3LUT


Conserved Protein Domain Family
Ion_trans

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pfam00520: Ion_trans (this model, PSSM-Id:215968 is obsolete and has been replaced by 395416)
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Ion transport protein
This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices
Statistics
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PSSM-Id: 215968
Aligned: 305 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3LUT_B  224 IVETLCIIWFSFEFLVRFFACPSk---------------AGFFTNIMNIIDIVAIIPYFITLGTELaekpedaqQGQQA- 287  Norway rat
Q9XSP9  139 IVETLCIIWFSFELVVRFFACPSk---------------TDFFKNIMNIIDIISIIPY---------------------- 181  rabbit
O88703  219 VFNVVSDTFFLMDLVLNFR-TGIviednteiildpekikKKYLRTWFV-VDFVSSIPVDYIFLIVE--------KGIDSe 288  house mouse
O08661  376 SIDVKYQMWKLGVVFTDNS----------------------FLYLAWY--MTMSVLGHYNNFFFAA-------------- 417  Norway rat
O61567 1241 SVDWRYQVWKAGVTVTDNQ----------------------FLYNLWY--LTFSVLGN-INYFFFA--------AH---- 1283 American lobster
O13054 4820 QIWKFGVVFTDGTFLYLCWYLI-----------------MSLLGHYNN--FFFACHLLDIAMGV---------------- 4864 Atlantic blue marlin
O96310  265 QVWKAGVTITDNSFLYSLWYFS-----------------FSVMGNFNN--FFFAAHLLDVAVGF---------------- 309  tobacco budworm
O77089 2376 VSLMGNKGTFAKRLEQQVTDGELl---------------YHVIYLVFC-VLGLSVHPF---CYSVL-------------- 2422 Caribbean spiny lob...
P29993 2410 IFSLVIVLALPRESGIRTFIGSVil-------------rFIFLLGPES----TLCLLGVVTVTLKS--------VHIVSi 2464 fruit fly
P11881 2362 CNKIIFLMSFVGNCGTFTRGYR------------------AMVLDVEFLYHLLYLLICAMGLFVHE-------------- 2409 house mouse
3LUT_B  288 --------------------------------MSlAILRVIRLVR---VFRIFKLSR----HSKGLQILG-QTLKaSMRE 327  Norway rat
Q9XSP9  182 -------------------------------------------------------------LATLITELVqEDGA-QRQQ 199  rabbit
O88703  289 vykt------------------------aralRIvRFTKILSLLRllrLSRLIRYIHqweeIFHMTYDLA-SAVM-RICN 342  house mouse
O08661  418 --------------------------------------------H---LLDIAMGFKt---LRTILSSVT-HNGK-QLVL 445  Norway rat
O61567 1284 ------------------------------------------------LLDVAVSIPs---LKTILQSVT-HNGK-QLIL 1310 American lobster
O13054 4865 --------------------------------------------------------Kt---LRTILSSVT-HNGK-QLMM 4883 Atlantic blue marlin
O96310  310 --------------------------------------------------------Kt---LRTILQSVT-HNGK-QLVL 328  tobacco budworm
O77089 2423 ------------------------------------------------LFDVVYREEt---LLNVIRSVT-RNGW-SIIL 2449 Caribbean spiny lob...
P29993 2465 mgnkgtlekqlikiitdfqllyhciyiafcfcGLiFHPFFYSLL----LFDVVYREEt---LVNVIRSVT-RNGR-SIVL 2535 fruit fly
P11881 2410 ---------------------------------------FFYSLL---LFDLVYREEt---LLNVIKSVT-RNGR-SIIL 2442 house mouse
3LUT_B  328 LGLLIFFLFIGVILFSSAVYFAEADE------------------------------------------------------ 353  Norway rat
Q9XSP9  200 NMSLAILRII-RLVRVFRIFK----------------------------------------------------------- 219  rabbit
O88703  343 LISMMLLLCHWDGCLQFLVPMLQDFPsdcwvs------------------------------------------------ 374  house mouse
O08661  446 TVGLLAVVVYLYTVVAFNLFRKFYNKse---------------------------------------------------- 473  Norway rat
O61567 1311 TCMLLTIIVYCYTVIAFNFFRKFYVSeeddv------------------------------------------------- 1341 American lobster
O13054 4884 TVGLLAVVVYLYTVVAFNFFRKFYNKsed--------------------------------------------------- 4912 Atlantic blue marlin
O96310  329 TVMLLTIIVYIYTVIAFNFFRKFYVQeedde------------------------------------------------- 359  tobacco budworm
O77089 2450 TAALALILVYMFSIIGYMFFRNDFIVdvtdndidwdtiqkhinqriesyvttslsvkknsvedtcemgvdcteedssnly 2529 Caribbean spiny lob...
P29993 2536 TAVLALILVYLFSIIGYMFFKDDFLVsvdfeeqdnapppsvpltlsvpvsgds----------------csapddlgncq 2599 fruit fly
P11881 2443 TAVLALILVYLFSIVGYLFFKDDFILevdrlpnetavpetgeslandflysdv---------------crvetgenctsp 2507 house mouse
3LUT_B  354 ---------------RDSQFPSIPDAFWWAVVSMTTVGYGD-----M------VPTTIGGKIVG-SLCAIAGVLTIALPV 406  Norway rat
Q9XSP9  220 -------------------LSRHSKGLQILG---QTL---Kas------------mRELGLLIF-FLFIGVILFSSAVYF 261  rabbit
O88703  375 ----------innmvNHSWSELYSFALFKAMSHMLCIGYGRqa-----------peSMTDIWLT-MLSMIVG----ATCY 428  house mouse
O08661  474 -------------dgDTPDMKCDDMLTCYMFHMYVGVRAGGgigdeIedp-agDEYEIYRIIFDiTFFFFVIVILLAIIQ 539  Norway rat
O61567 1342 -----------vdqkCHDMLTCFVFHLYKGVRAGGGIGDEIeapdgD-------EYELYRIIFDiTFFFFIIVILLAIIQ 1403 American lobster
O13054 4913 ------------edePDMKCDDMMTCYLFHM-YVGVRAGGGigdeiEdp--agDEYELYRVVFDiTFFFFVIVILLAIIQ 4977 Atlantic blue marlin
O96310  360 -----------vnrnCHDMLTCFVFNLYKGVRAGGGIGDELeppdgD-------DSEVYRIIFDiSFFFFIIVILLAILQ 421  tobacco budworm
O77089 2530 nvvdsitkevmveveDAKEEACSTLLMCIVTSLNHGLRSGGgigdiLrapsnkENLFAARVIYDlLFFFVVIIIVLNLIF 2609 Caribbean spiny lob...
P29993 2600 aakevappsagggevKERSCDSLVMCIVTTL--NQGLRNGGgigdiLrapsskEGLFVARVIYDlLFFFIVIIIVLNLIF 2677 fruit fly
P11881 2508 apkeellpaeeteqdKEHTCETLLMCIVTVL--SHGLRSGGgvgdvLrkpskeEPLFAARVIYDlLFFFMVIIIVLNLIF 2585 house mouse
3LUT_B  407 PVI 409  Norway rat
Q9XSP9  262 AEV 264  rabbit
O88703  429 AMF 431  house mouse
O08661  540 GLI 542  Norway rat
O61567 1404 GLI 1406 American lobster
O13054 4978 GLI 4980 Atlantic blue marlin
O96310  422 GLI 424  tobacco budworm
O77089 2610 GVI 2612 Caribbean spiny lobster
P29993 2678 GVI 2680 fruit fly
P11881 2586 GVI 2588 house mouse
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