3KB6,1QP8,1WWK


Conserved Protein Domain Family
2-Hacid_dh_C
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pfam02826: 2-Hacid_dh_C (this model, PSSM-Id:217244 is obsolete and has been replaced by 427007)
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D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
This domain is inserted into the catalytic domain, the large dehydrogenase and D-lactate dehydrogenase families in SCOP. N-terminal portion of which is represented by family pfam00389.
Links
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Statistics
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PSSM-Id: 217244
Aligned: 164 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3KB6_B 106 FAXILTLVKRLKRIEDRVk----KLnf-------sQDSEILAR----ELNRLTLGVIGTGRIGSRVAXYGLAFGX-KVLC 169 Aquifex aeolicus
Q7P6L5  14 MTLLLNELTRAERLSQEVk----QNkwee---isnKMDRYYHV----DTEGKVLGILGHGNIGKRVEQYAKSFGM-EVMI 81  Fusobacterium nucleat...
Q6KZ29 104 FGLIICIARRICSGYETIi----SNkwe----yrwKPDFMLGH----DVYGKTLGILGLGRIGHAVMRRASGFDM-NVIY 170 Picrophilus torridus
Q76KF6 105 IGLLMELTNKISKFDQYVk----SGrysssgiftcVGGEYDIH----EISNKKWCIVGLGSIGKNVARVAKGLGA-KVYY 175 Entamoeba histolytica
Q7VJR5 105 LSMALNLLARLHYYDEYCk----SGaw------arSKIFVHINgglrEIENLQWGIIGFGSIGQRVARLAQSFGA-KVSY 173 Helicobacter hepaticus
Q6L001  94 IGLMLAWARKICISNYNIh----NNny-------kRLDYKEYV----SLYNKSLGILGYGGIGRRTALIAKSFGM-NIYA 157 Picrophilus torridus
Q97A21  90 FALLLARAKNVIENDMNMk----NGk----------fIQSPTK----LLYSKTLGILGYGGIGRRVAELGKAFGM-DIAV 150 Thermoplasma volcanium
Q9YCJ2 108 VAAVLAALRGVVAGHMYTprwarEGw----------PSHLAGF----LVRGRSVGLLGAGRIGQSVAFKLAALGAgPFYY 173 Aeropyrum pernix
1QP8_B  91 LALLLAPYKRIIQYGEKXk----RGd--------yGRDVEIPL-----IQGEKVAVLGLGEIGTRVGKILAALGA-QVRG 152 Pyrobaculum aerophilum
Q8F5N8 113 IGLMISSTRKVFLAHQELk----TGg----------wSRFTGK----RLGESTIGIVGVGRVGLNVIRILSEFRP-KMIL 173 Leptospira interrogans
Q7P6L5  14 MTLLLNELTRAERLSQEVk----QNkwee---isnKMDRYYHV----DTEGKVLGILGHGNIGKRVEQYAKSFGM-EVMI 81  Fusobacterium nucleat...
Q6KZ29 104 FGLIICIARRICSGYETIi----SNkwe----yrwKPDFMLGH----DVYGKTLGILGLGRIGHAVMRRASGFDM-NVIY 170 Picrophilus torridus
Q76KF6 105 IGLLMELTNKISKFDQYVk----SGrysssgiftcVGGEYDIH----EISNKKWCIVGLGSIGKNVARVAKGLGA-KVYY 175 Entamoeba histolytica
Q7VJR5 105 LSMALNLLARLHYYDEYCk----SGaw------arSKIFVHINgglrEIENLQWGIIGFGSIGQRVARLAQSFGA-KVSY 173 Helicobacter hepaticus
Q6L001  94 IGLMLAWARKICISNYNIh----NNny-------kRLDYKEYV----SLYNKSLGILGYGGIGRRTALIAKSFGM-NIYA 157 Picrophilus torridus
Q97A21  90 FALLLARAKNVIENDMNMk----NGk----------fIQSPTK----LLYSKTLGILGYGGIGRRVAELGKAFGM-DIAV 150 Thermoplasma volcanium
Q9YCJ2 108 VAAVLAALRGVVAGHMYTprwarEGw----------PSHLAGF----LVRGRSVGLLGAGRIGQSVAFKLAALGAgPFYY 173 Aeropyrum pernix
1QP8_B  91 LALLLAPYKRIIQYGEKXk----RGd--------yGRDVEIPL-----IQGEKVAVLGLGEIGTRVGKILAALGA-QVRG 152 Pyrobaculum aerophilum
Q8F5N8 113 IGLMISSTRKVFLAHQELk----TGg----------wSRFTGK----RLGESTIGIVGVGRVGLNVIRILSEFRP-KMIL 173 Leptospira interrogans

3KB6_B 170 YDVVkr--------edLKEKGC-VYT-SLDELLKESDVISLHVPYTKETHHXINEERISLXKDGVYLINTARGKVVDTDA 239 Aquifex aeolicus
Q7P6L5  82 Akip---------greYTDNLE-NRF-ELDEVLEKCDIFSIHAPLTDLTRDLINLDRMKKMKKSAIILNLGRGPIINEDD 150 Fusobacterium nucleat...
