Conserved Protein Domain Family
Rab5-bind

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pfam09311: Rab5-bind (this model, PSSM-Id:220173 is obsolete and has been replaced by 430517)
Rabaptin-like protein
Members of this family are predominantly found in Rabaptin and allow for binding to the GTPase Rab5. This interaction is necessary and sufficient for Rab5-dependent recruitment of Rabaptin5 to early endosomal membranes.
Statistics
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PSSM-Id: 220173
Aligned: 20 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 22-Dec-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4SZ98  18 SLQQAFSEAQRSTQEHLMVLVKSREQVADELSRLQRDNESLQGKHRLHVELQ-----QQEAFQMPDTVQELQELVGQLRE 92  spotted green pufferfish
Q2TBQ9  79 ELGLGEAQVLLALSAHVGALEAEKQRLRAQARRLAQENAWLREELEETQRRLra--sEEAVAQLEEEKSHLEFLGQLRQY 156 cattle
Q28X22 349 DMQQKFLDTKDAVMRQLQRITDDRERVNKQLETLQADNDFLSGRYLATSEEI-----ENQYINLPNTVVELQELMLRQQS 423 Drosophila pseudoobscura
Q4S9M5 257 DLQKSFSQSQNAVQSRLTELSLSQRKMCCELSKLKGED--VEAEAAEASSPFsalqgPHCEERLRIEIVHLREQLDTRTE 334 spotted green pufferfish
Q3TZJ2 332 TLQGTVSQAQERVQLQMAELATSHKCLSQEVKRLNEENQGLRAEQLLSSALQgseqrEDQDEALPSSIQELHLLVQNTRQ 411 house mouse
Q4R6D1 294 TLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQglqqeQGEEESLPSSVPELQQLLRRTRQ 373 crab-eating macaque
Q8MQT4 124 ELEGYFKGETANIRRELSEVIASRRKIEDVYQTLSDQYDHLLGRHRQGARQL-----EEEKIDLPQDVEELQLLCLQLKE 198 Trichinella spiralis
P90665 118 ELSEKHRRERVKLFEQLEDANQLCARLELDIKNLASKYQQLLGANRATAAEM-----RAEPIDLPQSADQLQFLCLQMRE 192 rat lungworm
O35550 612 ELQQSFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-----LAEDFILPDTVQVLRELVLKYRE 686 Norway rat
Q5XGI7 603 DLQQAFTQAKRNIQDQMAVLMHSREQVSEELLRLQRDNESLQGKHSLHVSLQ-----QAENFSLPETSEELQNLVLKYRE 677 western clawed frog
Q2TBQ9  79 ELGLGEAQVLLALSAHVGALEAEKQRLRAQARRLAQENAWLREELEETQRRLra--sEEAVAQLEEEKSHLEFLGQLRQY 156 cattle
Q28X22 349 DMQQKFLDTKDAVMRQLQRITDDRERVNKQLETLQADNDFLSGRYLATSEEI-----ENQYINLPNTVVELQELMLRQQS 423 Drosophila pseudoobscura
Q4S9M5 257 DLQKSFSQSQNAVQSRLTELSLSQRKMCCELSKLKGED--VEAEAAEASSPFsalqgPHCEERLRIEIVHLREQLDTRTE 334 spotted green pufferfish
Q3TZJ2 332 TLQGTVSQAQERVQLQMAELATSHKCLSQEVKRLNEENQGLRAEQLLSSALQgseqrEDQDEALPSSIQELHLLVQNTRQ 411 house mouse
Q4R6D1 294 TLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQglqqeQGEEESLPSSVPELQQLLRRTRQ 373 crab-eating macaque
Q8MQT4 124 ELEGYFKGETANIRRELSEVIASRRKIEDVYQTLSDQYDHLLGRHRQGARQL-----EEEKIDLPQDVEELQLLCLQLKE 198 Trichinella spiralis
P90665 118 ELSEKHRRERVKLFEQLEDANQLCARLELDIKNLASKYQQLLGANRATAAEM-----RAEPIDLPQSADQLQFLCLQMRE 192 rat lungworm
O35550 612 ELQQSFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-----LAEDFILPDTVQVLRELVLKYRE 686 Norway rat
Q5XGI7 603 DLQQAFTQAKRNIQDQMAVLMHSREQVSEELLRLQRDNESLQGKHSLHVSLQ-----QAENFSLPETSEELQNLVLKYRE 677 western clawed frog
Q4SZ98  93 DLVASRTSsdhmEEKLKAEILFLKEqiqaeqcLKENLEDTLQLEIegykeemasfsslktqleHIRVEKEQLQISLSETT 172 spotted green pufferfish
Q2TBQ9 157 DPPAESQ-----QPESPPRRDSLAS-------LFPSEEEERRGPE--------------------AVGAAAAQQGGYEIP 204 cattle
Q28X22 424 ELIQARVSseyeKQRCVSTLDEIQI-------LRAQLEESNNERRty--------------krQTQLDIKSLQDRLTEHL 482 Drosophila pseudoobscura
Q4S9M5 335 ENEVLQVQfsslKTETE----------------------------------------------RIQAEKDQLQAELLASR 368 spotted green pufferfish
