2Y48,1SEZ,2VVL,1RSG,3KPF


Conserved Protein Domain Family
Amino_oxidase

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pfam01593: Amino_oxidase (this model, PSSM-Id:216593 is obsolete and has been replaced by 396255)
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Flavin containing amine oxidoreductase
This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.
Statistics
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PSSM-Id: 216593
Aligned: 84 rows
Threshold Bit Score: -1
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2Y48_A  166 VSGLAAARQLQSF--GMd--------------VTLLEARDRVGGRVA--TFRKG-----NYVADLGAMVVT---GL-GGN 218  human
O86101   11 FSGLKAARDLTNA--GKk--------------VLLLEGGERLGGRAY--SRESRnv--pGLRVEIGGAYLHrkhHPrLAA 70   Arthrobacter nicoti...
O82865   13 FAGLVAARELQMA--GVd--------------VEIVEARDRVGGRAW--TEERMg-----RPLELGATWVHwmqPH-VWS 68   Micrococcus luteus
2VVL_H   49 YCGLTATRDLTVA--GFk--------------TLLLEARDRIGGRSW--SSNIDg-----YPYEMGGTWVHwhqSH-VWR 104  Aspergillus niger
Q10135  516 LTGLICARQLTGL--FSqysssflsknelppkVIILEAKERTGGRIY--SRALPvshtsATQINHHTSNSNsisSNsTSL 591  Schizosaccharomyces...
Q9Y802  267 MAGISCARQLTNL--FAqyeqdflsrgekpprIVIYEASERLGGHIY--THMVPlsdneVSEKSSLATTVNatnECmVNL 342  Schizosaccharomyces...
Q9XXU5   55 LTGLTAARNIQQNrpGLs--------------VLVLEARGQVGGRIRyaTMQTRn---gVEFVDTGSQFISptdTQ-LLS 116  Caenorhabditis elegans
Q55629   32 LSGLIAARNLSRV--NYs--------------VLVIEAQERLGGRMY--GEYLPs----GQWIDRGGQWV----GP-TQD 84   Synechocystis sp. P...
P40974   24 PAGLMAARTLVAA--GRt--------------VAVLEARDRVGGRTW--SKTVD-----GAFLEIGGQWI----SP-DQT 75   Kocuria rosea
P63533   23 FAGLAAARELTRQ--GHe--------------VLVFEGRDRVGGRSL--TGRVAg-----VPADMGGSFI----GP-TQD 74   Mycobacterium tuber...
2Y48_A  219 PMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNrlle-----------------------atsyLSHQLD 275  human
O86101   71 ELDRYGIPTAAASEFTSFRHRLGPTAVDQAFPIPGSEAVA---------------------------------------- 110  Arthrobacter nicoti...
O82865   69 EITRYDQSIYPSPFCDDAYWITGGRVEHGTEADLDAALARPMAk-----------------------------iFEDSRE 119  Micrococcus luteus
2VVL_H  105 EITRYKMHNALSPSFNFSRGVNHFQLRTNPTTSTYMTHEAEDEl------------------------------LRSALH 154  Aspergillus niger
Q10135  592 NPKDVTDPSHIPSAIDLGFQFLFSPMDDILLNLLNKQLGIEVTemtgsdlvydetdtkvldmvevkklnilwekLLEYVS 671  Schizosaccharomyces...
Q9Y802  343 LTDSLIGMPTLDSDPLYIISSQQLSLDAVHTRNREFILHDIENgridtehvqrifr-----lfdallfyfnasaSKQPLH 417  Schizosaccharomyces...
Q9XXU5  117 LIQELNV--RTTQQLTCGNNTVFQQTRKKRQ------------------------------------------------- 145  Caenorhabditis elegans
Q55629   85 RFLALLNEYNIERFPSPADGLKVLLFDGKRYEFDGFFQGVFQGeap-------------------------kisSDEWND 139  Synechocystis sp. P...
