1YAL,1PPO,1PIP,1ME3,1M6D,2O6X,7PCK


Conserved Protein Domain Family
Peptidase_C1

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pfam00112: Peptidase_C1 (this model, PSSM-Id:215726 is obsolete and has been replaced by 425470)
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Papain family cysteine protease
Statistics
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PSSM-Id: 215726
Aligned: 158 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1YAL_A   1 YPQSIDWRA--Kg-A--VTPVKNQGACGSXWAFSTIATVEGINKIVTg--NLLELSEQELVDCDK-HSY----GCKGGYQ 68  papaya
Q18740 140 LPKTFDLRNkkVggHyiIGPIKTQDSCACCWGFAATAVAEAALTVHLk--KAMNLSEQEVCDCAP-KHGp---GCNGGDP 213 Caenorhabditis elegans
P90850 184 LPEHFDARD--KwgPl-IHPVADQGDCGSSWSVSTTAISSDRLAIISegrINSTLSSQQLLSCNQhRQK----GCEGGYL 256 Caenorhabditis elegans
P92131  79 IPPQFDFRDeyPq-C--VKPALDQGSCGSCWAFSAIGVFGDRRCAMGidkEAVSYSQQHLISCSL-ENF----GCDGGDF 150 Giardia intestinalis
O15555  77 LPKDYDPRVerAhcL---PEVADQASCGSCWAFSAVATFADRRCAYGldsKQVHYSEQYVVSCDfg-----dgACNGGWL 148 Giardia muris
Q40413 100 LPQEFDARVawSncSt-IGRILDQGHCGSCWAFGAVESLSDRFCIHYg--LNISLSANDLYACCG---FlcgdGCDGGYP 173 Aztec tobacco
O23681 103 LPKEFDARTawShcTs-IRRILG--HCGSCWAFGAVESLSDRFCIKYn--LNVSLSANDVIACCG---LlcgfGCNGGFP 174 thale cress
Q9ZSI0 103 LPKAFDARTawPqcTs-IGNILGLGHCGSCWAFGAVESLSDRFCIQFg--MNISLSVNDLLACCG---FrcgdGCDGGYP 176 thale cress
O61066  92 LQDRFDAGEawPkcPt-ITEIRDQSSCGSCWAVAAASAMSDRYCTLGg-vRDLRISAGDLMSCCDvc----gyGCNGGYP 165 Trypanosoma cruzi
P90627  98 LPEFFDAAEhwPmcLt-ISEIRDQSNCGSCWAIAAVEAISDRYCTFGg-vPDRRMSTSNLLSCCFic----glGCHGGIP 171 Leishmania major
Q18740 140 LPKTFDLRNkkVggHyiIGPIKTQDSCACCWGFAATAVAEAALTVHLk--KAMNLSEQEVCDCAP-KHGp---GCNGGDP 213 Caenorhabditis elegans
P90850 184 LPEHFDARD--KwgPl-IHPVADQGDCGSSWSVSTTAISSDRLAIISegrINSTLSSQQLLSCNQhRQK----GCEGGYL 256 Caenorhabditis elegans
P92131  79 IPPQFDFRDeyPq-C--VKPALDQGSCGSCWAFSAIGVFGDRRCAMGidkEAVSYSQQHLISCSL-ENF----GCDGGDF 150 Giardia intestinalis
O15555  77 LPKDYDPRVerAhcL---PEVADQASCGSCWAFSAVATFADRRCAYGldsKQVHYSEQYVVSCDfg-----dgACNGGWL 148 Giardia muris
Q40413 100 LPQEFDARVawSncSt-IGRILDQGHCGSCWAFGAVESLSDRFCIHYg--LNISLSANDLYACCG---FlcgdGCDGGYP 173 Aztec tobacco
O23681 103 LPKEFDARTawShcTs-IRRILG--HCGSCWAFGAVESLSDRFCIKYn--LNVSLSANDVIACCG---LlcgfGCNGGFP 174 thale cress
Q9ZSI0 103 LPKAFDARTawPqcTs-IGNILGLGHCGSCWAFGAVESLSDRFCIQFg--MNISLSVNDLLACCG---FrcgdGCDGGYP 176 thale cress
O61066  92 LQDRFDAGEawPkcPt-ITEIRDQSSCGSCWAVAAASAMSDRYCTLGg-vRDLRISAGDLMSCCDvc----gyGCNGGYP 165 Trypanosoma cruzi
P90627  98 LPEFFDAAEhwPmcLt-ISEIRDQSNCGSCWAIAAVEAISDRYCTFGg-vPDRRMSTSNLLSCCFic----glGCHGGIP 171 Leishmania major
1YAL_A  69 TTSLQYVANnG-VHTSKVYPYQ-----AKQ-------------------YKCRAT-DKPGPk--VKITGYKRVPSn---X 117 papaya
