2QC1,2BG9,2BG9,2BG9


Conserved Protein Domain Family
Neur_chan_LBD

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pfam02931: Neur_chan_LBD (this model, PSSM-Id:217293 is obsolete and has been replaced by 427061)
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Neurotransmitter-gated ion-channel ligand binding domain
This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.
Statistics
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PSSM-Id: 217293
Aligned: 107 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 22-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2QC1_B   5 ETRLEAKLFED--YSSVVRPV-EDHREiVQVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDD--YGGVKKI 79  house mouse
Q08861  34 IVRLAHDTYDD---LKTAPPSyDKLEP-ARIQVLLYVSSIDAVNEASMDFTVGILLHLRWTDTRIYHDKAHnlFLQSKLQ 109 great pond snail
Q20105  43 DHLLIDRALY---YNKHKLP---SPQ--VDVRIEMWVQEVTSVSELTQDFEIDLYMNEYWTDPGLAYDILN-----PCQG 109 Caenorhabditis elegans
Q20828  66 DKTIIEKLLNN--YKSFRTP---SESG-VIVWIEVWVQEVNSVNEITSDFDMDIYVTELWMDSALRYEHLN-----PCKY 134 Caenorhabditis elegans
Q9U358  52 DDAIIAQILDG--YNKLDLP---GGGH-VVVSIEIWVQEVSKIIEITSEFELDIYVTERWTDPSLAYSHLN-----PCKS 120 Caenorhabditis elegans
Q21420  54 QPAIIDKLLNGtgYNKFRIP---NENG-VPVQVEFWVQAITSINEITNDFEMDIYINEMWLDPALKFDHLN-----PCKQ 124 Caenorhabditis elegans
Q18812  50 DTDIIDRLLNGtgYNKFRIP---QEEG-MTVVVEIWIQAITSIDELTNDFDMDIYITETWLDPALNFQTMT-----PCKG 120 Caenorhabditis elegans
P91985  71 EAQLMEKLLKGsgYSKHKIP---RENG-ITVSVEFWIQEINSISEMTNDFELELFINEMWTDPSLRFPHLG---ACKANL 143 Caenorhabditis elegans
P41849  16 LGKLIDTLLTD--YDTHLLP---EAEG-VNVTIELHVQGVSGISEITGDFSLDVMYSEIWQDPRLSFKHLN---VCATNI 86  Caenorhabditis elegans
Q9TVI7  88 ATRILTELLSK--YDRNLVP---KMKG-VDVDVELLIQRVSEISEIQSSSTMHILFSQIWHDPGLSFEHEEg---AHCLT 158 Caenorhabditis elegans
2QC1_B  80 HIPSE------KIWRPDVVLYN-NADGDFAIVk-fTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTRT 151 house mouse
Q08861 110 SLDFDsen-ikKVWVPDIFFPNeKKGSFHDIMtqnQMMRLYQGGTILYISRLSMTLSCPMDLINYPFDKQTCHILIMSFG 188 great pond snail
Q20105 110 NLSFDwav-mqNIWTPNTCFINsKKAQLHSSPftnVFLMVFPNGSVWSNWRIKSTGPCVMDLTKFPMDSIECTLTFESFN 188 Caenorhabditis elegans
Q20828 135 NLSLNsei-ldQIWKPNTVFINsKSANIHKSPfknVFLMIYPNGTVWVNYRVQVKGPCSMDFSAFPMDQQSCHLTLESFS 213 Caenorhabditis elegans
Q9U358 121 NMSVDgatilnKIWNPHACFVNsKLANIHESPfknIFLQIYSNGSIWHNYRIKLTGPCSSTLRTFPIDQQRCMLFYESFT 200 Caenorhabditis elegans
Q21420 125 NLSVShqv-leQLWTPNSCFVNsKFAEIHDSPfknVFLMIYPNGTVWVNYRVNVKGPCDLSLELFPLDIQECHLIYESFN 203 Caenorhabditis elegans
Q18812 121 NLSLNhqv-ldRLWTPNSCFINsKVAQIHNSPfrsVFLMLFPNGTVMVNYRVRVKGPCSLDLSNFPLDLQKCSLIYESFN 199 Caenorhabditis elegans
P91985 144 TLDQQtl---tKLWTPNTCFVNsKFAEIYESSfqnVFLTLFDNGTVWVNYRVRVKGACNMDLVDFPMDTQSCRLNYQSFT 220 Caenorhabditis elegans
P41849  87 TLKVSdf--rkKIWTPDTCIINsKSSSIHSSPsenTFVILYENGLVWSNFRLNVKTPCSVNLKMFPFDSLSCEIVLESYS 164 Caenorhabditis elegans
Q9TVI7 159 NLSLShrm-vdNIWLPNVCIVNsKGSAIHKSPtpnIFLAIFPNGTVWMNYRVVVESPCEMDFSFFPMDRVMCTTIFESYA 237 Caenorhabditis elegans
2QC1_B 152 YDGSAVAINPESDQp---------DLSNFMESGEWVIKEARGWKhwVFYSccpttP-----YLDITYHFVMQRLP 212 house mouse
Q08861 189 YSDQDLVLDWMNLTtaddl-tmnpDGKAIVVDSEVLLPQFEVKSviPSFCnr-ryHqkagnHSCIQAEFHLARNI 261 great pond snail
Q20105 189 YNKDEVFMRWGDPPltif---kpiELPDFTMTNFSTSNK----FqlYAAGyws----------elnVNFLFRRRS 246 Caenorhabditis elegans
Q20828 214 YNNQEVDMQWMNWTtplsllkkeiVLPDFVMSNYSTSLK----HeiYPAGvw-neLt---------MTFVFSRRY 274 Caenorhabditis elegans
Q9U358 201 HNTDQVKMEWITTVppitilkgniTLPDYVLVDFSSSSE----LrlYPPGifn----------eliATFTFQRLY 261 Caenorhabditis elegans
Q21420 204 YNNQEVRMRWNEKSaepvsvtnkiRLPDFELIKIESTRI----SapYPAGmwd----------elhVKLVFERRY 264 Caenorhabditis elegans
Q18812 200 YNRQEVEMRWSDAEhpvfn-lskiMLPDFDLFEIQTERR----QepYPAGmwd----------elhVTIIFERRF 259 Caenorhabditis elegans
P91985 221 YNNEEVRLQWNSQRspvfa-lqeiRIADFWLKDITPAVI----KrdYPAGlw-deLv---------VTFVFERRY 280 Caenorhabditis elegans
P41849 165 FNTDEVRLMWHDVPitmm---ekvELPDFDLIGWSTDHQ----RleYPNGiw-drAk---------VKFTFARRY 222 Caenorhabditis elegans
Q9TVI7 238 FNVGKVRLHWKRQGqpvef-iddvKLPDFHMTKFVHEKA----TfiYPAGvwd----------qlnIKLLFRRSY 297 Caenorhabditis elegans
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