Conserved Protein Domain Family
Sec6

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pfam06046: Sec6 (this model, PSSM-Id:218871 is obsolete and has been replaced by 336281)
Exocyst complex component Sec6
Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localise to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.
Statistics
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PSSM-Id: 218871
View PSSM: pfam06046
Aligned: 39 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 22-Dec-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74600848  180 VLPVKKTIKKFDDLLGEIIISLTEALKEGnVELVFKLIKIIEFESNEDMKFELMSNLKLMenrsissidyanfrGAKRNY 259
gi 82183660  177 FGKVHPLSEELAKQLWMVIQRSIVTVRRD-PTLLVSVVRIIEREEKVDRRMMDRKKQTGFip-----------pGRPKKW 244
gi 160385727 206 FSGVGRLVDALAKELWAVVGSGLSLAHQN-PTPFVSAVRIVEREEALDQFFLEERRSTSGhnip-------mpaGRPRNW 277
gi 122143510 188 FEGLGPLAEALGQAVEAAAGAAGQLAREN-PALLVAAVRVAEVDAGCTTSLEQA----------------------PRDW 244
gi 74729884  132 FQGLDLLFEALGQAVEAAAGAAGKLARED-PALLVAAVRVAEVETGRTTPLGQV----------------------PRDW 188
gi 81896216  189 FQGLGLLAEALGQAVEAAAGAAGRLARED-PALLVAAIRVAEVETER-TILGQA----------------------PRDW 244
gi 290457635 179 AMDVCLLYDGLAAEIGAIVRETLDSDGVD-AAALAELARVVSAEEEAHPSPPDDGDFLRT----------------PRRW 241
gi 125863838 181 AMDLCLHYDGMAAEIGAIVREALSSEGVD-RDALAELAQVVHLEEEAHQTSQAEGDFLST----------------PRHW 243
gi 82077517  161 edKLLRDSEIFRERLKFAILDSFNEEN---QETLKSALISILQEEAQDRRWAEVSENQRPi-------------WRPTEC 224
gi 93141326  122 QSKVEALYELLRDQVLGVLRRPLEAP----PERLRQALAVVAEQEREDRQAAAAGPGTSGla-----------aTRPRRW 186
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74600848  260 KKFFYKKLEESLVDTFDk-----cVEHFSYDRIL--VYDNLN-WLEDELVFVADTLSPMFPT-SWNIDNFIQNAYYNRLH 330
gi 82183660  245 KDKMFDVLDKTIITRIEgs---qaDTRESDKMWLvrHLEIIRrYMLEDLIIIKNLMVQCFPP-SYNIFNRVLDLYHQALS 320
gi 160385727 278 RDRFFKVMEEAVSARFRs-----vSYLHTRGPGLasHLSALQhCIMGDLSTVRHCLEQCVPA-HYHLTRAYLHFCHQFLQ 351
gi 122143510 245 RQRCLRALQQGLERVHFg------TSLQPGPGELakWLEALRvALPAELAMAEALVAPCCPP-HYKVVQLWAHTLHGGLR 317
gi 74729884  189 RQRCPRALQEGLEQAHFg------SPLLPAPGALpgWLEALRvALPVELATAEALVAPCCLP-QYNVVQLWAHTLHSGLR 261
gi 81896216  245 RQRCLRALQEGLERVHFa------SPVLPEPGALagWLEALQvALPAELATAEALVAPCCPP-SYRVVELWAHTLHSGLR 317
gi 290457635 242 RQHWEEAVRRSAQERVRrpgagwaFGEAEGASGLaqLLAELGgLVRRDLQKVRQEVQPAYAAaGFPAWEVYLRAFHSAVA 321
gi 125863838 244 RMHWEDAVRLSAQESVQqagakviPGAAEGSSDLaqLLAELGgVVRHDLQKVRLEMQPAYEAtDFPVWETYLRAFHSAVA 323
gi 82077517  225 RQKIHDPLLKTLVETRLknadgqeNKADKLSTSLkrEVCRTGkQVQKDLLIVVRNLKECYPA-DFDICRTYAQLYHQTFS 303
