQ-LKE 281 Lodderomyces elongisporus NRRL YB-4239
XP_001647499 231 ------DASVLCEY-LPQ 241 Vanderwaltozyma polyspora DSM 70294
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