Conserved Protein Domain Family
DUF21
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pfam01595: DUF21 (this model, PSSM-Id:216595 is obsolete and has been replaced by 426337)
Domain of unknown function DUF21
This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to Treponema hyodysenteriae hemolysin C that does not contain this domain. This domain is found in the N-terminus of the proteins adjacent to two intracellular CBS domains pfam00571.
Links
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Statistics
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PSSM-Id: 216595
Aligned: 127 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9Z8E9      5 MLMFFIICFTLCSGFISLSQIALFSLPTSLISHYK----RSKS-----KKQQRVATLLLHPHHLLITLIFcdiGLNIAIQ 75  Chlamydia pneumoniae
Q4E1V8     55 LLLIIFFINVALAAMFAGLTIGLFGMNFITLEIIS----SAGKep-dsAYARKIIPIRRYGHQLLATLLI---GNMLTMV 126 Trypanosoma cruzi
Q4S1X3    175 ALGVLVVLFLTICCVLRTVSLSLLWLDPVELYVLH----SCGSee-ekRVAKRLEPVRRRGNFLACSLLF---LCALGHS 246 spotted green puff...
Q8NE01    136 ALGLGAAGLLALAALARGLQLSALALAPAEVQVLR----ESGSea-erAAARRLEPARRWAGCALGALLL---LASLAQA 207 human
Q67XQ0     37 TYAGISCFLVLFAGIMSGLTLGLMSLGLVELEILQ----RSGTpn-ekKQAAAIFPVVQKQHQLLVTLLL---CNAMAME 108 thale cress
A0E6G9     32 FYGMISLFLILFSGFCSGATQGLLSIDQITIEVKL----R--------KWASRILSVIQEHHLLLSTLLV---ANSLANE 96  Paramecium tetraur...
Q4DHE1     13 TYSLGFVGLLIFTGITAGLQVALFSMDRLFLRILT----TTGSlr-erRQAKRLLGILRLGHWTLVALLL---SNASAMT 84  Trypanosoma cruzi
Q4UER3     20 AKILATIVCSALSALFSGLTIGYTSIDLFQLHLLSqftpTTKEdianqKRARKIIPLRSDPNNLMIALIA---CNAMINS 96  Theileria annulata
XP_627549  66 LCILFSIALIFFGGILSGLTTGLMSLDSVQLRVLI----EAGNeh-ekRWASIALDLIKRHHLLLVTLLL---ANSICME 137 Cryptosporidium pa...
CAM37990   66 DHLLRICLYAFLSAVFAGLTLGVMCANTFTLEIIA----ESGPkp-dcKYAATLLPLRKQGHKTLSTLII---SNMLCNV 137 Leishmania brazili...
Q4E1V8     55 LLLIIFFINVALAAMFAGLTIGLFGMNFITLEIIS----SAGKep-dsAYARKIIPIRRYGHQLLATLLI---GNMLTMV 126 Trypanosoma cruzi
Q4S1X3    175 ALGVLVVLFLTICCVLRTVSLSLLWLDPVELYVLH----SCGSee-ekRVAKRLEPVRRRGNFLACSLLF---LCALGHS 246 spotted green puff...
Q8NE01    136 ALGLGAAGLLALAALARGLQLSALALAPAEVQVLR----ESGSea-erAAARRLEPARRWAGCALGALLL---LASLAQA 207 human
Q67XQ0     37 TYAGISCFLVLFAGIMSGLTLGLMSLGLVELEILQ----RSGTpn-ekKQAAAIFPVVQKQHQLLVTLLL---CNAMAME 108 thale cress
A0E6G9     32 FYGMISLFLILFSGFCSGATQGLLSIDQITIEVKL----R--------KWASRILSVIQEHHLLLSTLLV---ANSLANE 96  Paramecium tetraur...
