Conserved Protein Domain Family
RasGEF

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pfam00617: RasGEF (this model, PSSM-Id:216025 is obsolete and has been replaced by 425780)
RasGEF domain
Guanine nucleotide exchange factor for Ras-like small GTPases.
Statistics
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PSSM-Id: 216025
Aligned: 153 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4P4A0       1433 LSYGSGSVARQMCLIEAEL----L----R----SVSWDELASSRWRErr-fG----------Aevtdweafyrdrvrdrl 1489 Ustilago maydis
Q6BZP3        408 LDTSIDLLASQVYYFHLQF----S----G----AWSPASDMSLLFGG----R----------Wny--------------- 446  Yarrowia lipo...
Q6CQ00        503 LKLDNAILADQIHAINLTYnkiwS----P----QKDYSLLYDSAF-Nkn-yI----------D----------------- 545  Kluyveromyces...
Q9HF75        468 LKLDTEKVANQIHKINLTFnrvwS----P----QADYSLLYDSQYTQkh-vE---------------------------- 510  Ashbya gossyp...
P39960        589 LSLDITTLADEVHHINLKFdkvwA----P----KFDYSLLYDSKFINrr-iV----------S----------------- 632  Saccharomyces...
Q6FQG1        602 MELDPSKFAEEVHSINLEFnkvwA----P----RKDFSLLYDSKFNNkn-iL----------S----------------- 645  Candida glabrata
Q5AGW7        552 KEINLIDFAYTISEIDLKFfsnwN----S----NIDKSLLLYSSISDdt-nR----------Dff--------------- 597  Candida albicans
EDK36060      377 kDIDLIEFAAVVTSIDLKF----FkawnS----NIDKSLLLFSSLNN----Shs-------sDyf--------------- 422  Pichia guilli...
XP_001523706  640 kDVNLIEFAKTISDLDLKY----F----SswnsNIDKSLLLASSINTtketK----------Nqf--------------- 686  Lodderomyces ...
XP_001383582  292 kDINLVDFVQAISAIDLKF----FkhwnS----NIDKSLLLYSSING----NfdsssshgtaDyf--------------- 344  Pichia stipit...
Q6BZP3        408 LDTSIDLLASQVYYFHLQF----S----G----AWSPASDMSLLFGG----R----------Wny--------------- 446  Yarrowia lipo...
Q6CQ00        503 LKLDNAILADQIHAINLTYnkiwS----P----QKDYSLLYDSAF-Nkn-yI----------D----------------- 545  Kluyveromyces...
Q9HF75        468 LKLDTEKVANQIHKINLTFnrvwS----P----QADYSLLYDSQYTQkh-vE---------------------------- 510  Ashbya gossyp...
P39960        589 LSLDITTLADEVHHINLKFdkvwA----P----KFDYSLLYDSKFINrr-iV----------S----------------- 632  Saccharomyces...
Q6FQG1        602 MELDPSKFAEEVHSINLEFnkvwA----P----RKDFSLLYDSKFNNkn-iL----------S----------------- 645  Candida glabrata
Q5AGW7        552 KEINLIDFAYTISEIDLKFfsnwN----S----NIDKSLLLYSSISDdt-nR----------Dff--------------- 597  Candida albicans
EDK36060      377 kDIDLIEFAAVVTSIDLKF----FkawnS----NIDKSLLLFSSLNN----Shs-------sDyf--------------- 422  Pichia guilli...
XP_001523706  640 kDVNLIEFAKTISDLDLKY----F----SswnsNIDKSLLLASSINTtketK----------Nqf--------------- 686  Lodderomyces ...
XP_001383582  292 kDINLVDFVQAISAIDLKF----FkhwnS----NIDKSLLLYSSING----NfdsssshgtaDyf--------------- 344  Pichia stipit...
Q4P4A0       1490 eaqrlgelhQEHAVEAIVARFNLTSNWVASEVVLT-Q-------NI----------DERAAVISKLIRIAWK-CYLQSNF 1550 Ustilago maydis
Q6BZP3        447 -------wrHNPLIFDSLS-VHFLGGVLLEHLFSG-Sga----vSS----------AYRGKLLSHWISLGNA-LKNCGDM 502  Yarrowia lipo...
Q6CQ00        546 ---------LNPLVFNNRSNIHYVSRLLIEHLFKQiDgt---plHP----------KERALVLTKWVQLG-CtFEKIGDM 602  Kluyveromyces...
Q9HF75        511 ---------LNPLVFFNDKNVQYLSRLMVSHIFCEeTg-----fTP----------KKRAEVLTKWVQLG-CkFERLGDM 565  Ashbya gossyp...
P39960        633 ---------LNPLVFNNDQNIHFLGRLLISHLFPTnPefs-kkvTP----------KVRAELLDKWVQIG-CrFEHLGDM 691  Saccharomyces...
