2K3S,1SJJ,2QJX,1WYM,1P2X,1WYN,1WYR,3KY9,1PXY,1RT8,1PXY,1RT8,1WYL,1WYQ,2EYI,2E9K,2D88,2D89,1BHD,1SH5,1QAG,2WA5,2WA5,1AOA,2D85,1WYO,1H67,1WJO


Conserved Protein Domain Family
CH

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pfam00307: CH (this model, PSSM-Id:215849 is obsolete and has been replaced by 333996)
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Calponin homology (CH) domain
The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.
Statistics
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PSSM-Id: 215849
View PSSM: pfam00307
Aligned: 217 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2K3S_A    6 KNMLLEWCRAMTRNYEHVDIQNFsSSWSSGMAFCALIHKFFPEAF-DYAELd-pAKRRHNFTLAFSta---ekLADCAQL 80   house mouse
Q18109  128 KKLVMAWIQSALP---ELKLTNFrTNWNDGIALSALLEYCQPGLCpEWRNLd-pSEARENCHRALLla---erYLEVPPI 200  Caenorhabditis elegans
Q9TYW4  153 KQKLLNWIRNRLP---GMPISNFtSDWNDGVALGALVNSMAPGALeDWENWs-pNDALENTEKAMKsa---qdLLKVAPL 225  Caenorhabditis elegans
Q9GQV2  142 KQRLLNWIHAKIP---DLPINNFtNDWTTGKAVGALVDACAPGLCpDWELWd-pKDAVQNASEAMGla---ddWLNVRQL 214  fruit fly
Q90574  161 KQRLLGWIQNKIP---YLPITNFnQNWQDGKALGALVDSCAPGLCpDWETWd-pSKPVDNAREAMQqa---ddWLGVPQL 233  chicken
Q9YGW4  162 KQRLLGWVQHRVP---QLRITNFnRDWNDGRALGALVDNCAPGLCpDWQSWd-pAQPVQNAREAMQqa---ddWLGVPQV 234  chicken
P13466  128 KAALLEWVRKQVAPY-KVVVNNFtDSWCDGRVLSALTDSLKPG-VrEMSTLt--gDAVQDIDRSMDia---leEYEIPKI 200  Dictyostelium disco...
P90545  123 KNALLEWVNSKLT---SRKIKSFsNDWNTGDVLNELIHALEPDFI-DLADSaskgEGEERIQYGLSia---edKMEIPAI 195  Entamoeba histolytica
Q9U3Z8  132 NNALLDWVNSF-----GLNVSNFsSDWKDGVALVKLTEAVSAGQI-KFEQF----SGLDNTQMVIDcqklayeQFKIPIL 201  Entamoeba histolytica
2WA5_A  145 KQRLLGWIQNKI---PYLPITNFnQNWQDGKALGALVDSCAPGLCpDWESWd-pQKPVDNAREAMQqa---ddWLGVPQV 217  human
2K3S_A   81 LEVDDMVRlaVPDSKCVYTYIQELYRSLV 109  house mouse
Q18109  201 ISSDHLSSp-HLDELSCLTYLSYFITKGA 228  Caenorhabditis elegans
Q9TYW4  226 IAPAEMIHp-EIDEMSVMTYLSQFPATKP 253  Caenorhabditis elegans
Q9GQV2  215 IKPEELVNp-NVDEQSMMTYLSQYPNSKL 242  fruit fly
Q90574  234 LPPEEIIHp-DVDEHSVMTYLYTFPKAKL 261  chicken
Q9YGW4  235 IAPEEIADp-NVDEHSVMTYLSQFPKAKL 262  chicken
P13466  201 MDANDMNS--LPDELSVITYVSYFRDYAL 227  Dictyostelium discoideum
P90545  196 IAAEDMALp-EPDELSVMAYVSYFRHYEA 223  Entamoeba histolytica
Q9U3Z8  202 MDVKDL-VceRPDPKSIMTYVSVYKERYE 229  Entamoeba histolytica
2WA5_A  218 ITPEEIIHp-DVDEHSVMTYLSQFpkakl 245  human
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