3DZU,1YY4,1N83


Conserved Protein Domain Family
Hormone_recep

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pfam00104: Hormone_recep (this model, PSSM-Id:215719 is obsolete and has been replaced by 333840)
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Ligand-binding domain of nuclear hormone receptor
This all helical domain is involved in binding the hormone in these receptors.
Statistics
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PSSM-Id: 215719
View PSSM: pfam00104
Aligned: 93 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3DZU_A       269 PVTNIC-QAADKQLFTLVEWAKR-IPHFS-EL-PLDDQV-ILLRAGWNELLIASFSHRSI-------A------VKDGIL 330
gi 82257428  234 RSPEPQ-PGQSRCFTTSPLWLQV-----------------TLLKYGVHEAIFAMLPSLMN---------------KDGLL 280
gi 10720385  288 IVLSAEsTVLSNSLNESLSLAREnLSELLfKViKHSRNK-TSISAANSLSTILHFVYESRnla--srI------RQSQQP 358
gi 17369901  205 GSSEQR-NAVANA-----------FEIIE-RL-QLDNREyMMLKH-FTMWRDTPSAIQIV-----------------FQL 252
gi 14917017  394 DETIAL-RILHGELHATKKLLMA-MPQIS-EI-QPADFQ-ILLSRSFFAIMAIRVANRCG-------N------STDTIM 455
gi 74959553  103 PLNYRC--WLFLTAVSTIDFMKK-FPFVF-LS-NSHDQT-IILRKKFVKVASFCEAFRVYl------F------RDKQLA 164
gi 75037406  105 VVFTSH-DWVAIEAFTTLEFMKR-IHFVK-ML-NADEAN-LILKHSFFTLSIVFMAGRSYf------D------KKEFMV 167
gi 268561418 198 PVRQMF-AIFEKQMIVVAEWLIQ-QPDFR-LL-DATERW-QFFKCVWNMWRRFERFEMSVk------MfgmktvNEKKFA 266
gi 309361926 219 RLDQLV-DMWGSEMTKVAEFMMH-SEEFR-HL-SSEEKF-SIFKLVWQISQRFEKLTMSLeifgkraL------EEKILI 287
gi 268558602 199 DVTTTV-EWLNERIYKYSCWFAS-SKSLM-SL-PMDQKM-QVFRSSWNVVRTFERLEQSVk------V------FEEDVM 261
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3DZU_A       331 LA-------------TGLHVHR-NSAH---SAgv------gAIFD-------R-----------VLT---------ELVS 360
gi 82257428  281 VA-------------NGKGFVT-REFL---RSlr------kPFSEi-----mE-----------PKF---------EFAV 312
gi 10720385  359 FF-------------VRDSDPK-IPFH---KIlt------dIINPe-----vSdlllttancrkLST---------QMGS 401
gi 17369901  253 AS-------------IQNFTHR-TEPT---RYiqcinaiaaIPTTs-----iIdvlfrpsigsaSMP---------RLIQ 301
gi 14917017  456 FE-------------SGELFSL-NAFP---AC----------FQQi-----iR-----------FMV---------DKAR 483
gi 74959553  165 FP-------------DGSSILI-EGLD---SE----------LGDr-----iK-------------Y---------RLVV 190
gi 75037406  168 FP-------------GKVDVFP-EEIS---DQ---------YPLDl-----lN-----------RIR---------CRLI 196
gi 268561418 267 IS-------------NEQVINVgFHID---FTei-----tdIPNEk-----vQ-----------QMFrdsmvklfhEVAK 309
gi 309361926 288 TS-------------NTTAIQM-EHVNvdlSKit------dYTSIe-----lR-----------NMFhpfcsrlydDVAR 331
gi 268558602 262 KFgsmvvtddfamqwDKTYVDL-ASIT---ELtn------qYFNKlfepfmhR-----------YIE---------EVAR 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3DZU_A       361 -KMRDM-QM----DKTELGCLRAIVLFNP-----DSKGLS--------NPAeVEALREKVYASLEAYCk-------HKY- 413
gi 82257428  313 -KFNAL-EL----DDSDLALFVAAIILCGge-aaGGFHTRgr-----rSPRv--DQREAGGAEPGQHP--------AGPg 370
gi 10720385  402 -SLSSV-PPvpppSDTVPLFHFSPPSLSP-----CQISAPp-------PPQ--QQYTDYSQMPSTSSYpans-spfQSPy 464
gi 17369901  302 dMFKPPqQP----TPTSLFPMANFNLNFL-----LKQEKTe-------TEE-GEDIEEEDDATSSNQF--------DENs 356
gi 14917017  484 -TFSSLvDW----EPQAFAAFIALQFLAGn----TEHNVLgl-----tNKPlVDQVQSTIINALKDHCsgsqnklaKIVr 549
gi 74959553  191 -TFFEL-HI----TNEEFLLLLVLLFSNPgcfleAGIQSLlnfhlpftIES-LSQTGSRLLSAYQNYYsss---llEYCm 260
gi 75037406  197 sKFIEL-RI----TTEEFLLMVITYFCQI-----SSMLVGs------sAKRiIEEYLSIYLSTLGINC--------NFRf 252
gi 268561418 310 -PLFEL-RP----SSVEMAYMLTQMSWQV-----AGKQMQg------kVVEiGERVCDEMANNLHSYYl-------KEEm 365
gi 309361926 332 -PLLDL-DP----SSIEISYMLCQIIWHI-----AGKTMQg------dILAaGEKFIAKIADDLHQYYm-------KEYk 387
gi 268558602 312 -PLLDL-KP----TTEEVVFCMVHLI-GL-----EDADFAl------eTQEaCEQMRAEIADQMHTYYt-------NQTd 366
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
3DZU_A       414 -PEq---PGRFAKL--LLRLPALR------------SI----------GLKCLEH--------------LFFFKLI 447
gi 82257428  371 pPPp---SQPLGLS--LPLPQAAAedgrpppagdgeRP----------PGSENQK--------------DGVGDLA 417
gi 10720385  465 rPNs---LSSFPKIp-LEMTKSIE------------EFlrpngmttdeMNKPLEKnwadgfrltpvfnkDIVSQFF 524
gi 17369901  357 sTD----DRSVGELdpVQLFLALN------------SS----------TQPSSASspss-------srpRHSIRSI 399
gi 14917017  550 lTQe---FDVFHALg-LQALDILY------------PS----------HQLPEEF--------------MFLINLT 585
gi 74959553  261 lTYlkngPTRFAEL--LDVFQVVG------------QH----------YEDLNRY--------------FVLLQLT 298
gi 75037406  253 qKHg---RIRYLNI--IFLSQLIE------------KT----------IEDLAQL--------------FTLFQLN 287
gi 268561418 366 rSNy---AGRLVRL--MSVVNAVK------------KI----------HMERRKT--------------MELARIF 400
gi 309361926 388 mANy---AGRLIKL--MTVVNSLQ------------RI----------HLDRLKI--------------MELAKIF 422
gi 268558602 367 iKMy---SHRLLIL--MKLVKSMK------------RI----------SREKSKI--------------KELIWLF 401
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