gi 93141326  187 LQLWRRGVAEAAEERMG-------QRPAAGAEVPesVFLHLGrTMKEDLEAVVERLKPLFPA-EFGVVAAYAESYHQHFA 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74600848  331 NFTMDL-IKTDPPAEDLLKILAY-DSHYGK--FVVALHTspeiegdekrkstqKKEQKSIMGEELKKVVLDDYLKVIVAK 406
gi 82183660  321 SRIQEL-ASEELEANEIVSLLTWvLNTYQSveMMGNPELipe---------inVKSLKPLLSQDIVDQLLHKYMATLRSN 390
gi 160385727 352 THLGLV-SGWELEGGEIFAVLNWvLHIYNSseMMGEPALlae---------leIENLGPLISQEGLEQLQNKYVQKVRKS 421
gi 122143510 318 RCLQQLlEGPELEEADTFTLLHWvLHVYQGpeMMGSLELgpe---------adVSDLEPLLTLENIEQLEATFVAKVQAK 388
gi 74729884  262 RSLQNLlAGPELEAADAFALLHWaLHVYLGqeMMGSLELgpe---------adVSQLEPLLTLENIEQLEATFVANI--- 329
gi 81896216  318 RSVQQLlAGPELGAADTFALLHWaLHVYTGkeMMGNLELgpe---------adVSQLEPLLTSENIEQLEAAFVAQVQVS 388
gi 290457635 322 QRLQEL-ARDARGCEQLYILLDWaANVYGSpdFLGAPGLal-----------pAEPLPPLLAPDVWARLESDYTSFLEAK 389
gi 125863838 324 QRLQEL-ARDARGCEQLYVLLDWaANVYGSpdFLGAPDLal-----------pTEPLPPLLEPALWARLESDYTSFLETK 391
gi 82077517  304 ARLQEL-TRSSIEFEDCAYILSW-IKIYYPkdVLKHKELeqh---------inSSLLGPLLPEEHLKRLEDQYFSCKENE 372
gi 93141326  259 AHLAAV-AQFELCERDTYMLLLWvQNLYPNd-IINSPKLvge---------lqGMGLGSLLPPRQIRLLEATFLSSEAAN 327
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74600848  407 MNEWTDTLLKLEAnsfvqrETPPDiytyyqtIEDEDiqdqpitleihgeVFVLPDFKTPLTMLKEQADVAvdsgyg---s 483
gi 82183660  391 IIAWLRKALETDKkdw-dkNTEPE-------ADQDG-------------YFQTTLPAIVFQMFEQNLQVAaqisddlkkk 449
gi 160385727 422 VSEWMQKALEVELtdw-qrDQEPD-------IDHEG-------------YYHTSLPTIITQMLEENARVAlmisealrdq 480
gi 122143510 389 VAQWLQKALDGEVvew-grEQEPD-------TDLSG-------------FYHSPLPAIVLQILEENIRVTrivsvsleqr 447
gi 74729884  330 ------------------------------------------------------------QILEENIRVAslvseslqqr 349
gi 81896216  389 VAQWLKKALDGEVaew-sgEQEPP-------TDPSG-------------FYHSPMPAIVLQILAENIQVTnlisdslhrr 447
gi 290457635 390 IASCFDSILQLEQshw-aaAEVPE--------VLQG-------------LYQAPLSMDVHMLVAEHVKAAgaisaeleat 447
gi 125863838 392 ITSCFDSILQLEQnrw-eaDEDRE--------VLQG-------------LYHAPLSIDVHMLVAEHVKAAgaisaeleat 449
gi 82077517  373 VRNWLSNAFDKEVdkw-sdGFEPE--------LIEG-------------CYFGNLAVDVLPLIEGTVKEVnallecesks 430
gi 93141326  328 VRELMDRALELEArrw-aeDVPPQ--------RLDG-------------HCHSELAIDIIQITSQAQAKAesitldlgsq 385
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74600848  484 ilvgvIENWSSCYIKRVLNYKEIIEEEFDkymsvynnerfliqesktkrlfrrhapqptfdienmtpeelanvskPGLIE 563
gi 82183660  450 vlhlcLQQMNTFLNRYAEEAQLYKEDHLRsrq-----------------------------------------hpACYVQ 488
