2ZMD,3R00,3Q4T,3Q4U,1X8B,1YM7


Conserved Protein Domain Family
Pkinase

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pfam00069: Pkinase (this model, PSSM-Id:215690 is obsolete and has been replaced by 333812)
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Protein kinase domain
Statistics
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PSSM-Id: 215690
View PSSM: pfam00069
Aligned: 54 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ZMD_A        58 YSILKQIGSGGSSKVFQVLNEKKQI-YAIKYVNLEEADNQTLdsy------rnEIAYLNKL-QqhSDKIIRLYDYEIT-- 127
gi 464401     59 FRLVRRLGRGGMGAVYLGEHVSIGSrVAVKVLHAHLTMYPELvqr-----fhaEARAVNLI-G--HENIVSIFDMDAT-- 128
gi 341940540  25 YHLKQVIGRGSYGVVYKAINKHTDQvVAIKEVVYENDEELNDim--------aEISLLKNL-N--HNNIVKYHGFIRK-- 91
gi 115195    394 WIRGALIGSGSFGQVYLGMNASSGElMAVKQVILDSVSESKDrhaklldalagEIALLQEL-S--HEHIVQYLGSNLN-- 468
gi 417818    620 YANLVKIGQGASGGVYTAYEIGTNVsVAIKQMNLEKQPKKELii--------nEILVMKGS-K--HPNIVNFIDSYVL-- 686
gi 134968    191 LVQLGKIGAGNSGTVVKALHVPDSKiVAKKTIPVEQNNSTIInql------vrELSIVKNVkP--HENIITFYGAYYNqh 262
gi 417302    221 IETLGILGEGAGGSVSKCKLKNGSKiFALKVINTLNTDPEYQkqi------frELQFNRSF-Q--SEYIVRYYGMFTDd- 290
gi 115194     66 LEVVRHLGEGNGGAVSLVKHRNI---FMARKTVYVGSDSKLQkqi------lrELGVLHHC-R--SPYIVGFYGAFQY-- 131
gi 125616    191 FTIHGALTPGSEGCVFDSSHPDYPQrVIVKAGWYTSTSH--------------EARLLRRL-D--HPAILPLLDLHVV-- 251
gi 125620     53 FEVLQPLQSGSEGRVFVARRPGEADtVVLKVGQKPSTLM--------------EGMLLQRL-S--HDNVMRMKQMLAR-- 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ZMD_A       128 -DQYIYMVMECGn-iDLNswl-------------kkKKSIDPWERKSYWKNMLEAVHTIHQ-HGIVHSDLKPANFLIV-D 190
gi 464401    129 -PPRPYLIMEFLdgaPLSaw---------------vGTPLAAGAVVSVLSQVCDALQAAHA-RGIVHRDLKPDNIFLVrR 191
gi 341940540  92 -SYELYILLEYCangSLRrli------------srsSTGLSENESKTYVTQTLLGLKYLHG-EGVIHRDIKAANILLSaD 157
gi 115195    469 -SDHLNIFLEYVpggSVAgll-------------tmYGSFEETLVKNFIKQTLKGLEYLHS-RGIVHRDIKGANILVDnK 533
gi 417818    687 -KGDLWVIMEYMeggSLTdv--------------vtHCILTEGQIGAVCRETLSGLEFLHS-KGVLHRDIKSDNILLSmE 750
gi 134968    263 iNNEIIILMEYSdcgSLDkilsvykrfvqrgtvsskKTWFNELTISKIAYGVLNGLDHLYRqYKIIHRDIKPSNVLINsK 342
gi 417302    291 eNSSIYIAMEYMggrSLDaiykn---------llerGGRISEKVLGKIAEAVLRGLSYLHE-KKVIHRDIKPQNILLNeN 360
gi 115194    132 -KNNISLCMEYMdcgSLDail-------------reGGPIPLDILGKIINSMVKGLIYLYNvLHIIHRDLKPSNVVVNsR 197
gi 125616    252 -SGVTCLVLPKYq-aDLYtyl------------srrLNPLGRPQIAAVSRQLLSAVDYIHR-QGIIHRDIKTENIFINtP 316
gi 125620    114 -GPATCLVLPHFr-cDLYsyl------------tmrDGPLDMRDAGCVIRAVLRGLAYLHG-MRIMHRDVKAENIFLEdV 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ZMD_A       191 GML----KLIDFGIAnqm----qpDTTSVVKDSQVGAVNYMPPEAIKdmsssrengksKSKISPKSDVWSLGCILYYMTY 262
