3ODX,3KZ1,1KI1,1TXD,2Z0Q,2KR9,3MPX


Conserved Protein Domain Family
RhoGEF

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pfam00621: RhoGEF (this model, PSSM-Id:216028 is obsolete and has been replaced by 306973)
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RhoGEF domain
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.
Statistics
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PSSM-Id: 216028
View PSSM: pfam00621
Aligned: 199 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3ODX_B         71 VISELLVTEAAHVRMLRVLHDLFFQPM------AEc---------LFFPLEELQNIFPSLDELIEVH-SLF-LDRLMKr- 132  human
Q5RAB8        544 IAKEVSTTERTYLKDLEVITSWFQSAV------SKe---------DAMPEALKSLIFPNFEPLHKFH-TNF-LKEIEQrl 606  Sumatran oran...
Q6ZNL6        896 IAQELLSSEKAYVEMLQHLNLDFHGAV------MRalddmdhegrDTLAREELRQGLSELPAIHDLH-QGI-LEELEE-- 965  human
Q4SBE9        955 VAKDLVDSERLHVSVLKHLQEDFRSAV------MEaege---egePVLEEQQLGEILGVLPQVYALH-SSI-LTELEE-- 1021 spotted green...
Q968Z5        301 AAKELVDSEQRYVDKLKLLGDTFRNRL------IKe---------ELITNDKITRLLANVSSLYQFHnTHF-LPQLLE-- 362  Caenorhabditi...
Q921L2        376 IANELLQTEKAYVSRLHLLDQVFCARL------LEear-----nrSSFPADVVHGIFSNICSIYCFH-QQFlLPELEK-- 441  house mouse
XP_001640295    7 ITHEILSTERTFVESLRLAYEDCYGSV------KAa---------EVVPESTLNEIFKDLGNIYHLD-VKF-LQELEE-- 67   starlet sea a...
AAI25227       84 IAKEIMSSEKVFVDVLKLLHIDFRDAVahasrqLGk---------PVIEDRILNQILYYLPQLYELN-RDL-LKELEE-- 150  human
XP_001625726  701 IAKELLNTERTYVKDLEVITIAFREVV------SSp---------GVLPEATKKLLFSTIDPIYDFH-CAF-LSELEE-- 761  starlet sea a...
3MPX_A         26 IAQELLSSEKAYVEXLQHLNLDFHGAV------XRalddxdhegrDTLAREELRQGLSELPAIHDLH-QGI-LEELEE-- 95   human
3ODX_B        133 RQ-ESG-----YLI--------EEIGDVL---LA-RFDgaegswfqkiSSRFCSRQSFALEQLKAKQRKDPrFCAFVQ-- 192  human
Q5RAB8        607 ALwEGRsnaqiRDY--------QRIGDVMlknIQgMKH----------LAVHLWKHSEALEALENGIKSSRrLENFCRdf 668  Sumatran oran...
Q6ZNL6        966 RL-SNW-----ESQ--------QKVADVF---LA-REQgf------dhHATHILQFDRYLGLLSENCLHSPrLAAAVRef 1021 human
Q4SBE9       1022 RI-SQW-----EEN--------QSMVDVI---LS-RREdf------rvFDTYISEYDRSMCLLEESCRDNLaFASVVKkf 1077 spotted green...
Q968Z5        363 SI-RDW-----HTT--------KRIANVV---RK-QAPfl------kmYSEYTNNYDRATKLFEELKKKKK-FADVVKei 417  Caenorhabditi...
Q921L2        442 RM-EEW-----DRY--------PRIGDIL---QK-LAPfl------kmYGEYVKNFDRAVELVNTWTERSTqFKVIIHev 497  house mouse
XP_001640295   68 RM-KTW-----EDH--------ERIGDIV---KK-YGHfl------kmYTTYINNYDKAANVLQETMKENPqFAELVLef 123  starlet sea a...
AAI25227      151 RM-LHW-----TEQ--------QRIADIF---VK-KGPyl------kmYSTYIKEFDKNIALLDEQCKKNPgFAAVVRef 206  human
XP_001625726  762 RM-TLW-----DQSfttstgtePRIGDLM---HK-NMKqi------krYVHHLKKHDEVMLELEAATKKFKqFELAYKef 825  starlet sea a...
3MPX_A         96 RL-SNW-----ESQ--------QKVADVF---LA-REQgf------dhHATHILQFDRYLGLLSENCLHSPrLAAAVRef 151  human
3ODX_B        193 EAesrpRC-RRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEe-PT-EREKVELAAECCREILHHVNQ 255  human
Q5RAB8        669 EL----QKvCYLPLNTFLLRPLHRHMHYKQVLERLCKHHPp-SHaDFRDCRAALAGITEMVAQLHG 729  Sumatran orangutan
Q6ZNL6       1022 EQs---VQgGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCp-DSaEYDNTQGALSLISKVTDRAND 1083 human
Q4SBE9       1078 EKr--sLDgAEVPLKHQLLQIIVRVLQYRMLLTDYLNNLSp-DSkEYEDTQAALVIVSEVSDQASD 1140 spotted green pufferfish
Q968Z5        418 EKq---AEcEGLPLGHHLICPVQRVMRYQLLLQEYKKHLQpsDV-DFDDTTVALELVLQAAAHANE 479  Caenorhabditis elegans
Q921L2        498 QKe---EAcGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPh-GSpDSKDAQKSLELIATAAEHSNA 559  house mouse
XP_001640295  124 QAs---KKcKGLMLNSFMLKPVQRIPSYRLLLIDYLKHLPp-ESaEYQDIKVALDIVSEVATHINE 185  starlet sea anemone
AAI25227      207 EMs---PRcANLALKHYLLKPVQRIPQYRLLLTDYLKNLIe-DAgDYRDTQDALAVVIEVANHAND 268  human
XP_001625726  826 ETq---KIc-YLPLNAFLLKPSQRLLHYRFLLERLLKYCVr-DSeDSQDIQGALEELvgavkstee 886  starlet sea anemone
3MPX_A        152 EQs---VQgGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCp-DSaEYDNTQGALSLISKVTDRAND 213  human
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