Conserved Protein Domain Family
Sarcoglycan_1

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pfam04790: Sarcoglycan_1 (this model, PSSM-Id:218266 is obsolete and has been replaced by 428124)
Sarcoglycan complex subunit protein
The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains. This family contains beta, gamma and delta members.
Statistics
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PSSM-Id: 218266
Aligned: 16 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 22-Dec-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q29B29        66 LHP-GQHGRNSFAFWTVVIILLALTVGNLILTLTIVGVLRLG-KGVHGMELIPEvDVVKfYGSTELerLQTNSIGQVHGF 143 Drosophila pseu...
Q8BX51        36 LYPvGIYGWRKRCLYFFVLLLLVTMIVNLAMTIWILKVMNFTvDGMGNLRVTKK-GIRL-EGISEF--LLPLYVKEIHSR 111 house mouse
Q92629        21 VYKvGIYGWRKRCLYFFVLLLMILILVNLAMTIWILKVMNFTiDGMGNLRITEK-GLKL-EGDSEF--LQPLYAKEIQSR 96  human
Q6TGT8        21 VYKvGIYGWRKRCLYFFVLLLMILIVVNLALTIWILKVMNFTiDGMGHLRITER-GLKL-EGDSEF--LQPLYAKEIQSR 96  zebrafish
Q177R0        20 MYN----EKNSFAFWVVMILLFSLALGNLCLTLTITGILKIY-KGMENIELIQGeETVKfFGNIDFdrVYK-RDGKLEGF 93  yellow fever mo...
Q9GT65        57 LHP-GHQGRNTFAFWTIVVLLLVLTVGNLLLTLTIVGVLRLG-KGVQGMEVIPEvDLVKfYGTTDLerVQTNSIGQIHGF 134 fruit fly
Q28635        52 LHKtGLRGRKGNLAICVIVLLFLLAVINLIITLVIWAVIRIGpNGCDSMEFHES-GLLRfKQVSDMgvIHPLYKSTVGGR 130 rabbit
Q29J24       121 ETYlGLIGWRKKCLYTLLLLLMLLIVTNLVLTLWIIKVMQFSlEGMGQLKILPG-GIQL-SGTAII--MDMLRTSTIRSR 196 Drosophila pseu...
XP_001627521  22 IYKvGIYGWRKRCIYFLILLIMVLAVINLSLTIWIMRVMDFNwEGMGNLRITDI-GVKL-YGHAEF--VESLYAKELRAR 97  starlet sea ane...
XP_002631343  71 IYRvGIYGWRKRFLYTFILVLAIGIVLNLSLTFWIMSVLDFSpNGIGTLKIEED-GIRV-EGRAQF--DRPVHFSKLSTL 146 Caenorhabditis ...
Q8BX51        36 LYPvGIYGWRKRCLYFFVLLLLVTMIVNLAMTIWILKVMNFTvDGMGNLRVTKK-GIRL-EGISEF--LLPLYVKEIHSR 111 house mouse
Q92629        21 VYKvGIYGWRKRCLYFFVLLLMILILVNLAMTIWILKVMNFTiDGMGNLRITEK-GLKL-EGDSEF--LQPLYAKEIQSR 96  human
Q6TGT8        21 VYKvGIYGWRKRCLYFFVLLLMILIVVNLALTIWILKVMNFTiDGMGHLRITER-GLKL-EGDSEF--LQPLYAKEIQSR 96  zebrafish
Q177R0        20 MYN----EKNSFAFWVVMILLFSLALGNLCLTLTITGILKIY-KGMENIELIQGeETVKfFGNIDFdrVYK-RDGKLEGF 93  yellow fever mo...
Q9GT65        57 LHP-GHQGRNTFAFWTIVVLLLVLTVGNLLLTLTIVGVLRLG-KGVQGMEVIPEvDLVKfYGTTDLerVQTNSIGQIHGF 134 fruit fly
Q28635        52 LHKtGLRGRKGNLAICVIVLLFLLAVINLIITLVIWAVIRIGpNGCDSMEFHES-GLLRfKQVSDMgvIHPLYKSTVGGR 130 rabbit
Q29J24       121 ETYlGLIGWRKKCLYTLLLLLMLLIVTNLVLTLWIIKVMQFSlEGMGQLKILPG-GIQL-SGTAII--MDMLRTSTIRSR 196 Drosophila pseu...
