Conserved Protein Domain Family
COG6

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smart01087: COG6 
Conserved oligomeric complex COG6
COG6 is a component of the conserved oligomeric golgi complex, which is composed of eight different subunits and is required for normal golgi morphology and localisation.
Statistics
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PSSM-Id: 215018
Aligned: 22 rows
Threshold Bit Score: 417.108
Created: 13-Jul-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001468426  170 KTITSTALRSALDHRTIDVHKSFLQEFTAVYQSYQRVAAQVNELQSKCSSLEDTLNTTagrpSREVEDFFYQIQAYQAEL 249  Leishmania in...
XP_959603      76 VAENRRKLRLDLQKEVIDSNGEIIHEFGKVAEQLKRIGYTIGKLNESYNDMRTQIHAA----HASTASTLGEASQLMTQK 151  Neurospora cr...
XP_751125      68 TAETRRQLRLDVQKEVVECNAEIVRDFGKVAEQLQRIGTVISSLNQTCEEMRQHIVRA----KQDTAPVIEEASALMNQK 143  Aspergillus f...
XP_505497      38 TASIRRSLRANTEAEVIKANGEALKKFAPLVAQIQASGNTIADLNHKFTLMQQLVNTC----KNDTRHVVSEGSELMAQQ 113  Yarrowia lipo...
XP_459774     145 S-NSRKKLRGEIENDLIKTQGLMLKEYQPVIKNLSNLENDLKNLNGLRDSITEKVNKD----FQSTKDLNGEVKNLNDTK 219  Debaryomyces ...
XP_001384029  166 SM-SRKKLRGKVENELIKNQSLVLKEYQPVIKQLKVVEDRLSKLNDLNKVTNDNIENK----FKYSSEFNTKVKELNSEK 240  Pichia stipit...
A6ZS37        193 TL-ARRALRTDLESQLLKEHITVLEEFKPIIRRIKRLSSSVEKIQRTSEKLLSNETNE----VPTNNVVLQEIDQYRLKA 267  Saccharomyces...
XP_446427     187 TL-ARKSLRTDLETQLLKDHVTVLEDFKPIVRRIKRLAAPVQQIENIGEEILKNDKET----FSQKY--ISDIDDCRNHL 259  Candida glabr...
XP_455261     150 TL-NRKSLRSKLENSMLNSHSDILSNFQSIARRIKRLSGPLERINNAMQNFKD-----------TTESIDFEFEHVKDRL 217  Kluyveromyces...
Q75AZ8        170 SL-SRKTLRSQLEKELLKDHLATLENFQPIARRIMRLRQPVKNIQEISEKVLD-AQEA----QNKSPLQDPLVSEVREKL 243  Ashbya gossyp...
XP_001468426  250 QLVRSHDKEVDEFRKQHHFGAAEQQVL--EEGAVDMNFLNVLERARQVHQRSSELMQsQEYHQ-GALAVMESTYGAITRA 326  Leishmania in...
XP_959603     152 RQIESKQKLLSTFKTHFILTQDEVDALtlTSEPVDDLFFTVLAKAKKISRDCEVLLG-FEDQT-LGLGIMEQVTRNLNHG 229  Neurospora cr...
XP_751125     144 KESETKQQLLDAFVKHFIVSEDDLLVLtsAEEPIDDRFFNVLDRVKQVHHDCEVLLG-GENQR-LGLELMEKSSRNLNSA 221  Aspergillus f...
XP_505497     114 ENISKKRDLLKRYTDAFVLTEREMDILkgNDEVPFETFKQVFIKAQKIHKDSEILLA-NDDTR-AGQITMYKANQALENA 191  Yarrowia lipo...
XP_459774     220 SLINLKKGLLISFQNKFALDVYEEYVL--QNGEINDEFFQVLIKCEKIHENCSILLS-VDNPQ-LGLKIMSKFNQLINKS 295  Debaryomyces ...
