1VF1,1ML6,1YDK,1U88,2WRT,1YKC,1M0U,1NHY,1K0D


Conserved Protein Domain Family
GST_N

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pfam02798: GST_N (this model, PSSM-Id:217234 is obsolete and has been replaced by 335096)
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Glutathione S-transferase, N-terminal domain
Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST activity; similarity not previously recognised. * HSP26 family of stress-related proteins. including auxin-regulated proteins in plants and stringent starvation proteins in E. coli. Not known to have GST activity. Similarity not previously recognised. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.
Statistics
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PSSM-Id: 217234
View PSSM: pfam02798
Aligned: 53 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                      10        20        30        40        50        60        70        80
              ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1VF1_A      5 PVLYYFNGRG--KMESIRWLLA-AAGVEFEE--VFLET---REQY---EKLLQSGILm----fQQVPMVEID-GmKLVQT 68
gi 461995   1 MSLTLWSGVNp-ENARTHKLLAaAALANVAV--TLKACeygRENEt--AEYCRNCSPc-----GRYPVLQTEeG-CVFES 69
gi 119166   2 AGGTLYTYPDnwRAYKPLIAAQ-YSGFPIKV--ASSAPefqFGVTnktPEFLKKFPL------GKVPAFEGKdGfCLFES 72
gi 119164   2 VAGKLYTYPEnfRAFKALIAAQ-YSGAKLEI--A-KSFvfgETNKs--DAFLKSFPL------GKVPAFESAdGhCIAES 69
gi 119165   2 AAGTLYTYPEnwRAFKALIAAQ-YSGAQVRVlsAPPHFhfgQTNRt--PEFLRKFPA------GKVPAFEGDdGfCVFES 72
gi 729399   2 SVGTVYGKIGspRVLFCVSVAA-VAGVEVEH--VDVQPhnfP------ADLAAKFPL------QKMPVFVGKdGfPLSET 66
gi 544232   2 SQGTLYINRSp-RNYASEALIS-YFKLDVKI--VDLEq--sSE-------FASLFPL------KQAPAFLGPkGlKLTEA 62
gi 134260  84 DDACLGQGRG--EVDTGMSYDA-STGVCTDI--NRGDMssdIN-----SGLYSGGRMddschtSESRRMDDPcGtDESRR 153
gi 465674  23 GSFRVYNMRFcpWAERAMLYVA-AKGIEAEV--VNLNVtd-------kLEWYWTKHYq-----GKAPAVEHng-kVVIES 86
gi 126289  15 ESGC--TISP--YVWRTKYALK-HKGFDIDI--VPGGFt-gI------LERTGGRSE-------RVPVIVDD-GeWVLDS 72

              ....*....
1VF1_A     69 RAILNYIAG 77
gi 461995  70 NAILRHIAR 78
gi 119166  73 SAIAHYVGN 81
gi 119164  70 NAIAYYVAN 78
gi 119165  73 NAIAYYVSN 81
gi 729399  67 LAIAFYLAS 75
gi 544232  63 LAIQFYLAN 71
gi 134260 154 LDVPCHSDD 162
gi 465674  87 GFIPEYLDD 95
gi 126289  73 WVIAEYLDE 81
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