Q4DHE1     13 TYSLGFVGLLIFTGITAGLQVALFSMDRLFLRILT----TTGSlr-erRQAKRLLGILRLGHWTLVALLL---SNASAMT 84  Trypanosoma cruzi
Q4UER3     20 AKILATIVCSALSALFSGLTIGYTSIDLFQLHLLSqftpTTKEdianqKRARKIIPLRSDPNNLMIALIA---CNAMINS 96  Theileria annulata
XP_627549  66 LCILFSIALIFFGGILSGLTTGLMSLDSVQLRVLI----EAGNeh-ekRWASIALDLIKRHHLLLVTLLL---ANSICME 137 Cryptosporidium pa...
CAM37990   66 DHLLRICLYAFLSAVFAGLTLGVMCANTFTLEIIA----ESGPkp-dcKYAATLLPLRKQGHKTLSTLII---SNMLCNV 137 Leishmania brazili...

Q9Z8E9     76 NCFaILFGDA-------------------ASWWFTVGLPLAITLILGEILPKAVAL-P--FNTQIASSVAPLILCVTKIF 133 Chlamydia pneumoniae
Q4E1V8    127 IISqMVTAIIq------------------STEFVNFIVATAVVFVFSEIIPMAVCN-KgpYALWIGAKSATIISIALFLL 187 Trypanosoma cruzi
Q4S1X3    247 VLGvFFYRLL-------------------GSVLSAAFTSGILIFLVAELAPHIVCS-G--YGFRMAPALTWLAQVCMVLT 304 spotted green puff...
Q8NE01    208 ALAvLLYRAAg------------------QRAVPAVLGSAGLVFLVGEVVPAAVSG-R--WTLALAPRALGLSRLAVLLT 266 human
Q67XQ0    109 GLPiYLDKLF--------------------NEYVAIILSVTFVLAFGEVIPQAICT-R--YGLAVGANFVWLVRILMTLC 165 thale cress
A0E6G9     97 SLPiFIKKST--------------------GDWIALLISVILVVLFGEIFPSAIMTgK--HQLSIASFITPYIQFLISIL 154 Paramecium tetraur...
Q4DHE1     85 GLPiLLEDIF--------------------DQLTALLVSLTAVLFISDIIPLSIFV-R--WSFPICSFFVPLVWVLLVVT 141 Trypanosoma cruzi
Q4UER3     97 LLVlFVGELF--------------------EFAMGFIVSSLIVTIFGEIFPQTVFF-R--YQLQLCSFFAPLTFVVKYVL 153 Theileria annulata
XP_627549 138 ALPlFLDRII--------------------PSWVAVICSVTAILIFGEILPQAICTgK--HQLRIAASCATFVRCLIICL 195 Cryptosporidium pa...
CAM37990  138 LIVqEFSDVFdvveairtrgtithvvddsGSGIWKFIVSTLVIVLFAEILPMSICCsK--YSLRVAAAGSIFVKVAMILT 215 Leishmania brazili...
Q4E1V8    127 IISqMVTAIIq------------------STEFVNFIVATAVVFVFSEIIPMAVCN-KgpYALWIGAKSATIISIALFLL 187 Trypanosoma cruzi
Q4S1X3    247 VLGvFFYRLL-------------------GSVLSAAFTSGILIFLVAELAPHIVCS-G--YGFRMAPALTWLAQVCMVLT 304 spotted green puff...
Q8NE01    208 ALAvLLYRAAg------------------QRAVPAVLGSAGLVFLVGEVVPAAVSG-R--WTLALAPRALGLSRLAVLLT 266 human
Q67XQ0    109 GLPiYLDKLF--------------------NEYVAIILSVTFVLAFGEVIPQAICT-R--YGLAVGANFVWLVRILMTLC 165 thale cress
A0E6G9     97 SLPiFIKKST--------------------GDWIALLISVILVVLFGEIFPSAIMTgK--HQLSIASFITPYIQFLISIL 154 Paramecium tetraur...
