Conserved Protein Domain Family
Myc_N

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pfam01056: Myc_N (this model, PSSM-Id:216269 is obsolete and has been replaced by 426019)
Myc amino-terminal region
The myc family belongs to the basic helix-loop-helix leucine zipper class of transcription factors, see pfam00010. Myc forms a heterodimer with Max, and this complex regulates cell growth through direct activation of genes involved in cell replication. Mutations in the C-terminal 20 residues of this domain cause unique changes in the induction of apoptosis, transformation, and G2 arrest.
Statistics
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PSSM-Id: 216269
Aligned: 9 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P18444   1 MP---GMISKNPDLEFDSLQPCFYPDEDD--FYL--CGPD--SAP--PGEDIWKKFELLPTPPLSPSRAGLQEpppgggs 69  chicken
P52160   1 MPvsaSLACKNYDYDYDSIQPYFYFDNDDedFYH--HQQGq-TQPsaPSEDIWKKFELLPTPPLSPSRRQSLS------- 70  zebrafish
Q90341   1 MPvsaSLAYKNYDYDYDSIQPYFYFDNDDedFYH--HQQGq-TQPpaPSEDIWKKFELLPTPPLSPSRRQSLS------- 70  common carp
P49709   1 MPvsaSLAYKNYDYDYDSIQPYFYFDNDDedFYH--HQQGq-PQPpaPSEDIWKKFELLPTPPLSPSRRQSLS------- 70  goldfish
Q91421   1 MQlysSLASKN--YDYDSIQPYFYVDNEDedFYH--QEQGq-LQPpaPSEDISKKFELLSTPPLSPSRRPSLSslf---- 71  rainbow trout
P04198   9 MP---GMICKNPDLEFDSLQPCFYPDEDD--FYF--GGPD--STP--PGEDIWKKFELLPTPPLSPSR-GFAEhs----- 71  human
P06171   1 MPlnaNFPSKNYDYDYD-LQPCFFFLEEEn-FYH--QQSR--LQPpaPSEDIWKKFELLPTPPLSPSRRSSQSslf---- 70  African clawed frog
P10395   1 MPlsaSLPSKNYDYDYDSVQPYFYFEEEEenFYLaaQQRGseLQPpaPSEDIWKKFELLPTPPLSPSRRSSLAaasc--- 77  Avian myelocytomatosi...
P22555   1 MPlnvSFANRNYDLDYDSVQPYFYCDEEEn-FYQ--QQQQseLQPpaPSEDIWKKFELLPTPPLSPSRRSGLCsppcvtv 77  woodchuck
P52160   1 MPvsaSLACKNYDYDYDSIQPYFYFDNDDedFYH--HQQGq-TQPsaPSEDIWKKFELLPTPPLSPSRRQSLS------- 70  zebrafish
Q90341   1 MPvsaSLAYKNYDYDYDSIQPYFYFDNDDedFYH--HQQGq-TQPpaPSEDIWKKFELLPTPPLSPSRRQSLS------- 70  common carp
P49709   1 MPvsaSLAYKNYDYDYDSIQPYFYFDNDDedFYH--HQQGq-PQPpaPSEDIWKKFELLPTPPLSPSRRQSLS------- 70  goldfish
Q91421   1 MQlysSLASKN--YDYDSIQPYFYVDNEDedFYH--QEQGq-LQPpaPSEDISKKFELLSTPPLSPSRRPSLSslf---- 71  rainbow trout
P04198   9 MP---GMICKNPDLEFDSLQPCFYPDEDD--FYF--GGPD--STP--PGEDIWKKFELLPTPPLSPSR-GFAEhs----- 71  human
P06171   1 MPlnaNFPSKNYDYDYD-LQPCFFFLEEEn-FYH--QQSR--LQPpaPSEDIWKKFELLPTPPLSPSRRSSQSslf---- 70  African clawed frog
P10395   1 MPlsaSLPSKNYDYDYDSVQPYFYFEEEEenFYLaaQQRGseLQPpaPSEDIWKKFELLPTPPLSPSRRSSLAaasc--- 77  Avian myelocytomatosi...