P40974   76 ELLALVDELGLETYQRYREGESVYLAPDGTRHTYTGSMFPAGE--------------------------------STIVE 123  Kocuria rosea
P63533   75 AVLALATELGIPTTPTHRDGRNVIQWRGSARSYRGTIPKLSLTg------------------------------LIDIGR 124  Mycobacterium tuber...
2Y48_A  276 FNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNkmvnlkekikelhqqykeasevkpprditae 355  human
O86101  111 -VEAATYTLLRDAHRIDLEKGLENQDLEDLDIPLNEYVDKLDLPPVSRQ------------------------------- 158  Arthrobacter nicoti...
O82865  120 FFPYPYEPLHVLDESSGSTPELRERFRAADQGSVLDCLKGGDFTQEERD------------------------------- 168  Micrococcus luteus
2VVL_H  155 KFTNVDGTNGRTVLPFPHDMFYVPEFRKYDEMSYSERIDQIRDELSLNEr------------------------------ 204  Aspergillus niger
Q10135  672 VCFFINVEESVRISWISQFQLFIDEMFPDHLSKSLSLNASHEFSFKKTMlili--------------------------- 724  Schizosaccharomyces...
Q9Y802  418 SLITPPEQEFIQKLDQIGWYISIEAFPLQIKDTLSEFLGNSANTLTSLLhl----------------------------- 468  Schizosaccharomyces...
Q9XXU5  146 -----LSLQQQWSTTLFTDLINSPETLGNLTNTSVSAMSQQMDTADADSv------------------------------ 190  Caenorhabditis elegans
Q55629  140 AMVAWEKFNTLAQSLDEQHPEATPENKKLDSQTFADWIKENTHTAFGHW------------------------------- 188  Synechocystis sp. P...
P40974  124 MEKLVALLDGLVAEIGATEPWAHPAARELDTISFHHWLRQHSDDEAACS------------------------------- 172  Kocuria rosea
P63533  125 LRWQFERIARGVPVAAPWDARRARELDDVSLGEWLRLVRATSSSRNLM-------------------------------- 172  Mycobacterium tuber...
2Y48_A  356 flvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssRDRQILDWHFANLEFANATP-LSTLSLKHWDQDD 434  human
O86101  159 -----------------------------------------------FLLAWAWNMLGQPADQASA-LWMLQLVAAHHYS 190  Arthrobacter nicoti...
O82865  169 -----------------------------------------------LCDAYWSAAYIGDPHQGSPlMAKQWAALSDHRL 201  Micrococcus luteus
2VVL_H  205 ----------------------------------------------SSLEAFILLCSGGTLENSSFgEFLHWWAMSGYTY 238  Aspergillus niger
Q10135  725 ------------------------------------------devsSYAKLGNSQKKFLIWCFKVAeLDDTLYPLNTVDT 762  Schizosaccharomyces...
Q9Y802  469 --------------------------------------------tvLDLKIFEWFKEYLSQSLSVS-LENVYPGSIPNLN 503  Schizosaccharomyces...
Q9XXU5  191 ---------------------------------------------nRMMQTFFDAPGEQVPEIQLA-LTCSSQNATAVEI 224  Caenorhabditis elegans
Q55629  189 -----------------------------------------------YFSYMCRAVGFLGPAEPSQ-VSLLHILWGHKSA 220  Synechocystis sp. P...
P40974  173 ----------------------------------------------NIGIFVAGGMLTKPAHAFSVlQAVLMAASAGSFS 206  Kocuria rosea
P63533  173 ------------------------------------------------AIMTRVTWGCEPDDVSMLhAARYVRAAGGLDR 204  Mycobacterium tuber...
2Y48_A  435 DF-EFTGSHLTVRNGYSCVPVALAEGLD------IKLNTAVRQVRYTA-SGCEVIAVNTRsts---qtfIYKCDA-VLCT 502  human
O86101  191 ILgVVLSLDEVFSNGSADLVDAMSQEIPe-----IRLQTVVTGIDQSG-DVVNVTVKDGH---------AFQAHS-VIVA 254  Arthrobacter nicoti...