Q6FQG1        646 ---------LSPLIFNNKDNVHFLGRLLVTHLFSTnHrs---keQC----------RKTAEVLNRWVLLG-CkFEQLGDM 702  Candida glabrata
Q5AGW7        598 -------ykKNPLIFNNDYHIHYLSRLLVNHLFVEnSsmnmssaNL----------ENKARLLEKWIDLG-ClLDKSGNM 659  Candida albicans
EDK36060      423 -------ykKNTLMFNNDTHIHYLSRLFINHLFIE-G-------TSpgistsalsfEKKARLIEKWIDLGCL-LDKLGNM 486  Pichia guilli...
XP_001523706  687 -------ykKNPLIFNNNKHIHYLSRLLINHIFVE-Q-------ALarsms-failESKARILEKWIDLGCL-LDKSGNM 749  Lodderomyces ...
XP_001383582  345 -------ykKNPLIFNNDHHIHYLSRLLINHIFVE-S-------SSstls--ssslERKARLLEKWIDLGCL-LDKSGNM 406  Pichia stipit...
Q6BZP3        447 -------wrHNPLIFDSLS-VHFLGGVLLEHLFSG-Sga----vSS----------AYRGKLLSHWISLGNA-LKNCGDM 502  Yarrowia lipo...
Q6CQ00        546 ---------LNPLVFNNRSNIHYVSRLLIEHLFKQiDgt---plHP----------KERALVLTKWVQLG-CtFEKIGDM 602  Kluyveromyces...
Q9HF75        511 ---------LNPLVFFNDKNVQYLSRLMVSHIFCEeTg-----fTP----------KKRAEVLTKWVQLG-CkFERLGDM 565  Ashbya gossyp...
P39960        633 ---------LNPLVFNNDQNIHFLGRLLISHLFPTnPefs-kkvTP----------KVRAELLDKWVQIG-CrFEHLGDM 691  Saccharomyces...
Q6FQG1        646 ---------LSPLIFNNKDNVHFLGRLLVTHLFSTnHrs---keQC----------RKTAEVLNRWVLLG-CkFEQLGDM 702  Candida glabrata
Q5AGW7        598 -------ykKNPLIFNNDYHIHYLSRLLVNHLFVEnSsmnmssaNL----------ENKARLLEKWIDLG-ClLDKSGNM 659  Candida albicans
EDK36060      423 -------ykKNTLMFNNDTHIHYLSRLFINHLFIE-G-------TSpgistsalsfEKKARLIEKWIDLGCL-LDKLGNM 486  Pichia guilli...
XP_001523706  687 -------ykKNPLIFNNNKHIHYLSRLLINHIFVE-Q-------ALarsms-failESKARILEKWIDLGCL-LDKSGNM 749  Lodderomyces ...
XP_001383582  345 -------ykKNPLIFNNDHHIHYLSRLLINHIFVE-S-------SSstls--ssslERKARLLEKWIDLGCL-LDKSGNM 406  Pichia stipit...
Q4P4A0       1551 ASLAQIIFGLNTPWVQRLRRTWSRVGYFETRM-W-----------------------------------R--------DL 1586 Ustilago maydis
Q6BZP3        503 VGWLGIAGVVCSPPVLRLRDSWGFVSTEIKDSvT-----------------------------------K--------EW 539  Yarrowia lipo...
Q6CQ00        603 VSWLAIATIICSTPILRLSLTWQYISDQTLKIiF-----------------------------------K--------DW 639  Kluyveromyces...
Q9HF75        566 VSWLAIATVICSIPVLRLTRTWQYVPDSYLKIiF-----------------------------------K--------DW 602  Ashbya gossyp...
P39960        692 VSWLAVATIICSIPVLR-SSSWKYVPDQSLKTiF-----------------------------------K--------DW 727  Saccharomyces...
Q6FQG1        703 VSWLAIATVICSIPILRLGAIWKYMPESTVKIiL-----------------------------------N--------DW 739  Candida glabrata
Q5AGW7        660 SSWLGISSVILSQPVLRLTKIWSLVAPDYIRLlK-----------------------------------S--------DW 696  Candida albicans
EDK36060      487 SSWLGISSIILSQPILRLTKIWSLVSPDYIKL-L-----------------------------------Kn-------DW 523  Pichia guilli...
XP_001523706  750 SSWLGISSIILSQPVLRLTKIWSLVSNDYIKL-L-----------------------------------KndwspvlfEL 793  Lodderomyces ...
XP_001383582  407 SSWLGISSIILSQPVLRLTKIWSLVSPNYIKL-LksdwspvlfeldrrhlangtsyeklhsspsaspdkD--------DL 477  Pichia stipit...