gi 160385727 481 tiqmgLYEMEKLLSRFRDAVIEFGKEHRKdpt-----------------------------------------vnKFYLH 519
gi 122143510 448 vhgmaLSELSAFLRSFTDALIRFSRDHLRgea-----------------------------------------vvPHYVP 486
gi 74729884  350 vhgmaLSELGTFLRSFSDALIRFSRDHFRgks-----------------------------------------maPHYVP 388
gi 81896216  448 ahnmaVSELGAFLRSFSDALIRFSRDHLRgda-----------------------------------------vaPHYVP 486
gi 290457635 448 tlricTRALGLFVPRFEKAFLASE---------------------------------------------------AVSEP 476
gi 125863838 450 tlqicARALCLFVPRFEKAFLASK---------------------------------------------------AVSEW 478
gi 82077517  431 wsllcL--LDSSLLSYGTSLKELVKRKQ-----------------------------------------------ENIPK 461
gi 93141326  386 ikrvlLVELPAFLRSYQRAFNEFLERGKQl---------------------------------------------TNYRA 420
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74600848  564 YLCALGNTYEINTDrLQDKFLPNYKSKVHsnyqSRIQVAFEDTVSPSTELNAQVIRAIIDIILNDLYPALSSVFTKTWYG 643
gi 82183660  489 YMIAIINNCQTFKE-SIVSLKRKYLRDED----DIIGFGSSAMDTTLDSIANDGCCSLLDEVFMDLEQHLNDLMTRKWLG 563
gi 160385727 520 YLLACINNCIILKT-STESLQQQICSFVS----NRYSRIPLGPLAALDRAVRKACRLVMDHLLFELQPHLQELLSSTWLD 594
gi 122143510 487 YLLATLNHQLALSS-SVSVLQPKWVVPGV----------LAPVEAELDKLQKRICRLVLEALLAELQPLFAALPSRRWLS 555
gi 74729884  389 YLLAALNHKSALSS-SVSVLQLDGAPSGA----------LAPVEAALDELQRRIYRLVLEALQAELQPLFADLPSRQWLS 457
gi 81896216  487 YLLSAFNHQSALRS-SVSVLLPDGEASGV----------LAPVEAALDDVQRRICRLVLEVLQVELQPLFSALPSRRWLL 555
gi 290457635 477 HLGAYINACEELRT----SLLSRFPGTQE------------ELEKPLVTATCSFQKHLLQGLQRELQPLFRVVCTRDWLT 540
gi 125863838 479 YLGAYINACVELRT----SLLARFPGTIK------------ELEKPLVAATNSFQKHLLQIVQQDMQPLFKVLYTKSWLT 542
gi 82077517  462 ILRDSLVNIYVFKN-YVQKVEHFFLED-----------TITTRMSILMDLRNICHTYFLSRIHKELKPVYRKLWTQTWFA 529
gi 93141326  421 NVIANINNCLSFRM----SMEQNWQVPQD---------TLSLLLGPLGELKSHGFDTLLQNLHEDLKPLFKRFTHTRWAA 487
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74600848  644 DksqtsdepNMAERILETISEYMQELRSyASYDIYLCTFALFLDSFISAYIRIGYEnilhgsgKKidptaTKKFKSFSEG 723
gi 82183660  564 Gs-------NTVDTICVTIEDYFNDFAK-IKTHYNQEMTIKAHRKVVTEYIKAIMQ-------KRisfrnAEERKEGAEK 628
gi 160385727 595 Qg-------DVTLNMCGVLERHCELYNR-VRQPCRQRLKEECQWLTVVEYVRAVMQ-------KRlvcrsSDEQKQLAQR 659
gi 122143510 556 Sp-------ELLDDVCKRTARFCQNFQH-VRNPAVQLLLVEAERTVVLQYLSALMQ-------GRlvcrgADERTQAAER 620
gi 74729884  458 Sp-------ELLESVCERTGRFCRDFWR-VRNPTVQLLLAEAERAVVLQYLSALMQ-------GRlvcrgADERTQAAER 522
gi 81896216  556 Ss-------ELLDGVCEQTSHFCQDFWR-VRKPGVQLLLAEAERTVVLQYLRALMQ-------GRlvcrgTDERSQAAER 620
