2XA4_B 15 LKFLQQ---LGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLq---hSTEEH--LRDFEREIEILKSLQHDNIVKYKGVC 83 human O60674 545 LIFNES---LGQGTFTKIFKGVRREvgdYGQLHETEVLLKVL-----DKAHRnySESFFEAASMMSKLSHKHLVLNYGVC 616 human O93596 509 LQTTEG---LGQGTFTQVFRGIRREvgdYGEVHKMEVVMKIL-----DKSHRnyTESFFESASMMSQLSHKHLLLNYGIC 580 zebrafish O42291 517 LIRGES---LGQGSFTHIYKGIKRDq-kDDEFYQTPVVLKVM-----DSSHRncSESFLEAASIMSQLSHKHLVLLHGVS 587 chicken Q63272 517 LEWHEN---LGHGSFTKIFHGHRREv-vDGETHDTEVLLKVM-----DSRHQncMESFLEAASLMSQVSYPHLVLLHGVC 587 Norway rat P18160 2115 LEFGQT---IGKGFFGEVKRGYWR---------ETDVAIKIIyr-dqFKTKSs-LVMFQNEVGILSKLRHPNVVQFLGAC 2180 Dictyostelium disco... P18161 853 IQFIQK---VGEGAFSEVWEGWWK---------GIHVAIKKLk---iIGDEEqfKERFIREVQNLKKGNHQNIVMFIGAC 917 Dictyostelium disco... Q54I36 1057 VAIVEK---VGAGSFANVFLGIWN---------GYKVAIKILk---nESISN--DEKFIKEVSSLIKSHHPNVVTFMGAC 1119 Dictyostelium disco... Q19380 474 IEFDKQapiIGRGRFGKVLRGFHY----------GDVAVKVYtmehiSDASKk-AEEFKLEVSAYKNTRHDNIALFLGYF 542 Caenorhabditis elegans Q24734 716 LHLLER---IGQGRFGTVHRALWH----------GDVAVKLLnedylQDEHM--LESFRNEVANFKKTRHENLVLFMGAC 780 Drosophila virilis
2XA4_B 84 Ys-AgrrnLKLIMEYLPYG-SLRDYLQAH-----AERIDHIKLLQYTSQICKGMEYLGTKR--YIHRDLATRNILVEN-- 152 human O60674 617 Vc-Gde--nILVQEFVKFG-SLDTYLKKN-----KNCINILWKLEVAKQLAWAMHFLEENT--LIHGNVCAKNILLIRee 685 human O93596 581 Vc-Ade--hIMVQEYVRFG-SLDTYLKRN-----RNTINITWKLEVAKQLAWALHHLEEKS--LTHGNVCARNVLVTRee 649 zebrafish O42291 588 L--Gkd--sIMVQEYIRHG-PLDLYLKKNh---sEGKVTTSWKLQVAKQLAYALNYLEDKK--ITHGNVSAKKVLLTReg 657 chicken Q63272 588 M--Agd--sIMVQEFVYLG-AIDTYLRKR-----GHLVPASWKLQVTKQLAYALNYLEDKG--LPHGNVSARKVLLAReg 655 Norway rat P18160 2181 TagGed-hHCIVTEWMGGG-SLRQFLTDHf---nLLEQNPHIRLKLALDIAKGMNYLHGWTppILHRDLSSRNILLDHni 2255 Dictyostelium disco... P18161 918 Yk-----pACIITEYMAGG-SLYNILHNPnsstpKVKYSFPLVLKMATDMALGLLHLHSIT--IVHRDLTSQNILLDE-- 987 Dictyostelium disco... Q54I36 1120 Id-----pPCIFTEYLQGG-SLYDVLHIQ-----KIKLNPLMMYKMIHDLSLGMEHLHSIQ--MLHRDLTSKNILLDE-- 1184 Dictyostelium disco... Q19380 543 Msd---gqYGMVMSLSKGSqSLYTLLHVV-----REKLDLATTRKIAQQICQAVSYLHTKK--ILHKDLRSKNILLE--- 609 Caenorhabditis elegans Q24734 781 Mnp---pyLAIVTALCKGN-TLYTYIHQR-----REKFAMNRTLLIAQQIAQGMGYLHARD--IIHKDLRTKNIFIE--- 846 Drosophila virilis
