Conserved Protein Domain Family
IBR
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pfam01485: IBR (this model, PSSM-Id:216524 is obsolete and has been replaced by 426285)
IBR domain
The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers (pfam00097). This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain. Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms. RBR family members play roles in protein quality control and can indirectly regulate transcription. Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes. The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease.
Links
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Statistics
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PSSM-Id: 216524
Aligned: 168 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4SJ42        89 EKYEEFMLRRWL-I----TEPDC---------R--WCPAPDCGYAVVAFGCATA----Rrspagataagrssattasscg 148  spotted green ...
A0CBB0       168 HEFENLLCRRFV-D----CSRYL---------A--YCTGVDCNKILKPQCSSVK----E--------------------- 206  Paramecium tet...
A0DMT6       176 EDYLKIVCRKFI-E----TNKAL---------A--YCQGVDCKKIIKPKDSSLT----T--------------------- 214  Paramecium tet...
A0C6V8       186 QKYLKF-------KnnisVATST---------DrmWCPNNQCLKIVIFQTSSNF-------------------------- 223  Paramecium tet...
A0BX70       182 TKYIKCHQNLEI-A----MNPNK---------A--WCPTINCNSVIEFKQLSTV-------------------------- 219  Paramecium tet...
XP_001640159 187 EKFINFLFNDQI-K----TFSKL---------R--WCPGINCGFLVRAEEPAAK----R--------------------- 225  starlet sea an...
XP_001629500  95 qnFQKMRAIKEI-Q----ISKSK---------A--FCPKPDCKGVVESIPGAAK----E--------------------- 133  starlet sea an...
XP_001639156 613 pKFLKRKLNRAL-E----MTSSW---------R--WCPGKNCRQVVNGTELSPNssawS--------------------- 655  starlet sea an...
XP_001329146 410 QRl--------------fQTEAMndviksglpNlvKCAN--CGFIVEFLGSSN--------------------------- 446  Trichomonas va...
XP_001305692 174 KKLEER-----IsSlsasMSKTV---------R--RCINPKCNLLVSMSHIFKG----Km-------------------- 213  Trichomonas va...
A0CBB0       168 HEFENLLCRRFV-D----CSRYL---------A--YCTGVDCNKILKPQCSSVK----E--------------------- 206  Paramecium tet...
A0DMT6       176 EDYLKIVCRKFI-E----TNKAL---------A--YCQGVDCKKIIKPKDSSLT----T--------------------- 214  Paramecium tet...
A0C6V8       186 QKYLKF-------KnnisVATST---------DrmWCPNNQCLKIVIFQTSSNF-------------------------- 223  Paramecium tet...
A0BX70       182 TKYIKCHQNLEI-A----MNPNK---------A--WCPTINCNSVIEFKQLSTV-------------------------- 219  Paramecium tet...
XP_001640159 187 EKFINFLFNDQI-K----TFSKL---------R--WCPGINCGFLVRAEEPAAK----R--------------------- 225  starlet sea an...
XP_001629500  95 qnFQKMRAIKEI-Q----ISKSK---------A--FCPKPDCKGVVESIPGAAK----E--------------------- 133  starlet sea an...
XP_001639156 613 pKFLKRKLNRAL-E----MTSSW---------R--WCPGKNCRQVVNGTELSPNssawS--------------------- 655  starlet sea an...
XP_001329146 410 QRl--------------fQTEAMndviksglpNlvKCAN--CGFIVEFLGSSN--------------------------- 446  Trichomonas va...
XP_001305692 174 KKLEER-----IsSlsasMSKTV---------R--RCINPKCNLLVSMSHIFKG----Km-------------------- 213  Trichomonas va...

Q4SJ42       149 tptrrddikpcprcaayiikmndgscnhMTCAVCGCEFCWLCMK-EisdlHYlsPSGC 205  spotted green pufferfish
A0CBB0       207 ----------------------------VTCV-CQNKFCFYCKEdL----HP--PCPC 229  Paramecium tetraurelia
A0DMT6       215 ----------------------------VTCP-CGTQFCFRCKHeL----HQ--PVPC 237  Paramecium tetraurelia
A0C6V8       224 ----------------------------EKCTFCQTEFCKICRQkS----HP--DINC 247  Paramecium tetraurelia
A0BX70       220 ----------------------------ATCAYCQIEVCKRCKQrA----HP--LQSC 243  Paramecium tetraurelia
XP_001640159 226 ----------------------------VICSKCNTMFCFSCGEkY----HA--PTDC 249  starlet sea anemone
XP_001629500 134 ----------------------------VCCSECGYSFCFACKGpW----HP--EKHC 157  starlet sea anemone
XP_001639156 656 ----------------------------VLC-KCGGIWCFKCGSqA----HW--PASC 678  starlet sea anemone
XP_001329146 447 ----------------------------MRCPQCQKETCSKCGLlA----HP--GKTC 470  Trichomonas vaginalis G3
XP_001305692 214 ----------------------------AVCS-CGYYTCFECGKeG----HS--PLPC 236  Trichomonas vaginalis G3
A0CBB0       207 ----------------------------VTCV-CQNKFCFYCKEdL----HP--PCPC 229  Paramecium tetraurelia
A0DMT6       215 ----------------------------VTCP-CGTQFCFRCKHeL----HQ--PVPC 237  Paramecium tetraurelia
A0C6V8       224 ----------------------------EKCTFCQTEFCKICRQkS----HP--DINC 247  Paramecium tetraurelia
A0BX70       220 ----------------------------ATCAYCQIEVCKRCKQrA----HP--LQSC 243  Paramecium tetraurelia
XP_001640159 226 ----------------------------VICSKCNTMFCFSCGEkY----HA--PTDC 249  starlet sea anemone
XP_001629500 134 ----------------------------VCCSECGYSFCFACKGpW----HP--EKHC 157  starlet sea anemone
XP_001639156 656 ----------------------------VLC-KCGGIWCFKCGSqA----HW--PASC 678  starlet sea anemone
XP_001329146 447 ----------------------------MRCPQCQKETCSKCGLlA----HP--GKTC 470  Trichomonas vaginalis G3
XP_001305692 214 ----------------------------AVCS-CGYYTCFECGKeG----HS--PLPC 236  Trichomonas vaginalis G3
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