1IHK,1FMM,3FJ8,1NUN,1QQK,2FDB


Conserved Protein Domain Family
FGF

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pfam00167: FGF (this model, PSSM-Id:215764 is obsolete and has been replaced by 425498)
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Fibroblast growth factor
Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerisation of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.
Statistics
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PSSM-Id: 215764
Aligned: 84 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1IHK_A  28 RRRQLYCRTGFHLEIFPNGTI-QGTRKDHSRFGILEFISI----AV-GLVSIRGVDSGLYLGMNEKGELY-------GSE 94  human
Q91BB2  26 RQIQLFVK-NQYIAVDGNGDV-MGSRDRTASRTVFHRISV----SH-NLMLLVNSVSCRYVCINACGYVYtlaanggAGG 98  Spodoptera litura NPV
Q9E225  33 RPIQIVMR-HRYLSVARNGTV-WGITNSTDSHSVFYRVPH----YM--NHLLKAAQTCRYICVNQCGYVY--------TA 96  Helicoverpa zea SNPV
P91672 249 RKIQLYIK-NRILQILRDGVV-NGTQDENSEFTILQRSTV----DV-GRIKLQSVATCLYLCMDACGVPY-------GSK 314 fruit fly
O92401  28 IPGRLFIN-RRFLAVNPNGTVyGGTIESDNADTTFKRLAV----DR-NRIVIQNAITCVYLCIDRCGQLY-------GSK 94  Bombyx mori NPV
Q1HGX9  32 RLVQLFIN-HRYLAVRPNGIV-EGTSDALSADTVLQRVRG----NTrGHILLRNAVTCMHVCLDRCGTMY-------ASA 98  Antheraea pernyi nucl...
Q6VTW1  28 RLVHIFVH-NRYLAVHTDGVV-NGTLYPYSLNTVLQRVSHfehpAR-RTILLRNAISCMHVCLDRCGVMY-------ASA 97  Choristoneura fumifer...
Q2NP32  29 RLTHIVIR-NRFLAVRPDGVV-NGTNDASDLDIVLQRVSY----HY-GRILLRNAISCMHVCLDRCGAMY-------ASA 94  Hyphantria cunea nucl...
O10284  29 RLVQVLIH-NRYLAVRSDGTV-GGTTYASSLDTVLQRIAI----AH-GRILLRNAVSCMYVCLDRCGAMY-------ASA 94  Orgyia pseudotsugata ...
Q3YAG3 203 QPTQLFCRTNFRLAVHEDGTI-NGTRDNMDVYASLYIQSQ----RR-SIVSIKGLRSQLYVCVDDSGSLY-------GDT 269 Strongylocentrotus pu...
Q91BB2  26 RQIQLFVK-NQYIAVDGNGDV-MGSRDRTASRTVFHRISV----SH-NLMLLVNSVSCRYVCINACGYVYtlaanggAGG 98  Spodoptera litura NPV
Q9E225  33 RPIQIVMR-HRYLSVARNGTV-WGITNSTDSHSVFYRVPH----YM--NHLLKAAQTCRYICVNQCGYVY--------TA 96  Helicoverpa zea SNPV
P91672 249 RKIQLYIK-NRILQILRDGVV-NGTQDENSEFTILQRSTV----DV-GRIKLQSVATCLYLCMDACGVPY-------GSK 314 fruit fly
O92401  28 IPGRLFIN-RRFLAVNPNGTVyGGTIESDNADTTFKRLAV----DR-NRIVIQNAITCVYLCIDRCGQLY-------GSK 94  Bombyx mori NPV
Q1HGX9  32 RLVQLFIN-HRYLAVRPNGIV-EGTSDALSADTVLQRVRG----NTrGHILLRNAVTCMHVCLDRCGTMY-------ASA 98  Antheraea pernyi nucl...
Q6VTW1  28 RLVHIFVH-NRYLAVHTDGVV-NGTLYPYSLNTVLQRVSHfehpAR-RTILLRNAISCMHVCLDRCGVMY-------ASA 97  Choristoneura fumifer...
Q2NP32  29 RLTHIVIR-NRFLAVRPDGVV-NGTNDASDLDIVLQRVSY----HY-GRILLRNAISCMHVCLDRCGAMY-------ASA 94  Hyphantria cunea nucl...
O10284  29 RLVQVLIH-NRYLAVRSDGTV-GGTTYASSLDTVLQRIAI----AH-GRILLRNAVSCMYVCLDRCGAMY-------ASA 94  Orgyia pseudotsugata ...
