1UH9,1OEW,1ZAP


Conserved Protein Domain Family
Asp

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pfam00026: Asp (this model, PSSM-Id:215663 is obsolete and has been replaced by 394983)
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Eukaryotic aspartyl protease
Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.
Statistics
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PSSM-Id: 215663
Aligned: 23 rows
Threshold Bit Score: -1
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1UH9_A  16 EYYGQVTIGTPGKKFNLDFDTGSSDLWIA---STLCTNC--------------------G-SRQTKYDPNQSSTYQAD-G 70  Rhizopus microsporus ...
P00799  88 EYAIPVSIGTPGQDFLLLFDTGSSDTWVP---HKGCTKSe-------------------GcVGSRFFDPSASSTFKAT-N 144 Mucor miehei
P12630  44 YYATTLDIGTPSQSLTVLFDTGSADFWVMdssNPFCLPNsntssysnatyngeevkpsiDcRSMSTYNEHRSSTYQYL-E 122 Saccharomyces cerevis...
1OEW_A  16 AYITPVQIGTPAQTLNLDFDTGSSDLWVF---SSETTAS--------------------EvX-QTIYTPSKSTTAKLLsG 71  chestnut blight fungus
P17946  84 EYLTPVTVG--KSTLHLDFDTGSADLWVF---SDELPSS--------------------EqTGHDLYTPS-SSATKLS-G 136 Aspergillus awamori
P22929  74 FYLTTIEIGTPGQKLQVDVDTGSSDLWVP----GQGTSS-----------------------LYGTYDHTKSTSYKKD-R 125 Saccharomycopsis fibu...
P32950  74 SYGIRVSVGSNKQEQQVVLDTGSSDFWVVd-sSASCQKG--------------------NcKQYGTFDPHSSTSFKSL-G 131 Candida parapsilosis
P32951  75 SYASKVSVGSNKQQQTVIIDTGSSDFWVVd-sNAQCGKGv-------------------DcKSSGTFTPSSSSSYKNL-G 133 Candida parapsilosis
1ZAP_A  13 TYAADITVGSNNQKLNVIVDTGSSDLWVPd-vNIDCQVTysdq-------------tadFcKQKGTYDPSGSSASQDL-N 77  Candida albicans
Q00663  73 SYAADIVVGSNQQKQTVVIDTGSSDLWVVd-tDAECQVTysgq-------------tnnFcKQEGTFDPSSSSSAQNL-N 137 Candida tropicalis
1UH9_A  71 RTW-SISYGDGSsASGILAKDNVNLGGLLIKGQTIELAKReaa------sfASGPNDGLLGLGFDTITTVRg-------- 135 Rhizopus microsporus ...
P00799 145 YNL-NITYGTGG-ANGLYFEDSIAIGDITVTKQILAYVDNvrgptaeqspnADIFLDGLFGAAYPDNTAMEaey----gs 218 Mucor miehei
P12630 123 NGRfYITYADGTfADGSWGTETVSINGIDIPNIQFGVAKY-----------ATTPVSGVLGIGFPRRESVKgyega-pne 190 Saccharomyces cerevis...
1OEW_A  72 ATW-SISYGDGSsSSGDVYTDTVSVGGLTVTGQAVESAKKvss-----sftEDSTIDGLLGLAFSTLNTVSpt------- 138 chestnut blight fungus
P17946 137 YTW-DISYGDGSsASGDVYRDTVTVGGVTTNKQAVEAASKiss-----efvQNTANDGLLGLAFSSINTVQpk------- 203 Aspergillus awamori
P22929 126 SGF-SISYGDGSsARGDWAQETVSIGGASITGLEFGDATS------------QDVGQGLLGIGLKGNEASAqssn---sf 189 Saccharomycopsis fibu...
P32950 132 SSFrSIGYGDKSsSIGTWGQDTIYLGGTSITNQRFADVTS------------TSVNQGILGVGRVETESANp-------- 191 Candida parapsilosis
P32951 134 AAF-TIRYGDGStSQGTWGKDTVTINGVSITGQQIADVTQ------------TSVDQGILGIGYTSNEAVYdtsgrqttp 200 Candida parapsilosis
1ZAP_A  78 TPF-SIGYGDGSsSQGTLYKDTVGFGGVSIKNQVLADVDS------------TSIDQGILGVGYKTNEAGGs-------- 136 Candida albicans
Q00663 138 QDF-SIEYGDLTsSQGSFYKDTVGFGGISIKNQQFADVTT------------TSVDQGIMGIGFTAVEAGYn-------- 196 Candida tropicalis
1UH9_A 136 -VKTPMDNLISQGLISRPIFGVYLGKAKngGGGEYIFGGYDSTKFKGSLTTVPIDn---------SRGWWGITVDRATVG 205 Rhizopus microsporus ...
P00799 219 tYNTVHVNLYKQGLISSPLFSVYMNTNS--GTGEVVFGGVNNTLLGGDIAYTDVMsr------ygGYYFWDAPVTGITVD 290 Mucor miehei
P12630 191 yYPNFPQILKSEKIIDVVAYSLFLNSPDs-GTGSIVFGAIDESKFSGDLFTFPMVneyp--tivdAPATLAMTIQGLGAQ 267 Saccharomyces cerevis...