gi 464401    192 NGNapfvKVLDFGIAkla----daHMPQTHAGIIVGTPEYMAPEQSL-----------GRGVDGRADLYALGVIAYQLLT 256
gi 341940540 158 NTV----KLADFGVS---------TIVNSSALTLAGTLNWMAPEILG-----------NRGASTLSDIWSLGATVVEMLT 213
gi 115195    534 GKI----KISDFGISkklelnstsTKTGGARPSFQGSSFWMAPEVVK-----------QTMHTEKTDIWSLGCLVIEMLT 598
gi 417818    751 GDI----KLTDFGFCaq------iNELNLKRTTMVGTPYWMAPEVVS-----------RKEYGPKVDIWSLGIMIIEMIE 809
gi 134968    343 GQI----KLCDFGVSk--------KLINSIADTFVGTSTYMSPERIQ-----------GNVYSIKGDVWSLGLMIIELVT 399
gi 417302    361 GQV----KLCDFGVSg--------EAVNSLATTFTGTSFYMAPERIQ-----------GQPYSVTSDVWSLGLTILEVAN 417
gi 115194    198 GEI----KLCDFGVSg--------ELVNSVAQTFVGTSTYMSPERIR-----------GGKYTVKSDIWSLGISIIELAT 254
gi 125616    317 EDI----CLGDFGAAcfv----qgSRSSPFPYGIAGTIDTNAPEVLA-----------GDPYTTTVDIWSAGLVIFETAV 377
gi 125620    179 DTV----CLGDLGAAr-------cNVAAPNFYGLAGTIETNAPEVLA-----------RDRYDTKVDVWGAGVVLFETLA 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ZMD_A       263 GKTPFQ-QI-------INQISKLHAIIDPNHEIEFPDIPE--------------------------------KDLQDVLK 302
gi 464401    257 GRLPFN-DEg-----lAAQLVAHQLRPPPPPSSVYPAVS---------------------------------AALEHVIL 297
gi 341940540 214 KNPPYH-NLt-----dANIYYAVENDTYYPPSSFS-------------------------------------EPLKDFLS 250
gi 115195    599 SKHPYP-NCd-----qMQAIFRIGENILPEFPSNIS------------------------------------SSAIDFLE 636
gi 417818    810 GEPPYL-NEt-----pLRALYLIATNGTPKLKEPENLS----------------------------------SSLKKFLD 849
gi 134968    400 GEFPLG-GHndtpdgiLDLLQRIVNEPSPRLPKDRIYS----------------------------------KEMTDFVN 444
gi 417302    418 GKFPCS-SEk-----mAANIAPFELLMWILTFTPELKDEPesni-------------------------iwsPSFKSFID 466
gi 115194    255 QELPWSfSNiddsigiLDLLHCIVQEEPPRLPSSFP------------------------------------EDLRLFVD 298
gi 125616    378 HNASLF-SAprgpkrgPCDSQITRIIRQAQVHVDEFSPHPesrltsryrsraagnnrppytrpawtryykmdIDVEYLVC 456
gi 125620    237 --YPKT-ITggdepaiNGEMHLIDLIRALGVHPEEFPPDTrlrsefvryagthrq---pytqyarvarlglpETGAFLIY 310
                        330       340
                 ....*....|....*....|...
2ZMD_A       303 CCLKRDPKQRIS-IPELLAHPYV 324
gi 464401    298 RALAKKPEDRYAsIAAFRNALQV 320
gi 341940540 251 KCFVKNMYKRPT-ADQLLKHVWI 272
gi 115195    637 KTFAIDCNLRPT-ASELLSHPFV 658
gi 417818    850 WCLCVEPEDRAS-ATELLHDEYI 871
gi 134968    445 RCCIKNERERSS-IHELLHHDLI 466
gi 417302    467 YCLKKDSRERPS-PRQMINHPWI 488
gi 115194    299 ACLHKDPTLRAS-PQQLCAMPYF 320
gi 125616    457 KALTFDGALRPS-AAELLCLPLF 478
gi 125620    311 KMLTFDPVRRPS-ADEILNFGMW 332
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