Q6BZP3        503 VGWLGIAGVVCSPPVLRLRDSWGFVSTEIKDSvT-----------------------------------K--------EW 539  Yarrowia lipo...
Q6CQ00        603 VSWLAIATIICSTPILRLSLTWQYISDQTLKIiF-----------------------------------K--------DW 639  Kluyveromyces...
Q9HF75        566 VSWLAIATVICSIPVLRLTRTWQYVPDSYLKIiF-----------------------------------K--------DW 602  Ashbya gossyp...
P39960        692 VSWLAVATIICSIPVLR-SSSWKYVPDQSLKTiF-----------------------------------K--------DW 727  Saccharomyces...
Q6FQG1        703 VSWLAIATVICSIPILRLGAIWKYMPESTVKIiL-----------------------------------N--------DW 739  Candida glabrata
Q5AGW7        660 SSWLGISSVILSQPVLRLTKIWSLVAPDYIRLlK-----------------------------------S--------DW 696  Candida albicans
EDK36060      487 SSWLGISSIILSQPILRLTKIWSLVSPDYIKL-L-----------------------------------Kn-------DW 523  Pichia guilli...
XP_001523706  750 SSWLGISSIILSQPVLRLTKIWSLVSNDYIKL-L-----------------------------------KndwspvlfEL 793  Lodderomyces ...
XP_001383582  407 SSWLGISSIILSQPVLRLTKIWSLVSPNYIKL-LksdwspvlfeldrrhlangtsyeklhsspsaspdkD--------DL 477  Pichia stipit...
Q4P4A0       1587 ----------------------NSF------------V----------------------------GPRHNFRHL--R-- 1600 Ustilago maydis
Q6BZP3        540 ----------------------APVvfdlerrlrvtdM----------------------------SRKSTYHVL--Apq 567  Yarrowia lipo...
Q6CQ00        640 ----------------------VPTivqler-rqlsfR----------------------------TTNSVFILAppNln 668  Kluyveromyces...
Q9HF75        603 ----------------------VPTivqldr-rqmssK----------------------------SMNSVFILAppNln 631  Ashbya gossyp...
P39960        728 ----------------------VPTiiqler-rqrtsK----------------------------STSSVFILAppNld 756  Saccharomyces...
Q6FQG1        740 ----------------------VPTivqldr-rqissK----------------------------STGSVFILAppNld 768  Candida glabrata
Q5AGW7        697 ----------------------SPVlfeldr-rylvnEstidhgksth--------lggneesrdlSTKDSYHIMapRgl 745  Candida albicans
EDK36060      524 ----------------------SPV------------LfeldrrhlanglvkantsgqtsngkeesNPRESYHIM--A-- 565  Pichia guilli...
XP_001523706  794 drrylvhetsggdnglstlgekQEL------------T----------------------------PSKESYHIMapR-- 831  Lodderomyces ...
XP_001383582  478 ----------------------RDS------------I----------------------------NFKDSYHIM--A-- 491  Pichia stipit...
Q6BZP3        540 ----------------------APVvfdlerrlrvtdM----------------------------SRKSTYHVL--Apq 567  Yarrowia lipo...
Q6CQ00        640 ----------------------VPTivqler-rqlsfR----------------------------TTNSVFILAppNln 668  Kluyveromyces...
Q9HF75        603 ----------------------VPTivqldr-rqmssK----------------------------SMNSVFILAppNln 631  Ashbya gossyp...
P39960        728 ----------------------VPTiiqler-rqrtsK----------------------------STSSVFILAppNld 756  Saccharomyces...
Q6FQG1        740 ----------------------VPTivqldr-rqissK----------------------------STGSVFILAppNld 768  Candida glabrata
Q5AGW7        697 ----------------------SPVlfeldr-rylvnEstidhgksth--------lggneesrdlSTKDSYHIMapRgl 745  Candida albicans
EDK36060      524 ----------------------SPV------------LfeldrrhlanglvkantsgqtsngkeesNPRESYHIM--A-- 565  Pichia guilli...
XP_001523706  794 drrylvhetsggdnglstlgekQEL------------T----------------------------PSKESYHIMapR-- 831  Lodderomyces ...
XP_001383582  478 ----------------------RDS------------I----------------------------NFKDSYHIM--A-- 491  Pichia stipit...
Q4P4A0       1601 ---NA-MLkvaegnagesgpgdfsaspravdagKAGStrACIPFFGlfvSDLMQYDAM---PTfldptvptmaattafdq 1673 Ustilago maydis
Q6BZP3        568 gigQS-YP---------------------------KE--RVVPFFG----DLCVRYED---GS----------------- 593  Yarrowia lipo...
Q6CQ00        669 --eKS-IRe------------------------------NVIPYFG----DLTIHTNDltqDTm---------------- 695  Kluyveromyces...
