3GMJ,1U7F


Conserved Protein Domain Family
MH2

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pfam03166: MH2 (this model, PSSM-Id:217398 is obsolete and has been replaced by 335246)
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MH2 domain
This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C-terminus of MH2.
Statistics
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PSSM-Id: 217398
View PSSM: pfam03166
Aligned: 13 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 22-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3GMJ_D  45 YSEPAFWASIAYYELNCRVGEVFHCNN--N---SVIVDGFTn----PSnn-sDRCCLGQLSNVNR--NSTIENTRRHIGK 112 fruit fly
O15968 394 NINSQVWCQIAYWEMAHRVGEFFHAKT--Na-vNIYTDGIV-----ASe--vDSMCLRDLTPAGNqiHSVVPTARHTVGL 463 fruit fly
O15105 255 PGDRSHWCVVAYWEEKTRVGRLYCVQE--P---SL-DIFYd-----LPq--gNGFCLGQLNSDNK--SQLVQKVRSKIGC 319 human
O57475 183 MSKQGHWCSVAYWEHRTRVGRLYAVCQ--P---SV-SIFYd-----LPq--gSGFCLGQLNLENR--SEAAARTRGKIGL 247 African clawed frog
O17532 555 SDLNEKWGTIVYYEKNLQIGEKKCSRG--N---FHVDGGFi------Cs--eNRYSLGLEPNPIR--EPVAFKVRKAIVD 619 Caenorhabditis elegans
Q21733 343 YEESPSWLKLIYYEEGTMIGEKADVEG--H---HCLIDGFTasrtdSEt--rSRFSLGWYNNPNR--SPQTAEVRGLIGK 413 Caenorhabditis elegans
P45897 344 PQLLDNWCSIIYYELDTPIGETFKVSA--RdhgKVIVDGGMd----PHgeneGRLCLGALSNVHR--TEASEKARIHIGR 415 Caenorhabditis elegans
P45896 191 FRHPKSWAQITYFELNSRVGEVFKLVN--L---SITVDGYTn----PSns-nTRICLGQLTNVNR--NGTIENTRMHIGK 258 Caenorhabditis elegans
Q02330 216 VWEEQFWATVSYYELNTRVGEQVKVSS--T---TITIDGFTd----PCin-gSKISLGLFSNVNR--NATIENTRRHIGN 283 Caenorhabditis elegans
P42003 255 YSEPAFWASIAYYELNCRVGEVFHCNN--N---SVIVDGFTn----PSnn-sDRCCLGQLSNVNR--NSTIENTRRHIGK 322 fruit fly
P84025 226 YCEPAFWCSISYYELNQRVGETFHASQ--P---SMTVDGFTd----PSn--sERFCLGLLSNVNR--NAAVELTRRHIGR 292 Norway rat
O70437 317 HPAPEYWCSIAYFEMDVQVGETFKVPS--Sc-pIVTVDGYVd----PSg--gDRFCLGQLSNVHR--TEAIERARLHIGK 385 Norway rat
1U7F_B   4 HPAPEYWCSIAYFEMDVQVGETFKVPSscP---IVTVDGYVd----PSg--gDRFCLGQLSNVHR--TEAIERARLHIGK 72  human
3GMJ_D 113 GVHLYYVt--GE--VYAECLSDSAIFVQSRNCNYQHGfh-psTVCKIPPG-CSLKIFNNQEFaQL--------------- 171 fruit fly
O15968 464 GVTLSLEn--GD--VWIYNRGNTTIFVDSPTLSENLD-----RVCKVMPG-YCLKAFETNRA-EL--------------- 517 fruit fly
O15105 320 GIQLTREv-dG---VWVYNRSSYPIFIKSATLDNPDSrt--lLVHKVFPG-FSIKAFDYEKAySL--------------- 377 human
O57475 248 GIVLSREt-dG---VWAYNRSDHPIFVNSPTLDAPACrp--lVVRKVMPG-YSLKVFDYKKScVL--------------- 305 African clawed frog
O17532 620 GIRFSYKk-dGS--VWLQNRMKYPVFVTSGYLDEQSGglkkdKVHKVYGC-ASIKTFGFNVSkQI--------------- 680 Caenorhabditis elegans
Q21733 414 GVRFYLLa--gE--VYVENLCNIPVFVQSIGANMKNGfq-lnTVSKLPPT-GTMKVFDMRLFsKQ--------------- 472 Caenorhabditis elegans
P45897 416 GVELTAHa-dGN--ISI--TSNCKIFVRSGYLDYTHGseyssKAHRFTPNeSSFTVFDIRWAyMQ--------------- 475 Caenorhabditis elegans