P22555   1 MPlnvSFANRNYDLDYDSVQPYFYCDEEEn-FYQ--QQQQseLQPpaPSEDIWKKFELLPTPPLSPSRRSGLCsppcvtv 77  woodchuck
P18444  70 iav-----grggpgecrPVDPLDWASELLLlppeaelwGSTDGADFFET-GLGASNNLNSIIIQDCMWSAFSAREKLERA 143 chicken
P52160  71 -----------------TAEQLEMVSEFLG--------DDVVSQSFICDdADYSQSFIKSIIIQDCMWSGFSAAAKLEKV 125 zebrafish
Q90341  71 -----------------TAEQLEMVSEFLG--------DDVVNQSFICD-ADYSQSFIKSIIIQDCMWSGFSAAAKLEKV 124 common carp
P49709  71 -----------------TAEQLEMVSEFLG--------DDVVNQSFICD-ADYSQSFIKSIIIQDCMWSGFSAAAKLEKA 124 goldfish
Q91421  72 ---------------psTSDQLEMVTEFLG--------DDVVNQSFICD-ADYSQTFLKSIIIQDCMWSGFSAAAKLEKV 127 rainbow trout
P04198  72 ------------------sEPPSWVTEMLLene---lwGSPAEEDAFGL-GGLGGLTPNPVILQDCMWSGFSAREKLERA 129 human
P06171  71 ---------------psTADQLEMVTEFLG--------GDMVNQSFICE--ADDEALLKSIVIQDCMWSGFSAAAKLEKV 125 African clawed frog
P10395  78 --------------fpsTADQLEMVTELLG--------GDMVNQSFICD--PDDESFVKSIIIQDCMWSGFSAAAKLEKV 133 Avian myelocytomatosi...
P22555  78 asfsppgdddggggsfsTADQLEMVTELLG--------GDMVNQSFICD--PDDETFIKNIIIQDCMWSGFSAAAKL--- 144 woodchuck
P52160  71 -----------------TAEQLEMVSEFLG--------DDVVSQSFICDdADYSQSFIKSIIIQDCMWSGFSAAAKLEKV 125 zebrafish
Q90341  71 -----------------TAEQLEMVSEFLG--------DDVVNQSFICD-ADYSQSFIKSIIIQDCMWSGFSAAAKLEKV 124 common carp
P49709  71 -----------------TAEQLEMVSEFLG--------DDVVNQSFICD-ADYSQSFIKSIIIQDCMWSGFSAAAKLEKA 124 goldfish
Q91421  72 ---------------psTSDQLEMVTEFLG--------DDVVNQSFICD-ADYSQTFLKSIIIQDCMWSGFSAAAKLEKV 127 rainbow trout
P04198  72 ------------------sEPPSWVTEMLLene---lwGSPAEEDAFGL-GGLGGLTPNPVILQDCMWSGFSAREKLERA 129 human
P06171  71 ---------------psTADQLEMVTEFLG--------GDMVNQSFICE--ADDEALLKSIVIQDCMWSGFSAAAKLEKV 125 African clawed frog
P10395  78 --------------fpsTADQLEMVTELLG--------GDMVNQSFICD--PDDESFVKSIIIQDCMWSGFSAAAKLEKV 133 Avian myelocytomatosi...
P22555  78 asfsppgdddggggsfsTADQLEMVTELLG--------GDMVNQSFICD--PDDETFIKNIIIQDCMWSGFSAAAKL--- 144 woodchuck
P18444 144 VSEKLQSK--PPAAaPPPPPPvvptaacr--------rreqpqrgPGRA------ELGGSVPECVDPAVVFPFPVNKRE- 206 chicken
P52160 126 VSERLASLhaERKE-LMSDSN------------------------SNRLnasylqDLSTSASECIDPSVVFPYPLTECGk 180 zebrafish
Q90341 125 VSERLASLhaARKE-LMSDs------------------------sSNRLnasylqDVSTSASECIDPSVVFPYPLPESGk 179 common carp
P49709 125 VSERLASLhaARKE-LISDs------------------------sSNRLsasylqDLSTSASECIDPSVVFPYPLTESSk 179 goldfish
Q91421 128 VSERLACLqaARKEpAFSDNAew---------------------tTTRLnanylqDLNTSASECIDPSVAFPYPITDTSk 186 rainbow trout
P04198 130 VSEKLQHGrgPPTAgSTAQSPgagaaspag-------rghggaagAGRAgaalpaELAHPAAECVDPAVVFPFPVNKREp 202 human
P06171 126 VSEKLASYqaSRKEsALSSSSpcqsqpppsplkspschgslslggTHRSshgflqDP---SSDCVDPSVVFPYPLNDSIs 202 African clawed frog
P10395 134 VSEKLATYqaSRREgGPAAASrpgpppsg---------pppppagPAASaglylhDLGAAAADCIDPSVVFPYPLSERAp 204 Avian myelocytomatosi...
