2QC1,2BG9,2BG9,2BG9


Conserved Protein Domain Family
Neur_chan_LBD

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pfam02931: Neur_chan_LBD (this model, PSSM-Id:217293 is obsolete and has been replaced by 335158)
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Neurotransmitter-gated ion-channel ligand binding domain
This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.
Statistics
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PSSM-Id: 217293
View PSSM: pfam02931
Aligned: 107 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 22-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2QC1_B        5 ETRLEAKLFED--YSSVVRPV-EDHREiVQVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDD--YGGVKKI 79
gi 74894632  34 IVRLAHDTYDD---LKTAPPSyDKLEP-ARIQVLLYVSSIDAVNEASMDFTVGILLHLRWTDTRIYHDKAHnlFLQSKLQ 109
gi 74964323  43 DHLLIDRALY---YNKHKLP---SPQ--VDVRIEMWVQEVTSVSELTQDFEIDLYMNEYWTDPGLAYDILN-----PCQG 109
gi 74964885  66 DKTIIEKLLNN--YKSFRTP---SESG-VIVWIEVWVQEVNSVNEITSDFDMDIYVTELWMDSALRYEHLN-----PCKY 134
gi 75025672  52 DDAIIAQILDG--YNKLDLP---GGGH-VVVSIEIWVQEVSKIIEITSEFELDIYVTERWTDPSLAYSHLN-----PCKS 120
gi 74965337  54 QPAIIDKLLNGtgYNKFRIP---NENG-VPVQVEFWVQAITSINEITNDFEMDIYINEMWLDPALKFDHLN-----PCKQ 124
gi 74963260  50 DTDIIDRLLNGtgYNKFRIP---QEEG-MTVVVEIWIQAITSIDELTNDFDMDIYITETWLDPALNFQTMT-----PCKG 120
gi 74961868  71 EAQLMEKLLKGsgYSKHKIP---RENG-ITVSVEFWIQEINSISEMTNDFELELFINEMWTDPSLRFPHLG---ACKANL 143
gi 32172432  16 LGKLIDTLLTD--YDTHLLP---EAEG-VNVTIELHVQGVSGISEITGDFSLDVMYSEIWQDPRLSFKHLN---VCATNI 86
gi 75024609  88 ATRILTELLSK--YDRNLVP---KMKG-VDVDVELLIQRVSEISEIQSSSTMHILFSQIWHDPGLSFEHEEg---AHCLT 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2QC1_B       80 HIPSE------KIWRPDVVLYN-NADGDFAIVk-fTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTRT 151
gi 74894632 110 SLDFDsen-ikKVWVPDIFFPNeKKGSFHDIMtqnQMMRLYQGGTILYISRLSMTLSCPMDLINYPFDKQTCHILIMSFG 188
gi 74964323 110 NLSFDwav-mqNIWTPNTCFINsKKAQLHSSPftnVFLMVFPNGSVWSNWRIKSTGPCVMDLTKFPMDSIECTLTFESFN 188
gi 74964885 135 NLSLNsei-ldQIWKPNTVFINsKSANIHKSPfknVFLMIYPNGTVWVNYRVQVKGPCSMDFSAFPMDQQSCHLTLESFS 213
gi 75025672 121 NMSVDgatilnKIWNPHACFVNsKLANIHESPfknIFLQIYSNGSIWHNYRIKLTGPCSSTLRTFPIDQQRCMLFYESFT 200
gi 74965337 125 NLSVShqv-leQLWTPNSCFVNsKFAEIHDSPfknVFLMIYPNGTVWVNYRVNVKGPCDLSLELFPLDIQECHLIYESFN 203
gi 74963260 121 NLSLNhqv-ldRLWTPNSCFINsKVAQIHNSPfrsVFLMLFPNGTVMVNYRVRVKGPCSLDLSNFPLDLQKCSLIYESFN 199
gi 74961868 144 TLDQQtl---tKLWTPNTCFVNsKFAEIYESSfqnVFLTLFDNGTVWVNYRVRVKGACNMDLVDFPMDTQSCRLNYQSFT 220
gi 32172432  87 TLKVSdf--rkKIWTPDTCIINsKSSSIHSSPsenTFVILYENGLVWSNFRLNVKTPCSVNLKMFPFDSLSCEIVLESYS 164
gi 75024609 159 NLSLShrm-vdNIWLPNVCIVNsKGSAIHKSPtpnIFLAIFPNGTVWMNYRVVVESPCEMDFSFFPMDRVMCTTIFESYA 237
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
2QC1_B      152 YDGSAVAINPESDQp---------DLSNFMESGEWVIKEARGWKhwVFYSccpttP-----YLDITYHFVMQRLP 212
gi 74894632 189 YSDQDLVLDWMNLTtaddl-tmnpDGKAIVVDSEVLLPQFEVKSviPSFCnr-ryHqkagnHSCIQAEFHLARNI 261
gi 74964323 189 YNKDEVFMRWGDPPltif---kpiELPDFTMTNFSTSNK----FqlYAAGyws----------elnVNFLFRRRS 246
gi 74964885 214 YNNQEVDMQWMNWTtplsllkkeiVLPDFVMSNYSTSLK----HeiYPAGvw-neLt---------MTFVFSRRY 274
gi 75025672 201 HNTDQVKMEWITTVppitilkgniTLPDYVLVDFSSSSE----LrlYPPGifn----------eliATFTFQRLY 261
gi 74965337 204 YNNQEVRMRWNEKSaepvsvtnkiRLPDFELIKIESTRI----SapYPAGmwd----------elhVKLVFERRY 264
gi 74963260 200 YNRQEVEMRWSDAEhpvfn-lskiMLPDFDLFEIQTERR----QepYPAGmwd----------elhVTIIFERRF 259
gi 74961868 221 YNNEEVRLQWNSQRspvfa-lqeiRIADFWLKDITPAVI----KrdYPAGlw-deLv---------VTFVFERRY 280
gi 32172432 165 FNTDEVRLMWHDVPitmm---ekvELPDFDLIGWSTDHQ----RleYPNGiw-drAk---------VKFTFARRY 222
gi 75024609 238 FNVGKVRLHWKRQGqpvef-iddvKLPDFHMTKFVHEKA----TfiYPAGvwd----------qlnIKLLFRRSY 297
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