P45896 259 GIQLDNKe--DQmhIMITNNSDMPVFVQSKNTNLMMNmp-lvKVCRIPPH-SQLCVFEFNLFfQM--------------- 319 Caenorhabditis elegans
Q02330 284 GVKLTYVrsnGS--LFAQCESDSAIFVQSSNCNYINGfh-stTVVKIANK-CSLKIFDMEIFrQL--------------- 344 Caenorhabditis elegans
P42003 323 GVHLYYVt--GE--VYAECLSDSAIFVQSRNCNYHHGfh-psTVCKIPPG-CSLKIFNNQEFaQL--------------- 381 fruit fly
P84025 293 GVRLYYIg--GE--VFAECLSDSAIFVQSPNCNQRYGwh-paTVCKIPPG-CNLKIFNNQEFaAL--------------- 351 Norway rat
O70437 386 GVQLECKg-eGD--VWVRCLSDHAVFVQSYYLDREAGrapgdAVHKIYPS-AYIKVFDLRQChRQ--------------- 446 Norway rat
1U7F_B  73 GVQLECKg-eGD--VWVRCLSDHAVFVQSYYLDREAGrapgdAVHKIYPS-AYIKVFDLRQChRQmqqqaataqaaaaaq 148 human
3GMJ_D 172 ----------------LSQSv-NNGFEA----------------------------------VYELTk-MCTIRMSFVKG 199 fruit fly
O15968 518 ----------------LSMR--DHGHHP----------------------------------MGPVD--YFSIKISFGKG 543 fruit fly
O15105 378 ----------------QRPNdh--------------------------------------efMQQPWt-GFTVQISFVKG 402 human
O57475 306 ----------------RHHPt-Ppe------------------------------------hTDGPYd-PNSVRISFAKG 331 African clawed frog
O17532 681 ----------------IRDAl-LSKQMAtmylqgkltpmnyiy----ekktqeelrreatrtTDSLAk-YCCVRVSFCKG 738 Caenorhabditis elegans
Q21733 473 ----------------LRTAa-EKTYq----------------------------------dVYCLSr-MCTVRVSFCKG 500 Caenorhabditis elegans
P45897 476 ----------------MLRRs-RSSNEAvraqaaavagyap---------msvmpaimpdsgVDRMRrdFCTIAISFVKA 529 Caenorhabditis elegans
P45896 320 ----------------LEQSc-NDS-DG----------------------------------LNELSk-HCFIRISFVKG 346 Caenorhabditis elegans
Q02330 345 ----------------LEDCs-RRGFDA----------------------------------SFDLQk-MTFIRMSFVKG 372 Caenorhabditis elegans
P42003 382 ----------------LSQSv-NNGFEA----------------------------------VYELTk-MCTIRMSFVKG 409 fruit fly
P84025 352 ----------------LAQSv-NQGFEA----------------------------------VYQLTr-MCTIRMSFVKG 379 Norway rat
O70437 447 ----------------MQQQa-ATAQAAaaaqaaavagnipgpgsvggiapaislsaaagigVDDLRr-LCILRMSFVKG 508 Norway rat
1U7F_B 149 aaavagnipgpgsvggIAPAisLSAAAGi--------------------------------gVDDLRr-LCILRMSFVKG 195 human
3GMJ_D 200 WGAEY-HRQDVTSTPCWIEIHLHGP 223 fruit fly
O15968 544 WGRDY-KRQDIMGCPCWLEVHFSHL 567 fruit fly
O15105 403 WGQCY-TRQFISSCPCWLEVIFNSR 426 human
O57475 332 WGPCY-SRQMITSCPCWLEVLLGR- 354 African clawed frog
O17532 739 FGEAYpERPSIHDCPVWIELKINIA 763 Caenorhabditis elegans
Q21733 501 WGEHY-RRSTVLRSPVWFQAHLNNP 524 Caenorhabditis elegans
P45897 530 WGDVY-QRKTIKETPCWIEVTLHRP 553 Caenorhabditis elegans
P45896 347 WGEDY-PRQDVTSTPCWLELRLNVP 370 Caenorhabditis elegans
Q02330 373 WGAEY-QRQDVTSTPCWIEIHLHAP 396 Caenorhabditis elegans
P42003 410 WGAEY-HRQDVTSTPCWIEIHLHGP 433 fruit fly
P84025 380 WGAEY-RRQTVTSTPCWIELHLNGP 403 Norway rat
O70437 509 WGPDY-PRQSIKETPCWIEIHLHRA 532 Norway rat
1U7F_B 196 WGPDY-PRQSIKETPCWIEIHLHRA 219 human
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