Q9HF75        632 --dAF-VRd------------------------------NVIPYFG----DLVIHSDDlprDSk---------------- 658  Ashbya gossyp...
P39960        757 --dDF-TRa------------------------------NVISYFG----DLLIHADDlpsDTk---------------- 783  Saccharomyces...
Q6FQG1        769 --dPN-IKn------------------------------NIVSYFG----DLIIHADDlpnDVk---------------- 795  Candida glabrata
Q5AGW7        746 --gKI-YPk-----------------------------eRVIPFFG----DLVINNSGnttDKsv--------------- 774  Candida albicans
EDK36060      566 ---PRgIG-------------------------KIYPkeRVIPYFG----DLV-IQNA---VP----------------- 592  Pichia guilli...
XP_001523706  832 ---GL-GK-------------------------IYAKe-RVIPYF----SDLVINNLG---LT----------------- 857  Lodderomyces ...
XP_001383582  492 ---PRgLG-------------------------KIYPkeRVIPYFG----DLVINNNS---TA----------------- 519  Pichia stipit...
Q6BZP3        568 gigQS-YP---------------------------KE--RVVPFFG----DLCVRYED---GS----------------- 593  Yarrowia lipo...
Q6CQ00        669 --eKS-IRe------------------------------NVIPYFG----DLTIHTNDltqDTm---------------- 695  Kluyveromyces...
Q9HF75        632 --dAF-VRd------------------------------NVIPYFG----DLVIHSDDlprDSk---------------- 658  Ashbya gossyp...
P39960        757 --dDF-TRa------------------------------NVISYFG----DLLIHADDlpsDTk---------------- 783  Saccharomyces...
Q6FQG1        769 --dPN-IKn------------------------------NIVSYFG----DLIIHADDlpnDVk---------------- 795  Candida glabrata
Q5AGW7        746 --gKI-YPk-----------------------------eRVIPFFG----DLVINNSGnttDKsv--------------- 774  Candida albicans
EDK36060      566 ---PRgIG-------------------------KIYPkeRVIPYFG----DLV-IQNA---VP----------------- 592  Pichia guilli...
XP_001523706  832 ---GL-GK-------------------------IYAKe-RVIPYF----SDLVINNLG---LT----------------- 857  Lodderomyces ...
XP_001383582  492 ---PRgLG-------------------------KIYPkeRVIPYFG----DLVINNNS---TA----------------- 519  Pichia stipit...
Q4P4A0       1674 dgHVRVHPadphvfddlaplppgvhlepLINVLKF--RS 1710 Ustilago maydis
Q6BZP3        594 --SFRQC---------------------ESRLNRI--RT 607  Yarrowia lipolytica
Q6CQ00        696 -fRYLEK---------------------KIYRTKNafQK 712  Kluyveromyces lactis
Q9HF75        659 -yKYLEK---------------------KIRRTKNafYK 675  Ashbya gossypii ATCC 10895
P39960        784 -fKYLEK---------------------KINRTKNafHK 800  Saccharomyces cerevisiae S288c
Q6FQG1        796 -iKYLAK---------------------KINRTKNafHK 812  Candida glabrata
Q5AGW7        775 diYELES---------------------IWKRVNYsfDR 792  Candida albicans
EDK36060      593 --NVTELE--------------------SIwkrinysfn 609  Pichia guilliermondii ATCC 6260
XP_001523706  858 --ENVDvyelesiwkrinysfdrwndylsnlnnhdeiik 894  Lodderomyces elongisporus NRRL YB-4239
XP_001383582  520 --DIFELE--------------------SIwkrinysfs 536  Pichia stipitis CBS 6054
Q6BZP3        594 --SFRQC---------------------ESRLNRI--RT 607  Yarrowia lipolytica
Q6CQ00        696 -fRYLEK---------------------KIYRTKNafQK 712  Kluyveromyces lactis
Q9HF75        659 -yKYLEK---------------------KIRRTKNafYK 675  Ashbya gossypii ATCC 10895
P39960        784 -fKYLEK---------------------KINRTKNafHK 800  Saccharomyces cerevisiae S288c
Q6FQG1        796 -iKYLAK---------------------KINRTKNafHK 812  Candida glabrata
Q5AGW7        775 diYELES---------------------IWKRVNYsfDR 792  Candida albicans
EDK36060      593 --NVTELE--------------------SIwkrinysfn 609  Pichia guilliermondii ATCC 6260
XP_001523706  858 --ENVDvyelesiwkrinysfdrwndylsnlnnhdeiik 894  Lodderomyces elongisporus NRRL YB-4239
XP_001383582  520 --DIFELE--------------------SIwkrinysfs 536  Pichia stipitis CBS 6054
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