P22555 145 VSEKLASYqaARKDtGcpspa--------------------rghsgCSSsslylqDLSPRASECIDPSVVFPYPLNDSSs 204 woodchuck
P52160 126 VSERLASLhaERKE-LMSDSN------------------------SNRLnasylqDLSTSASECIDPSVVFPYPLTECGk 180 zebrafish
Q90341 125 VSERLASLhaARKE-LMSDs------------------------sSNRLnasylqDVSTSASECIDPSVVFPYPLPESGk 179 common carp
P49709 125 VSERLASLhaARKE-LISDs------------------------sSNRLsasylqDLSTSASECIDPSVVFPYPLTESSk 179 goldfish
Q91421 128 VSERLACLqaARKEpAFSDNAew---------------------tTTRLnanylqDLNTSASECIDPSVAFPYPITDTSk 186 rainbow trout
P04198 130 VSEKLQHGrgPPTAgSTAQSPgagaaspag-------rghggaagAGRAgaalpaELAHPAAECVDPAVVFPFPVNKREp 202 human
P06171 126 VSEKLASYqaSRKEsALSSSSpcqsqpppsplkspschgslslggTHRSshgflqDP---SSDCVDPSVVFPYPLNDSIs 202 African clawed frog
P10395 134 VSEKLATYqaSRREgGPAAASrpgpppsg---------pppppagPAASaglylhDLGAAAADCIDPSVVFPYPLSERAp 204 Avian myelocytomatosi...
P22555 145 VSEKLASYqaARKDtGcpspa--------------------rghsgCSSsslylqDLSPRASECIDPSVVFPYPLNDSSs 204 woodchuck
P18444 207 ----------------------AAVPsg----------geTPRGGRRPGPAgesrASSSSGDDTLS--------DSDDED 246 chicken
P52160 181 a-------------------gkVASP--------------QPMLVLDTPPN----SSSSSGSDSEDeeeedeeeEEEEEE 223 zebrafish
Q90341 180 s-------------------skVAPS--------------EPMPVLDTPPN----SSSSSGSDSEe-------eEEEEEE 215 common carp
P49709 180 s-------------------nkVAPS--------------QPMLVLDTPPN----SSSSSGSDSEDeeeeeeeeEEEEEE 222 goldfish
Q91421 187 s-------------------skVKPP--------------TRIWHWTTHPN----SSSSRGSDSE--------------Y 215 rainbow trout
P04198 203 apvpaapasapaagpavasgagIAAPagap-------gvaPPRPGGRQTSGgdhkALSTSGEDTLS--------DSDDED 267 human
P06171 203 n---------------------aSSP--------------CQDLILETPPI----SSNSSSSESE---------EEPEDE 234 African clawed frog
P10395 205 ----------------------RAAP---------------------PGAN----PAALLGVDTPP--------TTSSDS 229 Avian myelocytomatosi...
P22555 205 p-------------------kpCASPdstafspssdsllsSTESSPRASPE----PLVLHEETPP---------TTSSDS 252 woodchuck
P52160 181 a-------------------gkVASP--------------QPMLVLDTPPN----SSSSSGSDSEDeeeedeeeEEEEEE 223 zebrafish
Q90341 180 s-------------------skVAPS--------------EPMPVLDTPPN----SSSSSGSDSEe-------eEEEEEE 215 common carp
P49709 180 s-------------------nkVAPS--------------QPMLVLDTPPN----SSSSSGSDSEDeeeeeeeeEEEEEE 222 goldfish
Q91421 187 s-------------------skVKPP--------------TRIWHWTTHPN----SSSSRGSDSE--------------Y 215 rainbow trout
P04198 203 apvpaapasapaagpavasgagIAAPagap-------gvaPPRPGGRQTSGgdhkALSTSGEDTLS--------DSDDED 267 human
P06171 203 n---------------------aSSP--------------CQDLILETPPI----SSNSSSSESE---------EEPEDE 234 African clawed frog
P10395 205 ----------------------RAAP---------------------PGAN----PAALLGVDTPP--------TTSSDS 229 Avian myelocytomatosi...