XP_001627521  22 IYKvGIYGWRKRCIYFLILLIMVLAVINLSLTIWIMRVMDFNwEGMGNLRITDI-GVKL-YGHAEF--VESLYAKELRAR 97  starlet sea ane...
XP_002631343  71 IYRvGIYGWRKRFLYTFILVLAIGIVLNLSLTFWIMSVLDFSpNGIGTLKIEED-GIRV-EGRAQF--DRPVHFSKLSTL 146 Caenorhabditis ...
Q29B29       144 TDVPVTISSdvssddNPDAGVHVrvfRNGNGASSerDRIVVDKDAiVIDATNVFDVKDPaDRQSIFSTHRPQ-------- 215 Drosophila pseu...
Q8BX51       112 KDSPLVLQS------DRNVTVNA---RNHMGQLT--GQLTVGAEA-VEAQCKRFEVRASeDGRVLFSADEDEitigaekl 179 house mouse
Q92629        97 PGNALYFKS------ARNVTVNI---LNDQTKVL--TQLITGPKA-VEAYGKKFEVKTV-SGKLLFSADNNEvvvgaerl 163 human
Q6TGT8        97 PGSPLFLQS------SKNVSVNI---LNEKKQLV--SQLVAGSHG-VHARGKMLEVKSS-SGKLLFSADDHEvvvgaerl 163 zebrafish
Q177R0        94 HDEPMEITGe-----NGPVSINL---VNRNGHSH--NKIHFSKNGsVLKGLNHFEVKDAvTGRQVFSTSRPS-------- 155 yellow fever mo...
Q9GT65       135 SDVPVTISSda---gDGEGGVHVrvfRNGNGAASerDRIVLNREGiLVQATNLFEVKDPvDKQPIFTTHRPQ-------- 203 fruit fly
Q28635       131 RNENLVITGn-----NQPIVFQQ-------GT----TKLSVEKNKtSITSDIGMQFFDPrTQNILFSTDYETh------- 187 rabbit
Q29J24       197 PGHPISIES------SRNFSINT---RDANGMIE--NHLFLGHDK-FECLAATFRINDT-NGRNLFSVNRKEvtvgahsl 263 Drosophila pseu...
XP_001627521  98 MDEPLLVQS------TRNLTVNA---RDRDGNIT--AQLFLGDDQiV-AKNKRLWIVTDeN-RQILYADKDKiifnasrl 164 starlet sea ane...
XP_002631343 147 DEETLTVDS------FRGVNLQA---RKPSGNVA--SKFSLMPEGkAQVTCERFEVFDE-DQKLLFFADSDEiglklenl 214 Caenorhabditis ...
Q8BX51       112 KDSPLVLQS------DRNVTVNA---RNHMGQLT--GQLTVGAEA-VEAQCKRFEVRASeDGRVLFSADEDEitigaekl 179 house mouse
Q92629        97 PGNALYFKS------ARNVTVNI---LNDQTKVL--TQLITGPKA-VEAYGKKFEVKTV-SGKLLFSADNNEvvvgaerl 163 human
Q6TGT8        97 PGSPLFLQS------SKNVSVNI---LNEKKQLV--SQLVAGSHG-VHARGKMLEVKSS-SGKLLFSADDHEvvvgaerl 163 zebrafish
Q177R0        94 HDEPMEITGe-----NGPVSINL---VNRNGHSH--NKIHFSKNGsVLKGLNHFEVKDAvTGRQVFSTSRPS-------- 155 yellow fever mo...
Q9GT65       135 SDVPVTISSda---gDGEGGVHVrvfRNGNGAASerDRIVLNREGiLVQATNLFEVKDPvDKQPIFTTHRPQ-------- 203 fruit fly
Q28635       131 RNENLVITGn-----NQPIVFQQ-------GT----TKLSVEKNKtSITSDIGMQFFDPrTQNILFSTDYETh------- 187 rabbit
Q29J24       197 PGHPISIES------SRNFSINT---RDANGMIE--NHLFLGHDK-FECLAATFRINDT-NGRNLFSVNRKEvtvgahsl 263 Drosophila pseu...