XP_001384029  241 RLINLKKNLLINFKAKFTLNEYEEFVLd--sGDINDEFFTVLKKAEEINANCSILLS-IENPQ-LGLKIMSKSNHLINRS 316  Pichia stipit...
A6ZS37        268 EQLKLKKKILLSIRDRFTLNQVEDDVIt--NGTIDNIFFEVVKKVINIKDESSFLLT-LPNLN-AGNALIMGVNEILEKT 343  Saccharomyces...
XP_446427     260 LKLEIKKKILKALQSKFTLNQLEDDLI--ENGPLKEEIFDIVDKLTKMKEHATYLLA-LPNSK-AGEVLIKQTNITLDTI 335  Candida glabr...
XP_455261     218 DQLKARRQVIIKLRDSLTLTQLELDHL--QNGTINDLFFQILNKINFIKEKATYLLS-NEKTTsAGVALLKTMNNNLTVS 294  Kluyveromyces...
Q75AZ8        244 EMLKLKKRVLVGIRESLTLNQLEDEQL--RNGEIEDSYLDVLDKMMEIKERSTYLIA-MNYEK-AGKALLGNINQYLQLA 319  Ashbya gossyp...
XP_001468426  327 TEKIARHL--------------LSTA-------GSG----EgrsagvaasaaaggagsiaADVP---------E----V- 367  Leishmania in...
XP_959603     230 FQKLYRWI--------------QREF-------KSL----N-------------------LENP---------Q----I- 251  Neurospora cr...
XP_751125     222 YQKLFRWI--------------QKKF-------KSL----N-------------------LEDP---------R----I- 243  Aspergillus f...
XP_505497     192 NNTLIRDT--------------ETSL-------INYaqlgE-------------------TDNF---------K----Q- 217  Yarrowia lipo...
XP_459774     296 VERIINFT--------------NKTL-------NNLy---S-------------------LNTT---------T----K- 318  Debaryomyces ...
XP_001384029  317 VERIINFT--------------NKTL-------SNL----Y-------------------SLNS---------K----Ar 339  Pichia stipit...
A6ZS37        344 NKKIFNYLidfly----sfessSNLL-------NDH----G-------------------TTEQ---------E----S- 375  Saccharomyces...
XP_446427     336 NKKISNYLidymytfesnsnmgTKHV-------IDP----T-------------------ERN----------------- 368  Candida glabr...
XP_455261     295 NKRIYNYL--------------INFI-------EEY----D-------------------TLSRqygertigdE----S- 325  Kluyveromyces...
Q75AZ8        320 NKRIYNYL--------------LRFLydyeyntDTF----G-------------------ERNF---------EgdnvG- 352  Ashbya gossyp...
XP_001468426  368 TGFQLR----------CVRLLYEEsPSLHEKFLDEVARLRRASVLRRYFHLLTTGSanTstglyqsggqpsaydggvgsr 437  Leishmania in...
XP_959603     252 GSAIRR----------ALRVLAER-PTLFQNCLDFFAEAREHVLSEAFYTALTGSSaaG--------------------- 299  Neurospora cr...
XP_751125     244 SSSIRR----------ALRVLAER-PSLFHSCLDFFADARDYALSDAFHYALTDTVsgS--------------------- 291  Aspergillus f...
XP_505497     218 DPQLRE----------RLSLLND---VNRAKTLGQFTETRRRQLLKSFTSALTENSqkN--------------------- 263  Yarrowia lipo...
XP_459774     319 LTTLHQ----------CLKFLRKR-LNYFNTVIDNFVDTRSRLIIDEFLNQINGDLdkS--------------------- 366  Debaryomyces ...
XP_001384029  340 LRTLHQ----------CMRYLKNK-LNYFSNVVNTFVDSRAKVLVDDFLSQIQGNLdsN--------------------- 387  Pichia stipit...