2XA4_B 153 -----------EN-RVKIGDFGLTKVLp-------QDKEXX--KVKEPGE-SPIFWY---APESLTESK----------- 196 human O60674 686 dr------ktgNPpFIKLSDPGISITV----------------LPKDILQ-ERIPWV---PPECIENPKn---------- 729 human O93596 650 dr------ktgTPpFIKLSDPGISITV----------------QPREILL-ERIPWV---PPECVKDSRn---------- 693 zebrafish O42291 658 da------assSPpFIKLNDPGVSITV----------------LAKEWLV-ERIPWV---APECLSDPQs---------- 701 chicken Q63272 656 v--------dgNPpFIKLSDPGVSPTV----------------LSLEMLT-DRIPWV---APECLQEAGt---------- 697 Norway rat P18160 2256 dpknpvvssrqDI-KCKISDFGLSRLK----------MEQA--SQMTQSV-GCIPYM---APEVFKGDS----------- 2307 Dictyostelium disco... P18161 988 -----------LG-NIKISDFGLSREK--------SREGSM--TMTNGGI-CNPRWR---PPELTKNLGh---------- 1031 Dictyostelium disco... Q54I36 1185 -----------FK-NIKIADFGLATTL------------SD--DMTLSGI-TNPRWR---SPELTKGLV----------- 1223 Dictyostelium disco... Q19380 610 -----------SKnKVVITDFGILSMK------------RLahPKQKSGYlTSKFWTnyiAPELAMAMRteydeyecddf 666 Caenorhabditis elegans Q24734 847 -----------NG-KVIITDFGLFSSTkllycdmgLG--------------VPQNWLcylAPELIRALQpckpp--gecl 898 Drosophila virilis
2XA4_B 197 -FSVASDVWSFGVVLYELFTYIEKSksppaefmrmigndkqgqmIVFHLIELL-KNNGRLPRPDGCPDEIYMIMTECWNN 274 human O60674 730 -LNLATDKWSFGTTLWEICSGGDKPls---------------alDSQR-KLQFyEDRHQLPAPK--WAELANLINNCMDY 790 human O93596 694 -LSLAADKWSFGTTLWEIYCGGEQPla---------------ayDTAK-KLLFyEDKHQLPAPK--WTELASVINSCMDY 754 zebrafish O42291 702 -LALPADKWGFGATLWEIFSGGNMPvs---------------llEPQK-KLQFyDSRLQLPAPR--WSELAALIAQCI-Y 761 chicken Q63272 698 -LNLEADKWGFGATTWEVFSGAPMHit---------------slEPAK-KLKFyEDRGQLPALK--WTELEGLIAQCMAY 758 Norway rat P18160 2308 -NSEKSDVYSYGMVLFELLT-SDEPqq---------------dmKPMKMAHLAaYESYRPPIPLTTSSKWKEILTQCWDS 2370 Dictyostelium disco... P18161 1032 -YSEKVDVYCFSLVVWEILT-GEIPfs---------------dlDGSQASAQVaYAGLRPPIPEYCDPELKLLLTQCWEA 1094 Dictyostelium disco... Q54I36 1224 -YNEKVDVYSFGLVVYEIYT-GKIPfeg--------------ldGTASAAKAA-FENYRPAIPPDCPVSLRKLITKCWAS 1286 Dictyostelium disco... Q19380 667 pFSENSDVYAFGCVWFEMLTGA-LPya---------------geLPHQILFAKtQGIRPVLPNVKCTQELKELLVSCWNT 730 Caenorhabditis elegans Q24734 899 eFTSYSDVYSFGTVWYELICGE-FTfk---------------dqPAESIIWQVgRGMKQSLANLQSGRDVKDLLMLCWTY 962 Drosophila virilis
2XA4_B 275 NVNQRPSFRDLALRV 289 human O60674 791 EPDFRPSFRAIIRDL 805 human O93596 755 EPLHRPSFRALIRDL 769 zebrafish O42291 762 APSRRPCFRAIIRDI 776 chicken Q63272 759 DPGRRPSFRAILRDL 773 Norway rat P18160 2371 NPDSRPTFKQIIVHL 2385 Dictyostelium discoideum P18161 1095 DPNDRPPFTYIVNKL 1109 Dictyostelium discoideum Q54I36 1287 DPSQRPSFTEILTEL 1301 Dictyostelium discoideum Q19380 731 APQDRPTLTDINLKL 745 Caenorhabditis elegans Q24734 963 EKEHRPDFARLLSLL 977 Drosophila virilis
Jiyao W et al.(2023). "The conserved domain database in 2023.",