Conserved Protein Domain Family
HlyIII

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pfam03006: HlyIII (this model, PSSM-Id:217315 is obsolete and has been replaced by 335184)
Haemolysin-III related
Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.
Statistics
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PSSM-Id: 217315
View PSSM: pfam03006
Aligned: 82 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75211531   73 FTIHNETLNVWTHLIGFFLFLALTIYTATKVPSvvdlHSlqhrlpdllrktdlhklhselmsrlpsspsswhvmdllync 152
gi 75018934   69 F-------NVWTHFIPAIILLFAYLIPEILAPL----P------------------------------------------ 95
gi 51316525   43 FQMTNETLNIWTHLLPFWFFVWRFMTALYVTDIqndsY------------------------------------------ 80
gi 124075960  44 FQLTNETLNIWTHFLPTWFFLWKLLTVVLVLEDwrdpF------------------------------------------ 81
gi 82241761   72 FQCHNELLNVWTHLLAIPAVLLQFSFFAGAWGLtlnlA------------------------------------------ 109
gi 82176922   70 FKKHNESVNVWTHLLVALAVVLRVVAFVEAGSLslnvV------------------------------------------ 107
gi 51316133   70 FQKHNEVVNVWTHLLAALAVLLRFWAFVETEGLpwtsAH----------------------------------------- 108
gi 51316132   68 FQQHNEAVNVWTHLLAALVLLLRLAIFVGTVDFwgdpH------------------------------------------ 105
gi 51316387   70 FQRHNETLNVWTHLLAAFIILVKWQEISETVDFlrdpH------------------------------------------ 107
gi 51316388   70 FQRHNESVNVWTHLLASLIILVKFQELSETVDFlrdpH------------------------------------------ 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75211531  153 lperfshgnytdmcvlhsvredlanliaplifrpitRWPFYAFLGGAIFCLLASSTCHLlschSE-RVSYIMLRL-DYAG 230
gi 75018934   96 ------------------------------------RVPVLILQVGIFLLLIASSLAHLm--hSRsELDHVFWFLiDFSG 137
gi 51316525   81 ------------------------------------SWPMLVYMCTSCVYPLASSCAHTfssmSK-NARHICYFL-DYGA 122
gi 124075960  82 ------------------------------------IWPFLVFLLSCCVYPLASSCAHTfstmSE-RARHICFFF-DYGA 123
gi 82241761  110 ------------------------------------SLPLFLYVLSSLTYLSFSVAAHLlqshSE-LAHYSLFFV-DYVG 151
gi 82176922  108 ------------------------------------SFPLYLYVLSSLTYLTCSILAHLlqskSE-LAHYTFYFI-DYVG 149
gi 51316133  109 ------------------------------------TLPLLLYVLSSITYLTFSLLAHLlqskSE-LSHYTFYFV-DYVG 150
gi 51316132  106 ------------------------------------ALPLFIIVLASFTYLSLSALAHLlqakSE-FWHYSFFFL-DYVG 147
gi 51316387  108 ------------------------------------AQPLFIVLLAAFTYLSFSALAHLlsakSE-LSYYTFYFL-DYVG 149
gi 51316388  108 ------------------------------------AQPMFILLLAAFTYLGCSALAHLlsakSE-ISHYTFYFL-DYVG 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75211531  231 IAALIATSFYPPVYYSFmCdPFFCNLYLGF----ITILGIATVLVSLLPVfq----------------------sLEFRV 284
gi 75018934  138 IALF---GITIGLQRYSsS-DDMSLIMKIIyvplLLVVVLGGQYFSTCYLfvyk------------------phyKRRME 195
gi 51316525  123 VNLFSLGSAIAYSAYTFpDaLVCSTFHECY----VALAVLNTILSTGLSCysrfl---------------elqkpRLCKL 183
gi 124075960 124 LSFYSLGSAIIYSSYSFpDkWVNGTFHLNY----VSIAVVNSIISTALACysrlglpfleynchsikrpsgkldqKLCKC 199
gi 82241761  152 VAVYQYGCSMGHYFYCSePeWRHSLVGVLF----LPGAAMLAWLSCASCCyskfry--------------rrpypFHRKI 213
gi 82176922  150 VSTYQYGCALAHYYYTSnEaW-YDKACYFF----LPGAAFLGWLSCVGCCyakycy--------------krpypVMRKI 210
gi 51316133  151 VSVYQYGSALVHFFYASdQaW-YERFWLFF----LPAAAFCGWLSCTGCCyakyry--------------rrpypVMRKV 211
gi 51316132  148 VAVYQFGSALAHFYYAIePaW-HAQVQTIF----LPMAAFLAWLSCTGSCynkyi----------------qkpgLLGRT 206
gi 51316387  150 VAVYQYGSALAHYYYAIeKeW-HTKVQGLF----LPAAAFLAWLTCFGCCygkyas--------------pelpkVANKL 210
gi 51316388  150 VAVYQYGSALAHFYYVVeEeW-HAQVRTFF----LPASAFLAWLSCTGCCygkyas--------------pklpkFVHKL 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75211531  285 VRASLFFGMGFSGLAPILH-KLIIF-WDqpea-lhmTGYEILMGLLYGLGAVVYATRiperwmPGKFdiaghSHQLFHVL 361
gi 75018934  196 LRMGSCFLLACWLYIPLHYrYQSEGsGGda-----aLPLHSRAFQWLVFSGIFMGAHiperfaPGVFdivgyGHQLFHLC 270
gi 51316525  184 LRVLAFAYPYTWDSLPIFYrLFLFP--Gessr-neaMLYHQKHMGMTLLASFFYSAHlperlaPGRFdyighSHQLFHVC 260
gi 124075960 200 LRIIAFVYPYLFDNIPLFYrIFVCA--GegctvneaNTVHYQHTSLAFFTGFLFATHlperlaPGSFdyighSHQLFHVF 277
gi 82241761  214 CQIIPTSLAYLLDISPVAHrLLTkswd------epvLVFHAMQVAFFLLAALFFSCPvperffPGRCdivghGHQIFHIF 287
gi 82176922  211 LQVVPAGLAYILDISPVVHrIVTCH--Medyt-dkaVWLHSLQMIFFIIGAYFFSCPvpekyfPGSCdfighGHQIFHVF 287
gi 51316133  212 CQVVPAGLAFILDISPVAHrVALCH--Lsgcq-eqaAWYHTLQIVFFLVSAYFFSCPvpekyfPGSCdivghGHQIFHAF 288
gi 51316132  207 CQEVPSALAYALDISPVAHrILASP--Epatd-dpaLLYHKCQVVFFLLAAAFFSAFmperwfPGSChifgqGHQLFHVF 283
gi 51316387  211 FQVVPSALAYCLDISPVVHrIYSCY--Qegcs-dpvVAYHFYHVVFFLIGAYFFCCPhpeslfPGKCdfigqGHQLFHVF 287
gi 51316388  211 FQVVPSGLAYCLDISPVLHrIYRCYsSEhwca-dqaVVYHCYQVLFFLISAYFFSYPhperwfPGRCdfigqGHQIFHVF 289

                 ....*....
gi 75211531  362 VVAGALTHY 370
gi 75018934  271 IDMVAWNLL 279
gi 51316525  261 VILATHLQM 269
gi 124075960 278 AIIGTYFQM 286
gi 82241761  288 LVLCTMCQL 296
gi 82176922  288 LGLCTLSQL 296
gi 51316133  289 LSICTLSQL 297
gi 51316132  284 LVLCTLAQL 292
gi 51316387  288 VVVCTLTQV 296
gi 51316388  290 LVLCTLVQI 298
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