A6ZS37        376 LNIFRK----------SLVFLSSD-LELFNELLKRVTTLRSKSILDEFLSQFDMNSt----------------------- 421  Saccharomyces...
XP_446427     369 LALFQK----------GLVYLSND-IQYYDDFLKRVTTMRSKTLLDEFLSQFGTTSelS--------------------- 416  Candida glabr...
XP_455261     326 LSNFQT----------SLIHLSND-VQFFQDFLNRIVGLRSKRLLDDFLSQFDIDNkkL--------------------- 373  Kluyveromyces...
Q75AZ8        353 LSSFNAvwytcpptggTLMILSKG------------TSMRSKKLLDEFLIPFVIDNneG--------------------- 399  Ashbya gossyp...
XP_001468426  438 hgsseaG---------------M--G-------ARPLEAELNNPTYFFSSLCAWLHQTIAEEQDFIHNFF--------Vs 485  Leishmania in...
XP_959603     300 ------Le-------------dP--S-------VKPIELVAHDPLRYVGDMLAWSHSAAVGEREALEVLFisegdeiaK- 350  Neurospora cr...
XP_751125     292 ------G---------------GdrN-------VKPIEFSAHDPLRYVGDMLAWVHSTTVSEREALEALFvadgeeiaK- 342  Aspergillus f...
XP_505497     264 ------G--------------------------TKALDFYAYDCQRYIGDILAWVYSCVVLETENTSILI--------G- 302  Yarrowia lipo...
XP_459774     367 ------G---------------D--NrsgsiqhDRPIILSAHDPVRFIGDLLAYIHSVVVNETETISSIF--------G- 414  Debaryomyces ...
XP_001384029  388 ------GnvstfkrrsssisseT--S-------SRPIYVSAHDPIRFIGDLLAYVHSLVVNESDTIISIF--------T- 443  Pichia stipit...
A6ZS37        422 -------------------------T-------SKPIILSAHDPIRYIGDVLASVHSIIANEADFVKSLF--------D- 460  Saccharomyces...
XP_446427     417 ------T-----------------------------TISSSEDPVRYIGDVLATIHTMIANEVDFVKSLF--------Kf 453  Candida glabr...
XP_455261     374 ------Q---------------------------RPIILSAHDPVRYLGDVLAYVHSMIVNELEFLKSTF--------K- 411  Kluyveromyces...
Q75AZ8        400 ----------------------------------RSIILSAHDPARYLGDVLAHVHSLLANEGDFLKSLF--------K- 436  Ashbya gossyp...
XP_001468426  486 d---epEVGQGGrrshattAA-----PSSAclqagsdaaraardkarqqALLEGVFGGVCKHIRAALDNVLER------- 550  Leishmania in...
XP_959603     351 ------GIQVGR-------EA-----EVWRlvaedgeemnifdpvvalnQLVDRDMSGAVRILRQRVEQVIQTneetila 412  Neurospora cr...
XP_751125     343 ------GIQAGL-------SS-----EPWSridegeevs--fdgrkalnDLVNRDLVGVSRALRQRIELVIQGhdepvtc 402  Aspergillus f...
XP_505497     303 ------Qnd---------------------------------------sELVDNCTQSLCSPLRLRVERAVASqtrgpqi 337  Yarrowia lipo...
XP_459774     415 ------ISKEEN-------ED-----DDIEykd-------------iidDVTGRILNSLSRSVKSKIEQVITSetklati 463  Debaryomyces ...
XP_001384029  444 ------FETSE--------SE-----VEKKefet------------iikDIIDKILKSLVKPVKSKVTQIISAetklsts 492  Pichia stipit...
A6ZS37        461 -----------F-------QD-----EDLKdtpisilqqnktflkgidnKLLNDIIQSLSNSCRIRIEQIVRFeenpiin 517  Saccharomyces...
