Conserved Protein Domain Family
Hox9_act

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pfam04617: Hox9_act (this model, PSSM-Id:218179 is obsolete and has been replaced by 309661)
Hox9 activation region
This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is thought to act as a transcription activation region. Activation is may be by interaction with proteins such as Btg proteins, which are thought to recruit a multi-protein Ccr4-like complex.
Statistics
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PSSM-Id: 218179
View PSSM: pfam04617
Aligned: 29 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 22-Dec-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82245499    1 MSSSGTISNYYVDSLIGHESEEGY-GGRFSQ-GGQNATS-------RPSG-D-GDPS-----DFHPCSFASKSGVFPTS- 63
gi 123900454   1 MAISGPLTNYFVQSIISPDTDETP-AAKF-S-AQFPNP--------RAPAqse-------plDFPSCS-------FSAS- 54
gi 82237641    1 MAISGTLSNYFVESIISPESEEAP-AAKF-S-GQYPSP--------RPAA----HSAhseplDFPSCSFQPKAPVFSAS- 64
gi 20141507    1 MSISGTLSSYYVDSIISHESEDAP-PAKFPS-GQYASS--------RQPGhae-------hlEFPSCSFQPKAPVFGAS- 62
gi 110825727   1 MSISGTLSNYYVDSIISHEGEDPN-ASRFSN-VQYSSA--------RQPG----PGEh---pEFPSCSFQPKPPVFSSS- 62
gi 123918012   1 MSISGTLSNYYVDSIISHDSDELSgPARFSA-VQYSSPNssvaagvRQPV-AaAHAEhphsdSYPSCSFQPKPPVFSPS- 77
gi 82263253    1 MSISGTLSNYYVDSIISHESDDLSaSTRFPS-VQYSSSSsaaaangRQPGa--VHAEhphaePYPSCSFQPKPPVFSSS- 76
gi 110282970   1 MSTSGALTGYYVDSIVIPGSEE----TRFSS-GLGLIQH-------RPTIlP-ADLS-----DLGPCTFPAKQPVYGTSd 62
gi 154183832   1 MSTSGTLTSYYVDSLILPESEELS-VPRYTS-GPGLQHA-------RQHAsI-SDHS-----EVGTCTFPSKPQVFGPS- 64
gi 154183801   1 MSTLGT--SYYIDSRILPEQED-M-APRYSSsAAGVEQA----------V-V-TEYG-----GQESCPLQAKSSIFGGS- 58
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82245499   64 WSTV--QP-QPSAGMTGIYHPYVa---QSHL--A-AAATdsgRYtVRSW-L-DPISSAApSFSEfqA-NGRNyGIKPES- 130
gi 123900454  55 WNPL--TP-H-----PPVYQPYIqqqqQQEEgaP-SAEG---RY-LRAW-L-DNGP-----------------SLKSEPl 102
gi 82237641   65 WSPL--NP-HPASPLPSVYHPYI----QQGA--P-TPEG---RY-LRGW-L-EPLQRAE-NGPG--Q-G----TVKSEPl 120
gi 20141507   63 WAPL--SP-HASGSLPSVYHPYI-----QPQgvP-PAES---RY-LRTW-L-EPAPRGE-AAPG--Q-GQA--AVKAEPl 121
gi 110825727  63 WSPF--SS-HASNGLPAVYHPYIp---TQPV--P-STDT---RY-LRTW-L-DCAPRAE-PLPG--Q-G----QVKMEPl 119
gi 123918012  78 WSPF--SPhHGAGALPAVYHPYLp---AQHV--P-AADT---RY-LRSW-L-DAAPRDPdSVSG--Q-SQTG-QVKLEPq 139
gi 82263253   77 WSPF--SPhHGASSLPAVYHPYLp---AQHV--P-SADT---RY-LRSW-L-DCAPRGSePV----Q-GQTG-QVKLEPq 136
gi 110282970  63 WGHI--PT-HFSTGVPSVYQPh----aQPPVv-G-DY--------VQSWlL-DSACG-L-PQTEp-P-TVNHnHAKSDTn 120
gi 154183832  65 WSHV--PA-QFPATVSSVYHPHYgh-pQGPV--GgDTDG---RY--QSW-LlEPMSGSL-PLTGl-P-TTHHyGIKPEGl 129
gi 154183801  59 WSAIsaHT-PNTAAPTYIHHPY-------PS--G-DSDG---MF-TRSWaL-DPVSASL-CLTGl-PsTGMHyEIKPEPl 120
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 82245499  131 AAKRT-ECsSFASQG-LSL---PEYTCNSFPESTEKpagKEPAAPASEESNSTEL-----KEEKeqqkQQIDP 193
gi 123900454 103 LGP------PGDKLG-P-----QHYTVASPGGAAAN-----TERSTHSGNFPDTKgtegtAGDT----DRTHQ 154
gi 82237641  121 LGP------PGELDK-LGA---QQYNLGSPAAREDA---------NERATFPDNKlc-egSGDK----DRTHQ 169
gi 20141507  122 LGA------PGELLK-QGT---PEYSLETSAGREAV-------LSNQRPGYGDNKic-egSEDK----ERPDQ 172
gi 110825727 120 LGHLGe---PPKLVG-Q-----HEYILESSTAREIN--------SGHSAGFEDNKdicegSEDK----EGPDQ 171
gi 123918012 140 LGHQGgDI-PLKVSV-QHPhetTTYILDPVSTAAREl--SLHPAAVPGRGFEESKegcegSEDK----DGPDQ 204
gi 82263253  137 LGHLGgEL-PAKLSG-QHPhdtTAYMLESTSTASRDl--SHHPAAIPGAGFEENKdicdgSEDK----DGLDQ 201
gi 110282970 121 ETND--DGtEYSPHT-ILQp--EVFTNGGCSTKTEA---ESSRTAEKSGDI----------EGK----PGADP 171
gi 154183832 130 -GARA-EGgLPGSHTaLLL---SEYANGTVASASPV---EKDELSVQAGDLSGE------GEEK----PGLDP 184
gi 154183801 121 IGT-A-ECtTLETHT-HLL---SDTENGASLVEIPC---ETASKATEDNPS---------VEEK----RKVDP 171
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