Q4DHE1     85 GLPiLLEDIF--------------------DQLTALLVSLTAVLFISDIIPLSIFV-R--WSFPICSFFVPLVWVLLVVT 141 Trypanosoma cruzi
Q4UER3     97 LLVlFVGELF--------------------EFAMGFIVSSLIVTIFGEIFPQTVFF-R--YQLQLCSFFAPLTFVVKYVL 153 Theileria annulata
XP_627549 138 ALPlFLDRII--------------------PSWVAVICSVTAILIFGEILPQAICTgK--HQLRIAASCATFVRCLIICL 195 Cryptosporidium pa...
CAM37990  138 LIVqEFSDVFdvveairtrgtithvvddsGSGIWKFIVSTLVIVLFAEILPMSICCsK--YSLRVAAAGSIFVKVAMILT 215 Leishmania brazili...

Q9Z8E9    134 KPLLHWGIVGINYVVQWILSKQqiDIIQPQELKEVLQSCK-DFG----VVNQEE 182 Chlamydia pneumoniae
Q4E1V8    188 YPVAKPLGMFLECIVTHDEGL----VYDRNELKKLIRIHYeKYG-----HESGL 232 Trypanosoma cruzi
Q4S1X3    305 CPLSCPLGLILDLALRRDIST----CGIRERAMEMIRTSV-NDP--------YR 345 spotted green pufferfish
Q8NE01    267 LPVALPVGQLLELAARPGRLRE-----------RVLELAR-GGGdpysDLSK-G 307 human
Q67XQ0    166 YPIAFPIGKILDLVLGHNDA-----LFRRAQLKALVSIHS-QEAgkggELTHDE 213 thale cress
A0E6G9    155 YLICYPLSLILDKVLGTKCKR-----YHLEYIRQLMEICK-QQD----VIKPEE 198 Paramecium tetraurelia
Q4DHE1    142 APVSYPVGKLLDRLLGEKED-----LLRSDELVALFLAQQnERA----FLRESE 186 Trypanosoma cruzi
Q4UER3    154 YPITKPMSMLLNLIIGTNTEV----IYNKQQWKALVDLQK-ECG----GVLSEE 198 Theileria annulata
XP_627549 196 FVFSWPISKFLDYFIGENGKTN--NFYARGQLKALIALHR-RTG----EFDNAP 242 Cryptosporidium parvum Iowa II
CAM37990  216 YPLSVSLGWFLDVVVGSEETGQ---LYDKKELRKLMVMHY-ERG----GGDDAR 261 Leishmania braziliensis MHOM/BR/75/M2904
Q4E1V8    188 YPVAKPLGMFLECIVTHDEGL----VYDRNELKKLIRIHYeKYG-----HESGL 232 Trypanosoma cruzi
Q4S1X3    305 CPLSCPLGLILDLALRRDIST----CGIRERAMEMIRTSV-NDP--------YR 345 spotted green pufferfish
Q8NE01    267 LPVALPVGQLLELAARPGRLRE-----------RVLELAR-GGGdpysDLSK-G 307 human
Q67XQ0    166 YPIAFPIGKILDLVLGHNDA-----LFRRAQLKALVSIHS-QEAgkggELTHDE 213 thale cress
A0E6G9    155 YLICYPLSLILDKVLGTKCKR-----YHLEYIRQLMEICK-QQD----VIKPEE 198 Paramecium tetraurelia
Q4DHE1    142 APVSYPVGKLLDRLLGEKED-----LLRSDELVALFLAQQnERA----FLRESE 186 Trypanosoma cruzi
Q4UER3    154 YPITKPMSMLLNLIIGTNTEV----IYNKQQWKALVDLQK-ECG----GVLSEE 198 Theileria annulata
XP_627549 196 FVFSWPISKFLDYFIGENGKTN--NFYARGQLKALIALHR-RTG----EFDNAP 242 Cryptosporidium parvum Iowa II
CAM37990  216 YPLSVSLGWFLDVVVGSEETGQ---LYDKKELRKLMVMHY-ERG----GGDDAR 261 Leishmania braziliensis MHOM/BR/75/M2904
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