XP_001627521  98 MDEPLLVQS------TRNLTVNA---RDRDGNIT--AQLFLGDDQiV-AKNKRLWIVTDeN-RQILYADKDKiifnasrl 164 starlet sea ane...
XP_002631343 147 DEETLTVDS------FRGVNLQA---RKPSGNVA--SKFSLMPEGkAQVTCERFEVFDE-DQKLLFFADSDEiglklenl 214 Caenorhabditis ...
Q29B29       216 -YNIPAGVaaLQAKVVSASGISSPIDVPLNMESDGR-IVVKGSEGVFFDAAS--IDLQAEHHVSINSTQGATVLEAgTGI 291 Drosophila pseu...
Q8BX51       180 kVTGTEGA--VFGHSVETPHIRAEPSQDLRLESPTRsLKMEAPRGVQVSAAAgdFKATCRKELHLQSTEGEIFLNA-DSI 256 house mouse
Q92629       164 rVLGAEGT--VFPKSIETPNVRADPFKELRLESPTRsLVMEAPKGVEINAEAgnMEATCRTELRLESKDGEIKLDA-AKI 240 human
Q6TGT8       164 rVMGAEGA--VFSNSVETPHVRAEPFKELRLESPTRsLYMEAPKGVKIEADAgdFQATCRSDLRLESKDGEISLDA-SKI 240 zebrafish
Q177R0       156 -YNMPEGAtmLHTHLVNAGRIASPINDTLKFQTRNK-FTLKGTEGTRMEAKE--IFWTADQNIFLKSDNGSIVIFGgNGV 231 yellow fever mo...
Q9GT65       204 -YNIPGGVeaLQAKVVSASGIVSPIDESLVLESDGR-MAIRGSEGVYFDGAS--VDMQAEHHILINSTQGATILEAgTGI 279 fruit fly
Q28635       188 eFHLPSGVksLNVQKASTERITSNATSDLNIKVDGR-AIVRGNEGVFIMGKT--IEFHMGGNMELKA-ENSIILNG--TV 261 rabbit
Q29J24       264 rIDGEGGA--VFRASVQTPHVRAEPGRELRLESPTRqLKMAAAKDINLQSRAgaIDLVALNDVKLRSLDGSVRLES-SKI 340 Drosophila pseu...
XP_001627521 165 eFSSPYGA--EFTGSVQTKAVRSPPKEHLTLESLTRqLHLNAPEGIQVKTVAggISLQSLTDVNIRSKKGKITLDA-QSI 241 starlet sea ane...
XP_002631343 215 rILDDGGS--VFEGAIQTSSVRPQPDSPLRLESPTRsVSVDAAQDIEILAAAgeVSVNSLLDISISSKQGEIRLES-SSI 291 Caenorhabditis ...
Q8BX51       180 kVTGTEGA--VFGHSVETPHIRAEPSQDLRLESPTRsLKMEAPRGVQVSAAAgdFKATCRKELHLQSTEGEIFLNA-DSI 256 house mouse
Q92629       164 rVLGAEGT--VFPKSIETPNVRADPFKELRLESPTRsLVMEAPKGVEINAEAgnMEATCRTELRLESKDGEIKLDA-AKI 240 human
Q6TGT8       164 rVMGAEGA--VFSNSVETPHVRAEPFKELRLESPTRsLYMEAPKGVKIEADAgdFQATCRSDLRLESKDGEISLDA-SKI 240 zebrafish
Q177R0       156 -YNMPEGAtmLHTHLVNAGRIASPINDTLKFQTRNK-FTLKGTEGTRMEAKE--IFWTADQNIFLKSDNGSIVIFGgNGV 231 yellow fever mo...
