2UXY,1J31,1F89,1EMS,2GGL


Conserved Protein Domain Family
CN_hydrolase

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pfam00795: CN_hydrolase (this model, PSSM-Id:216124 is obsolete and has been replaced by 425873)
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Carbon-nitrogen hydrolase
This family contains hydrolases that break carbon-nitrogen bonds. The family includes: Nitrilase EC:3.5.5.1, Aliphatic amidase EC:3.5.1.4, Biotidinase EC:3.5.1.12, Beta-ureidopropionase EC:3.5.1.6. Nitrilase-related proteins generally have a conserved E-K-C catalytic triad, and are multimeric alpha-beta-beta-alpha sandwich proteins.
Statistics
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PSSM-Id: 216124
Aligned: 62 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2UXY_A        14 GVAVVNykMPRlhTAAEVLDN-ARKIAEMI--------------------VGMKQGlpGMD-LVVFPEYSLQGIMY---- 67  Pseudomonas aer...
Q1M995        58 LAASRG--LPQgvAAFYQSDI-WPGLILWLvassgfvfvhvalwsrqsggWKALRYtiAMV-LMALPPFGIVGWAHpita 133 Rhizobium legum...
P76280         5 KVAAAQ--YEP--RKTSLTEQ-VAHHLEFV--------------------RAAARQ--QCQ-LLVFPSLSLLGCd----- 51  Escherichia col...
Q9JVA8       229 TVALLQ--GNIdqTLKWREDQ-VIPTIQKYy-------------------EQVGKT--TAD-IVILPETAIP-------- 275 Neisseria menin...
Q9CM14       228 LVTLAQ--GNIeqNLKWEPEY-LYQTLDIY--------------------HKLISQhlGKTdVIILPESALPVLENh--- 281 Pasteurella mul...
P23930       223 QVSMVQ--GDIpqSLKWDEGQ-LLNTLKIY--------------------YNATAPlmGKSsLIIWPESAITDL------ 273 Escherichia col...
Q9KTE4       221 SLALIQ--GNIeqGLKWLPSQrWPTIMKY---------------------TDLTREnwDAD-VIIWPEAAIPAF------ 270 Vibrio cholerae
Q9AC16       228 TVRIVQ--AD---IKQDLKWD-AERFAQIVqay--------------vslTATPYAakPAD-IVIWPEGALPAAvn---- 282 Caulobacter vib...
Q9ZDG3       216 KVRLVQp-SIPqtAKWDQEEF-WHNLMLHI---------------------NLSENlePTD-LIIWSEAALV-------- 263 Rickettsia prow...
YP_001965644  58 LAASRR--LPQgvAAFYQSDI-WPGLILWLtasigfvflhsilwspgrdnWSALRYsiVMI-VMAVPPFGIVGWAHplta 133 Sinorhizobium m...
Q1M995        58 LAASRG--LPQgvAAFYQSDI-WPGLILWLvassgfvfvhvalwsrqsggWKALRYtiAMV-LMALPPFGIVGWAHpita 133 Rhizobium legum...
P76280         5 KVAAAQ--YEP--RKTSLTEQ-VAHHLEFV--------------------RAAARQ--QCQ-LLVFPSLSLLGCd----- 51  Escherichia col...
Q9JVA8       229 TVALLQ--GNIdqTLKWREDQ-VIPTIQKYy-------------------EQVGKT--TAD-IVILPETAIP-------- 275 Neisseria menin...
Q9CM14       228 LVTLAQ--GNIeqNLKWEPEY-LYQTLDIY--------------------HKLISQhlGKTdVIILPESALPVLENh--- 281 Pasteurella mul...
P23930       223 QVSMVQ--GDIpqSLKWDEGQ-LLNTLKIY--------------------YNATAPlmGKSsLIIWPESAITDL------ 273 Escherichia col...
Q9KTE4       221 SLALIQ--GNIeqGLKWLPSQrWPTIMKY---------------------TDLTREnwDAD-VIIWPEAAIPAF------ 270 Vibrio cholerae
Q9AC16       228 TVRIVQ--AD---IKQDLKWD-AERFAQIVqay--------------vslTATPYAakPAD-IVIWPEGALPAAvn---- 282 Caulobacter vib...