O82865  202 SLvDEQTLRFKLTHGMRGLYENIAADLRc----pIRLNTPVTAVDHRS-DGATVTLGTGE---------KISCDS-VIVT 266  Micrococcus luteus
2VVL_H  239 QGcMDCLMSYKFKDGQSAFARRFWEEAAgtgrlgYVFGCPVRSVVNER-DAARVTARDGR---------EFVAKR-VVCT 307  Aspergillus niger
Q10135  763 DFsKDILIPKVARRGLSQLPWALQSYPSpl---nIHYEKFVSKVTIEN-DKCTLDCKDNS---------SYEVDQvVIAC 829  Schizosaccharomyces...
Q9Y802  504 LLlGENVASYSFKHGMADMLNSLASTPSpl---pILFDQCVHTVKLED-NTVNLSFVNET---------TVSVDK-VVIC 569  Schizosaccharomyces...
Q9XXU5  225 LR-RFGHGQSLLAQGGMNEVVRRLADgl-----lIEYSQRVVSVNDAA-FPAVVQTSAGR---------RFSGRQ-VIVA 287  Caenorhabditis elegans
Q55629  221 SQgENPEAE--LLHGGAGQIPQKIAAELgn---sILLGEPVIHIAQDD-KGVEVTTTTG----------KYQGKF-AIVA 283  Synechocystis sp. P...
P40974  207 NLvDEDFILDRRVVGGMQSVSETMAAELge--dvVFLDTPVRTIRWAGdGGTYAEHVPGTpvtvwsdrlTVRAKD-VVVA 283  Kocuria rosea
P63533  205 LLdVKNGAQQDRVPGGTQQIAQAAAAQLga---rVLLNAAVRRIDRHG-AGVTVTSDQGQ----------AEAGF-VIVA 269  Mycobacterium tuber...
2Y48_A  503 LPLGVLKqqppavQFVPPLPEWKtsavq-rmgfGNLN-KVVLCFDRVFWDPsvnlFGHVGSTTa--SRGELFLFWNL--Y 576  human
O86101  255 TPMNTWRr----iVFTPALPE-RrrsvieeghgGQGL-KILIHVRGAEAg------IECVGGG----IFPTLYDYCEvsE 318  Arthrobacter nicoti...
O82865  267 VPVGALPt----iEFTPGLPS-GmrtvidqrwnSTGC-KIWVKVKGHHSi-----LGYAPTPH----KAAVFRSEFFmdD 331  Micrococcus luteus
2VVL_H  308 IPLNVLSt----iQFSPALSTERisamq-aghvSMCT-KVHAEVDNKDMRSw---TGIAYPFN---KLCYAIGDGTTpaG 375  Aspergillus niger
Q10135  830 SPSHFSSn----iEFSPGLPNFVtenik-sidfKPGK-KVILRYAAAFWRKnirsFGIIPKSLsqeMNNDENDGKSCfvL 903  Schizosaccharomyces...
Q9Y802  570 IPMDKLNth--liTFEPPLEEKKlkaid-rchfTNVK-KVILIFKTQFWEPnisiFGSLPQDS---GRNFIFNDCTRfyE 642  Schizosaccharomyces...
Q9XXU5  288 VPIPTLEn----iELVPAPEAPFqqliq-nygpTGHAyYFTMSFQRATWRLng-rSGKVIYTS---ATGPLVWLTTFdtT 358  Caenorhabditis elegans
Q55629  284 TPPHLAGr----iTYSPPMPPLRqqltq-rvpmGTCC-KLLISYDRPFWREkg-lAGIGLGNT---TWIELCADSSDptT 353  Synechocystis sp. P...
P40974  284 VPPNLYSr----iSFEPPLPRLQhqmhq-hqslGLVI-KVHAVYETPFWRDkg-lSGTGFGAHe--LSQEVYDNTNHgdP 354  Kocuria rosea
P63533  270 IPPAHRVa----iEFDPPLPP-EyqqlahhwpqGRLS-KAYAAYSTPFWRAsg-ySGQALSDEa--P-VFITFDVSPhaD 339  Mycobacterium tuber...