Q9GT65       204 -YNIPGGVeaLQAKVVSASGIVSPIDESLVLESDGR-MAIRGSEGVYFDGAS--VDMQAEHHILINSTQGATILEAgTGI 279 fruit fly
Q28635       188 eFHLPSGVksLNVQKASTERITSNATSDLNIKVDGR-AIVRGNEGVFIMGKT--IEFHMGGNMELKA-ENSIILNG--TV 261 rabbit
Q29J24       264 rIDGEGGA--VFRASVQTPHVRAEPGRELRLESPTRqLKMAAAKDINLQSRAgaIDLVALNDVKLRSLDGSVRLES-SKI 340 Drosophila pseu...
XP_001627521 165 eFSSPYGA--EFTGSVQTKAVRSPPKEHLTLESLTRqLHLNAPEGIQVKTVAggISLQSLTDVNIRSKKGKITLDA-QSI 241 starlet sea ane...
XP_002631343 215 rILDDGGS--VFEGAIQTSSVRPQPDSPLRLESPTRsVSVDAAQDIEILAAAgeVSVNSLLDISISSKQGEIRLES-SSI 291 Caenorhabditis ...
Q29B29       292 FLDmdRIPIVSS-----ELGIRTGs-vQYKICVCmPQGTLFRIAIPRIHNg---PK 338 Drosophila pseudoobscura
Q8BX51       257 RLG--NLPIGSFssstsSSNSRQT---VYELCVC-PNGKLYLSPAGVGST----CQ 302 house mouse
Q92629       241 RLP--RLPHGSYt----PTGTRQK---VFEICVC-ANGRLFLSQAGAGST----CQ 282 human
Q6TGT8       241 KLP--RLPEGKAs----TSGPRQT---VFEVCVC-PNGKLFLSQAGTGST----CQ 282 zebrafish
Q177R0       232 YINvnSIPIVQG-----EHGPRSAs-sQYKLCVCyPQGRIFRVPVPKSHNmrvnCA 281 yellow fever mosquito
Q9GT65       280 FLDmdRIPIVSS-----ELGLRTGs-vQYKICVCmPHGTLFRIAIPRVHNg---PK 326 fruit fly
Q28635       262 MVSttRLPSSSS-----ADQLGGGdwvRYKLCMC-ADGTLFKVQVTGQNVg---CQ 308 rabbit
Q29J24       341 LMP--NLRTAQPpi-mgSAQSREHmhrVFQLCAC-SNGKLFLAAPHSI------CA 386 Drosophila pseudoobscura
XP_001627521 242 MLK--NIPLSKP-----ASGVSSD---ACEVCVS-QDGSIFYAADGSG------CK 280 starlet sea anemone
XP_002631343 292 YME--KLARSDG------RGSPQT---Q--VCVC-HNGRLFLAAPNADcradrdic 333 Caenorhabditis briggsae
Q8BX51       257 RLG--NLPIGSFssstsSSNSRQT---VYELCVC-PNGKLYLSPAGVGST----CQ 302 house mouse
Q92629       241 RLP--RLPHGSYt----PTGTRQK---VFEICVC-ANGRLFLSQAGAGST----CQ 282 human
Q6TGT8       241 KLP--RLPEGKAs----TSGPRQT---VFEVCVC-PNGKLFLSQAGTGST----CQ 282 zebrafish
Q177R0       232 YINvnSIPIVQG-----EHGPRSAs-sQYKLCVCyPQGRIFRVPVPKSHNmrvnCA 281 yellow fever mosquito
Q9GT65       280 FLDmdRIPIVSS-----ELGLRTGs-vQYKICVCmPHGTLFRIAIPRVHNg---PK 326 fruit fly
Q28635       262 MVSttRLPSSSS-----ADQLGGGdwvRYKLCMC-ADGTLFKVQVTGQNVg---CQ 308 rabbit
Q29J24       341 LMP--NLRTAQPpi-mgSAQSREHmhrVFQLCAC-SNGKLFLAAPHSI------CA 386 Drosophila pseudoobscura
XP_001627521 242 MLK--NIPLSKP-----ASGVSSD---ACEVCVS-QDGSIFYAADGSG------CK 280 starlet sea anemone
XP_002631343 292 YME--KLARSDG------RGSPQT---Q--VCVC-HNGRLFLAAPNADcradrdic 333 Caenorhabditis briggsae
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