Q6KZ29 171 YNRTe-------------rDVN-GHV-GLNELFSRSDFIVITLPLNDETRNIVNKDLISKMKKTAYIINASRGHIVNEDD 235 Picrophilus torridus
Q76KF6 176 YSTTgkh-------edPEIERV-----SFEEMIKTSDIITIHCPLTDKTKGMFNYKVFQEMKKNVIIINMARGPIVVNDD 243 Entamoeba histolytica
Q7VJR5 174 YSTSgkn-------tqSAFTRK-----ELNEILSQSDIISIHAPLNDKTKNLINRTNLPLLKDEAVLINVGRGGIVNEKD 241 Helicobacter hepaticus
Q6L001 158 YSRS------------YKNDGI-SSYmEPEDIMKKSDFVLISLPLTKETANSINDKMLSLFRGLA-IINVGRAGVVDRNS 223 Picrophilus torridus
Q97A21 151 FTRTl-----------VKEGGV-RFYkEPGPVLENSDVVVISLPLTDNTRGMINSSKLEMMKKDAMLINVARADIVVKED 218 Thermoplasma volcanium
Q9YCJ2 174 YSRSrkp-------glEAVLGA-KRL-EPRELFSRSMILVNSLPLTGETRGLVTAGLLRLLPRGAVYVNVGRGGTEEPGA 244 Aeropyrum pernix
1QP8_B 153 FSRTp-------------kEGPwRFTnSLEEALREARAAVCALPLNKHTRGLVKYQHLALXAEDAVFVNVGRAEVLDRDG 219 Pyrobaculum aerophilum
Q8F5N8 174 INDLkdkkkevseildFKNVPY-RFT-EKEEIYSSSDIVSLHIPLSHKTKNLIGKKEFDLFPKDSFLINTARGGIVNEND 251 Leptospira interrogans
Q7P6L5  82 Akip---------greYTDNLE-NRF-ELDEVLEKCDIFSIHAPLTDLTRDLINLDRMKKMKKSAIILNLGRGPIINEDD 150 Fusobacterium nucleat...