2Y48_A  577 -----KAPILLALVAGEaagiMENISDDVIVGRCLAILKGIFgssa---vpqPKet--vvSRWRADPWARGSYSYVAAGS 646  human
O86101  319 ------SERLLVAFTDSg--sFDPTDIGAVKDAVLYYLPEVEvl------giDYh------DWIADPLFEGPWVAPRVGQ 378  Arthrobacter nicoti...
O82865  332 ------DTTICVGFGSHh--dAVDLTDPRDAQAIVDQWRPDLev------vdCTg-----HDWVADRWSGQAWATLRSGQ 392  Micrococcus luteus
2VVL_H  376 -------NTHLVCFGTDanhiQPDEDVRETLKAVGQLAPGTFg--------vKRlv---fHNWVKDEFAKGAWFFSRPGM 437  Aspergillus niger
Q10135  904 riwnmLPETGVPILVADinpqMTSSSSNETSHLIQELHSLIVdhfqndsnssADlldawvTNWSRNGVYDGLNSYPNFAN 983  Schizosaccharomyces...
Q9Y802  643 ------HPTLSVFVKVEg---IDFMKDDDIVNGIVSQLKKVYkpks--eainPIrt--iiSNWENNSYTNHSSYQISNLF 709  Schizosaccharomyces...
Q9XXU5  359 faascDNSTSASSTLWGiahfSYDVPFETRRKLYTQAIMYSLrfa----dfsPLdv--sdVNFATDDLAKG---TIPTLK 429  Caenorhabditis elegans
Q55629  354 -----GVGVIASFVVGDrygkWIAMGEAERRQGVLSDLALYFgee----alsPEty--deVDWPSEQWVGGGYAAFMPPG 422  Synechocystis sp. P...
P40974  355 ------RGTLVGFVSDEradeLFGLPAEERRRLILESLSHYLgee----alhPVvy--yeSDFGSEEWTRGAYAASYDLG 422  Kocuria rosea
P63533  340 -----GPGILMGFVDARg---FDSLPIEERRRDALRCFASLFgde----aldPLdy--vdYRWGTEEFAPGGPTAAVPPG 405  Mycobacterium tuber...
2Y48_A  647 Sg-NDYDLMAQPitpgpsipgapqpipRLFFAGEHTIRNyp-aTVHGALLSGLREAGRIA 704  human
O86101  379 Fs-RVHKELGEPa-------------gRIHFVGSDVSLEfp-gYIEGALETAECAVNAIL 423  Arthrobacter nicotinovorans
O82865  393 Ft-NGWHHFRSTd-------------sRLRFAGADWARGwrgvVVDGAIETGLSTARDVL 438  Micrococcus luteus
2VVL_H  438 Vs-ECLQGLREKh-------------gGVVFANSDWALGwr-sFIDGAIEEGTRAARVVL 482  Aspergillus niger
Q10135  984 DkqQYEKRFRQSqlsy--------nlgRLHIAGDYIFSCvgcrTLQRSFLSGLSVCTGII 1035 Schizosaccharomyces pombe 972h-
Q9Y802  710 Le-EDYAILSEPid------------nTVFFASEAISQKns-gSIRGAFDSGILAARDVL 755  Schizosaccharomyces pombe 972h-
Q9XXU5  430 L---NIPLESLKylndf-----htlyqNVHIATADIASHnl-gGLNQTLTDCNFVQRQFR 480  Caenorhabditis elegans
Q55629  423 VwtSFGQALSAPv-------------gRIHWAGTEIAPRwa-gFFDGAIRTGEAAAKAII 468  Synechocystis sp. PCC 6803
P40974  423 GlhRYGAHQRTPv-------------gPIRWACSDLAAEgy-qHVDGALRQGRLAAAEVL 468  Kocuria rosea
P63533  406 SwtKYGHWLREPv-------------gPIHWASTETADEwt-gYFDGAVRSGQRAAAEVA 451  Mycobacterium tuberculosis
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