gi 290457635 541 Q--------DWLHPLMDKVVTFAGHLQR-VARPRAQETLQEVHRFVVREYLARALR-------PRer-frGMERMHGSQK 603
gi 125863838 543 Q--------DTLRPLMDKVVDFAHHLEH-VTPPLAQETLQEVHRFVVREYLGQVLR-------PHer-fsGQDRLKGSNK 605
gi 82077517  530 Gn------sEVVEELVKAIEKISNDFKD-LKPACREELLAELHVEVMVEYVRRMMK-------RKlklkdKEKQEAAAEF 595
gi 93141326  488 Pv-------ETLENIIATVDTRLPEFSE-LQGCFREELMEALHLHLVKEYIIQLSK-------GRlvlktAEQQQQLAGY 552
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74600848  724 VGRDVTIFYGGLEHLFtrkdSAYLLNSLRAIEFLGDLAtcedPMIFIPQM--------------------------WENE 777
gi 82183660  629 MIKEAEQFKFLFKRLT-----AGFIEDTDGLCNTIIDIaevlKLTDPSLLy------------------------lEVST 679
gi 160385727 660 MTQDAQQLRDHLQSME----IDGTIGEVN-PTALIAALadiiNLKDPGMLl------------------------lEISG 710
gi 122143510 621 MQHDAAQLQELFLGLG--------LEESVQCVPVLLALkellNLRDPTLLg------------------------lVVAG 668
gi 74729884  523 LRHDAAQLQQLFLSLV-------IASWAGRRARVSVAGwergLARDPTPTcsgpggeralragaarpegaakpprpRAAG 595
gi 81896216  621 LRQDAAQLKELFLGLG--------LEESAHCAPVLLALrellNLHDPTLLg------------------------lEVAG 668
gi 290457635 604 MSLDAQAISDTFQGLG---------SEATWLDQAIQCVaeilGETYKDDIq------------------------rHLET 650
gi 125863838 606 MNLDAQAISNTFQGLG---------SEAKWLDQAILSVaeilGETYKDDIr------------------------rHLET 652
gi 82077517  596 MSQDSNEICSVFIKLG---------SKEDWLSKILPKLseilKLQDPGSLq------------------------iEIAT 642
gi 93141326  553 ILANADTIQHFCTQHG---------SPATWLQPALPTLaeiiRLQDPSAIk------------------------iEVAT 599
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74600848  778 ILGSFYFCSVE------YVRGICLCRKDMDKNQVNTLVRQLEDIAKEYHENVP----VPSQLTGTL 833
gi 82183660  680 LVGRYPDLRDD------HIAALLAVRGDASREMKQTIIETVEQSQRQQSa-------NYTPIFKDI 732
gi 160385727 711 LLSKYPDISEE------HVSVLLDIRGDVPKEVRKSVLDFLDQSAPPLPp-------GYRPIFTEI 763
gi 122143510 669 LRQQFPDVSED------HVSALLDLRGDVSREQRLAALSSLRAGPQPSPq------aGRRALFSLV 722
gi 74729884  596 PGGGWPAATISrrergpRLRPLGPARGLVPGAAPGRAQLPAGCAAAVAPr------ePPRPLQPRA 655
gi 81896216  669 LRQQFPDVSED------HVSALLDLRGDVSREHRQAALSSLQAGPPPSPs------tGRRALFSLV 722
gi 290457635 651 LIRSYPDIRRD------HILAILALRR-LGRQRNQHLLQHTQDLLRAAAGAAGaeapRGRVLFEEI 709
gi 125863838 653 LIRSYPDIRRD------HILAILALRR-LGRRRNQNLLQHTQDLLRAAHetr---lpSHHVLFEEI 708
gi 82077517  643 LARDYPDISEQ------HVLALLNLKANISSSDLRRIKGCLTDNRSPQE--------SSTAFFSKV 694
gi 93141326  600 YATCYPDFSKG------HLSAILAIKGNLSNSEVKRIRSILDVSMGAQE--------PSRPLFSLI 651
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