Q9ZDG3       216 KVRLVQp-SIPqtAKWDQEEF-WHNLMLHI---------------------NLSENlePTD-LIIWSEAALV-------- 263 Rickettsia prow...
YP_001965644  58 LAASRR--LPQgvAAFYQSDI-WPGLILWLtasigfvflhsilwspgrdnWSALRYsiVMI-VMAVPPFGIVGWAHplta 133 Sinorhizobium m...
2UXY_A        68 -------------DPAEMMETAVAIP-----GEETEIFS----------------------------------------- 88  Pseudomonas aer...
Q1M995       134 agvlfpgwgwaglAAVTAGLALMTTQyrpavAITLAGFWlwsaafwtapdigrhwqgvdlqlgnrlgrdnslarhsdlva 213 Rhizobium legum...
P76280        52 -------------YSRRALPAPPDLS-------LLDPLC----------------------------------------- 70  Escherichia col...
Q9JVA8       276 -------------------VMRQNLP-----ENILAKFA----------------------------------------- 290 Neisseria menin...
Q9CM14       282 ------------------------------iQPFFQGLQ----------------------------------------- 290 Pasteurella mul...
P23930       274 -----------------------EINq----QPFLKALD----------------------------------------- 285 Escherichia col...
Q9KTE4       271 -------------------EYEI--------SSFLHNLD----------------------------------------- 282 Vibrio cholerae
Q9AC16       283 ------------dYLAPGTWVRQAIV------------------------------------------------------ 296 Caulobacter vib...
Q9ZDG3       264 --------------------VPDDIP-----QVKLKLLN----------------------------------------- 277 Rickettsia prow...
YP_001965644 134 agvllpgwgwaglAAMAAGLAIMTTRywpaaAITFAGLWlwsaafwttpnlgqhwqgvdlalgnslgrdnslvrhsdlaa 213 Sinorhizobium m...
Q1M995       134 agvlfpgwgwaglAAVTAGLALMTTQyrpavAITLAGFWlwsaafwtapdigrhwqgvdlqlgnrlgrdnslarhsdlva 213 Rhizobium legum...
P76280        52 -------------YSRRALPAPPDLS-------LLDPLC----------------------------------------- 70  Escherichia col...
Q9JVA8       276 -------------------VMRQNLP-----ENILAKFA----------------------------------------- 290 Neisseria menin...
Q9CM14       282 ------------------------------iQPFFQGLQ----------------------------------------- 290 Pasteurella mul...
P23930       274 -----------------------EINq----QPFLKALD----------------------------------------- 285 Escherichia col...
Q9KTE4       271 -------------------EYEI--------SSFLHNLD----------------------------------------- 282 Vibrio cholerae
Q9AC16       283 ------------dYLAPGTWVRQAIV------------------------------------------------------ 296 Caulobacter vib...
Q9ZDG3       264 --------------------VPDDIP-----QVKLKLLN----------------------------------------- 277 Rickettsia prow...
YP_001965644 134 agvllpgwgwaglAAMAAGLAIMTTRywpaaAITFAGLWlwsaafwttpnlgqhwqgvdlalgnslgrdnslvrhsdlaa 213 Sinorhizobium m...
2UXY_A        89 --------------------------------RACRKANVWGVFS-LTGErheehPRKA-----PYNTLVLIDNN----- 125 Pseudomonas aer...
Q1M995       214 tlrserrpgstfmllpesalgfwtpsvervwrQQLAEADLSVIAG-AAVV-----DREG-----YDNVLVRVSAT----- 277 Rhizobium legum...
P76280        71 --------------------------------YAATTWRMTIIAG-LPVE-----YNDR-----FIRGIAVFAPW----- 102 Escherichia col...
Q9JVA8       291 --------------------------------EQAQNNGSALAVG-ISQYt---sDGNG-----YENAVINLTGYqennq 329 Neisseria menin...
Q9CM14       291 --------------------------------AHAQQAGTEIVMG-TIYQd---kTANK-----LLNSIITLGNTdfpys 329 Pasteurella mul...
P23930       286 --------------------------------GELRDKGSSLVTG-IVDA-----RLNKqnrydTYNTIITLGKGapysy 327 Escherichia col...
Q9KTE4       283 --------------------------------AAARMNQSAVITGiINQS-----DDKQ-----YFNSVLTVGDTphgey 320 Vibrio cholerae
Q9AC16       297 --------------------------------DSLAPGQLLLIGG-YRYE-----GAGPhp--tYYNSLVALRRTet--d 334 Caulobacter vib...