XP_446427     454 tsedmdKSSSMI-------IN-----NNAQyfdg------------ldlKLVNDIVQYLANSCKLRIEQVIRFeenkvin 509  Candida glabr...
XP_455261     412 ------LKSELV-------TSdsvlkDNMDfigd------------lhlKLLNEIFTSLANTIRIRLEQIVRFennpmln 466  Kluyveromyces...
Q75AZ8        437 -----------Y-------QE-----ERMAdmtqsifqknkdilqslhvNMLNDIMSTLSNSVRIRLEQIVRFeeeatvt 493  Ashbya gossyp...
XP_001468426  551 ---------------------------LGRTAAVLGAAtcsse---gegrASGCGSIaLSG-SA--DALAPrkgPRGLTG 597  Leishmania in...
XP_959603     413 fklanlin----fykstfsrlvgpasiLVEAMGTLETEalrqfrslardhVATLQTEfQHT-PP---DLRP---PDFLTD 481  Neurospora cr...
XP_751125     403 ykvvhlls----fyratfsrllgtksnLADMMQTLEKFtfsrfeslmleqVNTLSNDhAALtPP--DDLSA---PEFFLD 473  Aspergillus f...
XP_505497     338 fkiaglve-----fyksmlskhlpnsqLVDTLTQLTAFcnthftktcesrVRNVSVSlPTT-LS--SDLQP---PEFLTQ 406  Yarrowia lipo...
XP_459774     464 yaiyslvelytimfakhlkessndkhnLLMTVRELVSSsqnkiisiiqnkLTTIKSSnSAQ-LElnTDLQP---PEWIIE 539  Debaryomyces ...
XP_001384029  493 ysifnlve----lysmmftkqlsdtseVSIALKSLVKAsqdrlasiisnrLASIRTSnSAQ-LElnLDLQP---PEWIIE 564  Pichia stipit...
A6ZS37        518 feivrllkl---yrvmferkgiqddssIINNLKSLEDIsknriigyyedyMKQTVMAeTKN-SS--DDLLP---PEWLSE 588  Saccharomyces...
XP_446427     510 feitqlldl---yssmfvnkgirddnpLVLHLIQLRDIsekkiinsltkqLAETENTqISS-P----DLLP---PQWLSD 578  Candida glabr...
XP_455261     467 ldivqclsl---yqmmlvknginessqLMTSLNDLENLarskivssvtsyLKDLDKNqIAA-----ADLLP---PDWFVD 535  Kluyveromyces...
Q75AZ8        494 fdisqllsl---yklmftkqgmlddnkLVKVFDDLAVLaktktmnyytefLSEAVKEePEV-----TDLLP---PKWLSK 562  Ashbya gossyp...
XP_001468426  598 GLTRLfMAATGRSPIAA----FRGAGHDEsnallqryagvttraqqeaVASSMLRPPLQGI----------QTCVtlvq- 662  Leishmania in...
XP_959603     482 ALEQL-SAIMKTYETSLs---SSGDDPEAef---------------asIMAEAFDPFMAGC----------INMAnhatp 532  Neurospora cr...
XP_751125     474 ALEEL-TSLMKTHDASL----EAEDAESEstaen----------kftpVLRVAFDPFLQLA----------KSSAaelpd 528  Aspergillus f...
XP_505497     407 TLVDL-KEIL---EANQ----QYSLDEQVvr----------------kHIDNSLDPYMEFC----------RRVAsdgad 452  Yarrowia lipo...
XP_459774     540 FYSDI-LPIID-QNTSD----TFMNLSTEnn---------------aeFMKMIINKPIEIF----------NEHIennis 588  Debaryomyces ...
XP_001384029  565 FYSDL-LPILDQTTTDT----IFNF-TAEen---------------eeFMKLLVDEPIEIF----------FEHIgsnki 613  Pichia stipit...
A6ZS37        589 YMNKL-VELFEIYEKTH----AAEDEESEdnkl-----------lsskNLQTIVEQPIKDV----------LLKQlqtsf 642  Saccharomyces...