Q18740 214 VDGLEYIKE-MgLTGGKEYPFNv----NRStq----------------lGRCESEkYDRELn-pLELDYYAIDPFn---A 268 Caenorhabditis elegans
P90850 257 DRAWWYIRK-LgVVGDHCYPYV-----SGQsrepghclipkrdytnrqgLRCPSG-SQDSTa--FKMTPPYKVSSr---- 323 Caenorhabditis elegans
P92131 151 QPTWSFLTF-TgATTAecvKYV-----DYGhtva-----------spcpAVCD-D-GSPIQl--YKAHGYGQVSKs---- 205 Giardia intestinalis
O15555 149 SNVWKFLTK-TgVPKLdclKYFs----GMTgd----------------rESCITHcTDGSPvelYQASHVIN--Yg--mD 203 Giardia muris
Q40413 174 LQAWKYFVR-KgVVTDecdPYFdnegcSHPgcep-----------ayptPKCHRKcVKQnl-lwSRSKHFGVNAYmissD 240 Aztec tobacco
O23681 175 MGAWLYFKY-HgVVTQecdPYFdntgcSHPgcep-----------typtPKCERKcVSRnq-lwGESKHYGVGAYrinpD 241 thale cress
Q9ZSI0 177 IAAWQYFSY-SgVVTEecdPYFdntgcSHPgcep-----------ayptPKCSRKcVSDnk-lwSESKHYSVSTYtvksN 243 thale cress
O61066 166 EVAWEYYAV-HgIVSEycqPYPfp-scAHHvnssdlsp----csgeydtPTCNSTcTdk---kiPLIKYRGNTSYil-sg 235 Trypanosoma cruzi
P90627 172 TVAWLWWVW-VgIATEdcqPYPfd-pcSHHgnsekypp---cpstiydtPKCNTTcErn---emDLVKYKGSTSYsv-kg 242 Leishmania major
Q18740 214 VDGLEYIKE-MgLTGGKEYPFNv----NRStq----------------lGRCESEkYDRELn-pLELDYYAIDPFn---A 268 Caenorhabditis elegans
P90850 257 DRAWWYIRK-LgVVGDHCYPYV-----SGQsrepghclipkrdytnrqgLRCPSG-SQDSTa--FKMTPPYKVSSr---- 323 Caenorhabditis elegans
P92131 151 QPTWSFLTF-TgATTAecvKYV-----DYGhtva-----------spcpAVCD-D-GSPIQl--YKAHGYGQVSKs---- 205 Giardia intestinalis
O15555 149 SNVWKFLTK-TgVPKLdclKYFs----GMTgd----------------rESCITHcTDGSPvelYQASHVIN--Yg--mD 203 Giardia muris
Q40413 174 LQAWKYFVR-KgVVTDecdPYFdnegcSHPgcep-----------ayptPKCHRKcVKQnl-lwSRSKHFGVNAYmissD 240 Aztec tobacco
O23681 175 MGAWLYFKY-HgVVTQecdPYFdntgcSHPgcep-----------typtPKCERKcVSRnq-lwGESKHYGVGAYrinpD 241 thale cress
Q9ZSI0 177 IAAWQYFSY-SgVVTEecdPYFdntgcSHPgcep-----------ayptPKCSRKcVSDnk-lwSESKHYSVSTYtvksN 243 thale cress
O61066 166 EVAWEYYAV-HgIVSEycqPYPfp-scAHHvnssdlsp----csgeydtPTCNSTcTdk---kiPLIKYRGNTSYil-sg 235 Trypanosoma cruzi
P90627 172 TVAWLWWVW-VgIATEdcqPYPfd-pcSHHgnsekypp---cpstiydtPKCNTTcErn---emDLVKYKGSTSYsv-kg 242 Leishmania major
1YAL_A 118 ETSFLGALAN--QPLSVLVEAGGkpfQLYKSgVFDG---PCGtk------lDHAVTAVGYGTSD-----GKNYIIIKNSW 181 papaya
Q18740 269 EYQMTHHLYLlnLPISVAFRTGAs-lSSYLSgILELa--DCDdek---gghWHSGAIVGYGTTKnsagrTVDYWIFRNSW 342 Caenorhabditis elegans
P90850 324 EEDIQTELMTn-GPVQATFVVHEd-fFMYAGgVYQHsdlAAQkgassvaegYHSVRVLGWGVDHst-gkPIKYWLCANSW 400 Caenorhabditis elegans
P92131 206 VPAIMGMLVAg-GPLQTMIVVYAd-lSYYESgVYKHtygTINl-------gFHALEIVGYGTTDd----GTDYWIIKNSW 272 Giardia intestinalis
O15555 204 LDRMMEALVYd-GPLQVAFVVYSd-fGYYSSgVYQHvngMMEg--------gHAVEMVGYGIDEs----GLKYWIIRNSW 269 Giardia muris
Q40413 241 PHSIMTEVYKn-GPVEVSFTVYEd-fAHYKSgVYKHvtgDIMg--------GHAVKLIGWGTSEd----GEDYWLLANQW 306 Aztec tobacco