Q9ZDG3       278 --------------------------------MLNSTNAILITGG-ISDNk---kHGDQf---eLYSAMYALDKN----- 313 Rickettsia prow...
YP_001965644 214 tvlnqrrdgaavillpestlgfwtptverfwrTRLARSGLTVVAG-AAIV-----GPGG-----YDNVLISISGH----- 277 Sinorhizobium m...
Q1M995       214 tlrserrpgstfmllpesalgfwtpsvervwrQQLAEADLSVIAG-AAVV-----DREG-----YDNVLVRVSAT----- 277 Rhizobium legum...
P76280        71 --------------------------------YAATTWRMTIIAG-LPVE-----YNDR-----FIRGIAVFAPW----- 102 Escherichia col...
Q9JVA8       291 --------------------------------EQAQNNGSALAVG-ISQYt---sDGNG-----YENAVINLTGYqennq 329 Neisseria menin...
Q9CM14       291 --------------------------------AHAQQAGTEIVMG-TIYQd---kTANK-----LLNSIITLGNTdfpys 329 Pasteurella mul...
P23930       286 --------------------------------GELRDKGSSLVTG-IVDA-----RLNKqnrydTYNTIITLGKGapysy 327 Escherichia col...
Q9KTE4       283 --------------------------------AAARMNQSAVITGiINQS-----DDKQ-----YFNSVLTVGDTphgey 320 Vibrio cholerae
Q9AC16       297 --------------------------------DSLAPGQLLLIGG-YRYE-----GAGPhp--tYYNSLVALRRTet--d 334 Caulobacter vib...
Q9ZDG3       278 --------------------------------MLNSTNAILITGG-ISDNk---kHGDQf---eLYSAMYALDKN----- 313 Rickettsia prow...
YP_001965644 214 tvlnqrrdgaavillpestlgfwtptverfwrTRLARSGLTVVAG-AAIV-----GPGG-----YDNVLISISGH----- 277 Sinorhizobium m...
2UXY_A       126 GeIVq-KYRKIIP-----WC-----PIEGWYPG---------GQTY-VSEG------PkG----MKISL--II---XDD- 168 Pseudomonas aer...
Q1M995       278 DsEI--LYRERMPvpgsmWQp---wLAPIGKSG---------GARAdFFAN------PvVsvggQRVAP--LI---CYEq 332 Rhizobium legum...
P76280       103 RkTPg-IYHQSHG--------------ACLGRR---------SRTItVVDE-------------QPQGM--DMdptC--- 140 Escherichia col...
Q9JVA8       330 DgIP--YYAKNHLvpfgeYKplpflTTPLYKMM---------NMPLsDFRKgggkqsA-LlmknQKIAF--NI---CYE- 391 Neisseria menin...
Q9CM14       330 LeTTn-RYSKHHLvpfgeYVpletlLRPLGSVF---------NLPMsAFQSgdeiqsP-LvvknRQLSA--AI---CYE- 392 Pasteurella mul...
P23930       328 EsAD--RYNKNHLvpfgeFVplesiLRPLAPFF---------DLPMsSFSRgpyiqpP-LsangIELTA--AI---CYE- 389 Escherichia col...
Q9KTE4       321 RyDLtqRYHKYHLlpfgeFVpfeeiLRPLAPFF---------NLPMsSFSQgay-vqPnLiakgFAFVT--AL---CYE- 384 Vibrio cholerae
Q9AC16       335 LeLVg-IYDKHRLvpfgeYLp---aDRFLTVIGfkslarlsdNFTTgPTPA------PlRispeLLVQP--LI---CYE- 398 Caulobacter vib...
Q9ZDG3       314 NnKLf-EYHKSHLvpfgeYMp----LKNILPFK---------KLTHgLIDYkeg-dgGlVyikkYHLKIkpLI---CYE- 374 Rickettsia prow...
YP_001965644 278 GaEV--MYNERMPvpgsmWQp----WLSFVGRDg--------GARAhFFAN------PvApvgnSLTAP--LI---CYEl 332 Sinorhizobium m...
Q1M995       278 DsEI--LYRERMPvpgsmWQp---wLAPIGKSG---------GARAdFFAN------PvVsvggQRVAP--LI---CYEq 332 Rhizobium legum...