XP_446427     579 YLNSI-TELFDHVERLYggkrFSKDDIDSdkym-----------fpydTLKTVIEEPFMTS----------LIKQikdsy 636  Candida glabr...
XP_455261     536 YLSKL-SQLLNK-----------LEQQNEtril------------tddLYDKLILDPINNNlvlnlqnwfpTAKKeksar 591  Kluyveromyces...
Q75AZ8        563 YLSDL-TALFDKINGS-------SEQTGIvd---------------knFFTKLVKTPCEST----------FLKQaelcf 609  Ashbya gossyp...
XP_001468426  663 ------------------lfeyYTATTFAP-L--------L-G-------EDSALTRLIRKTAPQKTRELFQRLLHVLTA 707  Leishmania in...
XP_959603     533 psks----------iflincfvAARTTLSG-F--------T-F-------VRKYAADIQTKIEEEKARLVIAQYELFRAE 585  Neurospora cr...
XP_751125     529 atar---------aiyttnvllTARSTISA-Fa-------F-A-------SATHMDPISTALSSLRMELLEIQHRYLLDA 583  Aspergillus f...
XP_505497     453 fdae----------ifllncldQIIITLKL-Y--------S-A-------SEYKVDSFQSSVDEIEQVLTERLFHKFVKQ 505  Yarrowia lipo...
XP_459774     589 klfnrr-----dqvilklnfldLILSKIMPiI--------L-L-------SDKILE-LNDLTEKLSLELTNLQLDSLISG 646  Debaryomyces ...
XP_001384029  614 feskkd------qlilkhnfldLILSKLLP-I--------TiV-------SDKVIE-INEMINTLTQELTQLQLEAILKE 670  Pichia stipit...
A6ZS37        643 plakknekekaslltieincfdLIKSRLQP-F--------E-GlfaqdddSRKITIWVCDKLKEYTKQMLTLQIKFLFEN 712  Saccharomyces...
XP_446427     637 plakkkeeirivmltlqincfeMINFRLQP-YslsifsydE-S-------CKHILENIQHTLDETVEKLQKLQISLLFER 707  Candida glabr...
XP_455261     592 idll----------ivqinsfdLVKSKLGP-Fhsti-fssD-Y-------GKSVFSKLETQYTLCVTKLKETMNSYLFES 651  Kluyveromyces...
Q75AZ8        610 plakkdrrvkfdllvleingldMIVSRLGP-Yrtni-fsdE-Y-------GSEVYDSLKRSLDTLLGQLEVHQTRNILES 679  Ashbya gossyp...
XP_001468426  708 HLLDSTAGI-------------------------IGrtatlR---RLASSHALKQAADGDDAQGV-------Splaaerr 752  Leishmania in...
XP_959603     586 SGLDSLIEA-------------------------LDgl-diR---KKDDVGKVATLEEVQPEALR-------Q------- 622  Neurospora cr...
XP_751125     584 SGLGVLLTAlepfapsptiskpesegkdghappqVD-----K---QPTDIAEIADLPAFQPEALI-------A------- 641  Aspergillus f...
XP_505497     506 VGLGE----------------------------------------------------DLEPAHLS-------E------- 519  Yarrowia lipo...
XP_459774     647 CQLTNFYNI-------------------------IN-----MicpFSDDFFDVSIYQPITENKLF-------Sedn-iia 688  Debaryomyces ...
XP_001384029  671 CGLYDYYNI-------------------------VN-----MicpFSDDFFDTSIYEPIKENQLY-------Nkse-llk 712  Pichia stipit...
A6ZS37        713 TGLDLYSNL-------------------------VNmifpvD---SVKDELDYDMYLALRDNSLM-------Eldmvrkn 757  Saccharomyces...
XP_446427     708 TGLNMYYNL-------------------------MNmifpiD---SIQDEIDYDMYMSLVDNPLM-------Slenlekn 752  Candida glabr...