Q3TZJ2 412 QARARQQAqeheAERLRIEIVKLRE----------ALDEETAAKA---------------------SLERQLRVQREETD 460 house mouse
Q4R6D1 374 EARARLQAqehgAERLRIEIVTLRE----------ALEEETAARA---------------------SLEGQLRVQREDTE 422 crab-eating macaque
Q8MQT4 199 ELIESRTVkehlEETLMSEIVLLKAeiasekqAKEEMEASLADDIc-----------------HLRSQLDCAQNCLLERE 261 Trichinella spiralis
P90665 193 ELIELKSArqheRDELRDEIALLKEqieeernAKVVMERDLLAQVnhlqtq-------lgiaaSKLSSADAMALCNESHS 265 rat lungworm
O35550 687 NIVHVRTAadhmEEKLKAEILFLKEqiqaeqcLKENLEETLQLEIenckeeiasisslkaeleRIKVEKGQLESTLREKS 766 Norway rat
Q5XGI7 678 DIISVRTAadhlEEKLKAEILFLKEqiqaeqcQKENIEETLQIEIenckeeiastsslkleldRVKAEREQLEASLQEKT 757 western clawed frog
Q2TBQ9 157 DPPAESQ-----QPESPPRRDSLAS-------LFPSEEEERRGPE--------------------AVGAAAAQQGGYEIP 204 cattle
Q28X22 424 ELIQARVSseyeKQRCVSTLDEIQI-------LRAQLEESNNERRty--------------krQTQLDIKSLQDRLTEHL 482 Drosophila pseudoobscura
Q4S9M5 335 ENEVLQVQfsslKTETE----------------------------------------------RIQAEKDQLQAELLASR 368 spotted green pufferfish
Q3TZJ2 412 QARARQQAqeheAERLRIEIVKLRE----------ALDEETAAKA---------------------SLERQLRVQREETD 460 house mouse
Q4R6D1 374 EARARLQAqehgAERLRIEIVTLRE----------ALEEETAARA---------------------SLEGQLRVQREDTE 422 crab-eating macaque
Q8MQT4 199 ELIESRTVkehlEETLMSEIVLLKAeiasekqAKEEMEASLADDIc-----------------HLRSQLDCAQNCLLERE 261 Trichinella spiralis
P90665 193 ELIELKSArqheRDELRDEIALLKEqieeernAKVVMERDLLAQVnhlqtq-------lgiaaSKLSSADAMALCNESHS 265 rat lungworm
O35550 687 NIVHVRTAadhmEEKLKAEILFLKEqiqaeqcLKENLEETLQLEIenckeeiasisslkaeleRIKVEKGQLESTLREKS 766 Norway rat
Q5XGI7 678 DIISVRTAadhlEEKLKAEILFLKEqiqaeqcQKENIEETLQIEIenckeeiastsslkleldRVKAEREQLEASLQEKT 757 western clawed frog
Q4SZ98 173 AALDKLQSIKTSVEQQLKDL-----------SEAKTALETQVLDEKDKAQRL 213 spotted green pufferfish
Q2TBQ9 205 ARLRTLHNLVIQYAGQGRYEva--------vPLCRQALEDLERSSGHCHPDV 248 cattle
Q28X22 483 LTVQSYETTKTQLERKEAELnkqlsesrveiIELQEANEKQNKTNADYKTKI 534 Drosophila pseudoobscura
Q4S9M5 369 TELDALRVALSHVQNTNKAL-----------TSDKAALQQQSLELRSQVISL 409 spotted green pufferfish
Q3TZJ2 461 VLEASLCSLRIETERVQQEQ-------------RKAQLTDLLSEQRAKTLRL 499 house mouse
Q4R6D1 423 VLEASLCSLRTEMERVQQEE-------------SKAQLPDL-SEQRAKVLRL 460 crab-eating macaque
Q8MQT4 262 SLYKWKAEAQSQFDKHRRRIselea-nvkelEKDKLQAKELIQEGQRRAQVL 312 Trichinella spiralis
P90665 266 RQIRDLQNTVAELEAQVKQV-----------QSERAAVEKTAQNYKSRCSSL 306 rat lungworm
O35550 767 QQLESLQEIKVNLEEQLKKE-----------TAAKATVEQLMFEEKNKAQRL 807 Norway rat
Q5XGI7 758 RELQNLQTLKDSLEDQLKKE-----------TGGKASLEQLVFEEKNKAQRL 798 western clawed frog
Q2TBQ9 205 ARLRTLHNLVIQYAGQGRYEva--------vPLCRQALEDLERSSGHCHPDV 248 cattle
Q28X22 483 LTVQSYETTKTQLERKEAELnkqlsesrveiIELQEANEKQNKTNADYKTKI 534 Drosophila pseudoobscura
Q4S9M5 369 TELDALRVALSHVQNTNKAL-----------TSDKAALQQQSLELRSQVISL 409 spotted green pufferfish
Q3TZJ2 461 VLEASLCSLRIETERVQQEQ-------------RKAQLTDLLSEQRAKTLRL 499 house mouse
Q4R6D1 423 VLEASLCSLRTEMERVQQEE-------------SKAQLPDL-SEQRAKVLRL 460 crab-eating macaque
Q8MQT4 262 SLYKWKAEAQSQFDKHRRRIselea-nvkelEKDKLQAKELIQEGQRRAQVL 312 Trichinella spiralis
P90665 266 RQIRDLQNTVAELEAQVKQV-----------QSERAAVEKTAQNYKSRCSSL 306 rat lungworm
O35550 767 QQLESLQEIKVNLEEQLKKE-----------TAAKATVEQLMFEEKNKAQRL 807 Norway rat
Q5XGI7 758 RELQNLQTLKDSLEDQLKKE-----------TGGKASLEQLVFEEKNKAQRL 798 western clawed frog
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