P22555 205 p-------------------kpCASPdstafspssdsllsSTESSPRASPE----PLVLHEETPP---------TTSSDS 252 woodchuck
P18444 247 EEEEDDEEEIDVVTVEKrrSSSN-KAVTTLTitvrpknttfpsvrTQQNELILKRC-APIHqQHNYAAPsPYMEsEDVPP 324 chicken
P52160 224 EEEEEEEEEIDVVTVEK--RQKRhETDASES--------------RYPSPLVLKRChVSTH-QHNYAAH-PSTR-HDQPA 284 zebrafish
Q90341 216 EEEEEEEEEIDVVTVEK--RQKKnETAVSDS--------------RYPSPLVLKRChVSTH-QHNYAAH-PSTR-HDQPA 276 common carp
P49709 223 EEEEEEEEEIDVVTVEK--RQKRnEADVSDS--------------RYPSPLVLKRChVSTH-QHNYAAH-PSTR-HDQPA 283 goldfish
Q91421 216 -------EEIDVVMWRRgtQSKRcDPNMSGT--------------RHHSPLVLKRChVSTH-QHNYAAH-PSTR-HESAS 271 rainbow trout
P04198 268 DEEEDEEEEIDVVTVEKrrSSSNtKAVTTFTitvrpknaalgpgrAQSSELILKRC-LPIHqQHNYAAPsPYVEsEDAPP 346 human
P06171 235 DEDCDEEEEIDVVTVEKrqSASKrVESSSHSqp----------srPHYSPLVLKRChVPIH-QHNYAAS-PSTK-VDYVS 301 African clawed frog
P10395 230 EEEQEEDEEIDVVTLAE----ANeSESSTESsteas----eehckPHHSPLVLKRChVNIH-QHNYAAP-PSTK-VEYPA 298 Avian myelocytomatosi...
P22555 253 EEEQEDEEEIDVVSVEKrqPSARrSESVSPPags--------hskPPHSPLVLKRChVSTH-QHNYAAP-PSTR-KDCPA 321 woodchuck
P52160 224 EEEEEEEEEIDVVTVEK--RQKRhETDASES--------------RYPSPLVLKRChVSTH-QHNYAAH-PSTR-HDQPA 284 zebrafish
Q90341 216 EEEEEEEEEIDVVTVEK--RQKKnETAVSDS--------------RYPSPLVLKRChVSTH-QHNYAAH-PSTR-HDQPA 276 common carp
P49709 223 EEEEEEEEEIDVVTVEK--RQKRnEADVSDS--------------RYPSPLVLKRChVSTH-QHNYAAH-PSTR-HDQPA 283 goldfish
Q91421 216 -------EEIDVVMWRRgtQSKRcDPNMSGT--------------RHHSPLVLKRChVSTH-QHNYAAH-PSTR-HESAS 271 rainbow trout
P04198 268 DEEEDEEEEIDVVTVEKrrSSSNtKAVTTFTitvrpknaalgpgrAQSSELILKRC-LPIHqQHNYAAPsPYVEsEDAPP 346 human
P06171 235 DEDCDEEEEIDVVTVEKrqSASKrVESSSHSqp----------srPHYSPLVLKRChVPIH-QHNYAAS-PSTK-VDYVS 301 African clawed frog
P10395 230 EEEQEEDEEIDVVTLAE----ANeSESSTESsteas----eehckPHHSPLVLKRChVNIH-QHNYAAP-PSTK-VEYPA 298 Avian myelocytomatosi...
P22555 253 EEEQEDEEEIDVVSVEKrqPSARrSESVSPPags--------hskPPHSPLVLKRChVSTH-QHNYAAP-PSTR-KDCPA 321 woodchuck
P18444 325 QKKLKAEV---PRPVKPMIQ----PKSKSSSP 349 chicken
P52160 285 VKRLRLEAsnnHSINSSSSNrh-vKQRKCASP 315 zebrafish
Q90341 277 VKRLRLEAs--SNSNSrh-----vKQRKCTSP 301 common carp
P49709 284 VKRLRLETs--SSNrh-------gKQRKCTSP 306 goldfish
Q91421 272 CQEAEAREq--TVAVAAGSSrrsaVTANARVP 301 rainbow trout
P04198 347 QKKIKSEAs--PRPLKSVIP----PKAKSLSP 372 human
P06171 302 SKRAKLESn--IRVLKQISN-----NRKCASP 326 African clawed frog
P10395 299 AKRLKLDS---GRVLKQISN-----NRKCSSP 322 Avian myelocytomatosis virus CMII
P22555 322 AKRAKLDS---GRVLKQISN-----NRKCASP 345 woodchuck
P52160 285 VKRLRLEAsnnHSINSSSSNrh-vKQRKCASP 315 zebrafish
Q90341 277 VKRLRLEAs--SNSNSrh-----vKQRKCTSP 301 common carp
P49709 284 VKRLRLETs--SSNrh-------gKQRKCTSP 306 goldfish
Q91421 272 CQEAEAREq--TVAVAAGSSrrsaVTANARVP 301 rainbow trout
P04198 347 QKKIKSEAs--PRPLKSVIP----PKAKSLSP 372 human
P06171 302 SKRAKLESn--IRVLKQISN-----NRKCASP 326 African clawed frog
P10395 299 AKRLKLDS---GRVLKQISN-----NRKCSSP 322 Avian myelocytomatosis virus CMII
P22555 322 AKRAKLDS---GRVLKQISN-----NRKCASP 345 woodchuck
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