O23681 242 PQDIMAEVYKn-GPVEVAFTVYEd-fAHYKSgVYKYitgTKIg--------GHAVKLIGWGTSDd----GEDYWLLANQW 307 thale cress
Q9ZSI0 244 PQDIMAEVYKn-GPVEVSFTVYEd-fAHYKSgVYKHitgSNIg--------GHAVKLIGWGTSSe----GEDYWLMANQW 309 thale cress
O61066 236 EESFKRELLLn-GPFEVSFSVYAd-fVAYTGgVYKHvtgVFLg--------GHAVRIVGWGELN-----GEPYWKIANSW 300 Trypanosoma cruzi
P90627 243 EKELMIELMTn-GPLELTMQVYSd-fVGYKSgVYKHvlgDFLg--------GHAVKLVGWGTQD-----GVPYWKVANSW 307 Leishmania major
Q18740 269 EYQMTHHLYLlnLPISVAFRTGAs-lSSYLSgILELa--DCDdek---gghWHSGAIVGYGTTKnsagrTVDYWIFRNSW 342 Caenorhabditis elegans
P90850 324 EEDIQTELMTn-GPVQATFVVHEd-fFMYAGgVYQHsdlAAQkgassvaegYHSVRVLGWGVDHst-gkPIKYWLCANSW 400 Caenorhabditis elegans
P92131 206 VPAIMGMLVAg-GPLQTMIVVYAd-lSYYESgVYKHtygTINl-------gFHALEIVGYGTTDd----GTDYWIIKNSW 272 Giardia intestinalis
O15555 204 LDRMMEALVYd-GPLQVAFVVYSd-fGYYSSgVYQHvngMMEg--------gHAVEMVGYGIDEs----GLKYWIIRNSW 269 Giardia muris
Q40413 241 PHSIMTEVYKn-GPVEVSFTVYEd-fAHYKSgVYKHvtgDIMg--------GHAVKLIGWGTSEd----GEDYWLLANQW 306 Aztec tobacco
O23681 242 PQDIMAEVYKn-GPVEVAFTVYEd-fAHYKSgVYKYitgTKIg--------GHAVKLIGWGTSDd----GEDYWLLANQW 307 thale cress
Q9ZSI0 244 PQDIMAEVYKn-GPVEVSFTVYEd-fAHYKSgVYKHitgSNIg--------GHAVKLIGWGTSSe----GEDYWLMANQW 309 thale cress
O61066 236 EESFKRELLLn-GPFEVSFSVYAd-fVAYTGgVYKHvtgVFLg--------GHAVRIVGWGELN-----GEPYWKIANSW 300 Trypanosoma cruzi
P90627 243 EKELMIELMTn-GPLELTMQVYSd-fVGYKSgVYKHvlgDFLg--------GHAVKLVGWGTQD-----GVPYWKVANSW 307 Leishmania major
1YAL_A 182 GPNWGEKGYMRLKRQSGnsqgTCGVYKSSYYPF 214 papaya
Q18740 343 WTDWGDDGYARIVRGED----WCSIESHGYGAR 371 Caenorhabditis elegans
P90850 401 GTQWGEDGYFKVLRGEN----HCEIESFVIGAW 429 Caenorhabditis elegans
P92131 273 GPDWGENGYFRIVRGVN----ECRIEDEIYAVY 301 Giardia intestinalis
O15555 270 GPDWGEGGYFRIIRRVN----ECGIEEQAYGPF 298 Giardia muris
Q40413 307 NRGWGDDGYFKIRRGTN----ECEIEDEVVAGL 335 Aztec tobacco
O23681 308 NRSWGDDGYFKIRRGTN----ECGIEQSVVAGL 336 thale cress
Q9ZSI0 310 NRGWGDDGYFMIRRGTN----ECGIEDEPVAGL 338 thale cress
O61066 301 NHEWGMNGYFLIARGVD----ECGIEGSGVAGI 329 Trypanosoma cruzi
P90627 308 NTDWGDKGYFLIQRGNN----ECKIESGGVAGI 336 Leishmania major
Q18740 343 WTDWGDDGYARIVRGED----WCSIESHGYGAR 371 Caenorhabditis elegans
P90850 401 GTQWGEDGYFKVLRGEN----HCEIESFVIGAW 429 Caenorhabditis elegans
P92131 273 GPDWGENGYFRIVRGVN----ECRIEDEIYAVY 301 Giardia intestinalis
O15555 270 GPDWGEGGYFRIIRRVN----ECGIEEQAYGPF 298 Giardia muris
Q40413 307 NRGWGDDGYFKIRRGTN----ECEIEDEVVAGL 335 Aztec tobacco
O23681 308 NRSWGDDGYFKIRRGTN----ECGIEQSVVAGL 336 thale cress
Q9ZSI0 310 NRGWGDDGYFMIRRGTN----ECGIEDEPVAGL 338 thale cress
O61066 301 NHEWGMNGYFLIARGVD----ECGIEGSGVAGI 329 Trypanosoma cruzi
P90627 308 NTDWGDKGYFLIQRGNN----ECKIESGGVAGI 336 Leishmania major
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