1OEW_A 139 qQKTFFDNAKAS--LDSPVFTADLGYHA---PGTYNFGFIDTTAYTGSITYTAVSt---------KQGFWEWTSTGYAVG 204 chestnut blight fungus
P17946 204 aQTTFFDTVKSQ--LDSPLFAVQLKHDA---PGVYDFGYIDDSKYTGSITYTDADs---------SQGYWGFSTDGYSIG 269 Aspergillus awamori
P22929 190 tYDNLPLKLKDQGLIDKAAYSLYLNSEDa-TSGSILFGGSDSSKYSGSLATLDLVniddegdstsGAVAFFVELEGIEAG 268 Saccharomycopsis fibu...
P32950 192 pYDNVPITLKKQGKIKTNAYSLYLNSPGa-ATGTIIFGGVDNAKYSGKLIEEPLV----------SDRYLAVNLKSLNYN 260 Candida parapsilosis
P32951 201 nYDNVPVTLKKQGKIRTNAYSLYLNSPSa-ETGTIIFGGVDNAKYSGKLVAEQVT----------SSQPLTISLASVNLK 269 Candida parapsilosis
1ZAP_A 137 -YDNVPVTLKKQGVIAKNAYSLYLNSPDs-ATGQIIFGGVDNAKYSGSLIALPVT----------SDRELRISLGSVEVS 204 Candida albicans
Q00663 197 lYSNVPVTLKKQGIINKNAYSCDLNSEDa-STGKIIFGGVDNAKYTGTLTALPVT----------SSVELRVHLGSINFD 265 Candida tropicalis
1UH9_A 206 TS------TVASS-FDGILDTGTTLLILPNNIAASVARAYGASDNG-----DGTYTISCDTS-RFKPLVFSINGASFQVS 272 Rhizopus microsporus ...
P00799 291 GSa----aVRFSRpQAFTIDTGTNFFIMPSSAASKIVKAALPDATEt----QQGWVVPCASYqNSKSTISIVMQKSGSSS 362 Mucor miehei
P12630 268 NKssceheTFTTTkYPVLLDSGTSLLNAPKVIADKMASFVNASYSEe----EGIYILDCPVSvGDVEYNFDFGDLQISVP 343 Saccharomyces cerevis...
1OEW_A 205 SG------TFKSTsIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSs---sVGGYVFPCSAT--LPSFTFGVGSARIVIP 273 chestnut blight fungus
P17946 270 DG------SSSSSgFSAIADTGTTLILLDDEIVSAYYEQVSGASGEt---eAGGYVFSCSTN--PPDFTVVIGDYKAVVP 338 Aspergillus awamori
P22929 269 SS------SITKTtYPALLDSGTTLIYAPSSIASSIGREYGTYSYS-----YGGYVTSCDAT--GPDFKFSFNGKTITVP 335 Saccharomycopsis fibu...
P32950 261 GD------NSNAG-FGVVVDSGTTISYLPDSIVNDLANKVGAYLEPvglgnE-LYFIDCNANpQGSASFTFDNGAKITVP 332 Candida parapsilosis
P32951 270 GS------SFSFG-DGALLDSGTTLTYFPSDFAAQLADKAGARLVQvardqY-LYFIDCNTDtSGTTVFNFGNGAKITVP 341 Candida parapsilosis
1ZAP_A 205 GK------TINTDnVDVLLDSGTTITYLQQDLADQIIKAFNGKLTQdsngnS-FYEVDCNLS--GDVVFNFSKNAKISVP 275 Candida albicans
Q00663 266 GT------SVSTN-ADVVLDSGTTITYFSQSTADKFARIVGAT--WdsrneI-YRLPSCDLS--GDAVVNFDQGVKITVP 333 Candida tropicalis
1UH9_A 273 PDSLVFEEFQGq----------CIAGFGYg--NWDFAIIGDTFLKNNYVVFN-QGVPEVQIAPV 323 Rhizopus microsporus var. chinensis
P00799 363 DTIEISVPVSKmllpvdqsnetCMFIILPd--GGNQYIVGNLFLRFFVNVYD-FGNNRIGFAPL 423 Mucor miehei
P12630 344 LSSLILSPETEgs--------yCGFAVQP---TNDSMVLGDVFLSSAYVVFD-LDNYKISLAQA 395 Saccharomyces cerevisiae S288c
1OEW_A 274 GDYIDFGPISTgs-------ssCFGGIQSs-aGIGINIFGDVALKAAFVVFNgATTPTLGFASK 329 chestnut blight fungus
P17946 339 GKYINYAPISTgs-------stCFGGIQSn-sGLGLSILGDVFLKSQYVVFN-SEGPKLGFAAQ 393 Aspergillus awamori
P22929 336 FSNLLFQNSEGds--------eCLVGVLSs--GSNYYILGDAFLRSAYVYYD-IDNSQVGIAQA 388 Saccharomycopsis fibuligera
P32950 333 LSEFVLQSTANa----------CVWGLQSsdrqNVPPILGDNFLRHAYAFQLdKETVLSRSGEV 386 Candida parapsilosis
P32951 342 NTEYVYQNGDGt----------CLWGIQPsd----dtILGDNFLRHAYYLLYnLDANTISIAQV 391 Candida parapsilosis
1ZAP_A 276 ASDFAASTQGDdgqp----ydkCQLLFDVnk----anILGDNFLRSAYIVYD-LDDNEISIAQV 330 Candida albicans
Q00663 334 LSELILKDSDSs---------iCYFGISRnd----anILGDNFLRRAYIVYD-LDDKTISLAQV 383 Candida tropicalis
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