XP_455261     652 TGMELYFNL-------------------------FNmifpiI---SVQDELDYDMYLSAVENPIMklavihdN------- 696  Kluyveromyces...
Q75AZ8        680 TGLELYYNL-------------------------FNmifpvA---SVQDPLDYDMYLSAQENQIMkletietN------- 724  Ashbya gossyp...
XP_001468426  753 AVTKTGPSTFVLDFLVtftygnD-A-NSL-GGAPNGSESALLNDSESDIYMSFSSLSAAAA------------------- 810  Leishmania in...
XP_959603     623 SSQKLDDFLPSALIDA------T-E-KLK-NLQDSKLASSVIEEAAERFCVDFEHVEEMLL------------------- 674  Neurospora cr...
XP_751125     642 VGQQLDDFLPSALMDA------T-D-NLK-HLQSASFVQSVTEEAVEAFCRDFEFVEGMIIgadeargrvhikrmedgsd 712  Aspergillus f...
XP_505497     520 ISFQLDDFLPSALTDL------H-S-MLF-RISSPVIVDNIARNSTKKFVEEFSKLEGKVK------------------- 571  Yarrowia lipo...
XP_459774     689 ANDIIQNFLPSALLDI------Q-Q-SLF-KVNSPMIVNNIITNSSLEFIKFYLKFNLIIN------------------- 740  Debaryomyces ...
XP_001384029  713 INEIIQSYIPNALLDI------Q-S-SLL-KLNPPSIVNEVTTNASLEFVKYYGKLSQI--------------------- 762  Pichia stipit...
A6ZS37        758 VHDKLNYYLPQALTDV------QgN-LLF-KLTSPMIADEICDECFKKLSLFYNIFRKLLI------------------- 810  Saccharomyces...
XP_446427     753 IHEKLNDYLPQALPDF------Q-D-NLLiKLTSPSIADDVCEICFRTLTDFYCIFRRILK------------------- 805  Candida glabr...
XP_455261     697 IHEKLNTYLPLAVSDF------Q-DvKLF-NLMPPAVEEDIVSTCFGNFIKFYKVFKSVLN------------------- 749  Kluyveromyces...
Q75AZ8        725 IAQKLSDYLPKALLDVq-----D-T-WLL-YLASPKFADDIASRSFHVFANFYVVFKSVLL------------------- 777  Ashbya gossyp...
XP_001468426  811 ---------------TTR-FRQAN--------------DGQLLHHSAHDLRRVL 834  Leishmania infantum JPCM5
XP_959603     675 ---------------SAD-ELEEQrrveedgdeehsqsFRALFPRTSSEIRVLL 712  Neurospora crassa OR74A
XP_751125     713 agvqddvatesgkvsDGD-EQESK--------------LRRLFPRTTGEIRVLL 751  Aspergillus fumigatus Af293
XP_505497     572 ---------------DTY-KVESD--------------YRQFFPRTTEDVELLL 595  Yarrowia lipolytica CLIB122
XP_459774     741 ---------------EYL--------------------DDASLIWSDIEVATLL 759  Debaryomyces hansenii CBS767
XP_001384029  763 ---------------NSA-FLQET------------------FTWSDFEIATLL 782  Pichia stipitis CBS 6054
A6ZS37        811 ---------------HLY-------------------------PNKKDQVFEIL 824  Saccharomyces cerevisiae YJM789
XP_446427     806 ---------------HLYpDNKEK--------------VEAILNFTESEFKTLa 830  Candida glabrata CBS 138
XP_455261     750 ---------------KIYpEDEEM--------------IMSTLNFTTNEVSTLL 774  Kluyveromyces lactis NRRL Y-1140
Q75AZ8        778 ---------------NIFpDDHQR--------------INSIFIYSEEEVKMLL 802  Ashbya gossypii ATCC 10895
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