P76280       103 RkTPg-IYHQSHG--------------ACLGRR---------SRTItVVDE-------------QPQGM--DMdptC--- 140 Escherichia col...
Q9JVA8       330 DgIP--YYAKNHLvpfgeYKplpflTTPLYKMM---------NMPLsDFRKgggkqsA-LlmknQKIAF--NI---CYE- 391 Neisseria menin...
Q9CM14       330 LeTTn-RYSKHHLvpfgeYVpletlLRPLGSVF---------NLPMsAFQSgdeiqsP-LvvknRQLSA--AI---CYE- 392 Pasteurella mul...
P23930       328 EsAD--RYNKNHLvpfgeFVplesiLRPLAPFF---------DLPMsSFSRgpyiqpP-LsangIELTA--AI---CYE- 389 Escherichia col...
Q9KTE4       321 RyDLtqRYHKYHLlpfgeFVpfeeiLRPLAPFF---------NLPMsSFSQgay-vqPnLiakgFAFVT--AL---CYE- 384 Vibrio cholerae
Q9AC16       335 LeLVg-IYDKHRLvpfgeYLp---aDRFLTVIGfkslarlsdNFTTgPTPA------PlRispeLLVQP--LI---CYE- 398 Caulobacter vib...
Q9ZDG3       314 NnKLf-EYHKSHLvpfgeYMp----LKNILPFK---------KLTHgLIDYkeg-dgGlVyikkYHLKIkpLI---CYE- 374 Rickettsia prow...
YP_001965644 278 GaEV--MYNERMPvpgsmWQp----WLSFVGRDg--------GARAhFFAN------PvApvgnSLTAP--LI---CYEl 332 Sinorhizobium m...
2UXY_A       169 -GNYPEIWRDCAM-------------KGAELIVRCQG 191 Pseudomonas aeruginosa
Q1M995       333 lIIWPVLQSMLHDpdlvvavgndwwtKGTAIIGIQRA 369 Rhizobium leguminosarum bv. viciae 3841
P76280       141 -SLFTTGQCL----------------GEPDLLASARR 160 Escherichia coli K-12
Q9JVA8       392 -DGFGDELIA-AA-------------KDATLLANASN 413 Neisseria meningitidis serogroup A
Q9CM14       393 -IILGEQLRKNVK-------------QDTDFILTVSN 415 Pasteurella multocida subsp. multocida str. Pm70
P23930       390 -IILGEQVRDNFR-------------PDTDYLLTISN 412 Escherichia coli K-12
Q9KTE4       385 -IIFNEQVRDNVT-------------PDTDFLLTLSN 407 Vibrio cholerae
Q9AC16       399 -SLFPGLAKP--D-------------PNVRALINVSN 419 Caulobacter vibrioides
Q9ZDG3       375 -SIFPNFVRTNNE--------------IVDVIINITN 396 Rickettsia prowazekii str. Madrid E
YP_001965644 333 lLIWPILQSMIYEpdlivaagngwwtKGTNIVAIQRA 369 Sinorhizobium meliloti SM11
Q1M995       333 lIIWPVLQSMLHDpdlvvavgndwwtKGTAIIGIQRA 369 Rhizobium leguminosarum bv. viciae 3841
P76280       141 -SLFTTGQCL----------------GEPDLLASARR 160 Escherichia coli K-12
Q9JVA8       392 -DGFGDELIA-AA-------------KDATLLANASN 413 Neisseria meningitidis serogroup A
Q9CM14       393 -IILGEQLRKNVK-------------QDTDFILTVSN 415 Pasteurella multocida subsp. multocida str. Pm70
P23930       390 -IILGEQVRDNFR-------------PDTDYLLTISN 412 Escherichia coli K-12
Q9KTE4       385 -IIFNEQVRDNVT-------------PDTDFLLTLSN 407 Vibrio cholerae
Q9AC16       399 -SLFPGLAKP--D-------------PNVRALINVSN 419 Caulobacter vibrioides
Q9ZDG3       375 -SIFPNFVRTNNE--------------IVDVIINITN 396 Rickettsia prowazekii str. Madrid E
YP_001965644 333 lLIWPILQSMIYEpdlivaagngwwtKGTNIVAIQRA 369 Sinorhizobium meliloti SM11
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