Q6KZ29 171 YNRTe-------------rDVN-GHV-GLNELFSRSDFIVITLPLNDETRNIVNKDLISKMKKTAYIINASRGHIVNEDD 235 Picrophilus torridus
Q76KF6 176 YSTTgkh-------edPEIERV-----SFEEMIKTSDIITIHCPLTDKTKGMFNYKVFQEMKKNVIIINMARGPIVVNDD 243 Entamoeba histolytica
Q7VJR5 174 YSTSgkn-------tqSAFTRK-----ELNEILSQSDIISIHAPLNDKTKNLINRTNLPLLKDEAVLINVGRGGIVNEKD 241 Helicobacter hepaticus
Q6L001 158 YSRS------------YKNDGI-SSYmEPEDIMKKSDFVLISLPLTKETANSINDKMLSLFRGLA-IINVGRAGVVDRNS 223 Picrophilus torridus
Q97A21 151 FTRTl-----------VKEGGV-RFYkEPGPVLENSDVVVISLPLTDNTRGMINSSKLEMMKKDAMLINVARADIVVKED 218 Thermoplasma volcanium
Q9YCJ2 174 YSRSrkp-------glEAVLGA-KRL-EPRELFSRSMILVNSLPLTGETRGLVTAGLLRLLPRGAVYVNVGRGGTEEPGA 244 Aeropyrum pernix
1QP8_B 153 FSRTp-------------kEGPwRFTnSLEEALREARAAVCALPLNKHTRGLVKYQHLALXAEDAVFVNVGRAEVLDRDG 219 Pyrobaculum aerophilum
Q8F5N8 174 INDLkdkkkevseildFKNVPY-RFT-EKEEIYSSSDIVSLHIPLSHKTKNLIGKKEFDLFPKDSFLINTARGGIVNEND 251 Leptospira interrogans

3KB6_B 240 LYRAYQRGKFSGLGLDVFEDEeililkkytegKATDK----NLkileLAc-KDN-----VIITPHIA 296 Aquifex aeolicus
Q7P6L5 151 LYYALKNNIIASAATDVMTSE-----------PPKSDc---KL----LE--LDN-----FTVTPHLA 192 Fusobacterium nucleatum subsp. vin...
Q6KZ29 236 LYNALLNRDIAGAALDVFDNE-----------PVRADn---RF----VK--LDN-----VLLTPHMA 277 Picrophilus torridus
Q76KF6 244 IAKALQENLIGGYGTDVFDEE-----------PINTSn---KL----LEvsNEK-----IVFSPHIG 287 Entamoeba histolytica
Q7VJR5 242 IAQILKS-KLMYFATDVLESE-----------PMEANh---PF--------LDKtiadkLLITPHVA 285 Helicobacter hepaticus
Q6L001 224 MLNFLRNHNDKYYLTDVWWNE-----------PIINE----NI--------PDN-----VIITPHSA 262 Picrophilus torridus
Q97A21 219 ILKHLISNPDFTYISDVWWNE-----------PNITE----------TN--IKN-----TILSPHIA 257 Thermoplasma volcanium
Q9YCJ2 245 VEAVASEREDLYFVLDVHPEE-----------PLPPSsgrmRL----HG--NPR-----VVMTPHIA 289 Aeropyrum pernix
1QP8_B 220 VLRILKERPQFIFASDVWWGRn----------DFAKDa---EF----FS--LPN-----VVATPWVA 262 Pyrobaculum aerophilum
Q8F5N8 252 LYDVLRSNRIGGAAIDVFEQE-----------PYKg-----NL----TE--LDN-----IILTEHMG 291 Leptospira interrogans
Q7P6L5 151 LYYALKNNIIASAATDVMTSE-----------PPKSDc---KL----LE--LDN-----FTVTPHLA 192 Fusobacterium nucleatum subsp. vin...
Q6KZ29 236 LYNALLNRDIAGAALDVFDNE-----------PVRADn---RF----VK--LDN-----VLLTPHMA 277 Picrophilus torridus
Q76KF6 244 IAKALQENLIGGYGTDVFDEE-----------PINTSn---KL----LEvsNEK-----IVFSPHIG 287 Entamoeba histolytica
Q7VJR5 242 IAQILKS-KLMYFATDVLESE-----------PMEANh---PF--------LDKtiadkLLITPHVA 285 Helicobacter hepaticus
Q6L001 224 MLNFLRNHNDKYYLTDVWWNE-----------PIINE----NI--------PDN-----VIITPHSA 262 Picrophilus torridus
Q97A21 219 ILKHLISNPDFTYISDVWWNE-----------PNITE----------TN--IKN-----TILSPHIA 257 Thermoplasma volcanium
Q9YCJ2 245 VEAVASEREDLYFVLDVHPEE-----------PLPPSsgrmRL----HG--NPR-----VVMTPHIA 289 Aeropyrum pernix
1QP8_B 220 VLRILKERPQFIFASDVWWGRn----------DFAKDa---EF----FS--LPN-----VVATPWVA 262 Pyrobaculum aerophilum
Q8F5N8 252 LYDVLRSNRIGGAAIDVFEQE-----------PYKg-----NL----TE--LDN-----IILTEHMG 291 Leptospira interrogans
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