Q3YAG3 203 QPTQLFCRTNFRLAVHEDGTI-NGTRDNMDVYASLYIQSQ----RR-SIVSIKGLRSQLYVCVDDSGSLY-------GDT 269 Strongylocentrotus pu...
1IHK_A  95 KLTQ-ECVFREQFEENWYNTYSSNlykh---vdtGRRYYVALNKDGTPREGT--RT---KRHQKFTHF-----L 154 human
Q91BB2  99 VLSQ-DCVLHEHMTESYYNWYYRDd--------nQTRSFLALNKSGRTKRVRirND---DPLHNHINSin--iI 158 Spodoptera litura NPV
Q9E225  97 IVPNsECLWSTEIKETAYVMYKQFd--------sNTRAYLALNREGKPRNVLvnSSgvhRPLEPSSVKlt--tL 160 Helicoverpa zea SNPV
P91672 315 DFTD-DCVFNENMGLQNYNTYSSTyhs-----qaRRVFYLALNGSGQPRRTQipAS---RSLGKLSTYtn--aI 377 fruit fly
O92401  95 TLSD-DCFMREIMEKNNYNTYYKMy--------dRKLTYVALKNDGTPRKLQisKG---RKLGKFSVYam--tL 154 Bombyx mori NPV
Q1HGX9  99 TVSS-DCFLNEMFTETNHNVLHKVy--------dRKVTYVALDNVGRARRVQisKH---RSLRNMSKYtf--iM 158 Antheraea pernyi nucleopoly...
Q6VTW1  98 VLSS-DCFLQETVVKNNYDVMFKIy--------nRKLTYVALDNFGKARRLQlsRR---RTLGNLSTYal--iL 157 Choristoneura fumiferana DE...
Q2NP32  95 ALSS-DCILNEIVLDNNYDVMFKIy--------dNKKTYVALDDRGQARRVQlpKR---RLLRNMSAYtl--iL 154 Hyphantria cunea nucleopoly...
O10284  95 ALSS-DCILNEVMLENNYDVMFKIy--------nGKKTYVALDNTGNPRRVQlpRQ---RPLRMMNVYtfimrI 156 Orgyia pseudotsugata MNPV
Q3YAG3 270 RVSR-NCYFQEKLEPNFFNTYAYKmpdstskrrrHRTLFLSINKYGESRIAK-------VRTQKKAQF-----I 330 Strongylocentrotus purpuratus
Q91BB2  99 VLSQ-DCVLHEHMTESYYNWYYRDd--------nQTRSFLALNKSGRTKRVRirND---DPLHNHINSin--iI 158 Spodoptera litura NPV
Q9E225  97 IVPNsECLWSTEIKETAYVMYKQFd--------sNTRAYLALNREGKPRNVLvnSSgvhRPLEPSSVKlt--tL 160 Helicoverpa zea SNPV
P91672 315 DFTD-DCVFNENMGLQNYNTYSSTyhs-----qaRRVFYLALNGSGQPRRTQipAS---RSLGKLSTYtn--aI 377 fruit fly
O92401  95 TLSD-DCFMREIMEKNNYNTYYKMy--------dRKLTYVALKNDGTPRKLQisKG---RKLGKFSVYam--tL 154 Bombyx mori NPV
Q1HGX9  99 TVSS-DCFLNEMFTETNHNVLHKVy--------dRKVTYVALDNVGRARRVQisKH---RSLRNMSKYtf--iM 158 Antheraea pernyi nucleopoly...
Q6VTW1  98 VLSS-DCFLQETVVKNNYDVMFKIy--------nRKLTYVALDNFGKARRLQlsRR---RTLGNLSTYal--iL 157 Choristoneura fumiferana DE...
Q2NP32  95 ALSS-DCILNEIVLDNNYDVMFKIy--------dNKKTYVALDDRGQARRVQlpKR---RLLRNMSAYtl--iL 154 Hyphantria cunea nucleopoly...
O10284  95 ALSS-DCILNEVMLENNYDVMFKIy--------nGKKTYVALDNTGNPRRVQlpRQ---RPLRMMNVYtfimrI 156 Orgyia pseudotsugata MNPV
Q3YAG3 270 RVSR-NCYFQEKLEPNFFNTYAYKmpdstskrrrHRTLFLSINKYGESRIAK-------VRTQKKAQF-----I 330 Strongylocentrotus purpuratus
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